Self assembly of the transmembrane domain promotes signal transduction through the erythropoietin receptor

Current Biology

Volumn 11, Issue 2, 2001, Pages 110-115

  Kubatzky, Katharina F ^a   Ruan, Weiming ^b   Gurezka, Rolf ^b   Cohen, Jacob ^c   Ketteler, Robin ^a   Watowich, Stephanie S ^d   Neumann, Drorit ^c   Langosch, Dieter ^b   Klingmüller, Ursula ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c TEL AVIV UNIVERSITY   (Israel)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 0035936596     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00018-5     Document Type: Article

References (20)

1. Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor
2. An antagonist peptide-Epo receptor complex suggests that receptor dimerization is not sufficient for activation
3. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
4. Efficiency of signalling through cytokine receptors depends critically on receptor orientation
5. Membrane insertion of the bacterial signal transduction protein ToxR and requirements of transcription activation studied by modular replacement of different protein substructures
6. Dimerisation of the glycophorin A transmembrane segment in membranes probed with the ToxR transcription activator
7. A heptad motif of leucine residues found in membrane proteins can drive self-assembly of artificial transmembrane segments
8. The dimerization motif of the glycophorin A transmembrane segment in membranes: Importance of glycine residues
9. Homodimerization and constitutive activation of the erythropoietin receptor
10. The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells signals emanating from the erythropoietin receptor
11. Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation
12. Erythropoietin receptor activation by a ligand-induced conformation change
13. Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: A fluorescence resonance energy transfer study
14. Activation of Neu (ErB-2) mediated by disulfide bond-induced dimerization reveals a receptor tyrosine kinase dimer interface
15. Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations
16. A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling
17. Expression cloning of the murine erythropoietin receptor
18. Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors
19. Multiple tyrosine residues in the cytosolic domain of the erythropoietin receptor promote activation of STAT5
20. Role of cytokine signaling molecules in erythroid differentiation of mouse fetal liver hematopoietic cells: Functional analysis of signaling molecules by retrovirus-mediated expression