메뉴 건너뛰기




Volumn 24, Issue 8, 2003, Pages 1047-1062

Pathology of presynaptic proteins in Alzheimer's disease: More than simple loss of terminals

Author keywords

Dementia; Neuropathology; SNARE proteins; Synaptophysin

Indexed keywords

CHROMOGRANIN A; GLUTAMATE TRANSPORTER; MESSENGER RNA; NERVE PROTEIN; PROTEIN; RAB PROTEIN; SECRETOGRANIN II; SECRETONEURIN; SNARE PROTEIN; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNAPTOTAGMIN; SYNTAXIN;

EID: 0344845129     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2003.04.005     Document Type: Conference Paper
Times cited : (124)

References (55)
  • 1
    • 0035857449 scopus 로고    scopus 로고
    • Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization
    • Arendt T. Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization. Neuroscience. 102:2001;723-765.
    • (2001) Neuroscience , vol.102 , pp. 723-765
    • Arendt, T.1
  • 2
    • 0035042440 scopus 로고    scopus 로고
    • Disturbance of neuronal plasticity is a critical pathogenic event in Alzheimer's disease
    • Arendt T. Disturbance of neuronal plasticity is a critical pathogenic event in Alzheimer's disease. Int. J. Dev. Neurosci. 19:2001;231-245.
    • (2001) Int. J. Dev. Neurosci. , vol.19 , pp. 231-245
    • Arendt, T.1
  • 3
    • 0029801332 scopus 로고    scopus 로고
    • Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles or the ApoE4 allele
    • Blennow K., Bogdanovic N., Alafuzoff I., Ekman R., Davidsson P. Synaptic pathology in Alzheimer's disease: relation to severity of dementia, but not to senile plaques, neurofibrillary tangles or the ApoE4 allele. J. Neural Trans. 103:1996;603-618.
    • (1996) J. Neural Trans. , vol.103 , pp. 603-618
    • Blennow, K.1    Bogdanovic, N.2    Alafuzoff, I.3    Ekman, R.4    Davidsson, P.5
  • 4
    • 0031783985 scopus 로고    scopus 로고
    • Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: A comparison with classic Alzheimer disease and normal aging
    • Brown D.F., Risser R.C., Bigio E.H., Tripp P., Stiegler A., Welch E.et al. Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: a comparison with classic Alzheimer disease and normal aging. J. Neuropathol. Exp. Neurol. 57:1998;955-960.
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 955-960
    • Brown, D.F.1    Risser, R.C.2    Bigio, E.H.3    Tripp, P.4    Stiegler, A.5    Welch, E.6
  • 5
    • 0029006492 scopus 로고
    • Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer's disease and in frontal lobe degeneration
    • Brun A., Liu X., Erikson C. Synapse loss and gliosis in the molecular layer of the cerebral cortex in Alzheimer's disease and in frontal lobe degeneration. Neurodegeneration. 4:1995;171-177.
    • (1995) Neurodegeneration , vol.4 , pp. 171-177
    • Brun, A.1    Liu, X.2    Erikson, C.3
  • 6
    • 0036098423 scopus 로고    scopus 로고
    • Progressive reduction of synaptophysin message in single neurons in Alzheimer disease
    • Callahan L.M., Vaules W.A., Coleman P.D. Progressive reduction of synaptophysin message in single neurons in Alzheimer disease. J. Neuropathol. Exp. Neurol. 61:2002;384-395.
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 384-395
    • Callahan, L.M.1    Vaules, W.A.2    Coleman, P.D.3
  • 7
    • 0033025080 scopus 로고    scopus 로고
    • Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles
    • Callahan L.M., Vaules W.A., Coleman P.D. Quantitative decrease in synaptophysin message expression and increase in cathepsin D message expression in Alzheimer disease neurons containing neurofibrillary tangles. J. Neuropathol. Exp. Neurol. 58:1999;275-287.
    • (1999) J. Neuropathol. Exp. Neurol. , vol.58 , pp. 275-287
    • Callahan, L.M.1    Vaules, W.A.2    Coleman, P.D.3
  • 8
    • 0028274689 scopus 로고
    • Differential synaptic loss in the cortex in Alzheimerr's disease: A study using archival material
