-
1
-
-
37549020378
-
Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008
-
Dellinger RP, Levy MM, Carlet JM et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit. Care Med. 36(1), 296-327 (2008).
-
(2008)
Crit. Care Med.
, vol.36
, Issue.1
, pp. 296-327
-
-
Dellinger, R.P.1
Levy, M.M.2
Carlet, J.M.3
-
2
-
-
39149097579
-
Host-pathogen interactions in sepsis
-
van der Poll T, Opal SM. Host-pathogen interactions in sepsis. Lancet Infect. Dis. 8(1), 32-43 (2008).
-
(2008)
Lancet Infect. Dis.
, vol.8
, Issue.1
, pp. 32-43
-
-
Van Der Poll, T.1
Opal, S.M.2
-
3
-
-
34547515353
-
The host response to endotoxin antilipopolysaccharide strategies and the management of severe sepsis
-
Opal SM. The host response to endotoxin, antilipopolysaccharide strategies, and the management of severe sepsis. Int. J. Med. Microbiol. 297(5), 365-377 (2007).
-
(2007)
Int. J. Med. Microbiol.
, vol.297
, Issue.5
, pp. 365-377
-
-
Opal, S.M.1
-
4
-
-
12444341944
-
Toll-like receptors in innate immunity
-
Takeda K, Akira S. Toll-like receptors in innate immunity. Int. Immunol. 17(1), 1-14 (2005).
-
(2005)
Int. Immunol.
, vol.17
, Issue.1
, pp. 1-14
-
-
Takeda, K.1
Akira, S.2
-
5
-
-
59649117667
-
Molecular biology of inflammation and sepsis: A primer
-
Cinel I, Opal SM. Molecular biology of inflammation and sepsis: a primer. Crit. Care Med. 37(1), 291-304 (2009).
-
(2009)
Crit. Care Med.
, vol.37
, Issue.1
, pp. 291-304
-
-
Cinel, I.1
Opal, S.M.2
-
6
-
-
27144526697
-
Clinical review: Role of triggering receptor expressed on myeloid cells-1 during sepsis
-
Gibot S. Clinical review: role of triggering receptor expressed on myeloid cells-1 during sepsis. Crit. Care 9(5), 485-489 (2005).
-
(2005)
Crit. Care
, vol.9
, Issue.5
, pp. 485-489
-
-
Gibot, S.1
-
8
-
-
0034112615
-
Immunologic response to infection and its role in septic shock
-
Casey LC. Immunologic response to infection and its role in septic shock. Crit. Care Clin. 16(2), 193-213 (2000).
-
(2000)
Crit. Care Clin.
, vol.16
, Issue.2
, pp. 193-213
-
-
Casey, L.C.1
-
9
-
-
33747514521
-
Up-regulation of MyD88s and SIGIRR molecules inhibiting toll-like receptor signaling in monocytes from septic patients
-
Adib-Conquy M, Adrie C, Fitting C, Gattolliat O, Beyaert R, Cavaillon JM. Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Crit. Care Med. 34(9), 2377-2385 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.9
, pp. 2377-2385
-
-
Adib-Conquy, M.1
Adrie, C.2
Fitting, C.3
Gattolliat, O.4
Beyaert, R.5
Cavaillon, J.M.6
-
10
-
-
23044477087
-
Leukocyte apoptosis and its significance in sepsis and shock
-
Wesche DE, Lomas-Neira JL, Perl M, Chung CS, Ayala A. Leukocyte apoptosis and its significance in sepsis and shock. J. Leukoc. Biol. 78(2), 325-337 (2005).
-
(2005)
J. Leukoc. Biol.
, vol.78
, Issue.2
, pp. 325-337
-
-
Wesche, D.E.1
Lomas-Neira, J.L.2
Perl, M.3
Chung, C.S.4
Ayala, A.5
-
11
-
-
43949122548
-
Immunoparalysis and adverse outcomes from critical illness
-
xi
-
Frazier WJ, Hall MW. Immunoparalysis and adverse outcomes from critical illness. Pediatr. Clin. North Am. 55(3), 647-668, xi (2008).
-
(2008)
Pediatr. Clin. North Am.
, vol.55
, Issue.3
, pp. 647-668
-
-
Frazier, W.J.1
Hall, M.W.2
-
12
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss RS, Karl IE. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 348(2), 138-150 (2003).
-
(2003)
N. Engl. J. Med.
, vol.348
, Issue.2
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
13
-
-
34250869345
-
Bench-to-bedside review: Endotoxin tolerance as a model of leukocyte reprogramming in sepsis
-
Cavaillon JM, Adib-Conquy M. Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis. Crit. Care 10(5), 233 (2006).
-
(2006)
Crit. Care
, vol.10
, Issue.5
, pp. 233
-
-
Cavaillon, J.M.1
Adib-Conquy, M.2
-
14
-
-
34250848196
-
Chronic sepsis mortality characterized by an individualized inflammatory response
-
Osuchowski MF, Welch K, Yang H, Siddiqui J, Remick DG. Chronic sepsis mortality characterized by an individualized inflammatory response. J. Immunol. 179(1), 623-630 (2007).
-
(2007)
J. Immunol.
, vol.179
, Issue.1
, pp. 623-630
-
-
Osuchowski, M.F.1
Welch, K.2
Yang, H.3
Siddiqui, J.4
Remick, D.G.5
-
15
-
-
28844475232
-
Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: Its use with CpG adjuvant and potential mechanisms
-
Opal SM, Palardy JE, Chen WH, Parejo NA, Bhattacharjee AK, Cross AS. Active immunization with a detoxified endotoxin vaccine protects against lethal polymicrobial sepsis: its use with CpG adjuvant and potential mechanisms. J. Infect. Dis. 192(12), 2074-2080 (2005).
-
(2005)
J. Infect. Dis.
, vol.192
, Issue.12
, pp. 2074-2080
-
-
Opal, S.M.1
Palardy, J.E.2
Chen, W.H.3
Parejo, N.A.4
Bhattacharjee, A.K.5
Cross, A.S.6
-
16
-
-
0142231015
-
Phase I study of detoxified escherichia coli J5 lipopolysaccharide J5dLPS/group B meningococcal outer membrane protein OMP complex vaccine in human subjects
-
Cross AS, Opal SM, Palardy JE et al. Phase I study of detoxified Escherichia coli J5 lipopolysaccharide (J5dLPS)/group B meningococcal outer membrane protein (OMP) complex vaccine in human subjects. Vaccine 21(31), 4576-4587 (2003).
-
(2003)
Vaccine
, vol.21
, Issue.31
, pp. 4576-4587
-
-
Cross, A.S.1
Opal, S.M.2
Palardy, J.E.3
-
17
-
-
79955475131
-
Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice
-
Ebrahimi F, Malo MS, Alam SN et al. Local peritoneal irrigation with intestinal alkaline phosphatase is protective against peritonitis in mice. J. Gastrointest. Surg. 15(5), 860-869 (2011).
-
(2011)
J. Gastrointest. Surg.
, vol.15
, Issue.5
, pp. 860-869
-
-
Ebrahimi, F.1
Malo, M.S.2
Alam, S.N.3
-
18
-
-
33748108004
-
Beneficial effects of alkaline phosphatase in septic shock
-
Su F, Brands R, Wang Z et al. Beneficial effects of alkaline phosphatase in septic shock. Crit. Care Med. 34(8), 2182-2187 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.8
, pp. 2182-2187
-
-
Su, F.1
Brands, R.2
Wang, Z.3
-
19
-
-
21544480563
-
Bovine intestinal alkaline phosphatase attenuates the inflammatory response in secondary peritonitis in mice
-
van Veen SQ, van Vliet AK, Wulferink M, Brands R, Boermeester MA, van Gulik TM. Bovine intestinal alkaline phosphatase attenuates the inflammatory response in secondary peritonitis in mice. Infect. Immun. 73(7), 4309-4314 (2005).
-
(2005)
Infect. Immun.
, vol.73
, Issue.7
, pp. 4309-4314
-
-
Van Veen, S.Q.1
Van Vliet, A.K.2
Wulferink, M.3
Brands, R.4
Boermeester, M.A.5
Van Gulik, T.M.6
-
20
-
-
67650361713
-
Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients
-
e1
-
Heemskerk S, Masereeuw R, Moesker O et al. Alkaline phosphatase treatment improves renal function in severe sepsis or septic shock patients. Crit. Care Med. 37(2), 417-423, e1 (2009).
-
(2009)
Crit. Care Med.
, vol.37
, Issue.2
, pp. 417-423
-
-
Heemskerk, S.1
Masereeuw, R.2
Moesker, O.3
-
21
-
-
0031776895
-
The bactericidal/permeability-increasing protein BPI in antibacterial host defense
-
Elsbach P. The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense. J. Leukoc. Biol. 64(1), 14-18 (1998).
-
(1998)
J. Leukoc. Biol.
, vol.64
, Issue.1
, pp. 14-18
-
-
Elsbach, P.1
-
22
-
-
38349106140
-
Recombinant bactericidal/permeability-increasing protein inhibits endotoxin-induced high-mobility group box 1 protein gene expression in sepsis
-
Zhang LT, Yao YM, Lu JQ, Yan XJ, Yu Y, Sheng ZY. Recombinant bactericidal/ permeability-increasing protein inhibits endotoxin-induced high-mobility group box 1 protein gene expression in sepsis. Shock 29(2), 278-284 (2008).
-
(2008)
Shock
, vol.29
, Issue.2
, pp. 278-284
-
-
Zhang, L.T.1
Yao, Y.M.2
Lu, J.Q.3
Yan, X.J.4
Yu, Y.5
Sheng, Z.Y.6
-
23
-
-
0034675328
-
Recombinant bactericidal/permeability-increasing protein rBPI21 as adjunctive treatment for children with severe meningococcal sepsis: A randomised trial
-
rBPI21 Meningococcal Sepsis Study Group
-
Levin M, Quint PA, Goldstein B et al. Recombinant bactericidal/ permeability-increasing protein (rBPI21) as adjunctive treatment for children with severe meningococcal sepsis: a randomised trial. rBPI21 Meningococcal Sepsis Study Group. Lancet 356(9234), 961-967 (2000).
-
(2000)
Lancet
, vol.356
, Issue.9234
, pp. 961-967
-
-
Levin, M.1
Quint, P.A.2
Goldstein, B.3
-
24
-
-
0034926041
-
Bactericidal/permeability-increasing protein - Lessons learned from the phase III randomized clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia
-
Giroir BP, Scannon PJ, Levin M. Bactericidal/permeability-increasing protein - lessons learned from the Phase III, randomized, clinical trial of rBPI21 for adjunctive treatment of children with severe meningococcemia. Crit. Care Med. 29(7 Suppl.), S130-S135 (2001).
