The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense

Journal of Leukocyte Biology

Volumn 64, Issue 1, 1998, Pages 14-18

  Elsbach, Peter ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Clinical application; Endogenous antibiotics; LPS binding protein; Structure function relations

Indexed keywords

ANTIBIOTIC AGENT; BACTERICIDAL PERMEABILITY INCREASING PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE;

AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; BACTEREMIA; BACTERIOSTASIS; BINDING AFFINITY; CELL GRANULE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYSTIC FIBROSIS; CYTOTOXICITY; ENDOTOXEMIA; GRAM NEGATIVE BACTERIUM; HOST RESISTANCE; HUMAN; MAJOR CLINICAL STUDY; MENINGOCOCCEMIA; NEUTROPHIL; PERITONITIS; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ANIMALIA; BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 0031776895     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1002/jlb.64.1.14     Document Type: Conference Paper

References (61)

1. Broekaert, W. F., Terras, F. R., Cammue, B. P., Osborn, R. W. (1995) Plant defensins: novel antimicrobial peptides as components of the host defense system. Plant Physiol. 108, 1353-1358.
2. Boman, H. G. (1995) Peptide antibiotics and their role in innate immunity. Annu. Rev. Immunol. 13, 61-92.
3. Hoffmann, J. A., Reichhart, J. (1997) Drosophila immunity. Trends Cell Biol. 7, 309-316.
4. Dushay, M. S., Asling, B., Hultmark, D. (1996) Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila. Proc. Natl. Acad. Sci. USA 93, 10343-10347.
5. Elsbach, P., Weiss, J. (1995) Prospects for the use of recombinant BPI in the treatment of Gram-negative bacterial infections. Infectious Agents Dis. 4, 102-109.
6. Lin, Y., Ammons, W. S., Leach, W. J., Kung, A. H. (1994) Protective effects of a recombinant N-terminal fragment of bactericidal/permeability increasing protein on endotoxic shock in conscious rabbits. Shock 2, 324-331.
7. Lin, Y., Kohn, F. R., Kung, A. H., Ammons, W. S. (1994) Protective effect of a recombinant fragment of bactericidal/permeability increasing protein against carbohydrate dyshomeostasis and tumor necrosis factor-alpha elevation in rat endotoxemia. Biochem. Pharmacol. 47, 1553-1559.
8. Lin, Y., Leach, W. J., Ammons, W. S. (1996) Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit gram-negative sepsis. Antimicrobial Agents Chemother. 40, 65-69.
9. Bauer, R. J., White, M. L., Wedel, N., Nelson, B. J., Friedmann, N., Cohen, A., Hustinx, W. N., Kung, A. H. (1996) A phase I safety and pharmacokinetic study of a recombinant amino terminal fragment of bactericidal/ permeability-increasing protein in healthy male volunteers. Shock 5, 91-96.
10. Larrick, J. W., Hirata, M., Balint, R. F., Lee, J., Zhong, J., Wright, S. C. (1995) Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein. Infect. Immun. 63, 1291-1297.
11. Steinberg, D. A., Hurst, M. A., Fujii, C. A., Kung, A. H., Ho, J. F., Cheng, F. C., Loury, D. J., Fiddes, J. C. (1997) Protegrin-1: a broad-spectrum, rapidly microbicidal peptide with in vivo activity. Antimicrob. Agents Chemother. 41, 1738-1742.
12. Giroir, B. P., Quint, P. A., Barton, P., Kirsch, E. A., Kitchen, L., Goldstein, B., Margraf, D., Sastry, S., Orlowski, J. P., Bradley, J. S., Nelson, B. J., Wedel, N. I., White, M. L., Bauer, R. J., Carroll, S. F., Scannon, P. J. (1997) Evaluation of rBPI21 (Recombinant amino terminal fragment of Human Bactericidal/Permeability-Increasing Protein) in children with severe meningococcal disease. Lancet 350, 1439-1443.
