Effect of N-acetylcysteine and fructose-1,6-bisphosphate in the treatment of experimental sepsis

Inflammation

Volumn 34, Issue 6, 2011, Pages 539-550

  De Mello, Ricardo Obalski ^a   Lunardelli, Adroaldo ^a   Caberlon, Eduardo ^a   De Moraes, Cristina MacHado Bragança ^a   Christ Vianna Santos, Roberto ^a   Da Costa, Vinicius Lorini ^a   Da Silva, Gabriela Viegas ^a   Da Silva Scherer, Patrícia ^a   Buaes, Luiz Eduardo Coimbra ^a   Da Silva Melo, Denizar Alberto ^a   Donadio, Márcio Vinícius Fagundes ^a   Nunes, Fernanda Bordignon ^a   De Oliveira, Jarbas Rodrigues ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

fructose 1,6 bisphosphate; N acetylcysteine; oxidative stress; sepsis

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CATALASE; FRUCTOSE 1,6 BISPHOSPHATE; GLUCOSE; GLUTATHIONE; IRON; LACTATE DEHYDROGENASE; SERUM ALBUMIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UREA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; ESCHERICHIA COLI; GLUCOSE BLOOD LEVEL; GLUTATHIONE METABOLISM; IRON BLOOD LEVEL; LACTATE DEHYDROGENASE BLOOD LEVEL; LEUKOCYTE COUNT; LIVER PROTECTION; MALE; MORBIDITY; MORTALITY; MOUSE; NEUTROPHIL COUNT; NONHUMAN; OXIDATIVE STRESS; RAT; RENAL PROTECTION; SEPSIS; SURVIVAL TIME; THROMBOCYTE COUNT; UREA BLOOD LEVEL;

ACETYLCYSTEINE; ANIMALS; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; FRUCTOSE-BISPHOSPHATASE; RATS; SEPSIS; SURVIVAL RATE; TREATMENT OUTCOME;

ANIMALIA; ESCHERICHIA COLI; MUS; RATTUS;

EID: 82955240870     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-010-9261-9     Document Type: Article

References (58)