    • Clinton J., Blackman S.E.-A., Royston M.C., Roberts G.W. Differential synaptic loss in the cortex in Alzheimerr's disease: a study using archival material. NeuroReport. 5:1994;497-500.
    • (1994) NeuroReport , vol.5 , pp. 497-500
    • Clinton, J.1    Blackman, S.E.-A.2    Royston, M.C.3    Roberts, G.W.4
  • 9
    • 0031778614 scopus 로고    scopus 로고
    • Neurochemical dissection of synaptic pathology in Alzheimer's disease
    • Davidsson P., Blennow K. Neurochemical dissection of synaptic pathology in Alzheimer's disease. Int. Psychogeriatr. 10:1998;11-23.
    • (1998) Int. Psychogeriatr. , vol.10 , pp. 11-23
    • Davidsson, P.1    Blennow, K.2
  • 10
    • 0029862711 scopus 로고    scopus 로고
    • Synaptotagmin, a synaptic vesicle protein, is present in human cerebrospinal fluid
    • Davidsson P., Jahn R., Bergquist J., Ekman R., Blennow K. Synaptotagmin, a synaptic vesicle protein, is present in human cerebrospinal fluid. Mol. Chem. Neuropathol. 27:1996;195-210.
    • (1996) Mol. Chem. Neuropathol. , vol.27 , pp. 195-210
    • Davidsson, P.1    Jahn, R.2    Bergquist, J.3    Ekman, R.4    Blennow, K.5
  • 11
    • 0031438917 scopus 로고    scopus 로고
    • Accumulation of SNAP-25 immunoreactive material in axons of Alzheimer's disease
    • Dessi F., Colle M.-A., Hauw J.-J., Duyckaerts C. Accumulation of SNAP-25 immunoreactive material in axons of Alzheimer's disease. NeuroReport. 8:1997;3685-3689.
    • (1997) NeuroReport , vol.8 , pp. 3685-3689
    • Dessi, F.1    Colle, M.-A.2    Hauw, J.-J.3    Duyckaerts, C.4
  • 12
    • 0036718272 scopus 로고    scopus 로고
    • B-secretase protein and activity are increased in the neocortex in Alzheimer disease
    • Fukumoto H., Cheung B.S., Hyman B.T., Irizarry M.C. B-secretase protein and activity are increased in the neocortex in Alzheimer disease. Arch. Neurol. 59:2002;1381-1389.
    • (2002) Arch. Neurol. , vol.59 , pp. 1381-1389
    • Fukumoto, H.1    Cheung, B.S.2    Hyman, B.T.3    Irizarry, M.C.4
  • 14
    • 0032051614 scopus 로고    scopus 로고
    • Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia
    • Heffernan J.M., Eastwood S.L., Nagy Z., Sanders M.W., McDonald B., Harrison P.J. Temporal cortex synaptophysin mRNA is reduced in Alzheimer's disease and is negatively correlated with the severity of dementia. Exp. Neurol. 150:1998;235-239.
    • (1998) Exp. Neurol. , vol.150 , pp. 235-239
    • Heffernan, J.M.1    Eastwood, S.L.2    Nagy, Z.3    Sanders, M.W.4    McDonald, B.5    Harrison, P.J.6
  • 15
    • 0027940505 scopus 로고
    • The relationship of quantitative brain magnetic resonance imaging measures to neuropathologic indices of human immunodeficiency virus infection
    • Heindel W.C., Jernigan T.L., Archibald S.L., Achim C.L., Masliah E., Wiley C.A. The relationship of quantitative brain magnetic resonance imaging measures to neuropathologic indices of human immunodeficiency virus infection. Arch. Neurol. 51:1994;1129-1135.
    • (1994) Arch. Neurol. , vol.51 , pp. 1129-1135
    • Heindel, W.C.1    Jernigan, T.L.2    Archibald, S.L.3    Achim, C.L.4    Masliah, E.5    Wiley, C.A.6
  • 17
    • 0028801680 scopus 로고
    • Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomena in Alzheimer's disease
    • Heinonen O., Soininen H., Sorvari H., Kosunen O., Paljärvi L., Koivisto E.et al. Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomena in Alzheimer's disease. Neuroscience. 64:1995;375-384.
    • (1995) Neuroscience , vol.64 , pp. 375-384
    • Heinonen, O.1    Soininen, H.2    Sorvari, H.3    Kosunen, O.4    Paljärvi, L.5    Koivisto, E.6
  • 18
    • 0042770090 scopus 로고    scopus 로고
    • Indications of abnormal connectivity in neuropsychiatric disorders in postmortem studies
    • Agam G, Belmaker RH, editors. Boston: Kluwer Academic Publishers
    • Honer WG. Indications of abnormal connectivity in neuropsychiatric disorders in postmortem studies. In: Agam G, Belmaker RH, editors. The postmortem brain in psychiatric research. Boston: Kluwer Academic Publishers; 2002. p. 75-91.
