메뉴 건너뛰기




Volumn 22, Issue 7, 2011, Pages 759-768

Interactions between subunits of the Mediator complex with gene-specific transcription factors

Author keywords

Coactivator; Mediator complex; RNA polymerase; Transcriptional regulation

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; CYCLIN DEPENDENT KINASE 8; GLUCOCORTICOID RECEPTOR; MEDIATOR COMPLEX; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN MED1; PROTEIN MED12; PROTEIN MED14; PROTEIN MED15; PROTEIN MED16; PROTEIN MED17; PROTEIN MED19; PROTEIN MED21; PROTEIN MED25; PROTEIN MED26; PROTEIN MED28; PROTEIN MED29; RNA POLYMERASE II; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 80455155050     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2011.07.022     Document Type: Review
Times cited : (104)

References (137)
  • 1
    • 77958111633 scopus 로고    scopus 로고
    • The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
    • Malik S., Roeder R.G. The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation. Nat Rev Genet 2010, 11:761-772.
    • (2010) Nat Rev Genet , vol.11 , pp. 761-772
    • Malik, S.1    Roeder, R.G.2
  • 2
    • 18844451820 scopus 로고    scopus 로고
    • Mediator and the mechanism of transcriptional activation
    • Kornberg R.D. Mediator and the mechanism of transcriptional activation. Trends Biochem Sci 2005, 30:235-239.
    • (2005) Trends Biochem Sci , vol.30 , pp. 235-239
    • Kornberg, R.D.1
  • 3
    • 77954759030 scopus 로고    scopus 로고
    • The human Mediator complex: a versatile, genome-wide regulator of transcription
    • Taatjes D.J. The human Mediator complex: a versatile, genome-wide regulator of transcription. Trends Biochem Sci 2010, 35:315-322.
    • (2010) Trends Biochem Sci , vol.35 , pp. 315-322
    • Taatjes, D.J.1
  • 4
    • 79953162883 scopus 로고    scopus 로고
    • Function and regulation of the Mediator complex
    • Conaway R.C., Conaway J.W. Function and regulation of the Mediator complex. Curr Opin Genet Dev 2011, 21:225-230.
    • (2011) Curr Opin Genet Dev , vol.21 , pp. 225-230
    • Conaway, R.C.1    Conaway, J.W.2
  • 5
    • 0025891809 scopus 로고
    • A mediator required for activation of RNA polymerase II transcription in vitro
    • Flanagan P.M., Kelleher R.J., Sayre M.H., Tschochner H., Kornberg R.D. A mediator required for activation of RNA polymerase II transcription in vitro. Nature 1991, 350:436-438.
    • (1991) Nature , vol.350 , pp. 436-438
    • Flanagan, P.M.1    Kelleher, R.J.2    Sayre, M.H.3    Tschochner, H.4    Kornberg, R.D.5
  • 6
    • 0025286261 scopus 로고
    • A novel mediator between activator proteins and the RNA polymerase II transcription apparatus
    • Kelleher R.J., Flanagan P.M., Kornberg R.D. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell 1990, 61:1209-1215.
    • (1990) Cell , vol.61 , pp. 1209-1215
    • Kelleher, R.J.1    Flanagan, P.M.2    Kornberg, R.D.3
  • 7
    • 0023805741 scopus 로고
    • Negative effect of the transcriptional activator GAL4
    • Gill G., Ptashne M. Negative effect of the transcriptional activator GAL4. Nature 1988, 334:721-724.
    • (1988) Nature , vol.334 , pp. 721-724
    • Gill, G.1    Ptashne, M.2
  • 8
    • 0024354605 scopus 로고
    • Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II
    • Nonet M.L., Young R.A. Intragenic and extragenic suppressors of mutations in the heptapeptide repeat domain of Saccharomyces cerevisiae RNA polymerase II. Genetics 1989, 123:715-724.
    • (1989) Genetics , vol.123 , pp. 715-724
    • Nonet, M.L.1    Young, R.A.2
  • 9
    • 0028282551 scopus 로고
    • A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II
    • Kim Y.J., Bjorklund S., Li Y., Sayre M.H., Kornberg R.D. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell 1994, 77:599-608.
    • (1994) Cell , vol.77 , pp. 599-608
    • Kim, Y.J.1    Bjorklund, S.2    Li, Y.3    Sayre, M.H.4    Kornberg, R.D.5
  • 10
    • 0029758906 scopus 로고    scopus 로고
    • Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex
    • Fondell J.D., Ge H., Roeder R.G. Ligand induction of a transcriptionally active thyroid hormone receptor coactivator complex. Proc Natl Acad Sci USA 1996, 93:8329-8333.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8329-8333
    • Fondell, J.D.1    Ge, H.2    Roeder, R.G.3
  • 11
    • 0040368298 scopus 로고    scopus 로고
    • Composite co-activator ARC mediates chromatin-directed transcriptional activation
    • Naar A.M., Beaurang P.A., Zhou S., Abraham S., Solomon W., Tjian R. Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 1999, 398:828-832.
    • (1999) Nature , vol.398 , pp. 828-832
    • Naar, A.M.1    Beaurang, P.A.2    Zhou, S.3    Abraham, S.4    Solomon, W.5    Tjian, R.6
  • 12
    • 0033614417 scopus 로고    scopus 로고
    • Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex
    • Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M., Naar A.M., et al. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature 1999, 398:824-828.
    • (1999) Nature , vol.398 , pp. 824-828
    • Rachez, C.1    Lemon, B.D.2    Suldan, Z.3    Bromleigh, V.4    Gamble, M.5    Naar, A.M.6
  • 13
    • 0033521956 scopus 로고    scopus 로고
    • The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1
    • Ryu S., Zhou S., Ladurner A.G., Tjian R. The transcriptional cofactor complex CRSP is required for activity of the enhancer-binding protein Sp1. Nature 1999, 397:446-450.
    • (1999) Nature , vol.397 , pp. 446-450
    • Ryu, S.1    Zhou, S.2    Ladurner, A.G.3    Tjian, R.4
  • 14
    • 0033636517 scopus 로고    scopus 로고
    • The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs
    • Malik S., Gu W., Wu W., Qin J., Roeder R.G. The USA-derived transcriptional coactivator PC2 is a submodule of TRAP/SMCC and acts synergistically with other PCs. Mol Cell 2000, 5:753-760.
    • (2000) Mol Cell , vol.5 , pp. 753-760
    • Malik, S.1    Gu, W.2    Wu, W.3    Qin, J.4    Roeder, R.G.5
  • 15
    • 0032135274 scopus 로고    scopus 로고
    • NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription
    • Sun X., Zhang Y., Cho H., Rickert P., Lees E., Lane W., et al. NAT, a human complex containing Srb polypeptides that functions as a negative regulator of activated transcription. Mol Cell 1998, 2:213-222.
    • (1998) Mol Cell , vol.2 , pp. 213-222
    • Sun, X.1    Zhang, Y.2    Cho, H.3    Rickert, P.4    Lees, E.5    Lane, W.6
  • 16
    • 0033587187 scopus 로고    scopus 로고
    • Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein
    • Boyer T.G., Martin M.E., Lees E., Ricciardi R.P., Berk A.J. Mammalian Srb/Mediator complex is targeted by adenovirus E1A protein. Nature 1999, 399:276-279.
