Control of mRNA translation and stability in haematopoietic cells: The function of hnRNPs K and E1/E2

Biology of the Cell

Volumn 96, Issue 6, 2004, Pages 407-411

  Ostareck Lederer, Antje ^a   Ostareck, Dirk H ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Haematopoietic cells; hnRNP E1 E2; hnRNP K; mRNA stability; Translational regulation

Indexed keywords

ALPHA GLOBULIN; HEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN E1; HEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN E2; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN K; MESSENGER RNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CHRONIC MYELOID LEUKEMIA; ERYTHROBLAST; ERYTHROID CELL; ERYTHROPOIESIS; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; RETICULOCYTE; RNA BINDING; RNA STABILITY; RNA TRANSLATION; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

ARACHIDONATE 15-LIPOXYGENASE; CELL DIFFERENTIATION; ERYTHROPOIESIS; GENE EXPRESSION REGULATION; GLOBINS; HEMATOPOIETIC STEM CELLS; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEIN K; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; LEUKEMIA, MYELOID, CHRONIC; PROTEIN BIOSYNTHESIS; RETICULOCYTES; RNA, MESSENGER;

EID: 4344575965     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biolcel.2004.03.010     Document Type: Article

References (47)

1. Dreyfuss G. Matunis M.J. Pinol-Roma S. Burd C.G. HnRNP proteins and the biogenesis of mRNA Annu. Rev. Biochem. 62 1993 289-321
2. Chkheidze A.N. Liebhaber S.A. A novel set of nuclear localization signals determine distributions of αCP RNA-binding proteins Mol. Cell. Biol. 23 2003 8405-8415
3. Chkheidze A.N. Lyakhov D.L. Makeyev A.V. Morales J. Kong J. Liebhaber S.A. Assembly of the α-globin mRNA stability complex reflects binary interaction between the pyrimidine-rich 3′ untranslated region determinant and poly (C)-binding protein αCP Mol. Cell Biol. 19 1999 4572-4581
4. Dejgaard K. Leffers H. Characterisation of the nucleic-acid-binding activity of KH domains: Different properties of different domains Eur. J. Biochem. 241 1996 425-431
5. Fleming J. Thiele B.J. Chester J. O'Prey J. Janetzky S. Aitken A. Anton I.A. Rapoport S.M. Harrison P. The complete sequence of the rabbit erythroid cell-specific 15-lipoxygenase mRNA: comparison of the predicted amino acid sequence of the erythroid lipoxygenase with other lipoxygenases Gene 79 1989 181-188
6. Gamarnik A.V. Andino R. Two functional complexes formed by KH domain containing proteins with the 5′ noncoding region of polivirus RNA RNA 3 1997 882-892
7. Gebauer F. Ostareck D.H. Ostareck-Lederer A. Grskovic M. Hentze M.W. Translational control of 15-lipoxygenase and msl-2 mRNAs: Single regulators or corepressor assemblies? Cold Spring Harb. Symp. Quant. Biol. 66 2001 329-336
8. Gibson T.J. Tompson J.D. Heringa J. The KH domain occurs in a diverse set of RNA-binding proteins that include the antiterminator NusA and is probably involved in binding to nucleic acid FEBS Lett. 324 1993 361-366
9. Grüllich C. Duvoisin R.M. Wiedmann M. van Leyen K. Inhibition of 15-lipoxygenase leads to delayed organelle degradation in the reticulocyte FEBS Lett. 489 2001 51-54
10. Habelhah H. Shah K. Huang L. Ostareck-Lederer A. Burlingame A.L. Shokat K.M. Hentze M.W. Ronai Z. ERK phosphorylation drives cytoplasmic accumulation of hnRNP K and inhibition of mRNA translation Nat. Cell Biol. 3 2001 325-330
11. Henics T. Differentiation-dependent cytoplasmic distribution and in vivo RNA association of proteins recognized by the 3′-UTR stability element of the α-globin mRNA in erythroleukemic cells Biochem. Biophys. Res. Commun. 279 2000 40-46
12. Hershey J.W.B. Merrick W.C. Pathways and mechanism of initiation of protein synthesis Sonenberg N. Hershey J.W.B. Mathews M.B. (Eds.). Translational Control of Gene Expression 2000 33-88 CSHL Press
13. Holcik M. Liebhaber S.A. Four highly stable eukaryotic mRNAs assemble 3′-untranslated region RNA-protein complexes sharing cis and trans components Proc. Natl. Acad. Sci. USA 94 1997 2410-2414
14. Kantarjian H.M. Deisseroth A. Kurzrock R. Estrov Z. Talpaz M. Chronic myelogenous leukemia: a concise update Blood 82 1993 691-703
15. Kiledjian M. DeMaria C.T. Brewer G. Novick K. Identification of AUF1 (Heterogeneous Nuclear Ribonucleoprotein D) as a component of the α-globin mRNA stability complex Mol. Cell. Biol. 17 1997 4870-4876
16. Kiledjian M. Wang X. Liebhaber S.A. Identification of two KH domain proteins in the α-globin mRNP stability complex EMBO J. 14 1995 4357-4364
17. Kim J.H. Hahm B. Kim Y.K. Choi M. Jang S.K. Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm J. Mol. Biol. 298 2000 395-405
18. Mattaj I.W. Engelmeier L. Nucleocytoplasmic transport: the soluble phase Annu. Rev. Biochem. 67 1998 265-306
