Identification of an oncogenic form of the thrombopoietin receptor MPL using retrovirus-mediated gene transfer

Blood

Volumn 88, Issue 4, 1996, Pages 1399-1406

  Onishi, Mayumi ^b   Mui, Alice L F ^b   Morikawa, Yoshihiro ^b   Cho, Lori ^b   Kinoshita, Shigemi ^b   Nolan, Garry P ^b   Gorman, Dan M ^b   Miyajima, Atsushi ^b   Kitamura, Toshio ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN MPL; PROTEIN TYROSINE KINASE; RECEPTOR; RECOMBINANT INTERLEUKIN 3; RECOMBINANT THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; GENE TRANSFER; LEUKEMIA; MOUSE; NONHUMAN; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETROVIRUS; SIGNAL TRANSDUCTION;

EID: 0029794142     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v88.4.1399.bloodjournal8841399     Document Type: Article

References (49)

1. Souyri M, Vigon I, Penciolelli JF, Heard JM, Tambourin P, Wendung F: A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 63:1137, 1990
2. Bazan JF: Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 87:6934, 1990
3. Vigon I, Mornon JP. Cocault L, Mitjavila MT, Tambourin P, Gisselbrecht S, Souyri M: Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: Identification of a member of the hematopoietic growth factor receptor superfamily. Proc Natl Acad Sci USA 89:5640, 1992
4. Vigon I, Florindo C, Fichelson S, Guenet JL, Mattei MG, Souyri M, Cosman D, Gisselbrecht S: Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: Molecular cloning, chromosomal location and evidence for a function in cell growth. Oncogene 8:2607, 1993
5. Skoda RC, Seldin DC, Chiang M-K, Peichel CL, Vogt TF, Leder P: Murine c-mpl: A member of the hematopietic growth factor receptor superfamily that transduces a proliferative signal. EMBO J 12:2645, 1993
6. Methia N, Louache F, Vainchenker W, Wendung F: Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 82:1395, 1993
7. Lok S, Kaushansky K, Holly RD, Kuijper JL, Lofton-Day CE, Oort PJ, Grant FJ, Heipel MD, Burkhead SK, Kramer JM, Bell LA. Sprecher CA, Blumberg H, Johnson R, Prunkard D, Ching AFT, Evans SJ, Sheppard PO, Presnell SR, O'Hara PJ, Hagen FS, Roth GJ, Foster DC: Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo. Nature 369:565, 1994
8. de Sauvage FJ, Hass PE, Spencer SD, Malloy BE, Gurney AL, Spencer SA, Darbonne WC, Henzel WJ, Wong SC, Kuang WJ, Oles KJ, Hultgren B, Lolberg LAJ, Goeddel DV, Eaton DL: Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369:533, 1994
9. Bartley TD, Bogenberger J, Hunt P, Li YS, Lu HS, Martin F, Chang MS, Samal B, Nichol JL, Swift S, Johnson ML, Hsu RY, Parker VP, Suggs S, Skrine JD, Merewether LA, Clogston C, Hsu E, Hokom MM, Hornkohl A, Choi E, Pangelinan M, Sun Y, Mar V, McNinch J, Simonet L, Jacobsen F, Xie C, Shutter J, Chute H, Basu R, Selander L, Trollinger D, Sieu L, Padilla D, Trail G, Elliott G, Izumi R, Covey T, Crouse J, Garcia A, Xu W, Castillo JD, Biron J, Cole S, Hu MCT, Pacifici R, Ponting I, Saris C, Wen D, Yung YP, Lin H, Bosselman RA: Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl. Cell 77:1117, 1994
10. Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth JD, Papapyannopoulou T, Foster DC: Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin. Nature 369:568, 1994
11. Kato T, Ogami K, Shimada Y, Iwamatsu A, Sohma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, Kobayashi K, Ohashi H, Ozawa T, Inoue H, Kawamura K, Miyazaki H: Purification and characterization of thrombopoietin. J Biochem 118:229, 1995
12. Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW: Thrombocytopenia in c-mpl-deficient mice. Science 265:1445, 1994
13. Yoshimura A, Longmore G, Lodish H: Point mutation in the exoplasmic domain of the erythropoietin receptor resulting in hormone-independent activation and tumorigenicity. Nature 348:647, 1990
14. Pear WS, Nolan GP, Scott ML, Baltimore D: Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 90:8392, 1993
15. Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. EMBO J 13:2182, 1994
16. Miyajima A, Schreurs J, Otsu K, Kondo A, Arai K, Maeda S: Use of the silkworm, Bombyx mori, and an insect baculovirus vector for high-level expression and secretion of biologically active mouse interleukin-3. Gene 58:273, 1987
17. Palacios R, Steinmetz, M: IL-3-dependent mouse clones that express B-220 surface antigen, contain lg genes in germ-line configuration, and generate B lymphocytes in vivo. Cell 41:727, 1985
18. Kitamura T, Tange T, Terasawa T, Chiba S, Kuwaki T, Miyagawa K, Piao Y-F, Miyazono K, Urabe A, Takaku F: Establishment and characterization of a unique human cell line that proliferates dependently on GM-CSF, IL-3, or erythropoietin. J Cell Physiol 140:323, 1989
19. Kitamura T, Onishi M, Kinoshita S, Shibuya A, Miyajima A, Nolan GP: Efficient screening of retroviral cDNA expression libraries. Proc Natl Acad Sci USA 92:9146, 1995
20. 3H]thymidine incorporation assay. J Immunol Methods 170:211, 1994