-
(2001)
Crit. Care Med.
, vol.29
, Issue.7
-
-
Giroir, B.P.1
Scannon, P.J.2
Levin, M.3
-
25
-
-
3242762938
-
Protective effects of lactoferrin in escherichia coli-induced bacteremia in mice: Relationship to reduced serum TNF a level and increased turnover of neutrophils
-
Zimecki M, Artym J, Chodaczek G, Kocieba M, Kruzel ML. Protective effects of lactoferrin in Escherichia coli-induced bacteremia in mice: relationship to reduced serum TNF a level and increased turnover of neutrophils. Inflamm. Res. 53(7), 292-296 (2004).
-
(2004)
Inflamm. Res.
, vol.53
, Issue.7
, pp. 292-296
-
-
Zimecki, M.1
Artym, J.2
Chodaczek, G.3
Kocieba, M.4
Kruzel, M.L.5
-
26
-
-
77952395053
-
Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model
-
Kruzel ML, Actor JK, Radak Z, Bacsi A, Saavedra-Molina A, Boldogh I. Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model. Innate Immun. 16(2), 67-79 (2010).
-
(2010)
Innate Immun.
, vol.16
, Issue.2
, pp. 67-79
-
-
Kruzel, M.L.1
Actor, J.K.2
Radak, Z.3
Bacsi, A.4
Saavedra-Molina, A.5
Boldogh, I.6
-
27
-
-
70349914008
-
Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: A randomized trial
-
Manzoni P, Rinaldi M, Cattani S et al. Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial. JAMA 302(13), 1421-1428 (2009).
-
(2009)
JAMA
, vol.302
, Issue.13
, pp. 1421-1428
-
-
Manzoni, P.1
Rinaldi, M.2
Cattani, S.3
-
28
-
-
78650233801
-
Endotoxin removal devices for the treatment of sepsis and septic shock
-
Davies B, Cohen J. Endotoxin removal devices for the treatment of sepsis and septic shock. Lancet Infect. Dis. 11(1), 65-71 (2011).
-
(2011)
Lancet Infect. Dis.
, vol.11
, Issue.1
, pp. 65-71
-
-
Davies, B.1
Cohen, J.2
-
29
-
-
20244379132
-
A pilot-controlled study of a polymyxin β-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection
-
Vincent JL, Laterre PF, Cohen J et al. A pilot-controlled study of a polymyxin β-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock 23(5), 400-405 (2005).
-
(2005)
Shock
, vol.23
, Issue.5
, pp. 400-405
-
-
Vincent, J.L.1
Laterre, P.F.2
Cohen, J.3
-
30
-
-
67649219652
-
Early use of polymyxin B hemoperfusion in abdominal septic shock: The EUPHAS randomized controlled trial
-
Cruz DN, Antonelli M, Fumagalli R et al. Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA 301(23), 2445-2452 (2009).
-
(2009)
JAMA
, vol.301
, Issue.23
, pp. 2445-2452
-
-
Cruz, D.N.1
Antonelli, M.2
Fumagalli, R.3
-
31
-
-
77954614452
-
Endotoxin removal: How far from the evidence from euphas to Euphrates
-
Rachoin JS, Foster D, Dellinger RP. Endotoxin removal: how far from the evidence? From EUPHAS to EUPHRATES. Contrib. Nephrol. 167, 111-118 (2010).
-
(2010)
Contrib. Nephrol.
, vol.167
, pp. 111-118
-
-
Rachoin, J.S.1
Foster, D.2
Dellinger, R.P.3
-
32
-
-
77954567135
-
Endotoxin removal: How far from the evidence the euphas 2 project
-
Martin EL, Cruz DN, Monti G et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib. Nephrol. 167, 119-125 (2010).
-
(2010)
Contrib. Nephrol.
, vol.167
, pp. 119-125
-
-
Martin, E.L.1
Cruz, D.N.2
Monti, G.3
-
33
-
-
3943092597
-
Open randomized Phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis
-
Reinhart K, Meier-Hellmann A, Beale R et al. Open randomized Phase II trial of an extracorporeal endotoxin adsorber in suspected Gram-negative sepsis. Crit. Care Med. 32(8), 1662-1668 (2004).
-
(2004)
Crit. Care Med.
, vol.32
, Issue.8
, pp. 1662-1668
-
-
Reinhart, K.1
Meier-Hellmann, A.2
Beale, R.3
-
34
-
-
33644609616
-
A novel adsorbent of circulating bacterial toxins and cytokines: The effect of direct hemoperfusion with CTR column for the treatment of experimental endotoxemia
-
Taniguchi T, Hirai F, Takemoto Y et al. A novel adsorbent of circulating bacterial toxins and cytokines: the effect of direct hemoperfusion with CTR column for the treatment of experimental endotoxemia. Crit. Care Med. 34(3), 800-806 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.3
, pp. 800-806
-
-
Taniguchi, T.1
Hirai, F.2
Takemoto, Y.3
-
35
-
-
58449111911
-
High-volume haemofiltration with a new haemofiltration membrane having enhanced adsorption properties in septic pigs
-
Rimmele T, Assadi A, Cattenoz M et al. High-volume haemofiltration with a new haemofiltration membrane having enhanced adsorption properties in septic pigs. Nephrol. Dial. Transplant. 24(2), 421-427 (2009).
-
(2009)
Nephrol. Dial. Transplant.
, vol.24
, Issue.2
, pp. 421-427
-
-
Rimmele, T.1
Assadi, A.2
Cattenoz, M.3
-
36
-
-
18744402182
-
Extracorporeal plasma treatment for the removal of endotoxin in patients with sepsis: Clinical results of a pilot study
-
Bengsch S, Boos KS, Nagel D, Seidel D, Inthorn D. Extracorporeal plasma treatment for the removal of endotoxin in patients with sepsis: clinical results of a pilot study. Shock 23(6), 494-500 (2005).
-
(2005)
Shock
, vol.23
, Issue.6
, pp. 494-500
-
-
Bengsch, S.1
Boos, K.S.2
Nagel, D.3
Seidel, D.4
Inthorn, D.5
-
37
-
-
0037442501
-
Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia
-
Lynn M, Rossignol DP, Wheeler JL et al. Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia. J. Infect. Dis. 187(4), 631-639 (2003).
-
(2003)
J. Infect. Dis.
, vol.187
, Issue.4
, pp. 631-639
-
-
Lynn, M.1
Rossignol, D.P.2
Wheeler, J.L.3
-
38
-
-
74049125175
-
Phase 2 trial of eritoran tetrasodium E5564 a toll-like receptor 4 antagonist in patients with severe sepsis
-
Tidswell M, Tillis W, Larosa SP et al. Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis. Crit. Care Med. 38(1), 72-83 (2010).
-
(2010)
Crit. Care Med.
, vol.38
, Issue.1
, pp. 72-83
-
-
Tidswell, M.1
Tillis, W.2
Larosa, S.P.3
-
39
-
-
77954953617
-
A randomized double-blind placebo-controlled trial of TAK-242 for the treatment of severe sepsis
-
Rice TW, Wheeler AP, Bernard GR et al. A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis. Crit. Care Med. 38(8), 1685-1694 (2010).
-
(2010)
Crit. Care Med.
, vol.38
, Issue.8
, pp. 1685-1694
-
-
Rice, T.W.1
Wheeler, A.P.2
Bernard, G.R.3
-
40
-
-
0022411888
-
Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin
-
Beutler B, Milsark IW, Cerami AC. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. Science 229(4716), 869-871 (1985).
-
(1985)
Science
, vol.229
, Issue.4716
, pp. 869-871
-
-
Beutler, B.1
Milsark, I.W.2
Cerami, A.C.3
-
41
-
-
0035100346
-
Lenercept p55 tumor necrosis factor receptor fusion protein in severe sepsis and early septic shock: A randomized double-blind placebo-controlled multicenter Phase III trial with 1342 patients
-
Abraham E, Laterre PF, Garbino J et al. Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter Phase III trial with 1,342 patients. Crit. Care Med. 29(3), 503-510 (2001).
-
(2001)
Crit. Care Med.
, vol.29
, Issue.3
, pp. 503-510
-
-
Abraham, E.1
Laterre, P.F.2
Garbino, J.3
-
42
-
-
8544262221
-
Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody Fab 2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels
-
Panacek EA, Marshall JC, Albertson TE et al. Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels. Crit. Care Med. 32(11), 2173-2182 (2004).
-
(2004)
Crit. Care Med.
, vol.32
, Issue.11
, pp. 2173-2182
-
-
Panacek, E.A.1
Marshall, J.C.2
Albertson, T.E.3
-
43
-
-
33747502519
-
Safety and efficacy of affinity-purified anti-tumor necrosis factor-a ovine fab for injection cytofab in severe sepsis
-
Rice TW, Wheeler AP, Morris PE et al. Safety and efficacy of affinity-purified, anti-tumor necrosis factor-a, ovine fab for injection (CytoFab) in severe sepsis. Crit. Care Med. 34(9), 2271-2281 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.9
, pp. 2271-2281
-
-
Rice, T.W.1
Wheeler, A.P.2
Morris, P.E.3
-
44
-
-
0028239555
-
Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome results from a randomized double-blind placebo-controlled trial
-
Phase III rhIL-1ra Sepsis Syndrome Study Group
-
Fisher CJ Jr, Dhainaut JF, Opal SM et al. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA 271(23), 1836-1843 (1994).
-
(1994)
JAMA
, vol.271
, Issue.23
, pp. 1836-1843
-
-
Fisher Jr., C.J.1
Dhainaut, J.F.2
Opal, S.M.3
-
45
-
-
0030877935
-
Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: A Phase III randomized double-blind placebo-controlled multicenter trial
-
The Interleukin-1 Receptor Antagonist Sepsis Investigator Group
-
Opal SM, Fisher CJ Jr, Dhainaut JF et al. Confirmatory interleukin-1 receptor antagonist trial in severe sepsis: a Phase III, randomized, double-blind, placebo-controlled, multicenter trial. The Interleukin-1 Receptor Antagonist Sepsis Investigator Group. Crit. Care Med. 25(7), 1115-1124 (1997).
-
(1997)
Crit. Care Med.
, vol.25
, Issue.7
, pp. 1115-1124
-
-
Opal, S.M.1
Fisher Jr., C.J.2
Dhainaut, J.F.3
-
46
-
-
79959738644
-
Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock
-
Barnay-Verdier S, Fattoum L, Borde C, Kaveri S, Gibot S, Marechal V. Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock. Intensive Care Med. 37(6), 957-962 (2011).