13. Elsbach, P., Weiss, J. (1992) Oxygen-independent antimicrobial systems of phagocytes. In Inflammation: Basic Principles and Clinical Correlates (J. I. Gallin, I. M. Goldstein, and R. Snyderman, eds.), New York: Raven, 603-636.
14. Levy, O. (1996) Antibiotic proteins of polymorphonuclear leukocytes. Eur. J. Haematol. 56, 263-277.
15. Ouellette, A. J., Selsted, M. E. (1996) Paneth cell defensins: endogenous peptide components of intestinal host defense. FASEB J. 10, 1280-1289.
16. Diamond, G., Russell, J. P., Bevins, C. L. (1996) Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells. Proc. Natl. Acad. Sci. USA 93, 5156-5160.
17. Ganz, T., Weiss, J. (1997) Antimicrobial peptides of phagocytes and epithelia. Semin. Hematol. 34, 342-354.
18. Elsbach, P., Weiss, J. (1993) Bactericidal/permeability increasing protein and host defense against gram-negative bacteria and endotoxin. Curr. Op. Immunol. 5, 103-107.
19. Elsbach, P., Weiss, J. (1993) The bactericidal/permeability-increasing protein (BPI), a potent element in host-defense against gram-negative bacteria and lipopolysaccharide. Immunobiol. 187, 417-429.
20. Elsbach, P., Weiss, J., Levy, O. (1994) Integration of antimicrobial host defenses: role of the bactericidal/permeability-increasing protein. Trends Microbiol. 2, 324-328.
21. Elsbach, P. (1994) Bactericidal permeability-increasing protein in host defence against Gram-negative bacteria and endotoxin. In Antimicrobial Peptides, Ciba Foundation Symposium 186 (J. Marsh and J. A. Goode, eds.), Chichester, UK: Wiley, 176-189.
22. Weiss, J., Elsbach, P., Olsson, I., Odeberg, H. (1978) Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes. J. Biol. Chem. 253, 2664-2672.
23. 2 from rabbit polymorphonuclear leukocytes. Observations on their relationship. J. Biol. Chem. 254, 11000-11009.
24. Gazzano-Santoro, H., Parent, J. B., Grinna, L., Horwitz, A., Parsons, T., Theofan, G., Elsbach, P., Weiss, J., Conlon, P. J. (1992) High-affinity binding of the bactericidal/permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide. Infect. Immun. 60, 4754-4761.
25. Rietschel, E. T., Brade, H., Holst, O., Brade, L., Muller-Loennies, S., Mamat, U., Zähringer, U., Beckmann, F., Seydel, U., Brandenburg, K., Ulmer, A. J., Mattern, T., Heine, H., Schletter, J., Loppnow, H., Schönbeck, U., Flad, H. D., Hauschildt, S., Schade, U. F., Di Padova, F., Kusumoto, S., Schumann, R. R. (1996) Bacterial endotoxin: Chemical constitution, biological recognition, host response, and immunological detoxification. Curr. Top. Microbiol. Immunol. 216, 39-81.
26. Wright, G. C., Weiss, J., Kim, K. S., Verheij, H., Elsbach, P. (1990) Bacterial phospholipid hydrolysis enhances the destruction of Escherichia coli ingested by rabbit neutrophils. Role of cellular and extracellular phospholipases. J. Clin. Invest. 85, 1925-1935.
27. 2 in concert with polymorphonuclear leukocytes. J. Biol. Chem. 269, 26331-26337.
28. 2 on cell-free prothrombinase complex. J. Biol. Chem. 269, 26338-26343.
29. 2 acting against Escherichia coli. Infect. Immun. 64, 2425-2430.
30. Mannion, B. A., Weiss, J., Elsbach, P. (1990) Separation of sublethal and lethal effects of polymorphonuclear leukocytes on Escherichia coli. J. Clin. Invest. 86, 631-641.
31. Mannion, B. A., Weiss, J., Elsbach, P. (1990) Separation of sublethal and lethal effects of the bactericidal/permeability increasing protein on Escherichia coli. J. Clin. Invest. 85, 853-860.