    • (1999) Nature , vol.399 , pp. 276-279
    • Boyer, T.G.1    Martin, M.E.2    Lees, E.3    Ricciardi, R.P.4    Berk, A.J.5
  • 17
    • 0004788326 scopus 로고    scopus 로고
    • Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
    • Jiang Y.W., Veschambre P., Erdjument-Bromage H., Tempst P., Conaway J.W., Conaway R.C., et al. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Proc Natl Acad Sci USA 1998, 95:8538-8543.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8538-8543
    • Jiang, Y.W.1    Veschambre, P.2    Erdjument-Bromage, H.3    Tempst, P.4    Conaway, J.W.5    Conaway, R.C.6
  • 18
    • 0036678409 scopus 로고    scopus 로고
    • Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase
    • Brower C.S., Sato S., Tomomori-Sato C., Kamura T., Pause A., Stearman R., et al. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proc Natl Acad Sci USA 2002, 99:10353-10358.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10353-10358
    • Brower, C.S.1    Sato, S.2    Tomomori-Sato, C.3    Kamura, T.4    Pause, A.5    Stearman, R.6
  • 19
    • 2942575993 scopus 로고    scopus 로고
    • A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology
    • Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., et al. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Mol Cell 2004, 14:685-691.
    • (2004) Mol Cell , vol.14 , pp. 685-691
    • Sato, S.1    Tomomori-Sato, C.2    Parmely, T.J.3    Florens, L.4    Zybailov, B.5    Swanson, S.K.6
  • 21
    • 2942610696 scopus 로고    scopus 로고
    • A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
    • Bourbon H.M., Aguilera A., Ansari A.Z., Asturias F.J., Berk A.J., Bjorklund S., et al. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell 2004, 14:553-557.
    • (2004) Mol Cell , vol.14 , pp. 553-557
    • Bourbon, H.M.1    Aguilera, A.2    Ansari, A.Z.3    Asturias, F.J.4    Berk, A.J.5    Bjorklund, S.6
  • 22
    • 33646829646 scopus 로고    scopus 로고
    • Role of the mediator complex in nuclear hormone receptor signaling
    • Belakavadi M., Fondell J.D. Role of the mediator complex in nuclear hormone receptor signaling. Rev Physiol Biochem Pharmacol 2006, 156:23-43.
    • (2006) Rev Physiol Biochem Pharmacol , vol.156 , pp. 23-43
    • Belakavadi, M.1    Fondell, J.D.2
  • 25
    • 0036671095 scopus 로고    scopus 로고
    • Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction
    • Davis J.A., Takagi Y., Kornberg R.D., Asturias F.A. Structure of the yeast RNA polymerase II holoenzyme: Mediator conformation and polymerase interaction. Mol Cell 2002, 10:409-415.
    • (2002) Mol Cell , vol.10 , pp. 409-415
    • Davis, J.A.1    Takagi, Y.2    Kornberg, R.D.3    Asturias, F.A.4
  • 26
    • 64049097892 scopus 로고    scopus 로고
    • Mediator structural conservation and implications for the regulation mechanism
    • Cai G., Imasaki T., Takagi Y., Asturias F.J. Mediator structural conservation and implications for the regulation mechanism. Structure 2009, 17:559-567.
    • (2009) Structure , vol.17 , pp. 559-567
    • Cai, G.1    Imasaki, T.2    Takagi, Y.3    Asturias, F.J.4
  • 27
    • 0035834772 scopus 로고    scopus 로고
    • The structural and functional organization of the yeast mediator complex
    • Kang J.S., Kim S.H., Hwang M.S., Han S.J., Lee Y.C., Kim Y.J. The structural and functional organization of the yeast mediator complex. J Biol Chem 2001, 276:42003-42010.
    • (2001) J Biol Chem , vol.276 , pp. 42003-42010
    • Kang, J.S.1    Kim, S.H.2    Hwang, M.S.3    Han, S.J.4    Lee, Y.C.5    Kim, Y.J.6
  • 28
    • 0037039776 scopus 로고    scopus 로고
    • Structure, function, and activator-induced conformations of the CRSP coactivator
    • Taatjes D.J., Naar A.M., Andel F., Nogales E., Tjian R. Structure, function, and activator-induced conformations of the CRSP coactivator. Science 2002, 295:1058-1062.
    • (2002) Science , vol.295 , pp. 1058-1062
    • Taatjes, D.J.1    Naar, A.M.2    Andel, F.3    Nogales, E.4    Tjian, R.5
  • 29
    • 79953713243 scopus 로고    scopus 로고
    • Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly
    • Bernecky C., Grob P., Ebmeier C.C., Nogales E., Taatjes D.J. Molecular architecture of the human Mediator-RNA polymerase II-TFIIF assembly. PLoS Biol 2011, 9:e1000603.
    • (2011) PLoS Biol , vol.9
    • Bernecky, C.1    Grob, P.2    Ebmeier, C.C.3    Nogales, E.4    Taatjes, D.J.5
  • 32
    • 80051729454 scopus 로고    scopus 로고
    • Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization
    • Seizl M., Lariviere L., Pfaffeneder T., Wenzeck L., Cramer P. Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization. Nucleic Acids Res 2011.
    • (2011) Nucleic Acids Res
    • Seizl, M.1    Lariviere, L.2    Pfaffeneder, T.3    Wenzeck, L.4    Cramer, P.5
  • 33
    • 24044470632 scopus 로고    scopus 로고
    • A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer
    • Baumli S., Hoeppner S., Cramer P. A conserved mediator hinge revealed in the structure of the MED7.MED21 (Med7.Srb7) heterodimer. J Biol Chem 2005, 280:18171-18178.
    • (2005) J Biol Chem , vol.280 , pp. 18171-18178
    • Baumli, S.1    Hoeppner, S.2    Cramer, P.3
  • 36
    • 0035833996 scopus 로고    scopus 로고
    • Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells
    • Spahr H., Samuelsen C.O., Baraznenok V., Ernest I., Huylebroeck D., Remacle J.E., et al. Analysis of Schizosaccharomyces pombe mediator reveals a set of essential subunits conserved between yeast and metazoan cells. Proc Natl Acad Sci USA 2001, 98:11985-11990.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11985-11990
    • Spahr, H.1    Samuelsen, C.O.2    Baraznenok, V.3    Ernest, I.4    Huylebroeck, D.5    Remacle, J.E.6
  • 37
    • 34249826038 scopus 로고    scopus 로고
    • Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit
    • Backstrom S., Elfving N., Nilsson R., Wingsle G., Bjorklund S. Purification of a plant mediator from Arabidopsis thaliana identifies PFT1 as the Med25 subunit. Mol Cell 2007, 26:717-729.
    • (2007) Mol Cell , vol.26 , pp. 717-729
    • Backstrom, S.1    Elfving, N.2    Nilsson, R.3    Wingsle, G.4    Bjorklund, S.5
  • 38
    • 0342817958 scopus 로고    scopus 로고
    • Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation
    • Kwon J.Y., Park J.M., Gim B.S., Han S.J., Lee J., Kim Y.J. Caenorhabditis elegans mediator complexes are required for developmental-specific transcriptional activation. Proc Natl Acad Sci USA 1999, 96:14990-14995.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 14990-14995
    • Kwon, J.Y.1    Park, J.M.2    Gim, B.S.3    Han, S.J.4    Lee, J.5    Kim, Y.J.6
  • 39
    • 0035107050 scopus 로고    scopus 로고
    • Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters
    • Park J.M., Gim B.S., Kim J.M., Yoon J.H., Kim H.S., Kang J.G., et al. Drosophila Mediator complex is broadly utilized by diverse gene-specific transcription factors at different types of core promoters. Mol Cell Biol 2001, 21:2312-2323.