-
(2011)
Intensive Care Med.
, vol.37
, Issue.6
, pp. 957-962
-
-
Barnay-Verdier, S.1
Fattoum, L.2
Borde, C.3
Kaveri, S.4
Gibot, S.5
Marechal, V.6
-
47
-
-
0038276946
-
Structural basis for the proinflammatory cytokine activity of high mobility group box 1
-
Li J, Kokkola R, Tabibzadeh S et al. Structural basis for the proinflammatory cytokine activity of high mobility group box 1. Mol. Med. 9(1-2), 37-45 (2003).
-
(2003)
Mol. Med.
, vol.9
, Issue.1-2
, pp. 37-45
-
-
Li, J.1
Kokkola, R.2
Tabibzadeh, S.3
-
48
-
-
9144241208
-
Reversing established sepsis with antagonists of endogenous high-mobility group box 1
-
USA
-
Yang H, Ochani M, Li J et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl Acad. Sci. USA 101(1), 296-301 (2004).
-
(2004)
Proc. Natl Acad. Sci.
, vol.101
, Issue.1
, pp. 296-301
-
-
Yang, H.1
Ochani, M.2
Li, J.3
-
49
-
-
33748108214
-
WAY-202196 a selective estrogen receptor-b agonist protects against death in experimental septic shock
-
Cristofaro PA, Opal SM, Palardy JE et al. WAY-202196, a selective estrogen receptor-b agonist, protects against death in experimental septic shock. Crit. Care Med. 34(8), 2188-2193 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.8
, pp. 2188-2193
-
-
Cristofaro, P.A.1
Opal, S.M.2
Palardy, J.E.3
-
50
-
-
80051892393
-
CKD712 S-1-a-naphthylmethyl-6 7-dihydroxy-1 2 3 4-tetrahydroisoquinoline inhibits the lipopolysaccharide-stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C
-
Oh YJ, Youn JH, Min HJ et al. CKD712, (S)-1-(a-naphthylmethyl)-6,7- dihydroxy- 1,2,3,4-tetrahydroisoquinoline, inhibits the lipopolysaccharide- stimulated secretion of HMGB1 by inhibiting PI3K and classical protein kinase C. Int. Immunopharmacol. 11(9), 1160-1165 (2011).
-
(2011)
Int. Immunopharmacol.
, vol.11
, Issue.9
, pp. 1160-1165
-
-
Oh, Y.J.1
Youn, J.H.2
Min, H.J.3
-
51
-
-
79953201486
-
The inhibitory effect of lidocaine on the release of high mobility group box 1 in lipopolysaccharide-stimulated macrophages
-
Wang HL, Zhang WH, Lei WF, Zhou CQ, Ye T. The inhibitory effect of lidocaine on the release of high mobility group box 1 in lipopolysaccharide- stimulated macrophages. Anesth. Analg. 112(4), 839-844 (2011).
-
(2011)
Anesth. Analg.
, vol.112
, Issue.4
, pp. 839-844
-
-
Wang, H.L.1
Zhang, W.H.2
Lei, W.F.3
Zhou, C.Q.4
Ye, T.5
-
52
-
-
21744439466
-
Suppression of HMGB1 release by stearoyl lysophosphatidylcholine: An additional mechanism for its therapeutic effects in experimental sepsis
-
Chen G, Li J, Qiang X et al. Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis. J. Lipid Res. 46(4), 623-627 (2005).
-
(2005)
J. Lipid Res.
, vol.46
, Issue.4
, pp. 623-627
-
-
Chen, G.1
Li, J.2
Qiang, X.3
-
53
-
-
10744229528
-
The pattern recognition receptor rage is a counterreceptor for leukocyte integrins: A novel pathway for inflammatory cell recruitment
-
Chavakis T, Bierhaus A, Al-Fakhri N et al. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment. J. Exp. Med. 198(10), 1507-1515 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, Issue.10
, pp. 1507-1515
-
-
Chavakis, T.1
Bierhaus, A.2
Al-Fakhri, N.3
-
54
-
-
57149101367
-
Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury
-
Calfee CS, Ware LB, Eisner MD et al. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury. Thorax 63(12), 1083-1089 (2008).
-
(2008)
Thorax
, vol.63
, Issue.12
, pp. 1083-1089
-
-
Calfee, C.S.1
Ware, L.B.2
Eisner, M.D.3
-
55
-
-
43049145039
-
SRAGE is elevated in septic patients and associated with patients outcome
-
Bopp C, Hofer S, Weitz J et al. sRAGE is elevated in septic patients and associated with patients outcome. J. Surg. Res. 147(1), 79-83 (2008).
-
(2008)
J. Surg. Res.
, vol.147
, Issue.1
, pp. 79-83
-
-
Bopp, C.1
Hofer, S.2
Weitz, J.3
-
56
-
-
79955528815
-
A monoclonal antibody against rage alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia
-
Christaki E, Opal SM, Keith JC Jr et al. A monoclonal antibody against RAGE alters gene expression and is protective in experimental models of sepsis and pneumococcal pneumonia. Shock 35(5), 492-498 (2011).
-
(2011)
Shock
, vol.35
, Issue.5
, pp. 492-498
-
-
Christaki, E.1
Opal, S.M.2
Keith Jr., J.C.3
-
57
-
-
37749005803
-
Inhibition of the rage products increases survival in experimental models of severe sepsis and systemic infection
-
Lutterloh EC, Opal SM, Pittman DD et al. Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection. Crit. Care 11(6), R122 (2007).
-
(2007)
Crit. Care
, vol.11
, Issue.6
-
-
Lutterloh, E.C.1
Opal, S.M.2
Pittman, D.D.3
-
58
-
-
34247608402
-
Blood and plasma treatments: The rationale of high-volume hemofiltration
-
Honore PM, Joannes-Boyau O, Gressens B. Blood and plasma treatments: the rationale of high-volume hemofiltration. Contrib. Nephrol. 156, 387-395 (2007).
-
(2007)
Contrib. Nephrol.
, vol.156
, pp. 387-395
-
-
Honore, P.M.1
Joannes-Boyau, O.2
Gressens, B.3
-
59
-
-
62149083295
-
Hemofiltration with the cascade system in an experimental porcine model of septic shock
-
Rimmele T, Wey PF, Bernard N et al. Hemofiltration with the Cascade system in an experimental porcine model of septic shock. Ther. Apher. Dial. 13(1), 63-70 (2009).
-
(2009)
Ther. Apher. Dial.
, vol.13
, Issue.1
, pp. 63-70
-
-
Rimmele, T.1
Wey, P.F.2
Bernard, N.3
-
60
-
-
33748111321
-
Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure
-
Morgera S, Haase M, Kuss T et al. Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure. Crit. Care Med. 34(8), 2099-2104 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.8
, pp. 2099-2104
-
-
Morgera, S.1
Haase, M.2
Kuss, T.3
-
61
-
-
0036270678
-
A pilot study of coupled plasma filtration with adsorption in septic shock
-
Ronco C, Brendolan A, Lonnemann G et al. A pilot study of coupled plasma filtration with adsorption in septic shock. Crit. Care Med. 30(6), 1250-1255 (2002).
-
(2002)
Crit. Care Med.
, vol.30
, Issue.6
, pp. 1250-1255
-
-
Ronco, C.1
Brendolan, A.2
Lonnemann, G.3
-
62
-
-
0042880976
-
Coupled plasma filtration adsorption
-
Bellomo R, Tetta C, Ronco C. Coupled plasma filtration adsorption. Intensive Care Med. 29(8), 1222-1228 (2003).
-
(2003)
Intensive Care Med.
, vol.29
, Issue.8
, pp. 1222-1228
-
-
Bellomo, R.1
Tetta, C.2
Ronco, C.3
-
63
-
-
42949146538
-
Effects of hemoadsorption on cytokine removal and short-term survival in septic rats
-
Peng ZY, Carter MJ, Kellum JA. Effects of hemoadsorption on cytokine removal and short-term survival in septic rats. Crit. Care Med. 36(5), 1573-1577 (2008).
-
(2008)
Crit. Care Med.
, vol.36
, Issue.5
, pp. 1573-1577
-
-
Peng, Z.Y.1
Carter, M.J.2
Kellum, J.A.3
-
64
-
-
34247554402
-
Renal assist device and treatment of sepsis-induced acute kidney injury in intensive care units
-
Issa N, Messer J, Paganini EP. Renal assist device and treatment of sepsis-induced acute kidney injury in intensive care units. Contrib. Nephrol. 156, 419-427 (2007).
-
(2007)
Contrib. Nephrol.
, vol.156
, pp. 419-427
-
-
Issa, N.1
Messer, J.2
Paganini, E.P.3
-
65
-
-
4644247004
-
Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure
-
Humes HD, Weitzel WF, Bartlett RH et al. Initial clinical results of the bioartificial kidney containing human cells in ICU patients with acute renal failure. Kidney Int. 66(4), 1578-1588 (2004).
-
(2004)
Kidney Int.
, vol.66
, Issue.4
, pp. 1578-1588
-
-
Humes, H.D.1
Weitzel, W.F.2
Bartlett, R.H.3
-
66
-
-
44049087772
-
Efficacy and safety of renal tubule cell therapy for acute renal failure
-
Tumlin J, Wali R, Williams W et al. Efficacy and safety of renal tubule cell therapy for acute renal failure. J. Am. Soc. Nephrol. 19(5), 1034-1040 (2008).
-
(2008)
J. Am. Soc. Nephrol.
, vol.19
, Issue.5
, pp. 1034-1040
-
-
Tumlin, J.1
Wali, R.2
Williams, W.3
-
67
-
-
33846439768
-
Longitudinal studies of inter-a inhibitor proteins in severely septic patients: A potential clinical marker and mediator of severe sepsis
-
Opal SM, Lim YP, Siryaporn E et al. Longitudinal studies of inter-a inhibitor proteins in severely septic patients: a potential clinical marker and mediator of severe sepsis. Crit. Care Med. 35(2), 387-392 (2007).
-
(2007)
Crit. Care Med.
, vol.35
, Issue.2
, pp. 387-392
-
-
Opal, S.M.1
Lim, Y.P.2
Siryaporn, E.3
-
68
-
-
34247463353
-
Clinical trial with a new immunomodulatory strategy: Treatment of severe sepsis with ulinastatin and maipuxin
-
Lin HY. [Clinical trial with a new immunomodulatory strategy: treatment of severe sepsis with Ulinastatin and Maipuxin]. Zhonghua Yi Xue Za Zhi 87(7), 451-457 (2007).
