Synaptic deficits are rescued in the p25/Cdk5 model of neurodegeneration by the reduction of β-Secretase (BACE1)

Journal of Neuroscience

Volumn 31, Issue 44, 2011, Pages 15751-15756

  Giusti Rodríguez, Paola ^a   Gao, Jun ^a,c   Gräff, Johannes ^a   Rei, Damien ^a   Soda, Takahiro ^a   Tsai, Li Huei ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c NANJING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE 1; CYCLIN DEPENDENT KINASE 5; PROTEIN P25;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; GENE DELETION; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SYNAPSE; WILD TYPE;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; AVOIDANCE LEARNING; BIOPHYSICS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL DEATH; CYCLIN-DEPENDENT KINASE 5; DISEASE MODELS, ANIMAL; ELECTRIC STIMULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FREEZING REACTION, CATALEPTIC; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROSENCEPHALON; SYNAPSES; SYNAPTOPHYSIN; TAU PROTEINS;

EID: 80155148255     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3588-11.2011     Document Type: Article

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