    • (2001) Mol Cell Biol , vol.21 , pp. 2312-2323
    • Park, J.M.1    Gim, B.S.2    Kim, J.M.3    Yoon, J.H.4    Kim, H.S.5    Kang, J.G.6
  • 40
    • 47249134314 scopus 로고    scopus 로고
    • Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex
    • Bourbon H.M. Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex. Nucleic Acids Res 2008, 36:3993-4008.
    • (2008) Nucleic Acids Res , vol.36 , pp. 3993-4008
    • Bourbon, H.M.1
  • 41
    • 0037178788 scopus 로고    scopus 로고
    • Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man
    • Boube M., Joulia L., Cribbs D.L., Bourbon H.M. Evidence for a mediator of RNA polymerase II transcriptional regulation conserved from yeast to man. Cell 2002, 110:143-151.
    • (2002) Cell , vol.110 , pp. 143-151
    • Boube, M.1    Joulia, L.2    Cribbs, D.L.3    Bourbon, H.M.4
  • 42
    • 0033786937 scopus 로고    scopus 로고
    • Mediator of transcriptional regulation
    • Myers L.C., Kornberg R.D. Mediator of transcriptional regulation. Annu Rev Biochem 2000, 69:729-749.
    • (2000) Annu Rev Biochem , vol.69 , pp. 729-749
    • Myers, L.C.1    Kornberg, R.D.2
  • 43
    • 0344270881 scopus 로고    scopus 로고
    • Association of the Mediator complex with enhancers of active genes
    • Kuras L., Borggrefe T., Kornberg R.D. Association of the Mediator complex with enhancers of active genes. Proc Natl Acad Sci USA 2003, 100:13887-13891.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 13887-13891
    • Kuras, L.1    Borggrefe, T.2    Kornberg, R.D.3
  • 44
    • 0034964368 scopus 로고    scopus 로고
    • Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF
    • Cosma M.P., Panizza S., Nasmyth K. Cdk1 triggers association of RNA polymerase to cell cycle promoters only after recruitment of the mediator by SBF. Mol Cell 2001, 7:1213-1220.
    • (2001) Mol Cell , vol.7 , pp. 1213-1220
    • Cosma, M.P.1    Panizza, S.2    Nasmyth, K.3
  • 45
    • 33646023157 scopus 로고    scopus 로고
    • Genome-wide location of the coactivator mediator: binding without activation and transient Cdk8 interaction on DNA
    • Andrau J.C., van de Pasch L., Lijnzaad P., Bijma T., Koerkamp M.G., van de Peppel J., et al. Genome-wide location of the coactivator mediator: binding without activation and transient Cdk8 interaction on DNA. Mol Cell 2006, 22:179-192.
    • (2006) Mol Cell , vol.22 , pp. 179-192
    • Andrau, J.C.1    van de Pasch, L.2    Lijnzaad, P.3    Bijma, T.4    Koerkamp, M.G.5    van de Peppel, J.6
  • 46
    • 33646075157 scopus 로고    scopus 로고
    • Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions
    • Zhu X., Wiren M., Sinha I., Rasmussen N.N., Linder T., Holmberg S., et al. Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions. Mol Cell 2006, 22:169-178.
    • (2006) Mol Cell , vol.22 , pp. 169-178
    • Zhu, X.1    Wiren, M.2    Sinha, I.3    Rasmussen, N.N.4    Linder, T.5    Holmberg, S.6
  • 48
    • 14844349559 scopus 로고    scopus 로고
    • Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator
    • Malik S., Baek H.J., Wu W., Roeder R.G. Structural and functional characterization of PC2 and RNA polymerase II-associated subpopulations of metazoan Mediator. Mol Cell Biol 2005, 25:2117-2129.
    • (2005) Mol Cell Biol , vol.25 , pp. 2117-2129
    • Malik, S.1    Baek, H.J.2    Wu, W.3    Roeder, R.G.4
  • 49
    • 0142123132 scopus 로고    scopus 로고
    • Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA
    • Cantin G.T., Stevens J.L., Berk A.J. Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA. Proc Natl Acad Sci USA 2003, 100:12003-12008.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12003-12008
    • Cantin, G.T.1    Stevens, J.L.2    Berk, A.J.3
  • 50
    • 33744948144 scopus 로고    scopus 로고
    • Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly
    • Baek H.J., Kang Y.K., Roeder R.G. Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly. J Biol Chem 2006, 281:15172-15181.
    • (2006) J Biol Chem , vol.281 , pp. 15172-15181
    • Baek, H.J.1    Kang, Y.K.2    Roeder, R.G.3
  • 51
    • 0036318299 scopus 로고    scopus 로고
    • TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4
    • Malik S., Wallberg A.E., Kang Y.K., Roeder R.G. TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4. Mol Cell Biol 2002, 22:5626-5637.
    • (2002) Mol Cell Biol , vol.22 , pp. 5626-5637
    • Malik, S.1    Wallberg, A.E.2    Kang, Y.K.3    Roeder, R.G.4
  • 52
    • 14644427848 scopus 로고    scopus 로고
    • Mediator requirement for both recruitment and postrecruitment steps in transcription initiation
    • Wang G., Balamotis M.A., Stevens J.L., Yamaguchi Y., Handa H., Berk A.J. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol Cell 2005, 17:683-694.
    • (2005) Mol Cell , vol.17 , pp. 683-694
    • Wang, G.1    Balamotis, M.A.2    Stevens, J.L.3    Yamaguchi, Y.4    Handa, H.5    Berk, A.J.6
  • 53
    • 13244272059 scopus 로고    scopus 로고
    • Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1
    • Vakoc C.R., Letting D.L., Gheldof N., Sawado T., Bender M.A., Groudine M., et al. Proximity among distant regulatory elements at the beta-globin locus requires GATA-1 and FOG-1. Mol Cell 2005, 17:453-462.
    • (2005) Mol Cell , vol.17 , pp. 453-462
    • Vakoc, C.R.1    Letting, D.L.2    Gheldof, N.3    Sawado, T.4    Bender, M.A.5    Groudine, M.6
  • 54
    • 38549113035 scopus 로고    scopus 로고
    • Differential chromatin looping regulates CD4 expression in immature thymocytes
    • Jiang H., Peterlin B.M. Differential chromatin looping regulates CD4 expression in immature thymocytes. Mol Cell Biol 2008, 28:907-912.
    • (2008) Mol Cell Biol , vol.28 , pp. 907-912
    • Jiang, H.1    Peterlin, B.M.2
  • 55
    • 58149333734 scopus 로고    scopus 로고
    • Long-range chromosomal interactions and gene regulation
    • Miele A., Dekker J. Long-range chromosomal interactions and gene regulation. Mol Biosyst 2008, 4:1046-1057.