-
(2007)
Zhonghua Yi. Xue. Za. Zhi.
, vol.87
, Issue.7
, pp. 451-457
-
-
Lin, H.Y.1
-
69
-
-
50949088722
-
Thymosin a1-and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria
-
Zhang Y, Chen H, Li YM et al. Thymosin a1- and ulinastatin-based immunomodulatory strategy for sepsis arising from intra-abdominal infection due to carbapenem-resistant bacteria. J. Infect. Dis. 198(5), 723-730 (2008).
-
(2008)
J. Infect. Dis.
, vol.198
, Issue.5
, pp. 723-730
-
-
Zhang, Y.1
Chen, H.2
Li, Y.M.3
-
70
-
-
68249138156
-
Treatment of patients with severe sepsis using ulinastatin and thymosin a1: A prospective randomized controlled pilot study
-
Engl.
-
Chen H, He MY, Li YM. Treatment of patients with severe sepsis using ulinastatin and thymosin a1: a prospective, randomized, controlled pilot study. Chin. Med. J. (Engl.), 122(8), 883-888 (2009).
-
(2009)
Chin. Med. J.
, vol.122
, Issue.8
, pp. 883-888
-
-
Chen, H.1
He, M.Y.2
Li, Y.M.3
-
71
-
-
35748965877
-
Inter-a-trypsin inhibitor attenuates complement activation and complement-induced lung injury
-
Garantziotis S, Hollingsworth JW, Ghanayem RB et al. Inter-a-trypsin inhibitor attenuates complement activation and complement-induced lung injury. J. Immunol. 179(6), 4187-4192 (2007).
-
(2007)
J. Immunol.
, vol.179
, Issue.6
, pp. 4187-4192
-
-
Garantziotis, S.1
Hollingsworth, J.W.2
Ghanayem, R.B.3
-
72
-
-
0038706369
-
The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases
-
Thiel M, Caldwell CC, Sitkovsky MV. The critical role of adenosine A2A receptors in downregulation of inflammation and immunity in the pathogenesis of infectious diseases. Microbes Infect. 5(6), 515-526 (2003).
-
(2003)
Microbes Infect.
, vol.5
, Issue.6
, pp. 515-526
-
-
Thiel, M.1
Caldwell, C.C.2
Sitkovsky, M.V.3
-
73
-
-
78650662869
-
Adenosine A 2A receptor agonist CGS-21680 prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes
-
Vuaden FC, Savio LE, Bastos CM, Bogo MR, Bonan CD. Adenosine A(2A) receptor agonist (CGS-21680) prevents endotoxin-induced effects on nucleotidase activities in mouse lymphocytes. Eur. J. Pharmacol. 651(1-3), 212-217 (2011).
-
(2011)
Eur. J. Pharmacol.
, vol.651
, Issue.1-3
, pp. 212-217
-
-
Vuaden, F.C.1
Savio, L.E.2
Bastos, C.M.3
Bogo, M.R.4
Bonan, C.D.5
-
74
-
-
57249084649
-
An A2A adenosine receptor agonist ATL313 reduces inflammation and improves survival in murine sepsis models
-
Moore CC, Martin EN, Lee GH, Obrig T, Linden J, Scheld WM. An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models. BMC Infect. Dis. 8, 141 (2008).
-
(2008)
BMC Infect. Dis.
, vol.8
, pp. 141
-
-
Moore, C.C.1
Martin, E.N.2
Lee, G.H.3
Obrig, T.4
Linden, J.5
Scheld, W.M.6
-
75
-
-
34250018882
-
SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis
-
Chung CS, Chen Y, Grutkoski PS, Doughty L, Ayala A. SOCS-1 is a central mediator of steroid-increased thymocyte apoptosis and decreased survival following sepsis. Apoptosis 12(7), 1143-1153 (2007).
-
(2007)
Apoptosis
, vol.12
, Issue.7
, pp. 1143-1153
-
-
Chung, C.S.1
Chen, Y.2
Grutkoski, P.S.3
Doughty, L.4
Ayala, A.5
-
76
-
-
33845421154
-
Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis
-
Watanabe H, Kubo M, Numata K et al. Overexpression of suppressor of cytokine signaling-5 in T cells augments innate immunity during septic peritonitis. J. Immunol. 177(12), 8650-8657 (2006).
-
(2006)
J. Immunol.
, vol.177
, Issue.12
, pp. 8650-8657
-
-
Watanabe, H.1
Kubo, M.2
Numata, K.3
-
77
-
-
38449099334
-
Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia
-
Qin H, Roberts KL, Niyongere SA, Cong Y, Elson CO, Benveniste EN. Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia. J. Immunol. 179(9), 5966-5976 (2007).
-
(2007)
J. Immunol.
, vol.179
, Issue.9
, pp. 5966-5976
-
-
Qin, H.1
Roberts, K.L.2
Niyongere, S.A.3
Cong, Y.4
Elson, C.O.5
Benveniste, E.N.6
-
78
-
-
77955477026
-
Endotoxin tolerance and cross-tolerance in mast cells involves TLR4 TLR2 and FceR1 interactions and SOCS expression: Perspectives on immunomodulation in infectious and allergic diseases
-
Saturnino SF, Prado RO, Cunha-Melo JR, Andrade MV. Endotoxin tolerance and cross-tolerance in mast cells involves TLR4, TLR2 and FceR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases. BMC Infect. Dis. 10, 240 (2010).
-
(2010)
BMC Infect. Dis.
, vol.10
, Issue.240
-
-
Saturnino, S.F.1
Prado, R.O.2
Cunha-Melo, J.R.3
Andrade, M.V.4
-
79
-
-
57649200412
-
Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-γ
-
Reddy RC, Narala VR, Keshamouni VG, Milam JE, Newstead MW, Standiford TJ. Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-γ. Blood 112(10), 4250-4258 (2008).
-
(2008)
Blood
, vol.112
, Issue.10
, pp. 4250-4258
-
-
Reddy, R.C.1
Narala, V.R.2
Keshamouni, V.G.3
Milam, J.E.4
Newstead, M.W.5
Standiford, T.J.6
-
80
-
-
0041887308
-
Peroxisome proliferator-activated receptors: Regulation of transcriptional activities and roles in inflammation
-
Blanquart C, Barbier O, Fruchart JC, Staels B, Glineur C. Peroxisome proliferator-activated receptors: regulation of transcriptional activities and roles in inflammation. J. Steroid Biochem. Mol. Biol. 85(2-5), 267-273 (2003).
-
(2003)
J. Steroid Biochem. Mol. Biol.
, vol.85
, Issue.2-5
, pp. 267-273
-
-
Blanquart, C.1
Barbier, O.2
Fruchart, J.C.3
Staels, B.4
Glineur, C.5
-
81
-
-
26444600114
-
Rosiglitazone a peroxisome proliferator-activated receptor-γ agonist reduces acute lung injury in endotoxemic rats
-
Liu D, Zeng BX, Zhang SH et al. Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, reduces acute lung injury in endotoxemic rats. Crit. Care Med. 33(10), 2309-2316 (2005).
-
(2005)
Crit. Care Med.
, vol.33
, Issue.10
, pp. 2309-2316
-
-
Liu, D.1
Zeng, B.X.2
Zhang, S.H.3
-
82
-
-
20844457637
-
Agonist of peroxisome proliferator-activated receptor-γ rosiglitazone reduces renal injury and dysfunction in a murine sepsis model
-
Lee S, Kim W, Kang KP et al. Agonist of peroxisome proliferator-activated receptor-γ, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model. Nephrol. Dial. Transplant. 20(6), 1057-1065 (2005).
-
(2005)
Nephrol. Dial. Transplant.
, vol.20
, Issue.6
, pp. 1057-1065
-
-
Lee, S.1
Kim, W.2
Kang, K.P.3
-
83
-
-
0037291286
-
Safety and anti-inflammatory activity of curcumin: A component of tumeric curcuma longa
-
Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J. Altern. Complement. Med. 9(1), 161-168 (2003).
-
(2003)
J. Altern. Complement. Med.
, vol.9
, Issue.1
, pp. 161-168
-
-
Chainani-Wu, N.1
-
84
-
-
33745632762
-
The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ
-
Siddiqui AM, Cui X, Wu R et al. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-γ. Crit. Care Med. 34(7), 1874-1882 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.7
, pp. 1874-1882
-
-
Siddiqui, A.M.1
Cui, X.2
Wu, R.3
-
85
-
-
34547101953
-
Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia
-
Chen HW, Kuo HT, Chai CY, Ou JL, Yang RC. Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia. J. Endotoxin Res. 13(1), 15-23 (2007).
-
(2007)
J. Endotoxin Res.
, vol.13
, Issue.1
, pp. 15-23
-
-
Chen, H.W.1
Kuo, H.T.2
Chai, C.Y.3
Ou, J.L.4
Yang, R.C.5
-
86
-
-
53449093510
-
Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat
-
Memis D, Hekimoglu S, Sezer A, Altaner S, Sut N, Usta U. Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat. Nutrition 24(11-12), 1133-1138 (2008).
-
(2008)
Nutrition
, vol.24
, Issue.11-12
, pp. 1133-1138
-
-
Memis, D.1
Hekimoglu, S.2
Sezer, A.3
Altaner, S.4
Sut, N.5
Usta, U.6
-
87
-
-
78650881177
-
The effects of a synthetic curcuminoid analogue 2 6-bis-4-hydroxyl-3- methoxybenzylidine cyclohexanone on proinflammatory signaling pathways and CLP-induced lethal sepsis in mice
-
Tham CL, Lam KW, Rajajendram R et al. The effects of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxyl-3- methoxybenzylidine)cyclohexanone on proinflammatory signaling pathways and CLP-induced lethal sepsis in mice. Eur. J. Pharmacol. 652(1-3), 136-144 (2011).
-
(2011)
Eur. J. Pharmacol.
, vol.652
, Issue.1-3
, pp. 136-144
-
-
Tham, C.L.1
Lam, K.W.2
Rajajendram, R.3
-
88
-
-
0034713266
-
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
-
Borovikova LV, Ivanova S, Zhang M et al. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 405(6785), 458-462 (2000).
-
(2000)
Nature
, vol.405
, Issue.6785
, pp. 458-462
-
-
Borovikova, L.V.1
Ivanova, S.2
Zhang, M.3
-
89
-
-
33747183943
-
Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats
-
van Westerloo DJ, Giebelen IA, Meijers JC et al. Vagus nerve stimulation inhibits activation of coagulation and fibrinolysis during endotoxemia in rats. J. Thromb. Haemost. 4(9), 1997-2002 (2006).
