The effects of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxyl-3- methoxybenzylidine)cyclohexanone on proinflammatory signaling pathways and CLP-induced lethal sepsis in mice

European Journal of Pharmacology

Volumn 652, Issue 1-3, 2011, Pages 136-144

  Tham, Chau Ling ^a   Lam, Kok Wai ^a   Rajajendram, Revathee ^a   Cheah, Yoke Kqueen ^a   Sulaiman, Mohd Roslan ^a   Lajis, Nordin H ^a   Kim, Min Kyu ^a,b   Israf, Daud A ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b Korea Foundation of Polytechnic Colleges   (South Korea)

Author keywords

BHMC; Curcumin; MAPK; Monocyte; NF B; Sepsis

Indexed keywords

2,6 BIS (4 HYDROXYL 3 METHOXYBENZYLIDINE)CYCLOHEXANONE; ACTIVATING TRANSCRIPTION FACTOR 2; ANTIINFLAMMATORY AGENT; CURCUMIN; I KAPPA B ALPHA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ELK 1; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL STRAIN U937; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TOLERABILITY; DRUG TREATMENT FAILURE; ENZYME ACTIVITY; EXPERIMENTAL LIGATION; LETHALITY; MALE; MOLECULAR DOCKING; MONOCYTE; MOUSE; NONHUMAN; OPTIMAL DRUG DOSE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL TIME;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CURCUMIN; CYCLOHEXANONES; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; IMMUNOPRECIPITATION; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED ICR; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; PHOSPHORYLATION; SEPSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 78650881177     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.092     Document Type: Article

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