    • (2008) Mol Biosyst , vol.4 , pp. 1046-1057
    • Miele, A.1    Dekker, J.2
  • 57
    • 0032493455 scopus 로고    scopus 로고
    • The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    • Yuan C.X., Ito M., Fondell J.D., Fu Z.Y., Roeder R.G. The TRAP220 component of a thyroid hormone receptor-associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci USA 1998, 95:7939-7944.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 7939-7944
    • Yuan, C.X.1    Ito, M.2    Fondell, J.D.3    Fu, Z.Y.4    Roeder, R.G.5
  • 58
    • 0030771856 scopus 로고    scopus 로고
    • Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor
    • Zhu Y., Qi C., Jain S., Rao M.S., Reddy J.K. Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptor. J Biol Chem 1997, 272:25500-25506.
    • (1997) J Biol Chem , vol.272 , pp. 25500-25506
    • Zhu, Y.1    Qi, C.2    Jain, S.3    Rao, M.S.4    Reddy, J.K.5
  • 59
    • 0037198679 scopus 로고    scopus 로고
    • Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis
    • Ge K., Guermah M., Yuan C.X., Ito M., Wallberg A.E., Spiegelman B.M., et al. Transcription coactivator TRAP220 is required for PPAR gamma 2-stimulated adipogenesis. Nature 2002, 417:563-567.
    • (2002) Nature , vol.417 , pp. 563-567
    • Ge, K.1    Guermah, M.2    Yuan, C.X.3    Ito, M.4    Wallberg, A.E.5    Spiegelman, B.M.6
  • 60
    • 0037022631 scopus 로고    scopus 로고
    • The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro
    • Kang Y.K., Guermah M., Yuan C.X., Roeder R.G. The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro. Proc Natl Acad Sci USA 2002, 99:2642-2647.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2642-2647
    • Kang, Y.K.1    Guermah, M.2    Yuan, C.X.3    Roeder, R.G.4
  • 61
    • 13044271699 scopus 로고    scopus 로고
    • Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer
    • Zhu Y., Qi C., Jain S., Le Beau M.M., Espinosa R., Atkins G.B., et al. Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP/PPARBP) gene in breast cancer. Proc Natl Acad Sci USA 1999, 96:10848-10853.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10848-10853
    • Zhu, Y.1    Qi, C.2    Jain, S.3    Le Beau, M.M.4    Espinosa, R.5    Atkins, G.B.6
  • 62
    • 0035968333 scopus 로고    scopus 로고
    • Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta
    • Warnmark A., Almlof T., Leers J., Gustafsson J.A., Treuter E. Differential recruitment of the mammalian mediator subunit TRAP220 by estrogen receptors ERalpha and ERbeta. J Biol Chem 2001, 276:23397-23404.
    • (2001) J Biol Chem , vol.276 , pp. 23397-23404
    • Warnmark, A.1    Almlof, T.2    Leers, J.3    Gustafsson, J.A.4    Treuter, E.5
  • 63
    • 0034617082 scopus 로고    scopus 로고
    • Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex
    • Burakov D., Wong C.W., Rachez C., Cheskis B.J., Freedman L.P. Functional interactions between the estrogen receptor and DRIP205, a subunit of the heteromeric DRIP coactivator complex. J Biol Chem 2000, 275:20928-20934.
    • (2000) J Biol Chem , vol.275 , pp. 20928-20934
    • Burakov, D.1    Wong, C.W.2    Rachez, C.3    Cheskis, B.J.4    Freedman, L.P.5
  • 65
    • 0033214780 scopus 로고    scopus 로고
    • Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins
    • Hittelman A.B., Burakov D., Iniguez-Lluhi J.A., Freedman L.P., Garabedian M.J. Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J 1999, 18:5380-5388.
    • (1999) EMBO J , vol.18 , pp. 5380-5388
    • Hittelman, A.B.1    Burakov, D.2    Iniguez-Lluhi, J.A.3    Freedman, L.P.4    Garabedian, M.J.5
  • 66
    • 35549006337 scopus 로고    scopus 로고
    • The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation
    • Chen W., Roeder R.G. The Mediator subunit MED1/TRAP220 is required for optimal glucocorticoid receptor-mediated transcription activation. Nucleic Acids Res 2007, 35:6161-6169.
    • (2007) Nucleic Acids Res , vol.35 , pp. 6161-6169
    • Chen, W.1    Roeder, R.G.2
  • 67
    • 4344689868 scopus 로고    scopus 로고
    • Identification of DRIP205 as a coactivator for the Farnesoid X receptor
    • Pineda Torra I., Freedman L.P., Garabedian M.J. Identification of DRIP205 as a coactivator for the Farnesoid X receptor. J Biol Chem 2004, 279:36184-36191.
    • (2004) J Biol Chem , vol.279 , pp. 36184-36191
    • Pineda Torra, I.1    Freedman, L.P.2    Garabedian, M.J.3
  • 68
    • 1842640322 scopus 로고    scopus 로고
    • Role of mediator in transcriptional activation by the aryl hydrocarbon receptor
    • Wang S., Ge K., Roeder R.G., Hankinson O. Role of mediator in transcriptional activation by the aryl hydrocarbon receptor. J Biol Chem 2004, 279:13593-13600.
    • (2004) J Biol Chem , vol.279 , pp. 13593-13600
    • Wang, S.1    Ge, K.2    Roeder, R.G.3    Hankinson, O.4
  • 69
    • 33845500700 scopus 로고    scopus 로고
    • The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220
    • Stumpf M., Waskow C., Krotschel M., van Essen D., Rodriguez P., Zhang X., et al. The mediator complex functions as a coactivator for GATA-1 in erythropoiesis via subunit Med1/TRAP220. Proc Natl Acad Sci USA 2006, 103:18504-18509.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18504-18509
    • Stumpf, M.1    Waskow, C.2    Krotschel, M.3    van Essen, D.4    Rodriguez, P.5    Zhang, X.6
  • 70
    • 0036479110 scopus 로고    scopus 로고
    • Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors
    • Crawford S.E., Qi C., Misra P., Stellmach V., Rao M.S., Engel J.D., et al. Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 2002, 277:3585-3592.
    • (2002) J Biol Chem , vol.277 , pp. 3585-3592
    • Crawford, S.E.1    Qi, C.2    Misra, P.3    Stellmach, V.4    Rao, M.S.5    Engel, J.D.6
  • 71
    • 0344413490 scopus 로고    scopus 로고
    • Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha
    • Wallberg A.E., Yamamura S., Malik S., Spiegelman B.M., Roeder R.G. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1alpha. Mol Cell 2003, 12:1137-1149.
    • (2003) Mol Cell , vol.12 , pp. 1137-1149
    • Wallberg, A.E.1    Yamamura, S.2    Malik, S.3    Spiegelman, B.M.4    Roeder, R.G.5
  • 72
    • 4043175687 scopus 로고    scopus 로고
    • BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220
    • Wada O., Oishi H., Takada I., Yanagisawa J., Yano T., Kato S. BRCA1 function mediates a TRAP/DRIP complex through direct interaction with TRAP220. Oncogene 2004, 23:6000-6005.
    • (2004) Oncogene , vol.23 , pp. 6000-6005
    • Wada, O.1    Oishi, H.2    Takada, I.3    Yanagisawa, J.4    Yano, T.5    Kato, S.6
  • 73
    • 33744962325 scopus 로고    scopus 로고
    • Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1
    • Udayakumar T.S., Belakavadi M., Choi K.H., Pandey P.K., Fondell J.D. Regulation of Aurora-A kinase gene expression via GABP recruitment of TRAP220/MED1. J Biol Chem 2006, 281:14691-14699.