-
(2006)
J. Thromb. Haemost.
, vol.4
, Issue.9
, pp. 1997-2002
-
-
Van Westerloo, D.J.1
Giebelen, I.A.2
Meijers, J.C.3
-
90
-
-
34247125289
-
Selective a7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis
-
Pavlov VA, Ochani M, Yang LH et al. Selective a7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit. Care Med. 35(4), 1139-1144 (2007).
-
(2007)
Crit. Care Med.
, vol.35
, Issue.4
, pp. 1139-1144
-
-
Pavlov, V.A.1
Ochani, M.2
Yang, L.H.3
-
91
-
-
9144263639
-
Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis
-
Wang H, Liao H, Ochani M et al. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 10(11), 1216-1221 (2004).
-
(2004)
Nat. Med.
, vol.10
, Issue.11
, pp. 1216-1221
-
-
Wang, H.1
Liao, H.2
Ochani, M.3
-
92
-
-
67650391166
-
The selective a7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2 TLR3 TLR4 TLR9 and rage
-
Rosas-Ballina M, Goldstein RS, Gallowitsch-Puerta M et al. The selective a7 agonist GTS-21 attenuates cytokine production in human whole blood and human monocytes activated by ligands for TLR2, TLR3, TLR4, TLR9, and RAGE. Mol. Med. 15(7-8), 195-202 (2009).
-
(2009)
Mol. Med.
, vol.15
, Issue.7-8
, pp. 195-202
-
-
Rosas-Ballina, M.1
Goldstein, R.S.2
Gallowitsch-Puerta, M.3
-
93
-
-
38549096008
-
Pharmacologic cholinesterase inhibition improves survival in experimental sepsis
-
Hofer S, Eisenbach C, Lukic IK et al. Pharmacologic cholinesterase inhibition improves survival in experimental sepsis. Crit. Care Med. 36(2), 404-408 (2008).
-
(2008)
Crit. Care Med.
, vol.36
, Issue.2
, pp. 404-408
-
-
Hofer, S.1
Eisenbach, C.2
Lukic, I.K.3
-
94
-
-
36448948021
-
Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis
-
Huston JM, Gallowitsch-Puerta M, Ochani M et al. Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis. Crit. Care Med. 35(12), 2762-2768 (2007).
-
(2007)
Crit. Care Med.
, vol.35
, Issue.12
, pp. 2762-2768
-
-
Huston, J.M.1
Gallowitsch-Puerta, M.2
Ochani, M.3
-
95
-
-
36448938357
-
Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock
-
Kreymann KG, de Heer G, Nierhaus A, Kluge S. Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock. Crit. Care Med. 35(12), 2677-2685 (2007).
-
(2007)
Crit. Care Med.
, vol.35
, Issue.12
, pp. 2677-2685
-
-
Kreymann, K.G.1
De Heer, G.2
Nierhaus, A.3
Kluge, S.4
-
96
-
-
0035142620
-
Inhibition of bacterial superantigens by peptides and antibodies
-
Visvanathan K, Charles A, Bannan J, Pugach P, Kashfi K, Zabriskie JB. Inhibition of bacterial superantigens by peptides and antibodies. Infect. Immun. 69(2), 875-884 (2001).
-
(2001)
Infect. Immun.
, vol.69
, Issue.2
, pp. 875-884
-
-
Visvanathan, K.1
Charles, A.2
Bannan, J.3
Pugach, P.4
Kashfi, K.5
Zabriskie, J.B.6
-
97
-
-
33744480780
-
Physiological response to superantigen-adsorbing hemoperfusion in toxin-concentration-controlled septic swine
-
Miwa K, Fukuyama M, Matsuno N, Shimada K, Ikeda K, Ikeda T. Physiological response to superantigen-adsorbing hemoperfusion in toxin-concentration- controlled septic swine. Blood Purif. 24(3), 319-326 (2006).
-
(2006)
Blood Purif.
, vol.24
, Issue.3
, pp. 319-326
-
-
Miwa, K.1
Fukuyama, M.2
Matsuno, N.3
Shimada, K.4
Ikeda, K.5
Ikeda, T.6
-
98
-
-
26244459813
-
Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model
-
Steinberg J, Halter J, Schiller H et al. Chemically modified tetracycline prevents the development of septic shock and acute respiratory distress syndrome in a clinically applicable porcine model. Shock 24(4), 348-356 (2005).
-
(2005)
Shock
, vol.24
, Issue.4
, pp. 348-356
-
-
Steinberg, J.1
Halter, J.2
Schiller, H.3
-
99
-
-
8144226374
-
Role of chemically modified tetracycline on TNF-a and mitogen-activated protein kinases in sepsis
-
Maitra SR, Bhaduri S, Chen E, Shapiro MJ. Role of chemically modified tetracycline on TNF-a and mitogen-activated protein kinases in sepsis. Shock 22(5), 478-481 (2004).
-
(2004)
Shock
, vol.22
, Issue.5
, pp. 478-481
-
-
Maitra, S.R.1
Bhaduri, S.2
Chen, E.3
Shapiro, M.J.4
-
100
-
-
46049096309
-
The anti-inflammatory activity of clarithromycin inhibits TNFa production and prolongs survival following lipopolysaccharide administration in mice
-
Tkalcevic VI, Bosnjak B, Pasalic I et al. The anti-inflammatory activity of clarithromycin inhibits TNFa production and prolongs survival following lipopolysaccharide administration in mice. Int. J. Antimicrob. Agents 32(2), 195-196 (2008).
-
(2008)
Int. J. Antimicrob. Agents
, vol.32
, Issue.2
, pp. 195-196
-
-
Tkalcevic, V.I.1
Bosnjak, B.2
Pasalic, I.3
-
101
-
-
33747057193
-
Anti-inflammatory activity of azithromycin attenuates the effects of lipopolysaccharide administration in mice
-
Ivetić Tkalcević V, Bosnjak B, Hrvacic B et al. Anti-inflammatory activity of azithromycin attenuates the effects of lipopolysaccharide administration in mice. Eur. J. Pharmacol. 539(1-2), 131-138 (2006).
-
(2006)
Eur. J. Pharmacol.
, vol.539
, Issue.1-2
, pp. 131-138
-
-
Ivetić Tkalcević, V.1
Bosnjak, B.2
Hrvacic, B.3
-
102
-
-
33846897243
-
The anti-inflammatory activity of telithromycin in a mouse model of septic shock
-
Leiva M, Ruiz-Bravo A, Moreno E, Jimenez-Valera M. The anti-inflammatory activity of telithromycin in a mouse model of septic shock. Int. J. Antimicrob. Agents 29(3), 364-365 (2007).
-
(2007)
Int. J. Antimicrob. Agents
, vol.29
, Issue.3
, pp. 364-365
-
-
Leiva, M.1
Ruiz-Bravo, A.2
Moreno, E.3
Jimenez-Valera, M.4
-
103
-
-
42549119145
-
Effect of clarithromycin in patients with sepsis and ventilator- associated pneumonia
-
Giamarellos-Bourboulis EJ, Pechere JC, Routsi C et al. Effect of clarithromycin in patients with sepsis and ventilator-associated pneumonia. Clin. Infect. Dis. 46(8), 1157-1164 (2008).
-
(2008)
Clin. Infect. Dis.
, vol.46
, Issue.8
, pp. 1157-1164
-
-
Giamarellos-Bourboulis, E.J.1
Pechere, J.C.2
Routsi, C.3
-
104
-
-
21844463540
-
Statin treatment after onset of sepsis in a murine model improves survival
-
Merx MW, Liehn EA, Graf J et al. Statin treatment after onset of sepsis in a murine model improves survival. Circulation 112(1), 117-124 (2005).
-
(2005)
Circulation
, vol.112
, Issue.1
, pp. 117-124
-
-
Merx, M.W.1
Liehn, E.A.2
Graf, J.3
-
105
-
-
33750360916
-
Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo
-
Niessner A, Steiner S, Speidl WS et al. Simvastatin suppresses endotoxin-induced upregulation of Toll-like receptors 4 and 2 in vivo. Atherosclerosis 189(2), 408-413 (2006).
-
(2006)
Atherosclerosis
, vol.189
, Issue.2
, pp. 408-413
-
-
Niessner, A.1
Steiner, S.2
Speidl, W.S.3
-
106
-
-
0035887840
-
The effect of statins on mortality in patients with bacteremia
-
Liappis AP, Kan VL, Rochester CG, Simon GL. The effect of statins on mortality in patients with bacteremia. Clin. Infect. Dis. 33(8), 1352-1357 (2001).
-
(2001)
Clin. Infect. Dis.
, vol.33
, Issue.8
, pp. 1352-1357
-
-
Liappis, A.P.1
Kan, V.L.2
Rochester, C.G.3
Simon, G.L.4
-
107
-
-
4143083577
-
Prior statin therapy is associated with a decreased rate of severe sepsis
-
Almog Y, Shefer A, Novack V et al. Prior statin therapy is associated with a decreased rate of severe sepsis. Circulation 110(7), 880-885 (2004).
-
(2004)
Circulation
, vol.110
, Issue.7
, pp. 880-885
-
-
Almog, Y.1
Shefer, A.2
Novack, V.3
-
108
-
-
79961024148
-
Understanding the potential role of statins in pneumonia and sepsis
-
Yende S, Milbrandt EB, Kellum JA et al. Understanding the potential role of statins in pneumonia and sepsis. Crit. Care Med. 39(8), 1871-1878 (2011).
-
(2011)
Crit. Care Med.
, vol.39
, Issue.8
, pp. 1871-1878
-
-
Yende, S.1
Milbrandt, E.B.2
Kellum, J.A.3
-
109
-
-
79952047453
-
Statins do not prevent acute organ failure in ventilated ICU patients: Single-centre retrospective cohort study
-
Terblanche MJ, Pinto R, Whiteley C, Brett S, Beale R, Adhikari NK. Statins do not prevent acute organ failure in ventilated ICU patients: single-centre retrospective cohort study. Crit. Care 15(1), R74 (2011).
-
(2011)
Crit. Care
, vol.15
, Issue.1
-
-
Terblanche, M.J.1
Pinto, R.2
Whiteley, C.3
Brett, S.4
Beale, R.5
Adhikari, N.K.6
-
110
-
-
67649364708
-
The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: A randomized double-blind placebo controlled clinical trial
-
Novack V, Eisinger M, Frenkel A et al. The effects of statin therapy on inflammatory cytokines in patients with bacterial infections: a randomized double-blind placebo controlled clinical trial. Intensive Care Med. 35(7), 1255-1260 (2009).
-
(2009)
Intensive Care Med.