32. in't Veld, G., Mannion, B., Weiss, J., Elsbach, P. (1988) Effects of the bactericidal/permeability-increasing protein of polymorphonuclear leukocytes on isolated bacterial cytoplasmic membrane vesicles. Infect. Immun. 56, 1203-1208.
33. 2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein. J. Biol. Chem. 262, 14891-14894.
34. Ooi, C. E., Weiss, J., Doerfler, M. E., Elsbach, P. (1991) Endotoxin-neutralizing properties of the 25 kD N-terminal fragment and a newly isolated 30 kD C-terminal fragment of the 55-60 kD bactericidal/ permeability-increasing protein of human neutrophils. J. Exp. Med. 174, 649-655.
35. Gazzano-Santoro, H., Parent, J. B., Conlon, P. J., Kasler, H. G., Tsai, C. M., Lill-Elghanian, D. A., Hollingsworth, R. I. (1995) Characterization of the structural elements in lipid A required for binding of a recombinant fragment of Bactericidal/Permeability-Increasing protein rBPI23. Infect. Immun. 63, 2201-2205.
36. Mannion, B. A., Kalatzis, E. S., Weiss, J., Elsbach, P. (1989) Preferential binding of the neutrophil cytoplasmic granule-derived bactericidal/ permeability increasing protein to target bacteria. Implications and use as a means of purification. J. Immunol. 142, 2807-2812.
37. Beamer, L. J., Carroll, S. F., Eisenberg, D. (1997) Crystal structure of human BPI and two bound phospholipids at 2.4 Angstrom resolution. Science 276, 1881-1884.
38. Weiss, J., Victor, M., Elsbach, P. (1983) Role of charge and hydrophobic interactions in the action of the bactericidal/permeability-increasing protein of neutrophils on gram-negative bacteria. J. Clin. Invest. 71, 540-549.
39. Horwitz, A. H., Leigh, S. D., Abrahamson, S., Gazzano-Santoro, H., Liu, P. S., Williams, R. E., Carroll, S. F., Theofan, G. (1996) Expression and characterization of cysteine-modified variants of an amino-terminal fragment of Bactericidal/Permeability-Increasing protein. Protein Expression Purification 8, 28-40.
40. Tall, A. (1995) Plasma lipid transfer proteins. Annu. Rev. Biochem. 64, 235-257
41. Ulevitch, R. J., Dunn, D. L., Fink, M. P., Taylor, C. E. (1996) Endotoxin-related intracellular pathways: implications for therapeutic intervention. Shock 6, 1-2.
42. Abrahamson, S. L., Wu, H. M., Williams, R. E., Der, K., Ottah, N., Little, R., Gazzano-Santoro, H., Theofan, G., Bauer, R., Leigh, S., Orme, A., Horwitz, A. H., Carroll, S. F., Dedrick, R. L. (1997) Biochemical characterization of recombinant fusions of lipopolysaccharide binding protein and bactericidal/permeability-increasing protein. Implications in biological activity. J. Biol. Chem. 272, 2149-2155.
43. Capodici, C., Weiss, J. (1996) Both N-and C-terminal regions of the bioactive N-terminal fragment of the neutrophil granule bactericidal/ permeability-increasing protein are required for stability and function. J. Immunol. 156, 4789-4796.
44. Katz, S. S., Chen, K., Chen, S., Doerfler, M. E., Elsbach, P., Weiss, J. (1996) Potent CD14-mediated signalling of human leukocytes by Escherichia coli can be mediated by interaction of whole bacteria and host cells without extensive prior release of endotoxin. Infect. Immun. 64, 3592-3600.
45. Iovine, N., Elsbach, P., Weiss, J. (1997) An opsonic function of the neutrophil Bactericidal/Permeability-Increasing protein depends on both its N-and C-terminal domains. Proc. Natl. Acad. Sci. USA 94, 10973-10978.
46. Tobias, P. S., Soldau, K., Iovine, N., Elsbach, P., Weiss, J. (1997) Lipopolysaccharide (LPS) binding proteins BPI and LBP form different complexes with LPS. J. Biol. Chem. 272, 18682-18685.