    • (2006) J Biol Chem , vol.281 , pp. 14691-14699
    • Udayakumar, T.S.1    Belakavadi, M.2    Choi, K.H.3    Pandey, P.K.4    Fondell, J.D.5
  • 74
    • 33746498319 scopus 로고    scopus 로고
    • MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes
    • Gordon D.F., Tucker E.A., Tundwal K., Hall H., Wood W.M., Ridgway E.C. MED220/thyroid receptor-associated protein 220 functions as a transcriptional coactivator with Pit-1 and GATA-2 on the thyrotropin-beta promoter in thyrotropes. Mol Endocrinol 2006, 20:1073-1089.
    • (2006) Mol Endocrinol , vol.20 , pp. 1073-1089
    • Gordon, D.F.1    Tucker, E.A.2    Tundwal, K.3    Hall, H.4    Wood, W.M.5    Ridgway, E.C.6
  • 75
    • 45149089670 scopus 로고    scopus 로고
    • The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma
    • Li H., Gade P., Nallar S.C., Raha A., Roy S.K., Karra S., et al. The Med1 subunit of transcriptional mediator plays a central role in regulating CCAAT/enhancer-binding protein-beta-driven transcription in response to interferon-gamma. J Biol Chem 2008, 283:13077-13086.
    • (2008) J Biol Chem , vol.283 , pp. 13077-13086
    • Li, H.1    Gade, P.2    Nallar, S.C.3    Raha, A.4    Roy, S.K.5    Karra, S.6
  • 76
  • 77
    • 0031577734 scopus 로고    scopus 로고
    • Identification of RB18A, a 205kDa new p53 regulatory protein which shares antigenic and functional properties with p53
    • Drane P., Barel M., Balbo M., Frade R. Identification of RB18A, a 205kDa new p53 regulatory protein which shares antigenic and functional properties with p53. Oncogene 1997, 15:3013-3024.
    • (1997) Oncogene , vol.15 , pp. 3013-3024
    • Drane, P.1    Barel, M.2    Balbo, M.3    Frade, R.4
  • 78
    • 0034544577 scopus 로고    scopus 로고
    • RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity
    • Frade R., Balbo M., Barel M. RB18A, whose gene is localized on chromosome 17q12-q21.1, regulates in vivo p53 transactivating activity. Cancer Res 2000, 60:6585-6589.
    • (2000) Cancer Res , vol.60 , pp. 6585-6589
    • Frade, R.1    Balbo, M.2    Barel, M.3
  • 79
    • 18444401112 scopus 로고    scopus 로고
    • SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex
    • Zhou R., Bonneaud N., Yuan C.X., de Santa Barbara P., Boizet B., Schomber T., et al. SOX9 interacts with a component of the human thyroid hormone receptor-associated protein complex. Nucleic Acids Res 2002, 30:3245-3252.
    • (2002) Nucleic Acids Res , vol.30 , pp. 3245-3252
    • Zhou, R.1    Bonneaud, N.2    Yuan, C.X.3    de Santa Barbara, P.4    Boizet, B.5    Schomber, T.6
  • 80
    • 0037370376 scopus 로고    scopus 로고
    • Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation
    • Gwack Y., Baek H.J., Nakamura H., Lee S.H., Meisterernst M., Roeder R.G., et al. Principal role of TRAP/mediator and SWI/SNF complexes in Kaposi's sarcoma-associated herpesvirus RTA-mediated lytic reactivation. Mol Cell Biol 2003, 23:2055-2067.
    • (2003) Mol Cell Biol , vol.23 , pp. 2055-2067
    • Gwack, Y.1    Baek, H.J.2    Nakamura, H.3    Lee, S.H.4    Meisterernst, M.5    Roeder, R.G.6
  • 81
    • 33845219533 scopus 로고    scopus 로고
    • Mediator modulates Gli3-dependent Sonic hedgehog signaling
    • Zhou H., Kim S., Ishii S., Boyer T.G. Mediator modulates Gli3-dependent Sonic hedgehog signaling. Mol Cell Biol 2006, 26:8667-8682.
    • (2006) Mol Cell Biol , vol.26 , pp. 8667-8682
    • Zhou, H.1    Kim, S.2    Ishii, S.3    Boyer, T.G.4
  • 82
    • 33646580781 scopus 로고    scopus 로고
    • Mediator is a transducer of Wnt/beta-catenin signaling
    • Kim S., Xu X., Hecht A., Boyer T.G. Mediator is a transducer of Wnt/beta-catenin signaling. J Biol Chem 2006, 281:14066-14075.
    • (2006) J Biol Chem , vol.281 , pp. 14066-14075
    • Kim, S.1    Xu, X.2    Hecht, A.3    Boyer, T.G.4
  • 83
    • 48349122949 scopus 로고    scopus 로고
    • Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation
    • Ding N., Zhou H., Esteve P.O., Chin H.G., Kim S., Xu X., et al. Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Mol Cell 2008, 31:347-359.
    • (2008) Mol Cell , vol.31 , pp. 347-359
    • Ding, N.1    Zhou, H.2    Esteve, P.O.3    Chin, H.G.4    Kim, S.5    Xu, X.6
  • 84
    • 79952263667 scopus 로고    scopus 로고
    • Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling
    • Xu X., Zhou H., Boyer T.G. Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling. EMBO Rep 2011, 12:216-222.
    • (2011) EMBO Rep , vol.12 , pp. 216-222
    • Xu, X.1    Zhou, H.2    Boyer, T.G.3
  • 85
    • 0037222791 scopus 로고    scopus 로고
    • Role of metazoan mediator proteins in interferon-responsive transcription
    • Lau J.F., Nusinzon I., Burakov D., Freedman L.P., Horvath C.M. Role of metazoan mediator proteins in interferon-responsive transcription. Mol Cell Biol 2003, 23:620-628.
    • (2003) Mol Cell Biol , vol.23 , pp. 620-628
    • Lau, J.F.1    Nusinzon, I.2    Burakov, D.3    Freedman, L.P.4    Horvath, C.M.5
  • 86
  • 87
    • 77950643587 scopus 로고    scopus 로고
    • MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis
    • Grontved L., Madsen M.S., Boergesen M., Roeder R.G., Mandrup S. MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis. Mol Cell Biol 2010, 30:2155-2169.
    • (2010) Mol Cell Biol , vol.30 , pp. 2155-2169
    • Grontved, L.1    Madsen, M.S.2    Boergesen, M.3    Roeder, R.G.4    Mandrup, S.5
  • 88
    • 0037043739 scopus 로고    scopus 로고
    • A component of the ARC/Mediator complex required for TGF beta/Nodal signalling
    • Kato Y., Habas R., Katsuyama Y., Naar A.M., He X. A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature 2002, 418:641-646.
    • (2002) Nature , vol.418 , pp. 641-646
    • Kato, Y.1    Habas, R.2    Katsuyama, Y.3    Naar, A.M.4    He, X.5
  • 89
    • 33747053907 scopus 로고    scopus 로고
    • An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis
    • Yang F., Vought B.W., Satterlee J.S., Walker A.K., Jim Sun Z.Y., Watts J.L., et al. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature 2006, 442:700-704.