, vol.35
, Issue.7
, pp. 1255-1260
-
-
Novack, V.1
Eisinger, M.2
Frenkel, A.3
-
111
-
-
79952732359
-
Continuation of statin therapy in patients with presumed infection: A randomized controlled trial
-
Kruger PS, Harward ML, Jones MA et al. Continuation of statin therapy in patients with presumed infection: a randomized controlled trial. Am. J. Respir. Crit. Care Med. 183(6), 774-781 (2011).
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.183
, Issue.6
, pp. 774-781
-
-
Kruger, P.S.1
Harward, M.L.2
Jones, M.A.3
-
112
-
-
47049120122
-
High C5a levels are associated with increased mortality in sepsis patients - No enhancing effect by actin-free Gc-globulin
-
Gressner OA, Koch A, Sanson E, Trautwein C, Tacke F. High C5a levels are associated with increased mortality in sepsis patients - no enhancing effect by actin-free Gc-globulin. Clin. Biochem. 41(12), 974-980 (2008).
-
(2008)
Clin. Biochem.
, vol.41
, Issue.12
, pp. 974-980
-
-
Gressner, O.A.1
Koch, A.2
Sanson, E.3
Trautwein, C.4
Tacke, F.5
-
113
-
-
0033052453
-
Protective effects of C5a blockade in sepsis
-
Czermak BJ, Sarma V, Pierson CL et al. Protective effects of C5a blockade in sepsis. Nat. Med. 5(7), 788-792 (1999).
-
(1999)
Nat. Med.
, vol.5
, Issue.7
, pp. 788-792
-
-
Czermak, B.J.1
Sarma, V.2
Pierson, C.L.3
-
114
-
-
0036092494
-
Anti-c5a ameliorates coagulation/ fibrinolytic protein changes in a rat model of sepsis
-
Laudes IJ, Chu JC, Sikranth S et al. Anti-c5a ameliorates coagulation/ fibrinolytic protein changes in a rat model of sepsis. Am. J. Pathol. 160(5), 1867-1875 (2002).
-
(2002)
Am. J. Pathol.
, vol.160
, Issue.5
, pp. 1867-1875
-
-
Laudes, I.J.1
Chu, J.C.2
Sikranth, S.3
-
115
-
-
34250817675
-
C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice
-
Zwijnenburg PJ, van der Poll T, Florquin S et al. C1 inhibitor treatment improves host defense in pneumococcal meningitis in rats and mice. J. Infect. Dis. 196(1), 115-123 (2007).
-
(2007)
J. Infect. Dis.
, vol.196
, Issue.1
, pp. 115-123
-
-
Zwijnenburg, P.J.1
Van Der Poll, T.2
Florquin, S.3
-
116
-
-
78049437566
-
C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia
-
Dorresteijn MJ, Visser T, Cox LA et al. C1-esterase inhibitor attenuates the inflammatory response during human endotoxemia. Crit. Care Med. 38(11), 2139-2145 (2010).
-
(2010)
Crit. Care Med.
, vol.38
, Issue.11
, pp. 2139-2145
-
-
Dorresteijn, M.J.1
Visser, T.2
Cox, L.A.3
-
117
-
-
0008021312
-
Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist deltibant CP- 0127 results of a randomized, double-blind, placebo-controlled trial
-
CP-0127 SIRS and Sepsis Study Group
-
Fein AM, Bernard GR, Criner GJ et al. Treatment of severe systemic inflammatory response syndrome and sepsis with a novel bradykinin antagonist, deltibant (CP- 0127). Results of a randomized, double-blind, placebo-controlled trial. CP-0127 SIRS and Sepsis Study Group. JAMA 277(6), 482-487 (1997).
-
(1997)
JAMA
, vol.277
, Issue.6
, pp. 482-487
-
-
Fein, A.M.1
Bernard, G.R.2
Criner, G.J.3
-
118
-
-
0038690407
-
Efficacy and safety of tifacogin recombinant tissue factor pathway inhibitor in severe sepsis: A randomized controlled trial
-
Abraham E, Reinhart K, Opal S et al. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA 290(2), 238-247 (2003).
-
(2003)
JAMA
, vol.290
, Issue.2
, pp. 238-247
-
-
Abraham, E.1
Reinhart, K.2
Opal, S.3
-
119
-
-
79957948640
-
Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: A randomized trial
-
Wunderink RG, Laterre PF, Francois B et al. Recombinant tissue factor pathway inhibitor in severe community-acquired pneumonia: a randomized trial. Am. J. Respir. Crit. Care Med. 183(11), 1561-1568 (2011).
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.183
, Issue.11
, pp. 1561-1568
-
-
Wunderink, R.G.1
Laterre, P.F.2
Francois, B.3
-
120
-
-
0035904368
-
Caring for the critically ill patient high-dose antithrombin III in severe sepsis: A randomized controlled trial
-
Warren BL, Eid A, Singer P et al. Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA 286(15), 1869-1878 (2001).
-
(2001)
JAMA
, vol.286
, Issue.15
, pp. 1869-1878
-
-
Warren, B.L.1
Eid, A.2
Singer, P.3
-
121
-
-
31344451275
-
High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: Efficacy and safety
-
Wiedermann CJ, Hoffmann JN, Juers M et al. High-dose antithrombin III in the treatment of severe sepsis in patients with a high risk of death: efficacy and safety. Crit. Care Med. 34(2), 285-292 (2006).
-
(2006)
Crit. Care Med.
, vol.34
, Issue.2
, pp. 285-292
-
-
Wiedermann, C.J.1
Hoffmann, J.N.2
Juers, M.3
-
122
-
-
33746636356
-
The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis
-
Van de Wouwer M, Plaisance S, De Vriese A et al. The lectin-like domain of thrombomodulin interferes with complement activation and protects against arthritis. J. Thromb. Haemost. 4(8), 1813-1824 (2006).
-
(2006)
J. Thromb. Haemost.
, vol.4
, Issue.8
, pp. 1813-1824
-
-
Van De Wouwer, M.1
Plaisance, S.2
De Vriese, A.3
-
123
-
-
20944436774
-
The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein a novel antiinflammatory mechanism
-
Abeyama K, Stern DM, Ito Y et al. The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism. J. Clin. Invest. 115(5), 1267-1274 (2005).
-
(2005)
J. Clin. Invest.
, vol.115
, Issue.5
, pp. 1267-1274
-
-
Abeyama, K.1
Stern, D.M.2
Ito, Y.3
-
124
-
-
67649766887
-
Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels whereas improving the acute liver injury and survival rates in experimental endotoxemia
-
Nagato M, Okamoto K, Abe Y, Higure A, Yamaguchi K. Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia. Crit. Care Med. 37(7), 2181-2186 (2009).
-
(2009)
Crit. Care Med.
, vol.37
, Issue.7
, pp. 2181-2186
-
-
Nagato, M.1
Okamoto, K.2
Abe, Y.3
Higure, A.4
Yamaguchi, K.5
-
125
-
-
33845513582
-
Efficacy and safety of recombinant human soluble thrombomodulin ART-123 in disseminated intravascular coagulation: Results of a Phase III randomized double-blind clinical trial
-
Saito H, Maruyama I, Shimazaki S et al. Efficacy and safety of recombinant human soluble thrombomodulin (ART-123) in disseminated intravascular coagulation: results of a Phase III, randomized, double-blind clinical trial. J. Thromb. Haemost. 5(1), 31-41 (2007).
-
(2007)
J. Thromb. Haemost.
, vol.5
, Issue.1
, pp. 31-41
-
-
Saito, H.1
Maruyama, I.2
Shimazaki, S.3
-
126
-
-
79955786719
-
Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: A historical control study
-
Yamakawa K, Fujimi S, Mohri T et al. Treatment effects of recombinant human soluble thrombomodulin in patients with severe sepsis: a historical control study. Crit. Care 15(3), R123 (2011).
-
(2011)
Crit. Care
, vol.15
, Issue.3
-
-
Yamakawa, K.1
Fujimi, S.2
Mohri, T.3
-
127
-
-
77951644463
-
Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model
-
Iba T, Nakarai E, Takayama T, Nakajima K, Sasaoka T, Ohno Y. Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model. Crit. Care 13(6), R203 (2009).
-
(2009)
Crit. Care
, vol.13
, Issue.6
-
-
Iba, T.1
Nakarai, E.2
Takayama, T.3
Nakajima, K.4
Sasaoka, T.5
Ohno, Y.6
-
128
-
-
33745862736
-
Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis
-
Moreno SE, Alves-Filho JC, Rios-Santos F et al. Signaling via platelet-activating factor receptors accounts for the impairment of neutrophil migration in polymicrobial sepsis. J. Immunol. 177(2), 1264-1271 (2006).
-
(2006)
J. Immunol.
, vol.177
, Issue.2
, pp. 1264-1271
-
-
Moreno, S.E.1
Alves-Filho, J.C.2
Rios-Santos, F.3
-
129
-
-
33747199084
-
Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis
-
Gomes RN, Bozza FA, Amancio RT et al. Exogenous platelet-activating factor acetylhydrolase reduces mortality in mice with systemic inflammatory response syndrome and sepsis. Shock 26(1), 41-49 (2006).
-
(2006)
Shock
, vol.26
, Issue.1
, pp. 41-49
-
-
Gomes, R.N.1
Bozza, F.A.2
Amancio, R.T.3
-
130
-
-
0037709808
-
Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb multicenter randomized placebo-controlled clinical trial
-
Schuster DP, Metzler M, Opal S et al. Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. Crit. Care Med. 31(6), 1612-1619 (2003).
-
(2003)
Crit. Care Med.
, vol.31
, Issue.6
, pp. 1612-1619
-
-
Schuster, D.P.1
Metzler, M.2
Opal, S.3
-
131
-
-
0000918029
-
Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis
-
Vincent JL, Spapen H, Bakker J, Webster NR, Curtis L. Phase II multicenter clinical study of the platelet-activating factor receptor antagonist BB-882 in the treatment of sepsis. Crit. Care Med. 28(3), 638-642 (2000).
-
(2000)
Crit. Care Med.
, vol.28
, Issue.3
, pp. 638-642
-
-
Vincent, J.L.1
Spapen, H.2
Bakker, J.3
Webster, N.R.4
Curtis, L.5
-
132
-
-
11144356908
-
Efficacy and safety of the platelet-activating factor receptor antagonist BN 52021 ginkgolide B in patients with severe sepsis: A randomised double-blind placebo-controlled multicentre trial
-
Albrecht DM, van Ackern K, Bender HJ et al. Efficacy and safety of the platelet-activating factor receptor antagonist BN 52021 (ginkgolide B) in patients with severe sepsis: a randomised, double-blind, placebo-controlled, multicentre trial. Clin. Drug Investig. 24(3), 137-147 (2004).