47. Schumann, R. R., Leong, S. R., Flaggs, G. W., Gray, P. W., Wright, S. D., Mathison, J. C., Tobias, P. S., Ulevitch, R. J. (1990) Structure and function of lipopolysaccharide binding protein. Science 249, 1429-1431.
48. Weiss, J., Olsson, I. (1987) Cellular and subcellular localization of the bactericidal/permeability-increasing protein of neutrophils. Blood 69, 652-659.
49. Weersink, A. J., van Kessel, K. P., van den Tol. M. E., van Strijp, J. A., Torensma, R., Verhoef, J., Elsbach, P., Weiss, J. (1993) Human granulocytes express a 55-kDa lipopolysaccharide-binding protein on the cell surface that is identical to the bactericidal/permeability-increasing protein. J. Immunol. 150, 253-263.
50. Dentener, M. A., Francot, G. J., Buurman, W. A. (1996) Bactericidal/ permeability-increasing protein, a lipopolysaccharide-specific protein on the surface of human peripheral blood monocytes. J. Infect. Dis. 173, 252-255.
51. Weinrauch, Y., Foreman, A., Shu, C., Zarember, K., Levy, O., Elsbach, P., Weiss, J. (1995) Extracellular accumulation of potently microbicidal bactericidal/permeability-increasing protein and p15s in an evolving sterile rabbit peritoneal inflammatory exudate. J. Clin. Invest. 95, 1916-1924.
52. Ooi, C. E., Weiss, J., Levy, O., Elsbach, P. (1990) Isolation of two isoforms of a novel 15-kDa protein from rabbit polymorphonuclear leukocytes that modulate the antibacterial actions of other leukocyte proteins. J. Biol. Chem. 265, 15956-15962.
53. Levy, O., Weiss, J., Zarember, K., Ooi, C. E., Elsbach, P. (1993) Antibacterial 15-kDa protein isoforms (p15s) are members of a novel family of leukocyte proteins. J. Biol. Chem. 268, 6058-6063.
54. Zarember, K., Elsbach, P., Shin-Kim, K., Weiss, J. (1997) p15s (15-kD antimicrobial proteins) are stored in the secondary granules of rabbit granulocytes: Implications for antibacterial synergy with the bactericidal/ permeability-increasing protein in inflammatory fluids. Blood 89, 672-679.
55. Zanetti, M., Gennaro, R., Romeo, D. (1995) Cathelicidins: a novel protein family with a common proregion and a variable C-terminal antimicrobial domain. FEBS Lett. 374, 1-5.
56. Levy, O., Ooi, C. E., Weiss, J., Lehrer, R. I., Elsbach, P. (1994) Individual and synergistic effects of rabbit granulocyte proteins on Escherichia coli. J. Clin. Invest. 94, 672-682.
57. Weiss, J. (1994) Leukocyte-derived antimicrobial proteins. Curr. Op. Hematol. 1, 78-84.
58. von der Mohlen, M. A., Kimmings, A. N., Wedel, N. I., Mevissen, M. L., Jansen, J., Friedmann, N., Lorenz, T. J., Nelson, B. J., White, M. L., Bauer, R., et al. (1995) Inhibition of endotoxin-induced cytokine release and neutrophil activation in humans by use of recombinant bactericidal/ permeability-increasing protein. J. Infect. Dis. 172, 144-151.
59. von der Mohlen, M. A., van Deventer, S. J., Levi, M., van den Ende, B., Wedel, N. I., Nelson, B. J., Friedmann, N., ten Cate, J. W. (1995) Inhibition of endotoxin-induced activation of the coagulation and fibrinolytic pathways using a recombinant endotoxin-binding protein (rBPI23). Blood 85, 3437-3443.
60. Yao, Y. M., Bahrami, S., Leichtfried, G., Redl, H., Schlag, G. (1995) Pathogenesis of hemorrhage-induced bacteria/endotoxin translocation in rats. Effects of recombinant bactericidal/permeability-increasing protein. Ann. Surg. 221, 398-405.
61. Elsbach, P. (1998) Recent advances in therapy of sepsis: focus on recombinant bactericidal/permeability-increasing protein (BPI). BioDrugs in press.