    • (2006) Nature , vol.442 , pp. 700-704
    • Yang, F.1    Vought, B.W.2    Satterlee, J.S.3    Walker, A.K.4    Jim Sun, Z.Y.5    Watts, J.L.6
  • 90
    • 4344601432 scopus 로고    scopus 로고
    • MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators
    • Kim T.W., Kwon Y.J., Kim J.M., Song Y.H., Kim S.N., Kim Y.J. MED16 and MED23 of Mediator are coactivators of lipopolysaccharide- and heat-shock-induced transcriptional activators. Proc Natl Acad Sci USA 2004, 101:12153-12158.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 12153-12158
    • Kim, T.W.1    Kwon, Y.J.2    Kim, J.M.3    Song, Y.H.4    Kim, S.N.5    Kim, Y.J.6
  • 91
    • 0033105821 scopus 로고    scopus 로고
    • Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
    • Ito M., Yuan C.X., Malik S., Gu W., Fondell J.D., Yamamura S., et al. Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators. Mol Cell 1999, 3:361-370.
    • (1999) Mol Cell , vol.3 , pp. 361-370
    • Ito, M.1    Yuan, C.X.2    Malik, S.3    Gu, W.4    Fondell, J.D.5    Yamamura, S.6
  • 92
    • 0037315911 scopus 로고    scopus 로고
    • Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module
    • Park J.M., Kim J.M., Kim L.K., Kim S.N., Kim-Ha J., Kim J.H., et al. Signal-induced transcriptional activation by Dif requires the dTRAP80 mediator module. Mol Cell Biol 2003, 23:1358-1367.
    • (2003) Mol Cell Biol , vol.23 , pp. 1358-1367
    • Park, J.M.1    Kim, J.M.2    Kim, L.K.3    Kim, S.N.4    Kim-Ha, J.5    Kim, J.H.6
  • 93
    • 0034881496 scopus 로고    scopus 로고
    • Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock
    • Park J.M., Werner J., Kim J.M., Lis J.T., Kim Y.J. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Mol Cell 2001, 8:9-19.
    • (2001) Mol Cell , vol.8 , pp. 9-19
    • Park, J.M.1    Werner, J.2    Kim, J.M.3    Lis, J.T.4    Kim, Y.J.5
  • 94
    • 66149122282 scopus 로고    scopus 로고
    • Two modes of transcriptional activation at native promoters by NF-kappaB p65
    • van Essen D., Engist B., Natoli G., Saccani S. Two modes of transcriptional activation at native promoters by NF-kappaB p65. PLoS Biol 2009, 7:e73.
    • (2009) PLoS Biol , vol.7
    • van Essen, D.1    Engist, B.2    Natoli, G.3    Saccani, S.4
  • 95
    • 59149096820 scopus 로고    scopus 로고
    • MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression
    • Ding N., Tomomori-Sato C., Sato S., Conaway R.C., Conaway J.W., Boyer T.G. MED19 and MED26 are synergistic functional targets of the RE1 silencing transcription factor in epigenetic silencing of neuronal gene expression. J Biol Chem 2009, 284:2648-2656.
    • (2009) J Biol Chem , vol.284 , pp. 2648-2656
    • Ding, N.1    Tomomori-Sato, C.2    Sato, S.3    Conaway, R.C.4    Conaway, J.W.5    Boyer, T.G.6
  • 96
    • 3142540711 scopus 로고    scopus 로고
    • HSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor
    • Nevado J., Tenbaum S.P., Aranda A. hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor. Mol Cell Endocrinol 2004, 222:41-51.
    • (2004) Mol Cell Endocrinol , vol.222 , pp. 41-51
    • Nevado, J.1    Tenbaum, S.P.2    Aranda, A.3
  • 97
    • 0037177573 scopus 로고    scopus 로고
    • Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit
    • Stevens J.L., Cantin G.T., Wang G., Shevchenko A., Berk A.J. Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit. Science 2002, 296:755-758.
    • (2002) Science , vol.296 , pp. 755-758
    • Stevens, J.L.1    Cantin, G.T.2    Wang, G.3    Shevchenko, A.4    Berk, A.J.5
  • 98
    • 0036790811 scopus 로고    scopus 로고
    • External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator
    • Asada S., Choi Y., Yamada M., Wang S.C., Hung M.C., Qin J., et al. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci USA 2002, 99:12747-12752.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 12747-12752
    • Asada, S.1    Choi, Y.2    Yamada, M.3    Wang, S.C.4    Hung, M.C.5    Qin, J.6
  • 99
    • 0842310355 scopus 로고    scopus 로고
    • Ras induces mediator complex exchange on C/EBP beta
    • Mo X., Kowenz-Leutz E., Xu H., Leutz A. Ras induces mediator complex exchange on C/EBP beta. Mol Cell 2004, 13:241-250.
    • (2004) Mol Cell , vol.13 , pp. 241-250
    • Mo, X.1    Kowenz-Leutz, E.2    Xu, H.3    Leutz, A.4
  • 100
    • 0346993714 scopus 로고    scopus 로고
    • A novel docking site on Mediator is critical for activation by VP16 in mammalian cells
    • Mittler G., Stuhler T., Santolin L., Uhlmann T., Kremmer E., Lottspeich F., et al. A novel docking site on Mediator is critical for activation by VP16 in mammalian cells. EMBO J 2003, 22:6494-6504.
    • (2003) EMBO J , vol.22 , pp. 6494-6504
    • Mittler, G.1    Stuhler, T.2    Santolin, L.3    Uhlmann, T.4    Kremmer, E.5    Lottspeich, F.6
  • 101
    • 1442354965 scopus 로고    scopus 로고
    • The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator
    • Yang F., DeBeaumont R., Zhou S., Naar A.M. The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. Proc Natl Acad Sci USA 2004, 101:2339-2344.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2339-2344
    • Yang, F.1    DeBeaumont, R.2    Zhou, S.3    Naar, A.M.4
  • 102
    • 34547812030 scopus 로고    scopus 로고
    • MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation
    • Lee H.K., Park U.H., Kim E.J., Um S.J. MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation. EMBO J 2007, 26:3545-3557.
    • (2007) EMBO J , vol.26 , pp. 3545-3557
    • Lee, H.K.1    Park, U.H.2    Kim, E.J.3    Um, S.J.4
  • 103
    • 78751558863 scopus 로고    scopus 로고
    • Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver
    • Rana R., Surapureddi S., Kam W., Ferguson S., Goldstein J.A. Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver. Mol Cell Biol 2011, 31:466-481.
    • (2011) Mol Cell Biol , vol.31 , pp. 466-481
    • Rana, R.1    Surapureddi, S.2    Kam, W.3    Ferguson, S.4    Goldstein, J.A.5
  • 104
    • 79953242601 scopus 로고    scopus 로고
    • Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25
    • Nakamura Y., Yamamoto K., He X., Otsuki B., Kim Y., Murao H., et al. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun 2011, 2:251.
    • (2011) Nat Commun , vol.2 , pp. 251
    • Nakamura, Y.1    Yamamoto, K.2    He, X.3    Otsuki, B.4    Kim, Y.5    Murao, H.6
  • 105
    • 9944259011 scopus 로고    scopus 로고
    • Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2
    • Wiederhold T., Lee M.F., James M., Neujahr R., Smith N., Murthy A., et al. Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. Oncogene 2004, 23:8815-8825.