1. RC Bone 1991 The pathogenesis of sepsis Annals of Internal Medicine 115 457 469 1872494 1:CAS:528:DyaK38Xls1eksA%3D%3D
2. I Matot CL Sprung 2001 Definition of sepsis Intensive Care Medicine 27 S3 S9 11307368 10.1007/PL00003795
3. PY Bochud T Calandra 2003 Pathogenesis of sepsis: new concepts and implications for future treatment BMJ 326 262 266 12560281 10.1136/bmj.326.7383. 262 1:CAS:528:DC%2BD3sXhslKks70%3D (Pubitemid 36169594)
4. GS Martin DM Mannino S Eaton, et al. 2003 Epidemiology of sepsis in the United States from 1979 through 2000 The New England Journal of Medicine 348 1546 1554 12700374 10.1056/NEJMoa022139 (Pubitemid 36437931)
5. E Silva A Pedro Mde AC Sogayar T Mohovic CL Silva M Janiszewski RG Cal EF Sousa TP Abe J Andrade JD Matos E Rezende M Assunção A Avezum PC Rocha GF Matos AM Bento AD Corrêa PC Vieira E Knobel 2004 Brazilian Sepsis Epidemiological Study Critical Care 8 4 251 260 10.1186/cc2892
6. LB Hinshaw 1996 Sepsis/Septic shock: participation of the microcirculation: Na abbreviated review Critical Care Medicine 24 1072 1078 8681576 10.1097/00003246-199606000-00031 1:STN:280:DyaK283otlKqsw%3D%3D (Pubitemid 26189953)
7. J Creteur JL Vicente 2000 Hemoglobin solutions: an "all-in-one" therapeutic strategy in sepsis? Critical Care Medicine 28 894 896 10752855 10.1097/00003246-200003000-00054 1:STN:280:DC%2BD3c3hsVGhuw%3D%3D (Pubitemid 30174303)
8. LG Thijs, et al. 1995 Time course of citokine levels in sepsis Intensive Care Medicine 21 S258 S263 8636533 10.1007/BF01740764
9. MG Davies PO Hagen 1997 Systemic inflammatory response syndrome The British Journal of Surgery 84 7 920 935 9240130 10.1002/bjs.1800840707 1:STN:280:DyaK2szosVClsA%3D%3D (Pubitemid 27310857)
10. GM Rubanyi 1996 Fatores derivados do endotélio no choque Clin Bras Med Intensiva 3 13 26
11. ABC Groeneveld ADM Kester JJP Nauta 1987 Relation of arterial blood lactate to oxygen delivery and hemodynamic variables in human shock states Circulatory Shock 22 35 53 3608105 1:STN:280:DyaL2s3ntl2kuw%3D%3D (Pubitemid 17115560)
12. L Metrangolo M Fiorillo G Friedman, et al. 1995 Early hemodynamic course of septic shock Critical Care Medicine 23 1931 1975 10.1097/00003246-199512000- 00005 (Pubitemid 26002765)
13. E Benjamin AB Leibowitz J Oropello TJ Iberti 1992 Systemic hypoxic and inflammatory syndrome: an alternative designation for "sepsis syndrome" Critical Care Medicine 20 680 682 1572194 10.1097/00003246- 199205000-00022 1:STN:280:DyaK383ktFSjsw%3D%3D
14. LC Azevedo M Janiszewski FG Sorino FR Laurino 2006 Redox mechanisms of vascular cell dysfunction in sepsis Endocrine, Metabolic & Immune Disorders Drug Targets 6 159 164 1:CAS:528:DC%2BD28XlsVGqsbo%3D (Pubitemid 43881028)
15. Halliwell, B., and J.M.C. Gutteridge. 1999. Free radicals in biology and medicine, 3rd ed. New York: Oxford University Press.
16. I Dalle-Donne G Aldini M Carini R Colombo R Rossi A Milzani 2006 Protein carbonylation, cellular dysfunction and disease progression Journal of Cellular and Molecular Medicine 10 2 389 406 16796807 10.1111/j.1582-4934.2006.tb00407.x 1:CAS:528:DC%2BD2sXlvFCltb0%3D (Pubitemid 44870187)
17. PRA Carvalho EA Trotta 2003 Avanços no diagnóstico e tratamento da sepse Jornal de Pediatria 79 2 S195 S204 14647716 10.1590/S0021-75572003000800009
18. CAF Aiub R Bortolini AA Azambuja 2003 Alves Filho JCF, Nunes FB, Oliveira JR. Alterations in the indexes of apoptosis and necrosis induced by galactosamine in the liver of Wistar rats treated with fructose-1, 6-bisphosphate Hepatology Research 25 1 83 91 10.1016/S1386-6346(02)00171-7 (Pubitemid 36367267)
19. JR Oliveira JL Rosa S Ambrosio, et al. 1992 Effect of galactosamine on hepatic carbohydrate metabolism: protective role of fructose-1, 6-bisphosphate Hepatology 15 1147 1153 1317340 10.1002/hep.1840150628
20. FB Nunes CM Graziottin 2003 Alves Filho JCF, Lunardelli A, Pires MGS, Wächter PH, Oliveira JR. An assessment of fructose-1, 6-bisphosphate as an antimicrobial and anti-inflammatory agent in sepsis Pharmacological Research 47 1 35 41 12526859 10.1016/S1043-6618(02)00255-4 1:CAS:528:DC%2BD3sXjtFGnsA%3D%3D (Pubitemid 36259620)