-
(2004)
Clin. Drug Investig.
, vol.24
, Issue.3
, pp. 137-147
-
-
Albrecht, D.M.1
Van Ackern, K.2
Bender, H.J.3
-
133
-
-
0036892452
-
Bench-to-bedside review: Cytopathic hypoxia
-
Fink MP. Bench-to-bedside review: cytopathic hypoxia. Crit. Care 6(6), 491-499 (2002).
-
(2002)
Crit. Care
, vol.6
, Issue.6
, pp. 491-499
-
-
Fink, M.P.1
-
134
-
-
0036251182
-
Protective effect of a novel potent inhibitor of poly adenosine 5-diphosphate-ribose synthetase in a porcine model of severe bacterial sepsis
-
Goldfarb RD, Marton A, Szabo E et al. Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis. Crit. Care Med. 30(5), 974-980 (2002).
-
(2002)
Crit. Care Med.
, vol.30
, Issue.5
, pp. 974-980
-
-
Goldfarb, R.D.1
Marton, A.2
Szabo, E.3
-
135
-
-
3342896466
-
Inhibition of poly ADP-ribose polymerase attenuates acute lung injury in an ovine model of sepsis
-
Murakami K, Enkhbaatar P, Shimoda K et al. Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis. Shock 21(2), 126-133 (2004).
-
(2004)
Shock
, vol.21
, Issue.2
, pp. 126-133
-
-
Murakami, K.1
Enkhbaatar, P.2
Shimoda, K.3
-
136
-
-
68149183642
-
Selenium and inflammation: Underlying anti-inflammatory mechanisms
-
Duntas LH. Selenium and inflammation: underlying anti-inflammatory mechanisms. Horm. Metab. Res. 41(6), 443-447 (2009).
-
(2009)
Horm. Metab. Res.
, vol.41
, Issue.6
, pp. 443-447
-
-
Duntas, L.H.1
-
137
-
-
79953200838
-
Randomised trial of glutamine selenium or both to supplement parenteral nutrition for critically ill patients
-
Andrews PJ, Avenell A, Noble DW et al. Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ 342, d1542 (2011).
-
(2011)
BMJ
, vol.342
-
-
Andrews, P.J.1
Avenell, A.2
Noble, D.W.3
-
138
-
-
82955240870
-
Effect of N-acetylcysteine and fructose-1 6- bisphosphate in the treatment of experimental sepsis
-
10.1007/s10753-010-9261-9 Epub ahead of print
-
de Mello RO, Lunardelli A, Caberlon E et al. Effect of N-acetylcysteine and fructose-1,6- bisphosphate in the treatment of experimental sepsis. Inflammation DOI: 10.1007/s10753-010-9261-9 (2010) (Epub ahead of print).
-
(2010)
Inflammation
-
-
De Mello, R.O.1
Lunardelli, A.2
Caberlon, E.3
-
139
-
-
33749528921
-
Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats
-
Hsu BG, Lee RP, Yang FL, Harn HJ, Chen HI. Post-treatment with N-acetylcysteine ameliorates endotoxin shock-induced organ damage in conscious rats. Life Sci. 79(21), 2010-2016 (2006).
-
(2006)
Life Sci.
, vol.79
, Issue.21
, pp. 2010-2016
-
-
Hsu, B.G.1
Lee, R.P.2
Yang, F.L.3
Harn, H.J.4
Chen, H.I.5
-
140
-
-
33750288937
-
Apoptosis and caspases regulate death and inflammation in sepsis
-
Hotchkiss RS, Nicholson DW. Apoptosis and caspases regulate death and inflammation in sepsis. Nat. Rev. Immunol. 6(11), 813-822 (2006).
-
(2006)
Nat. Rev. Immunol.
, vol.6
, Issue.11
, pp. 813-822
-
-
Hotchkiss, R.S.1
Nicholson, D.W.2
-
141
-
-
78650419440
-
Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock
-
Landelle C, Lepape A, Voirin N et al. Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med. 36(11), 1859-1866 (2010).
-
(2010)
Intensive Care Med.
, vol.36
, Issue.11
, pp. 1859-1866
-
-
Landelle, C.1
Lepape, A.2
Voirin, N.3
-
142
-
-
66749164669
-
The sepsis seesaw: Tilting toward immunosuppression
-
Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA. The sepsis seesaw: tilting toward immunosuppression. Nat. Med. 15(5), 496-497 (2009).
-
(2009)
Nat. Med.
, vol.15
, Issue.5
, pp. 496-497
-
-
Hotchkiss, R.S.1
Coopersmith, C.M.2
McDunn, J.E.3
Ferguson, T.A.4
-
143
-
-
58149217137
-
A silent killer: Cytomegalovirus infection in the nonimmunocompromised critically ill patient
-
Kalil AC. A silent killer: cytomegalovirus infection in the nonimmunocompromised critically ill patient. Crit. Care Med. 36(12), 3261-3264 (2008).
-
(2008)
Crit. Care Med.
, vol.36
, Issue.12
, pp. 3261-3264
-
-
Kalil, A.C.1
-
144
-
-
58149235661
-
Increased mortality in long-term intensive care patients with active cytomegalovirus infection
-
Ziemann M, Sedemund-Adib B, Reiland P, Schmucker P, Hennig H. Increased mortality in long-term intensive care patients with active cytomegalovirus infection. Crit. Care Med. 36(12), 3145-3150 (2008).
-
(2008)
Crit. Care Med.
, vol.36
, Issue.12
, pp. 3145-3150
-
-
Ziemann, M.1
Sedemund-Adib, B.2
Reiland, P.3
Schmucker, P.4
Hennig, H.5
-
145
-
-
0027055454
-
A randomized prospective clinical trial to determine the efficacy of interferon-g in severely injured patients
-
Polk HC Jr, Cheadle WG, Livingston DH et al. A randomized prospective clinical trial to determine the efficacy of interferon-g in severely injured patients. Am. J. Surg. 163(2), 191-196 (1992).
-
(1992)
Am. J. Surg.
, vol.163
, Issue.2
, pp. 191-196
-
-
Polk Jr., H.C.1
Cheadle, W.G.2
Livingston, D.H.3
-
146
-
-
0031911123
-
Interferon-g in the prevention of severe burn-related infections: A European Phase III multicenter trial
-
The Severe Burns Study Group
-
Wasserman D, Ioannovich JD, Hinzmann RD, Deichsel G, Steinmann GG. Interferon-g in the prevention of severe burn-related infections: a European Phase III multicenter trial. The Severe Burns Study Group. Crit. Care Med. 26(3), 434-439 (1998).
-
(1998)
Crit. Care Med.
, vol.26
, Issue.3
, pp. 434-439
-
-
Wasserman, D.1
Ioannovich, J.D.2
Hinzmann, R.D.3
Deichsel, G.4
Steinmann, G.G.5
-
147
-
-
0028046930
-
Effect of interferon g on infection-related death in patients with severe injuries a randomized double-blind placebo-controlled trial
-
discussion 1042
-
Dries DJ, Jurkovich GJ, Maier RV et al. Effect of interferon g on infection-related death in patients with severe injuries. A randomized, double-blind, placebo-controlled trial. Arch Surg. 129(10), 1031-1041; discussion 1042 (1994).
-
(1994)
Arch Surg.
, vol.129
, Issue.10
, pp. 1031-1041
-
-
Dries, D.J.1
Jurkovich, G.J.2
Maier, R.V.3
-
148
-
-
17344363557
-
A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia
-
CAP Study Group
-
Nelson S, Belknap SM, Carlson RW et al. A randomized controlled trial of filgrastim as an adjunct to antibiotics for treatment of hospitalized patients with community-acquired pneumonia. CAP Study Group. J. Infect. Dis. 178(4), 1075-1080 (1998).
-
(1998)
J. Infect. Dis.
, vol.178
, Issue.4
, pp. 1075-1080
-
-
Nelson, S.1
Belknap, S.M.2
Carlson, R.W.3
-
149
-
-
0028905843
-
Enhancement of neutrophil function by in vivo filgrastim treatment for prophylaxis of sepsis in surgical intensive care patients
-
Weiss M, Gross-Weege W, Schneider M et al. Enhancement of neutrophil function by in vivo filgrastim treatment for prophylaxis of sepsis in surgical intensive care patients. J. Crit. Care 10(1), 21-26 (1995).
-
(1995)
J. Crit. Care
, vol.10
, Issue.1
, pp. 21-26
-
-
Weiss, M.1
Gross-Weege, W.2
Schneider, M.3
-
150
-
-
0033823702
-
A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia
-
Nelson S, Heyder AM, Stone J et al. A randomized controlled trial of filgrastim for the treatment of hospitalized patients with multilobar pneumonia. J. Infect. Dis. 182(3), 970-973 (2000).
-
(2000)
J. Infect. Dis.
, vol.182
, Issue.3
, pp. 970-973
-
-
Nelson, S.1
Heyder, A.M.2
Stone, J.3
-
151
-
-
0037323852
-
Multicenter double-blind placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis
-
Root RK, Lodato RF, Patrick W et al. Multicenter, double-blind, placebo-controlled study of the use of filgrastim in patients hospitalized with pneumonia and severe sepsis. Crit. Care Med. 31(2), 367-373 (2003).
-
(2003)
Crit. Care Med.
, vol.31
, Issue.2
, pp. 367-373
-
-
Root, R.K.1
Lodato, R.F.2
Patrick, W.3
-
152
-
-
70349469854
-
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: A double-blind randomized placebo-controlled multicenter trial
-
Meisel C, Schefold JC, Pschowski R et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am. J. Respir. Crit. Care Med. 180(7), 640-648 (2009).
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.180
, Issue.7
, pp. 640-648
-
-
Meisel, C.1
Schefold, J.C.2
Pschowski, R.3
-
153
-
-
42649125225
-
PD-1 and its ligands in tolerance and immunity
-
Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 26, 677-704 (2008).
-
(2008)
Annu. Rev. Immunol.
, vol.26
, pp. 677-704
-
-
Keir, M.E.1
Butte, M.J.2
Freeman, G.J.3
Sharpe, A.H.4
-
154
-
-
79953121419
-
Programmed death-1 levels correlate with increased mortality nosocomial infection and immune dysfunctions in septic shock patients
-
Guignant C, Lepape A, Huang X et al. Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit. Care 15(2), R99 (2011).