    • (2004) Oncogene , vol.23 , pp. 8815-8825
    • Wiederhold, T.1    Lee, M.F.2    James, M.3    Neujahr, R.4    Smith, N.5    Murthy, A.6
  • 106
    • 0036801801 scopus 로고    scopus 로고
    • Intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation
    • Garrett-Engele C.M., Siegal M.L., Manoli D.S., Williams B.C., Li H., Baker B.S. intersex, a gene required for female sexual development in Drosophila, is expressed in both sexes and functions together with doublesex to regulate terminal differentiation. Development 2002, 129:4661-4675.
    • (2002) Development , vol.129 , pp. 4661-4675
    • Garrett-Engele, C.M.1    Siegal, M.L.2    Manoli, D.S.3    Williams, B.C.4    Li, H.5    Baker, B.S.6
  • 107
    • 0037131186 scopus 로고    scopus 로고
    • Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter
    • Eberhardy S.R., Farnham P.J. Myc recruits P-TEFb to mediate the final step in the transcriptional activation of the cad promoter. J Biol Chem 2002, 277:40156-40162.
    • (2002) J Biol Chem , vol.277 , pp. 40156-40162
    • Eberhardy, S.R.1    Farnham, P.J.2
  • 108
    • 0033635048 scopus 로고    scopus 로고
    • Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action
    • Ito M., Yuan C.X., Okano H.J., Darnell R.B., Roeder R.G. Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell 2000, 5:683-693.
    • (2000) Mol Cell , vol.5 , pp. 683-693
    • Ito, M.1    Yuan, C.X.2    Okano, H.J.3    Darnell, R.B.4    Roeder, R.G.5
  • 109
    • 0347480263 scopus 로고    scopus 로고
    • The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development
    • Landles C., Chalk S., Steel J.H., Rosewell I., Spencer-Dene B., Lalani el N., et al. The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. Mol Endocrinol 2003, 17:2418-2435.
    • (2003) Mol Endocrinol , vol.17 , pp. 2418-2435
    • Landles, C.1    Chalk, S.2    Steel, J.H.3    Rosewell, I.4    Spencer-Dene, B.5    Lalani el, N.6
  • 110
    • 0034685547 scopus 로고    scopus 로고
    • Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality
    • Zhu Y., Qi C., Jia Y., Nye J.S., Rao M.S., Reddy J.K. Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem 2000, 275:14779-14782.
    • (2000) J Biol Chem , vol.275 , pp. 14779-14782
    • Zhu, Y.1    Qi, C.2    Jia, Y.3    Nye, J.S.4    Rao, M.S.5    Reddy, J.K.6
  • 111
    • 2942577583 scopus 로고    scopus 로고
    • Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex
    • Taatjes D.J., Tjian R. Structure and function of CRSP/Med2; a promoter-selective transcriptional coactivator complex. Mol Cell 2004, 14:675-683.
    • (2004) Mol Cell , vol.14 , pp. 675-683
    • Taatjes, D.J.1    Tjian, R.2
  • 112
    • 4444333428 scopus 로고    scopus 로고
    • Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    • Malik S., Guermah M., Yuan C.X., Wu W., Yamamura S., Roeder R.G. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Mol Cell Biol 2004, 24:8244-8254.
    • (2004) Mol Cell Biol , vol.24 , pp. 8244-8254
    • Malik, S.1    Guermah, M.2    Yuan, C.X.3    Wu, W.4    Yamamura, S.5    Roeder, R.G.6
  • 113
    • 21244466640 scopus 로고    scopus 로고
    • MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription
    • Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., et al. MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell 2005, 19:89-100.
    • (2005) Mol Cell , vol.19 , pp. 89-100
    • Zhang, X.1    Krutchinsky, A.2    Fukuda, A.3    Chen, W.4    Yamamura, S.5    Chait, B.T.6
  • 114
    • 44949188489 scopus 로고    scopus 로고
    • MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling
    • Belakavadi M., Pandey P.K., Vijayvargia R., Fondell J.D. MED1 phosphorylation promotes its association with mediator: implications for nuclear receptor signaling. Mol Cell Biol 2008, 28:3932-3942.
    • (2008) Mol Cell Biol , vol.28 , pp. 3932-3942
    • Belakavadi, M.1    Pandey, P.K.2    Vijayvargia, R.3    Fondell, J.D.4
  • 115
    • 77951032219 scopus 로고    scopus 로고
    • Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation
    • Jiang P., Hu Q., Ito M., Meyer S., Waltz S., Khan S., et al. Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation. Proc Natl Acad Sci USA 2010, 107:6765-6770.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 6765-6770
    • Jiang, P.1    Hu, Q.2    Ito, M.3    Meyer, S.4    Waltz, S.5    Khan, S.6
  • 117
    • 33745178477 scopus 로고    scopus 로고
    • A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans
    • Taubert S., Van Gilst M.R., Hansen M., Yamamoto K.R. A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. Genes Dev 2006, 20:1137-1149.
    • (2006) Genes Dev , vol.20 , pp. 1137-1149
    • Taubert, S.1    Van Gilst, M.R.2    Hansen, M.3    Yamamoto, K.R.4
  • 118
    • 65549113969 scopus 로고    scopus 로고
    • Mediator MED23 links insulin signaling to the adipogenesis transcription cascade
    • Wang W., Huang L., Huang Y., Yin J.W., Berk A.J., Friedman J.M., et al. Mediator MED23 links insulin signaling to the adipogenesis transcription cascade. Dev Cell 2009, 16:764-771.
    • (2009) Dev Cell , vol.16 , pp. 764-771
    • Wang, W.1    Huang, L.2    Huang, Y.3    Yin, J.W.4    Berk, A.J.5    Friedman, J.M.6
  • 119
    • 33344459086 scopus 로고    scopus 로고
    • MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor
    • Chen W., Rogatsky I., Garabedian M.J. MED14 and MED1 differentially regulate target-specific gene activation by the glucocorticoid receptor. Mol Endocrinol 2006, 20:560-572.
    • (2006) Mol Endocrinol , vol.20 , pp. 560-572
    • Chen, W.1    Rogatsky, I.2    Garabedian, M.J.3
  • 120
    • 38549087992 scopus 로고    scopus 로고
    • Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression
    • Ge K., Cho Y.W., Guo H., Hong T.B., Guermah M., Ito M., et al. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol 2008, 28:1081-1091.
    • (2008) Mol Cell Biol , vol.28 , pp. 1081-1091
    • Ge, K.1    Cho, Y.W.2    Guo, H.3    Hong, T.B.4    Guermah, M.5    Ito, M.6
  • 121
    • 3042692982 scopus 로고    scopus 로고
    • Distinct conformational states of nuclear receptor-bound CRSP-Med complexes
    • Taatjes D.J., Schneider-Poetsch T., Tjian R. Distinct conformational states of nuclear receptor-bound CRSP-Med complexes. Nat Struct Mol Biol 2004, 11:664-671.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 664-671
    • Taatjes, D.J.1    Schneider-Poetsch, T.2    Tjian, R.3
  • 122
    • 77954922964 scopus 로고    scopus 로고
    • Activator-Mediator binding regulates Mediator-cofactor interactions
    • Ebmeier C.C., Taatjes D.J. Activator-Mediator binding regulates Mediator-cofactor interactions. Proc Natl Acad Sci USA 2010, 107:11283-11288.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11283-11288
    • Ebmeier, C.C.1    Taatjes, D.J.2
  • 123
    • 0036606879 scopus 로고    scopus 로고
    • Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation
    • Naar A.M., Taatjes D.J., Zhai W., Nogales E., Tjian R. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev 2002, 16:1339-1344.
