Cytosolic monothiol glutaredoxins function in intracellular iron sensing and trafficking via their bound iron-sulfur cluster

Cell Metabolism

Volumn 12, Issue 4, 2010, Pages 373-385

  Mühlenhoff, Ulrich ^a   Molik, Sabine ^a   Godoy, José R ^a   Uzarska, Marta A ^a   Richter, Nadine ^a   Seubert, Andreas ^a   Zhang, Yan ^b   Stubbe, Joanne ^b   Pierrel, Fabien ^c   Herrero, Enrique ^d   Lillig, Christopher Horst ^a   Lill, Roland ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c CEA GRENOBLE   (France)

^d UNIVERSITY OF LLEIDA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAREDOXIN; GLUTAREDOXIN 3; GLUTAREDOXIN 4; HEME; INTRACELLULAR IRON; IRON; MANGANESE SUPEROXIDE DISMUTASE; SULFUR; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS; CYTOSOL; INTRACELLULAR TRANSPORT; IRON METABOLISM; IRON OVERLOAD; MITOCHONDRION; NUTRIENT; PRIORITY JOURNAL;

BIOLOGICAL TRANSPORT; CYTOSOL; GLUTAREDOXINS; IRON; IRON-SULFUR PROTEINS; OXIDATION-REDUCTION; OXIDOREDUCTASES; PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SULFUR; YEASTS;

EID: 77957674907     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2010.08.001     Document Type: Article

References (45)