19. Matunis M.J. Michael W.M. Dreyfuss G. Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein Mol. Cell. Biol. 12 1992 164-171
20. Michael W.M. Choi M. Dreyfuss G. A nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathway Cell 83 1995 415-422
21. Michael W.M. Eder P.S. Dreyfuss G. The K nuclear shuttling domain: a novel signal for the nuclear import and nuclear export in the hnRNP K protein EMBO J. 16 1997 3587-3598
22. Mili S. Shu H.J. Zhao Y. Pinol-Roma S. Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA Mol. Cell. Biol. 21 2001 7307-7319
23. Musco G. Stier G. Joseph C. Castiglione Morelli M.A. Nilges M. Gibson T.J. Pastore A. Three-dimensional structure and stability of the KH domain: molecular insights into the fragile X syndrome Cell 85 1996 237-245
24. Ostareck D.H. Ostareck-Lederer A. Wilm M. Thiele B.J. Mann M. Hentze M.W. mRNA silencing in erythroid maturation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3′ end Cell 89 1997 597-606
25. Ostareck D.H. Ostareck-Lederer A. Shatsky I.N. Hentze M.W. Lipoxygenase mRNA silencing in erythroid differentiation: The 3′UTR regulatory complex controls 60S ribosomal subunit joining Cell 104 2001 281-290
26. Ostareck-Lederer A. Ostareck D.H. Cans C. Neubauer G. Bomsztyk K. Superti-Furga G. Hentze M.W. c-Src mediated phosphorylation of hnRNP K drives translational activation of specifically silenced mRNAs Mol. Cell. Biol. 22 2002 4535-4543
27. Ostareck-Lederer A. Ostareck D.H. Hentze M.W. Cytoplasmic regulatory functions of the KH-domain proteins hnRNPs K and E1/E2 TIBS 23 1998 409-411
28. Ostareck-Lederer A. Ostareck D.H. Standart N. Thiele B.J. Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region EMBO J. 13 1994 1476-1481
29. Perrotti D. Cesi V. Trotta R. Guerzoni C. Santilli G. Campbell K. Iervolino A. Condorelli F. Gambacorti-Passerini C. Caligiuri M.A. Calabretta B. BCR-ABL suppresses C/EBPα expression through inhibitory action of hnRNP E2 Nature Genetics 30 2002 48-58
30. Perrotti D. Calabretta B. Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins Oncogene 21 2002 8577-8583
31. Rapoport S.M. Schewe T. The maturational breakdown of mitochondria in reticulocytes Biochem. Biophys. Acta 864 1986 471-495
32. Reimann I. Huth A. Thiele H. Thiele B.J. Suppression of 15-lipoxygenase synthesis by hnRNP E1 is dependent on repetitive nature of LOX mRNA 3′-UTR control element DICE J. Mol. Biol. 315 2002 965-974
33. Siomi H. Matunis M.J. Michael W.M. Dreyfuss G. The pre-mRNA binding K protein contains a novel evolutionarily conserved motif Nucl. Acids Res. 21 1993 1193-1198
34. Smith L.T. Hohaus S. Gonzalez D.A. Dziennis S.E. Tenen D.G. PU.1 (Spi-1) and C/EBPα regulate the granulocyte colony-stimulating factor receptor promoter in myeloid cells Blood 88 1996 1234-1247
35. Taylor S.J. Shalloway D. An RNA-binding protein associated with Src through its SH2 and SH3 domains in mitosis Nature 368 1994 867-871
36. Van Seuningen I. Ostrowski J. Bustelo X.R. Sleath P.R. Bomsztyk K. The K protein domain that recruits the interleukin1-responsive K protein kinase lies adjacent to a cluster of c-Src and Vav SH3-binding sites. Implications that K protein acts as a docking platform J. Biol. Chem. 270 1995 26976-26985
37. Waggoner S.A. Liebhaber S.A. Regulation of α-globin mRNA stability Exp. Biol. Med. 228 2003 387-395
38. Wang Z. Day N. Trifillis P. Kiledjian M. An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro Mol. Cell Biol. 19 1999 4552-4560
39. Wang Z. Kiledjian M. Identification of an erythroid-enriched endoribonuclease ativity involved in specific mRNA cleavage EMBO J. 19 2000a 295-305
40. Wang Z. Kiledjian M. The poly(A)-binding protein and an mRNA stability protein jointly regulate an endoribonuclease activity Mol. Cell Biol. 20 2000b 6334-6341
41. Wang X. Scott E. Sawyers C.L. Friedman A.D. C/EBPα bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D c13 myeloblasts Blood 94 1999 560-571
42. Ward A.C. Loeb D.M. Soede-Bobok A.A. Touw I.P. Friedman A.D. Regulation of granulopoiesis by transcription factors and cytokine signals Leukemia 14 2000 973-990
43. Weiss I.M. Liebhaber S.A. Erythroid cell-specific mRNA stability determinants of α-globin mRNA stability Mol. Cell Biol. 14 1994 8123-8132
44. Weng Z. Thomas S.M. Rickles R.J. Taylor J.A. Brauer A.W. Seidel-Dugan C. Michael W.M. Dreyfuss G. Brugge J.S. Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains Mol. Cell. Biol. 14 1994 4509-4521
45. Wilson J.E. Pestova T.V. Hellen C.U.T. Sarnow P. Initiation of protein synthesis from the A site of the ribosome Cell 102 2000 511-520
46. Yu J. Russell J.E. Structural and functional anlysis of an mRNP complex that mediates the high stability of human β-globin mRNA Mol. Cell Biol. 21 2001 5879-5888
47. Zucker-Franklin D. Graeves M.F. Grossi C.E. Marmont A.M. Atlas of blood cells 1988 Lea & Febiger, Philadelphia Edi-Ermes, Milano