An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models

BMC Infectious Diseases

Volumn 8, Issue , 2008, Pages

  Moore, Christopher C ^a   Martin, Edward N ^a   Lee, Grace H ^a   Obrig, Tom ^a   Linden, Joel ^b   Michael, W Michael ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [3 [6 AMINO 9 (5 CYCLOPROPYLCARBAMOYL 3,4 DIHYDROTETRAHYDROFURAN 2 YL) 9H PURIN 2 YL]PROP 2 YNYL]PIPERIDINE 1 CARBOXYLIC ACID METHYL ESTER; ADENOSINE A2A RECEPTOR AGONIST; ANTIBIOTIC AGENT; ATL 313; CEFTRIAXONE; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 17; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHATE BUFFERED SALINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADENOSINE A2A RECEPTOR; ANTIINFLAMMATORY AGENT; PIPERIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DEATH; DRUG DOSE INCREASE; ESCHERICHIA COLI; FEMALE; INFLAMMATION; LEUKOCYTE; MONOTHERAPY; MOUSE; NONHUMAN; OPTIMAL DRUG DOSE; PROTEIN BLOOD LEVEL; SEPSIS; SEPTIC SHOCK; STAPHYLOCOCCUS AUREUS; SURVIVAL; ANIMAL; BAGG ALBINO MOUSE; BLOOD; C57BL MOUSE; DISEASE MODEL; DRUG EFFECT; ESCHERICHIA COLI INFECTION; STAPHYLOCOCCUS INFECTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CEFTRIAXONE; CYTOKINES; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI INFECTIONS; FEMALE; INFLAMMATION; LEUKOCYTES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PIPERIDINES; RECEPTOR, ADENOSINE A2A; SEPSIS; STAPHYLOCOCCAL INFECTIONS; SURVIVAL ANALYSIS;

EID: 57249084649     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-8-141     Document Type: Article

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