21. Mui AL-F, Wakao H, O'Farrell A, Harada N, Miyajima A: Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 14:1166, 1995
22. Greenberger JS, Sakakeeny MA, Humphries RK, Eaves CJ, Eckner RJ: Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell line. Proc Natl Acad Sci USA 80:2931, 1983
23. Hawley TS, McLeish WA, Hawley RG: Establishment of a novel factor-dependent myeloid cell line from primary cultures of mouse bone marrow. Cytokine 3:60, 1991
24. Morgenstern JP, Land H: Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 18:3587, 1990
25. Miyajima A, Mui AL, Ogorochi T, Sakamaki K: Receptors for granulocyte-macrophage colony-stimulating factor, interleukin3, and interleukin-5. Blood 82:1960, 1993
26. Darnell J Jr, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415, 1994
27. Mui AL, Miyajima A: Interleukin-3 and granulocyte-macrophage colony-stimulating factor receptor signal transduction. Proc Soc Exp Biol Med 206:284, 1994
28. Ihle JN, Kerr IM: Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet 11:69, 1995
29. Okuda K, Sanghera JS, Pelech SL, Hallek M, Griffin JD, Druker BJ: Granulocyte-macrophage colony-stimulating factor, interleukin-3, and Steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 79:2880, 1992
30. Welham MJ, Duronio V, Sanghera JS, Pelech SL, Schrader JW: Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members. J Immunol 149:1683, 1992
31. Sato N, Sakamaki K, Terada N, Arai K, Miyajima A: Signal transduction by the high-affinity GM-CSF receptor: Two distinct cytoplasmic regions of the common beta subunit responsible for different signaling. EMBO J 12:4181, 1993
32. Silvennoinen O, Witthuhn BA, Quelle FW, Cleveland JL, Yi T, Ihle JN: Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci USA 90:8429, 1993
33. Azam M, Erdjument-Bromage H, Kreider BL, Xia M, Quelle F, Basu R, Saris C, Tempst P, Ihle JN, Schindler C: Interleukin-3 signals through multiple isoforms of Stat5. EMBO J 14:1402, 1995
34. Sattler M, Durstin MA, Frank DA, Okuda K. Kaushansky K, Salgia R, Griffin JD: The thrombopoietin receptor c-MPL activates JAK2 and TYK tyrosine kinases. Exp Hematol 23:1040, 1995
35. Pallard C, Gouilleux F, Benit L, Cocault L, Souyri M, Levy D, Groner B, Gisselbrecht S, Dusanter-Fourt I: Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J 14:2847, 1995
36. Drachman JG, Griffin JD, Kaushansky K: The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl. J Biol Chem 270:4979, 1995
37. Gurney AL, Wong SC, Henzel WJ, de Sauvage FJ: Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and She phosphorylation. Proc Natl Acad Sci USA 92:5292, 1995
38. Ullrich A, Schlessinger J: Signal transduction by receptors with tyrosine kinase activity. Cell 61:203, 1990
39. Kitayama H, Kanakura Y, Furitsu T, Tsujimura T, Oritani K, Ikeda H, Sugahara H, Mitsui H, Kanayama Y, Kitamura Y, Matsuzawa Y: Constitutively activating mutations of c-kit receptor tyrosine kinase confer factor-independent growth and tumorigenicity of factor-dependent hematopoietic cell lines. Blood 85:790, 1995
40. Weiner DB, Liu J, Cohen JA, Williams WV, Greene MI: A point mutation in the neu oncogene mimics ligand induction of receptor aggregation. Nature 339:230, 1989
41. Watowich SS, Hilton DJ, Lodish HF: Activation and inhibition of erythropoietin receptor function: Role of receptor dimerization. Mol Cell Biol 14:3535, 1994
42. D'Andrea R, Rayner J, Moretti P, Lopez A, Goodall GJ, Gonda TJ, Vadas M: A mutation of the common receptor subunit for interleukin-3 (IL-3), granulocyte-macrophage colony-stimulating factor, and IL-5 that leads to ligand independence and tumorigenicity. Blood 83:2802, 1994
43. Mui ALF, Wakao H, Kinoshita T, Kitamura T, Miyajima A: Dominant negative STAT5 inhibits interleukin-3-dependent proliferation. EMBO J 15:2425, 1996
44. Witthuhn BA, Silvennoinen O, Miura O, Lai KS, Cwik C, Liu ET, Ihle JN: Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 370:153, 1994
45. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA. Ihle JN, Taniguchi T: Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science 266:1045, 1994
46. Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM. Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O, Goldman AS, Schmalstieg FC, Ihle JN, O'Shea JJ, Leonard WJ: Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: Implications for XSCID and XCID. Science 266:1042, 1994
47. Lin JX, Migone TS, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ: The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331, 1995
48. Jenkins BJ, D'Andrea R, Gonda TJ: Activating point mutations in the common β subunit of the human GM-CSF, IL-3 and IL-5 receptors suggest the involvement of βsubunit dimerization and cell type-specific molecules in signalling. EMBO J 14:4276, 1995
49. Alexander WS, Metcalf D, Dunn AR: Point mutations within a dimer interface homology domain of c-Mpl induce constitutive receptor activity and tumorgenicity. EMBO J 14:5569, 1995