1. J. Balk, A.J. Pierik, D.J. Netz, U. Mühlenhoff, and R. Lill The hydrogenase-like Nar1p is essential for maturation of cytosolic and nuclear iron-sulphur proteins EMBO J. 23 2004 2105 2115
2. S. Bandyopadhyay, F. Gama, M.M. Molina-Navarro, J.M. Gualberto, R. Claxton, S.G. Naik, B.H. Huynh, E. Herrero, J.P. Jacquot, M.K. Johnson, and N. Rouhier Chloroplast monothiol glutaredoxins as scaffold proteins for the assembly and delivery of [2Fe-2S] clusters EMBO J. 27 2008 1122 1133
3. H. Beinert, R.H. Holm, and E. Munck Iron-sulfur clusters: nature's modular, multipurpose structures Science 277 1997 653 659
4. K.Z. Bencze, K.C. Kondapalli, J.D. Cook, S. McMahon, C. Millan-Pacheco, N. Pastor, and T.L. Stemmler The structure and function of frataxin Crit. Rev. Biochem. Mol. Biol. 41 2006 269 291
5. C. Berndt, C. Hudemann, E.M. Hanschmann, R. Axelsson, A. Holmgren, and C.H. Lillig How does iron-sulfur cluster coordination regulate the activity of human glutaredoxin 2? Antioxid. Redox Signal. 9 2007 151 157
6. R.R. Crichton, and M. Charloteaux-Wauters Iron transport and storage Eur. J. Biochem. 164 1987 485 506
7. J.J.R. da Silva, and R.J.P. Williams Non-haem iron: redox reactions and controls J.J.R. da Silva, R.J.P. Williams, The biological chemistry of the elements 2001 Oxford University Press Oxford, UK 340 369
8. S.J. Elledge, and R.W. Davis Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability Mol. Cell. Biol. 7 1987 2783 2793
9. L.A. Finney, and T.V. O'Halloran Transition metal speciation in the cell: insights from the chemistry of metal ion receptors Science 300 2003 931 936
10. L. Flohe, and F. Otting Superoxide dismutase assays Methods Enzymol. 105 1984 93 104
11. H. Haas, M. Eisendle, and B.G. Turgeon Siderophores in fungal physiology and virulence Annu. Rev. Phytopathol. 46 2008 149 187
12. E. Harlow, and D. Lane Antibodies: A Laboratory Manual 1988 Cold Spring Harbour Laboratory Press Cold Spring Harbour, NY
13. A. Hausmann, B. Samans, R. Lill, and U. Mühlenhoff Cellular and mitochondrial remodeling upon defects in iron-sulfur protein biogenesis J. Biol. Chem. 283 2008 8318 8330
14. M.W. Hentze, M.U. Muckenthaler, and N.C. Andrews Balancing acts: molecular control of mammalian iron metabolism Cell 117 2004 285 297
15. E. Herrero, and M.A. de la Torre-Ruiz Monothiol glutaredoxins: a common domain for multiple functions Cell. Mol. Life Sci. 64 2007 1518 1530
16. J. Ihrig, A. Hausmann, A. Hain, N. Richter, R. Lill, and U. Mühlenhoff Iron regulation through the back door: iron-dependent metabolite levels contribute to the transcriptional adaptation to iron deprivation in S. cerevisiae Eukaryot. Cell 9 2010 460 471
17. C. Johansson, K.L. Kavanagh, O. Gileadi, and U. Oppermann Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria J. Biol. Chem. 282 2007 3077 3082
18. D.C. Johnson, D.R. Dean, A.D. Smith, and M.K. Johnson Structure, function, and formation of biological iron-sulfur clusters Annu. Rev. Biochem. 74 2005 247 281
19. C.D. Kaplan, and J. Kaplan Iron acquisition and transcriptional regulation Chem. Rev. 109 2009 4536 4552
20. A. Kumanovics, O.S. Chen, L. Li, D. Bagley, E.M. Adkins, H. Lin, N.N. Dingra, C.E. Outten, G. Keller, and D. Winge Identification of FRA1 and FRA2 as genes involved in regulating the yeast iron regulon in response to decreased mitochondrial iron-sulfur cluster synthesis J. Biol. Chem. 283 2008 10276 10286
21. H. Li, D.T. Mapolelo, N.N. Dingra, S.G. Naik, N.S. Lees, B.M. Hoffman, P.J. Riggs-Gelasco, B.H. Huynh, M.K. Johnson, and C.E. Outten The yeast iron regulatory proteins Grx3/4 and Fra2 form heterodimeric complexes containing a [2Fe-2S] cluster with cysteinyl and histidyl ligation Biochemistry 48 2009 9569 9581
22. R. Lill Function and biogenesis of iron-sulphur proteins Nature 460 2009 831 838
23. R. Lill, and U. Mühlenhoff Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases Annu. Rev. Biochem. 77 2008 669 700
24. C.H. Lillig, C. Berndt, and A. Holmgren Glutaredoxin systems Biochim. Biophys. Acta 1780 2008 1304 1317
25. T.J. Lyons, and D.J. Eide Transport and storage of metal ions in biology I. Bertini, H.B. Gray, E.I. Stiefel, J.S. Valentine, Biological Inorganic Chemistry 2007 University Science Books Sausalito, CA 57 77
26. A. Mercier, and S. Labbe Both Php4 function and subcellular localization are regulated by iron via a multistep mechanism involving the glutaredoxin Grx4 and the exportin Crm1 J. Biol. Chem. 284 2009 20249 20262
27. S. Molik, R. Lill, and U. Mühlenhoff Methods for studying iron metabolism in yeast mitochondria Methods Cell Biol. 80 2007 261 280
28. U. Mühlenhoff, J.A. Stadler, N. Richhardt, A. Seubert, T. Eickhorst, R.J. Schweyen, R. Lill, and G. Wiesenberger A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions J. Biol. Chem. 278 2003 40612 40620
29. L. Ojeda, G. Keller, U. Mühlenhoff, J.C. Rutherford, R. Lill, and D.R. Winge Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae J. Biol. Chem. 281 2006 17661 17669
30. D.L. Perlstein, J. Ge, A.D. Ortigosa, J.H. Robblee, Z. Zhang, M. Huang, and J. Stubbe The active form of the Saccharomyces cerevisiae ribonucleotide reductase small subunit is a heterodimer in vitro and in vivo Biochemistry 44 2005 15366 15377
31. C.C. Philpott, and O. Protchenko Response to iron deprivation in Saccharomyces cerevisiae Eukaryot. Cell 7 2008 20 27
32. A. Picciocchi, C. Saguez, A. Boussac, C. Cassier-Chauvat, and F. Chauvat CGFS-type monothiol glutaredoxins from the cyanobacterium Synechocystis PCC6803 and other evolutionary distant model organisms possess a glutathione-ligated [2Fe-2S] cluster Biochemistry 46 2007 15018 15026
33. A.J. Pierik, D.J. Netz, and R. Lill Analysis of iron-sulfur protein maturation in eukaryotes Nat. Protoc. 4 2009 753 766
34. N. Pujol-Carrion, G. Belli, E. Herrero, A. Nogues, and M.A. de la Torre-Ruiz Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae J. Cell Sci. 119 2006 4554 4564
35. D.R. Richardson, and P. Ponka The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells Biochim. Biophys. Acta 1331 1997 1 40 (Pubitemid 27168147)
36. M.T. Rodriguez-Manzaneque, J. Ros, E. Cabiscol, A. Sorribas, and E. Herrero Grx5 glutaredoxin plays a central role in protection against protein oxidative damage in Saccharomyces cerevisiae Mol. Cell. Biol. 19 1999 8180 8190
37. N. Rouhier, H. Unno, S. Bandyopadhyay, L. Masip, S.K. Kim, M. Hirasawa, J.M. Gualberto, V. Lattard, M. Kusunoki, and D.B. Knaff Functional, structural, and spectroscopic characterization of a glutathione-ligated [2Fe-2S] cluster in poplar glutaredoxin C1 Proc. Natl. Acad. Sci. USA 104 2007 7379 7384
38. J. Sambrook, and D.W. Russel Molecular cloning: a laboratory manual Third Edition 2001 Cold Spring Harbour Laboratory Press Cold Spring Harbour, NY
39. M. Shakoury-Elizeh, J. Tiedeman, J. Rashford, T. Ferea, J. Demeter, E. Garcia, R. Rolfes, P.O. Brown, D. Botstein, and C.C. Philpott Transcriptional remodeling in response to iron deprivation in Saccharomyces cerevisiae Mol. Biol. Cell 15 2004 1233 1243
40. F. Sherman Getting started with Yeast Methods Enzymol. 350 2002 3 41
41. H. Shi, K.Z. Bencze, T.L. Stemmler, and C.C. Philpott A cytosolic iron chaperone that delivers iron to ferritin Science 320 2008 1207 1210
42. K. Sipos, H. Lange, Z. Fekete, P. Ullmann, R. Lill, and G. Kispal Maturation of cytosolic iron-sulfur proteins requires glutathione J. Biol. Chem. 277 2002 26944 26949
43. U.C. Tran, B. Marbois, P. Gin, M. Gulmezian, T. Jonassen, and C.F. Clarke Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis J. Biol. Chem. 281 2006 16401 16409
44. S.V. Vergara, and D.J. Thiele Post-transcriptional regulation of gene expression in response to iron deficiency: co-ordinated metabolic reprogramming by yeast mRNA-binding proteins Biochem. Soc. Trans. 36 2008 1088 1090
45. J. Wang, G.J. Lohman, and J. Stubbe Mechanism of inactivation of human ribonucleotide reductase with p53R2 by gemcitabine 5′-diphosphate Biochemistry 48 2009 11612 11621