21. L Cattani R Costrini C Cerilli MP Rigobello M Bianchi L Galzigna 1980 Fructose-1, 6-diphosphate dependence on the toxicity and uptake of potassium ions Agressologie 21 263 264 7246913 1:STN:280:DyaL3M3jtVSrtg%3D%3D (Pubitemid 11219258)
22. A Sola J Panes C Xaus G Hotter 2003 Fructose-1, 6-biphosphate and nucleoside pool modifications prevent neutrophil accumulation in the reperfused intestine Journal of Leukocyte Biology 73 74 81 12525564 10.1189/jlb.0602299 (Pubitemid 36125677)
23. FB Nunes CM Graziottin JCF Alves-Filho A Lunardelli E Caberlon A Peres JR Rodrigues 2003 Immunomodulatory effect of fructose-1, 6-bisphosphate on T-lymphocytes International Immunopharmacology 3 267 272 10.1016/S1567-5769(02) 00295-3 (Pubitemid 36183385)
24. FB Nunes MGS Pires 2002 Alves Filho JCF, Wachter PH, Oliveira JR. Physiopathological studies in septic rats and the use of fructose-1, 6-bisphosphate as cellular protection Critical Care Medicine 30 2069 2074 12352043 10.1097/00003246-200209000-00020 1:CAS:528:DC%2BD38XnsVWmtr0%3D
25. RA Pinho PCL Silveira LA Silva EL Streck F Dal-Pizzol JCF Moreira 2005 N-acetycysteine and deferoxamine reduce pulmonary oxidative stress and inflammation in rats after coal dust exposure Environmental Research 99 355 360 16307977 10.1016/j.envres.2005.03.005 1:CAS:528:DC%2BD2MXht1GhtLvN (Pubitemid 41676845)
26. DJ Reed MW Fariss 1984 Glutathione depletion and susceptibility Pharmacological Reviews 36 25S 33S 6382355 1:STN:280:DyaL2c3pvVGguw%3D%3D (Pubitemid 14093514)
27. SN Heyman M Goldfarb A Shina F Karmeli S Rosen 2003 N-acetylcysteine ameliorates renal microcirculation: studies in rats Kidney International 63 2 634 641 12631128 10.1046/j.1523-1755.2003.00783.x 1:CAS:528:DC%2BD3sXht1yrtrk%3D (Pubitemid 36126809)
28. LF Prescott RN Illingworth JA Critchley MJ Stewart RD Adam AT Proudfoot 1979 Intravenous n-acetylcysteine: the treatment of choice for paracetamol poisoning British Medical Journal 2 1097 1100 519312 10.1136/bmj.2.6198.1097 1:CAS:528:DyaL3cXht1ejs7k%3D (Pubitemid 10249121)
29. J Miquel ML Ferrandiz E De Juan I Sevila M Martinez 1995 N-acetylcysteine protects against age-related decline of oxidative phosphorylation in liver mitochondria European Journal of Pharmacology 292 333 335 7796874 1:CAS:528:DyaK2MXktlCjt7g%3D
30. C Ritter ME Andrades A Reinke S Menna-Barreto JC Moreira F Dal-Pizzol 2004 Treatment with N-acetylcysteine plus deferoxamine protects rats against oxidative stress and improves survival in sepsis Critical Care Medicine 32 342 349 14758146 10.1097/01.CCM.0000109454.13145.CA 1:CAS:528:DC%2BD2cXos1CqtA%3D%3D (Pubitemid 38234109)
31. FB Nunes JR Oliveira MGS Pires PH Wächter 2000 Septic induction in rats (Wistar): experimental model Revista de Medicina da PUCRS 10 183 187
32. JA Buege SD Aust 1978 Microsomal Lipid Peroxidation Methods Enzymology 52 302 310 10.1016/S0076-6879(78)52032-6 1:CAS:528:DyaE1MXltVajsw%3D%3D
33. A Boveris CG Fraga AI Varsavsks OR Koch 1983 Archives of Biochemistry and Biophysics 227 534 541 6320728 10.1016/0003-9861(83)90482-4 1:CAS:528:DyaL2cXks1yisA%3D%3D
34. H Aebi 1984 Catalase in vitro Methods Enzymol 105 121 126 6727660 10.1016/S0076-6879(84)05016-3 1:CAS:528:DyaL2cXltVKis7s%3D
35. Faure, P., and J.L. Lafond. 1995. Measurement of sulphydryl and carbonyl groups as a possible indicator of protein oxidation. Analysis of free radicals in biological systems. Boston: Verlag.
36. D Vandijck JM Decruyenaere SI Blot 2006 The value of sepsis definitions in daily ICU-practice Acta Clinica Belgica 61 5 220 226 17240735 1:STN:280:DC%2BD2s%2FktFKitQ%3D%3D (Pubitemid 44912909)
37. A Rudiger M Stotz M Singer 2008 Cellular processes in sepsis Swiss Medical Weekly 138 629 634 19005868 1:CAS:528:DC%2BD1cXhsVOktL%2FM
38. LL Dunn YS Rahmanto DR Richardson 2007 Iron uptake and metabolism in the new millennium Trends in Cell Biology 17 2 93 100 17194590 10.1016/j.tcb.2006. 12.003 1:CAS:528:DC%2BD2sXhs1Sms7g%3D (Pubitemid 46199183)
39. JM Cooper AH Schapira 2007 Friedreich's ataxia: coenzyme Q10 andvitamin E therapy Mitochondrion 7 Suppl1 S127 135 17485244 10.1016/j.mito.2007.04.001 1:CAS:528:DC%2BD2sXlt1aksbY%3D (Pubitemid 46712240)
40. T Barichello JJ Fortunato AM Vitali G Feier A Reinke JC Moreira J Quevedo F Dal-Pizzol 2006 Oxidative variables in the rat brain after sepsis induced by cecal ligation and perforation Critical Care Medicine 34 886 889 16505668 10.1097/01.CCM.0000201880.50116.12