-
(2011)
Crit. Care
, vol.15
, Issue.12
-
-
Guignant, C.1
Lepape, A.2
Huang, X.3
-
155
-
-
65549084772
-
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
-
USA
-
Huang X, Venet F, Wang YL et al. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc. Natl Acad. Sci. USA 106(15), 6303-6308 (2009).
-
(2009)
Proc. Natl Acad. Sci.
, vol.106
, Issue.15
, pp. 6303-6308
-
-
Huang, X.1
Venet, F.2
Wang, Y.L.3
-
156
-
-
79959716811
-
Dose-dependent effect of anti-CTLA-4 on survival in sepsis
-
Inoue S, Bo L, Bian J, Unsinger J, Chang K, Hotchkiss RS. Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock 36(1), 38-44 (2011).
-
(2011)
Shock
, vol.36
, Issue.1
, pp. 38-44
-
-
Inoue, S.1
Bo, L.2
Bian, J.3
Unsinger, J.4
Chang, K.5
Hotchkiss, R.S.6
-
157
-
-
77949317183
-
IL-15 prevents apoptosis reverses innate and adaptive immune dysfunction and improves survival in sepsis
-
Inoue S, Unsinger J, Davis CG et al. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J. Immunol. 184(3), 1401-1409 (2010).
-
(2010)
J. Immunol.
, vol.184
, Issue.3
, pp. 1401-1409
-
-
Inoue, S.1
Unsinger, J.2
Davis, C.G.3
-
158
-
-
77951648850
-
IL-7 promotes T cell viability trafficking and functionality and improves survival in sepsis
-
Unsinger J, McGlynn M, Kasten KR et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J. Immunol. 184(7), 3768-3779 (2010).
-
(2010)
J. Immunol.
, vol.184
, Issue.7
, pp. 3768-3779
-
-
Unsinger, J.1
McGlynn, M.2
Kasten, K.R.3
-
159
-
-
0032933560
-
IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense
-
Steinhauser ML, Hogaboam CM, Kunkel SL, Lukacs NW, Strieter RM, Standiford TJ. IL-10 is a major mediator of sepsis-induced impairment in lung antibacterial host defense. J. Immunol. 162(1), 392-399 (1999).
-
(1999)
J. Immunol.
, vol.162
, Issue.1
, pp. 392-399
-
-
Steinhauser, M.L.1
Hogaboam, C.M.2
Kunkel, S.L.3
Lukacs, N.W.4
Strieter, R.M.5
Standiford, T.J.6
-
160
-
-
0035115013
-
Alveolar macrophage deactivation in murine septic peritonitis: Role of interleukin 10
-
Reddy RC, Chen GH, Newstead MW et al. Alveolar macrophage deactivation in murine septic peritonitis: role of interleukin 10. Infect. Immun. 69(3), 1394-1401 (2001).
-
(2001)
Infect. Immun.
, vol.69
, Issue.3
, pp. 1394-1401
-
-
Reddy, R.C.1
Chen, G.H.2
Newstead, M.W.3
-
161
-
-
77950208700
-
Characterization and modulation of the immunosuppressive phase of sepsis
-
Muenzer JT, Davis CG, Chang K et al. Characterization and modulation of the immunosuppressive phase of sepsis. Infect. Immun. 78(4), 1582-1592 (2010).
-
(2010)
Infect. Immun.
, vol.78
, Issue.4
, pp. 1582-1592
-
-
Muenzer, J.T.1
Davis, C.G.2
Chang, K.3
-
162
-
-
5944251623
-
Caspase inhibitors improve survival in sepsis: A critical role of the lymphocyte
-
Hotchkiss RS, Chang KC, Swanson PE et al. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat. Immunol. 1(6), 496-501 (2000).
-
(2000)
Nat. Immunol.
, vol.1
, Issue.6
, pp. 496-501
-
-
Hotchkiss, R.S.1
Chang, K.C.2
Swanson, P.E.3
-
163
-
-
0142093069
-
Inhibition of Fas/Fas ligand signaling improves septic survival: Differential effects on macrophage apoptotic and functional capacity
-
Chung CS, Song GY, Lomas J, Simms HH, Chaudry IH, Ayala A. Inhibition of Fas/ Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J. Leukoc. Biol. 74(3), 344-351 (2003).
-
(2003)
J. Leukoc. Biol.
, vol.74
, Issue.3
, pp. 344-351
-
-
Chung, C.S.1
Song, G.Y.2
Lomas, J.3
Simms, H.H.4
Chaudry, I.H.5
Ayala, A.6
-
164
-
-
0034068769
-
An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients
-
Galban C, Montejo JC, Mesejo A et al. An immune-enhancing enteral diet reduces mortality rate and episodes of bacteremia in septic intensive care unit patients. Crit. Care Med. 28(3), 643-648 (2000).
-
(2000)
Crit. Care Med.
, vol.28
, Issue.3
, pp. 643-648
-
-
Galban, C.1
Montejo, J.C.2
Mesejo, A.3
-
165
-
-
0028935349
-
Early enteral administration of a formula impact supplemented with arginine nucleotides and fish oil in intensive care unit patients: Results of a multicenter prospective randomized clinical trial
-
Bower RH, Cerra FB, Bershadsky B et al. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized, clinical trial. Crit. Care Med. 23(3), 436-449 (1995).
-
(1995)
Crit. Care Med.
, vol.23
, Issue.3
, pp. 436-449
-
-
Bower, R.H.1
Cerra, F.B.2
Bershadsky, B.3
-
166
-
-
0029815057
-
A randomized trial of isonitrogenous enteral diets after severe trauma an
-
discussion 540-533
-
Kudsk KA, Minard G, Croce MA et al. A randomized trial of isonitrogenous enteral diets after severe trauma. An immune-enhancing diet reduces septic complications. Ann. Surg. 224(4), 531-540; discussion 540-533 (1996).
-
(1996)
Ann. Surg.
, vol.224
, Issue.4
, pp. 531-540
-
-
Kudsk, K.A.1
Minard, G.2
Croce, M.A.3
-
167
-
-
0032487082
-
Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma
-
Houdijk AP, Rijnsburger ER, Jansen J et al. Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma. Lancet 352(9130), 772-776 (1998).
-
(1998)
Lancet
, vol.352
, Issue.9130
, pp. 772-776
-
-
Houdijk, A.P.1
Rijnsburger, E.R.2
Jansen, J.3
-
168
-
-
2942755759
-
Why do animal models sometimes fail to mimic human sepsis
-
Esmon CT. Why do animal models (sometimes) fail to mimic human sepsis? Crit. Care Med. 32(5 Suppl.), S219-S222 (2004).
-
(2004)
Crit. Care Med.
, vol.32
, Issue.5
-
-
Esmon, C.T.1
-
169
-
-
58849093274
-
Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting
-
Dyson A, Singer M. Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting? Crit. Care Med. 37(1 Suppl.), S30-S37 (2009).
-
(2009)
Crit. Care Med.
, vol.37
, Issue.1
-
-
Dyson, A.1
Singer, M.2
-
170
-
-
33646787140
-
The use of immunocompromised animals as models for human septic shock
-
Opal SM, Cross AS. The use of immunocompromised animals as models for human septic shock. Shock 24(Suppl. 1), 64-70 (2005).
-
(2005)
Shock
, vol.24
, Issue.1
, pp. 64-70
-
-
Opal, S.M.1
Cross, A.S.2
-
171
-
-
0029164732
-
Neutralization of IL-10 increases lethality in endotoxemia cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor
-
Standiford TJ, Strieter RM, Lukacs NW, Kunkel SL. Neutralization of IL-10 increases lethality in endotoxemia. Cooperative effects of macrophage inflammatory protein-2 and tumor necrosis factor. J. Immunol. 155(4), 2222-2229 (1995).
-
(1995)
J. Immunol.
, vol.155
, Issue.4
, pp. 2222-2229
-
-
Standiford, T.J.1
Strieter, R.M.2
Lukacs, N.W.3
Kunkel, S.L.4
-
172
-
-
19444367817
-
Concept of PIRO as a new conceptual framework to understand sepsis
-
Opal SM. Concept of PIRO as a new conceptual framework to understand sepsis. Pediatr Crit Care Med. 6(3 Suppl.), S55-S60 (2005).
-
(2005)
Pediatr Crit Care Med.
, vol.6
, Issue.3
-
-
Opal, S.M.1
-
173
-
-
0032734726
-
Clinical aspects: From systemic inflammation to 'immunoparalysis
-
Volk HD, Reinke P, Docke WD. Clinical aspects: from systemic inflammation to 'immunoparalysis'. Chem. Immunol. 74, 162-177 (2000).
-
(2000)
Chem. Immunol.
, vol.74
, pp. 162-177
-
-
Volk, H.D.1
Reinke, P.2
Docke, W.D.3
-
174
-
-
0031054684
-
Interferon γ-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: Proof of principle
-
Kox WJ, Bone RC, Krausch D et al. Interferon γ-1b in the treatment of compensatory anti-inflammatory response syndrome. A new approach: proof of principle. Arch. Intern. Med. 157(4), 389-393 (1997).
-
(1997)
Arch. Intern. Med.
, vol.157
, Issue.4
, pp. 389-393
-
-
Kox, W.J.1
Bone, R.C.2
Krausch, D.3
-
175
-
-
0032997973
-
Cytokines and anticytokines in the pathogenesis of sepsis
-
ix
-
van der Poll T, van Deventer SJ. Cytokines and anticytokines in the pathogenesis of sepsis. Infect. Dis. Clin. North Am. 13(2), 413-426, ix (1999).
-
(1999)
Infect. Dis. Clin. North Am.
, vol.13
, Issue.2
, pp. 413-426
-
-
Van Der Poll, T.1
Van Deventer, S.J.2
-
176
-
-
0035172366
-
Sepsis-induced immunosuppression: From bad to worse
-
Reddy RC, Chen GH, Tekchandani PK, Standiford TJ. Sepsis-induced immunosuppression: from bad to worse. Immunol. Res. 24(3), 273-287 (2001).
-
(2001)
Immunol. Res.
, vol.24
, Issue.3
, pp. 273-287
-
-
Reddy, R.C.1
Chen, G.H.2
Tekchandani, P.K.3
Standiford, T.J.4
-
177
-
-
77951943661
-
Recent insights into the pathogenesis of bacterial sepsis
-
Anas AA, Wiersinga WJ, de Vos AF, van der Poll T. Recent insights into the pathogenesis of bacterial sepsis. Neth. J. Med. 68(4), 147-152 (2010).
-
(2010)
Neth. J. Med.
, vol.68
, Issue.4
, pp. 147-152
-
-
Anas, A.A.1
Wiersinga, W.J.2
De Vos, A.F.3
Van Der Poll, T.4
|