    • (2002) Genes Dev , vol.16 , pp. 1339-1344
    • Naar, A.M.1    Taatjes, D.J.2    Zhai, W.3    Nogales, E.4    Tjian, R.5
  • 124
    • 20144389926 scopus 로고    scopus 로고
    • PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    • Pavri R., Lewis B., Kim T.K., Dilworth F.J., Erdjument-Bromage H., Tempst P., et al. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell 2005, 18:83-96.
    • (2005) Mol Cell , vol.18 , pp. 83-96
    • Pavri, R.1    Lewis, B.2    Kim, T.K.3    Dilworth, F.J.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 125
    • 0037113938 scopus 로고    scopus 로고
    • A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast
    • Borggrefe T., Davis R., Erdjument-Bromage H., Tempst P., Kornberg R.D. A complex of the Srb8, -9, -10, and -11 transcriptional regulatory proteins from yeast. J Biol Chem 2002, 277:44202-44207.
    • (2002) J Biol Chem , vol.277 , pp. 44202-44207
    • Borggrefe, T.1    Davis, R.2    Erdjument-Bromage, H.3    Tempst, P.4    Kornberg, R.D.5
  • 126
    • 33750481873 scopus 로고    scopus 로고
    • The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II
    • Elmlund H., Baraznenok V., Lindahl M., Samuelsen C.O., Koeck P.J., Holmberg S., et al. The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II. Proc Natl Acad Sci USA 2006, 103:15788-15793.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 15788-15793
    • Elmlund, H.1    Baraznenok, V.2    Lindahl, M.3    Samuelsen, C.O.4    Koeck, P.J.5    Holmberg, S.6
  • 127
    • 61449143491 scopus 로고    scopus 로고
    • The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function
    • Knuesel M.T., Meyer K.D., Bernecky C., Taatjes D.J. The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function. Genes Dev 2009, 23:439-451.
    • (2009) Genes Dev , vol.23 , pp. 439-451
    • Knuesel, M.T.1    Meyer, K.D.2    Bernecky, C.3    Taatjes, D.J.4
  • 128
    • 0032110627 scopus 로고    scopus 로고
    • Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases
    • Hengartner C.J., Myer V.E., Liao S.M., Wilson C.J., Koh S.S., Young R.A. Temporal regulation of RNA polymerase II by Srb10 and Kin28 cyclin-dependent kinases. Mol Cell 1998, 2:43-53.
    • (1998) Mol Cell , vol.2 , pp. 43-53
    • Hengartner, C.J.1    Myer, V.E.2    Liao, S.M.3    Wilson, C.J.4    Koh, S.S.5    Young, R.A.6
  • 129
    • 0034618762 scopus 로고    scopus 로고
    • TFIIH is negatively regulated by cdk8-containing mediator complexes
    • Akoulitchev S., Chuikov S., Reinberg D. TFIIH is negatively regulated by cdk8-containing mediator complexes. Nature 2000, 407:102-106.
    • (2000) Nature , vol.407 , pp. 102-106
    • Akoulitchev, S.1    Chuikov, S.2    Reinberg, D.3
  • 130
    • 8844229536 scopus 로고    scopus 로고
    • Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
    • Fryer C.J., White J.B., Jones K.A. Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 2004, 16:509-520.
    • (2004) Mol Cell , vol.16 , pp. 509-520
    • Fryer, C.J.1    White, J.B.2    Jones, K.A.3
  • 131
    • 0842347413 scopus 로고    scopus 로고
    • Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex
    • Liu Y., Kung C., Fishburn J., Ansari A.Z., Shokat K.M., Hahn S. Two cyclin-dependent kinases promote RNA polymerase II transcription and formation of the scaffold complex. Mol Cell Biol 2004, 24:1721-1735.
    • (2004) Mol Cell Biol , vol.24 , pp. 1721-1735
    • Liu, Y.1    Kung, C.2    Fishburn, J.3    Ansari, A.Z.4    Shokat, K.M.5    Hahn, S.6
  • 132
    • 33845765695 scopus 로고    scopus 로고
    • A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation
    • Furumoto T., Tanaka A., Ito M., Malik S., Hirose Y., Hanaoka F., et al. A kinase subunit of the human mediator complex, CDK8, positively regulates transcriptional activation. Genes Cells 2007, 12:119-132.
    • (2007) Genes Cells , vol.12 , pp. 119-132
    • Furumoto, T.1    Tanaka, A.2    Ito, M.3    Malik, S.4    Hirose, Y.5    Hanaoka, F.6
  • 133
    • 77951987104 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation
    • Belakavadi M., Fondell J.D. Cyclin-dependent kinase 8 positively cooperates with Mediator to promote thyroid hormone receptor-dependent transcriptional activation. Mol Cell Biol 2010, 30:2437-2448.
    • (2010) Mol Cell Biol , vol.30 , pp. 2437-2448
    • Belakavadi, M.1    Fondell, J.D.2
  • 134
    • 34250847654 scopus 로고    scopus 로고
    • CDK8 is a stimulus-specific positive coregulator of p53 target genes
    • Donner A.J., Szostek S., Hoover J.M., Espinosa J.M. CDK8 is a stimulus-specific positive coregulator of p53 target genes. Mol Cell 2007, 27:121-133.
    • (2007) Mol Cell , vol.27 , pp. 121-133
    • Donner, A.J.1    Szostek, S.2    Hoover, J.M.3    Espinosa, J.M.4
  • 135
    • 76349090199 scopus 로고    scopus 로고
    • CDK8 is a positive regulator of transcriptional elongation within the serum response network
    • Donner A.J., Ebmeier C.C., Taatjes D.J., Espinosa J.M. CDK8 is a positive regulator of transcriptional elongation within the serum response network. Nat Struct Mol Biol 2010, 17:194-201.
    • (2010) Nat Struct Mol Biol , vol.17 , pp. 194-201
    • Donner, A.J.1    Ebmeier, C.C.2    Taatjes, D.J.3    Espinosa, J.M.4
  • 136
    • 52949111487 scopus 로고    scopus 로고
    • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity
    • Firestein R., Bass A.J., Kim S.Y., Dunn I.F., Silver S.J., Guney I., et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 2008, 455:547-551.
    • (2008) Nature , vol.455 , pp. 547-551
    • Firestein, R.1    Bass, A.J.2    Kim, S.Y.3    Dunn, I.F.4    Silver, S.J.5    Guney, I.6
  • 137
    • 59249093974 scopus 로고    scopus 로고
    • The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator
    • Knuesel M.T., Meyer K.D., Donner A.J., Espinosa J.M., Taatjes D.J. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator. Mol Cell Biol 2009, 29:650-661.
    • (2009) Mol Cell Biol , vol.29 , pp. 650-661
    • Knuesel, M.T.1    Meyer, K.D.2    Donner, A.J.3    Espinosa, J.M.4    Taatjes, D.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.