41. Burdman, E. 1997. Epidemiologia. In IRA, insuficiência renal aguda: fisiopatologia, clínica e tratamento, ed. N. Schor, M.A. Boim, and O.F.P. Santos. São Paulo: Sarvier.
42. D Salvemini S Cuzzocrea 2003 Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine Critical Care Medicine 31 S29 S38 12544974 10.1097/00003246-200301001-00005 1:CAS:528:DC%2BD3sXitVynsbo%3D
43. C Thiemermann 2003 Membrane-permeable radical scavengers (tempol) for shock, ischemia-reperfusion injury, and inflammation Critical Care Medicine 31 S76 S84 12544980 10.1097/00003246-200301001-00011 1:CAS:528:DC%2BD3sXitVyntrs%3D
44. RC Sprong AML Winkelhuyzen-Janssen CJM Aarsman JF Oirschot T Bruggen BS Asbeck 1998 Low-dose Nacetylcysteine protects rats against endotoxin-mediated oxidative stress, but high-dose increases mortality American Journal of Respiratory and Critical Care Medicine 157 1283 1293 9563752 1:STN:280:DyaK1c3itlansw%3D%3D
45. GC Brown V Borutaite 2004 Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols Biochimica et Biophysica Acta 1658 44 49 15282173 10.1016/j.bbabio.2004.03.016 1:CAS:528: DC%2BD2cXmt1Wktrc%3D (Pubitemid 39013232)
46. MM Levy MP Fink JC Marshall E Abraham D Angus D Cook J Cohen SM Opal JL Vincent G Ramsay 2003 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference Critical Care Medicine 31 4 1250 1256 12682500 10.1097/01.CCM. 0000050454.01978.3B (Pubitemid 36444440)
47. LM Oliveira MGS Pires AB Magrisso TP Munhoz R Roesler JR Oliveira 2009 Fructose-1, 6-bisphosphate inhibits in vitro and ex vivo platelet aggregation induced by ADP and ameliorates coagulation alterations in experimental sepsis in rats Journal of Thrombosis and Thrombolysis 29 387 394 19705256 10.1007/s11239-009-0387-2
48. SC Andrade C Dezoti CA Shibuya M Watanabe MFF Vattimo 2004 Insuficiência Renal Aguda Isquêmica: Efeitos Comparativos do Alopurinol e N-Acetilcisteína como antioxidantes Jornal Brasileiro De Nefrologia 26 2 69 75
49. G Pereira-Filho C Ferreira A Schwengber C Marroni C Zettler N Marroni 2008 Role of N-acetylcysteine on fibrosis and oxidative stress in cirrhotic rats Arquivos de Gastroenterologia 45 2 156 162 18622472 10.1590/S0004- 28032008000200013
50. HM Power HV Heese DW Beatty J Hughes WS Dempster 1991 Iron fortification of infant milk formula: the effect on iron status and immune function Annals of Tropical Paediatrics 11 57 66 1714697 1:STN:280:DyaK3Mzjs1KqsQ%3D%3D
51. RL Souza RCM Succi 1996 Oligoelementos e Infecção Pediatria Moderna 31 660 667
52. S Kent ED Weinberg P Stuart-Macadam 1994 The etiology of the anemia of chronic disease and infection Journal of Clinical Epidemiology 47 23 33 8283191 10.1016/0895-4356(94)90030-2 1:STN:280:DyaK2c7htVOqtw%3D%3D (Pubitemid 24034287)
53. RD Cançado CS Chiattone 2002 Anemia de doença crônica Revista Brasileira de Hematologia e Hemoterapia 4 127 136
54. Beaumont, C., and S. Vailont. 2006. Iron homeostasis. In Disorders of iron homeostasis, erythrocytes, erythropoiesis, ed. C. Beaumont, P. Beris, Y. Beuzard, and C. Brugnara. Genova: Forum Service Editore.
55. R Garcia Branco RC Tasker PC Ramos Garcia JP Piva L Dias Xavier 2007 Glycemic control and insulin therapy in sepsis and critical illness Jornal de Pediatria 83 5 S128 136 18038018 10.1590/S0021-75572007000700003
56. RP Bowler M Nicks K Tran, et al. 2004 Extracellular superoxide dismutase attenuates lipopolysaccharide-induced neutrophilic in-flammation American Journal of Respiratory Cell and Molecular Biology 31 432 439 15256385 10.1165/rcmb.2004-0057OC 1:CAS:528:DC%2BD2cXot12ntLw%3D (Pubitemid 39330953)
57. RP Bowler JD Crapo 2002 Oxidative stress in airways: Is there a role for extracellular superoxide dismutase? American Journal of Respiratory and Critical Care Medicine 166 S38 S43 12471087 10.1164/rccm.2206014
58. C Ritter AA Cunha IC Echer M Andrades A Reinke N Lucchiari J Rocha EL Streck S Menna-Barreto JCF Moreira F Dal-Pizzol 2006 Effects of N-acetylcysteine plus deferoxamine in lipopolysaccharide-induced acute lung injury in the rat Critical Care Medicine 34 471 477 16424730 10.1097/01.CCM.0000199069.19193.89 1:CAS:528:DC%2BD28Xls1Gguw%3D%3D (Pubitemid 43145628)