    • (2002) The Postmortem Brain in Psychiatric Research , pp. 75-91
    • Honer, W.G.1
  • 20
    • 0000455191 scopus 로고    scopus 로고
    • Synaptic pathology
    • Harrison PJ, Roberts GW, editors. Oxford: Oxford University Press
    • Honer WG, Young C, Falkai P. Synaptic pathology. In: Harrison PJ, Roberts GW, editors. The neuropathology of schizophrenia. Oxford: Oxford University Press; 2000. p. 105-36.
    • (2000) The Neuropathology of Schizophrenia , pp. 105-136
    • Honer, W.G.1    Young, C.2    Falkai, P.3
  • 21
    • 0026567733 scopus 로고
    • Synaptic pathology in Alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles
    • Lassmann H., Weiler R., Fischer P., Bancher C., Jellinger K., Floor E.et al. Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles. Neuroscience. 46:1992;1-8.
    • (1992) Neuroscience , vol.46 , pp. 1-8
    • Lassmann, H.1    Weiler, R.2    Fischer, P.3    Bancher, C.4    Jellinger, K.5    Floor, E.6
  • 23
    • 0029981501 scopus 로고    scopus 로고
    • Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration
    • Liu X., Erikson C., Brun A. Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration. Dementia. 7:1996;128-134.
    • (1996) Dementia , vol.7 , pp. 128-134
    • Liu, X.1    Erikson, C.2    Brun, A.3
  • 24
    • 0029795517 scopus 로고    scopus 로고
    • Inflammation, Aβ deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration
    • Lue L.-F., Brachova L., Civin H., Rogers J. Inflammation, Aβ deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J. Neuropathol. Exp. Neurol. 55:1996;1083-1088.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 1083-1088
    • Lue, L.-F.1    Brachova, L.2    Civin, H.3    Rogers, J.4
  • 25
    • 0029795517 scopus 로고    scopus 로고
    • Inflammation, Aβ deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration
    • Lue L.-F., Brachova L., Civin W.H., Rogers J. Inflammation, Aβ deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J. Neuropathol. Exp. Neurol. 55:1996;1083-1088.
    • (1996) J. Neuropathol. Exp. Neurol. , vol.55 , pp. 1083-1088
    • Lue, L.-F.1    Brachova, L.2    Civin, W.H.3    Rogers, J.4
  • 26
    • 0032888131 scopus 로고    scopus 로고
    • Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease
    • Lue L.-F., Kuo Y.-M., Roher A.E., Brachova L., Shen Y., Sue L.et al. Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155:1999;853-862.
    • (1999) Am. J. Pathol. , vol.155 , pp. 853-862
    • Lue, L.-F.1    Kuo, Y.-M.2    Roher, A.E.3    Brachova, L.4    Shen, Y.5    Sue, L.6
  • 28
    • 0035078270 scopus 로고    scopus 로고
    • Recent advances in the understanding of the role of synaptic proteins in Alzheimer's disease and other neurodegenerative disorders
    • Masliah E. Recent advances in the understanding of the role of synaptic proteins in Alzheimer's disease and other neurodegenerative disorders. J. Alzheimer Dis. 3:2001;121-129.
    • (2001) J. Alzheimer Dis. , vol.3 , pp. 121-129
    • Masliah, E.1
  • 29
    • 0029811226 scopus 로고    scopus 로고
    • Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease
    • Masliah E., Alford M., DeTeresa R., Mallory M., Hansen L. Deficient glutamate transport is associated with neurodegeneration in Alzheimer's disease. Ann. Neurol. 40:1996;759-766.
    • (1996) Ann. Neurol. , vol.40 , pp. 759-766
    • Masliah, E.1    Alford, M.2    Deteresa, R.3    Mallory, M.4    Hansen, L.5
  • 30
    • 0026691420 scopus 로고
    • Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer disease
    • Masliah E., Ellisman M., Carragher B., Mallory M., Young S., Hansen L.et al. Three-dimensional analysis of the relationship between synaptic pathology and neuropil threads in Alzheimer disease. J. Neuropathol. Exp. Neurol. 51:1992;404-414.
    • (1992) J. Neuropathol. Exp. Neurol. , vol.51 , pp. 404-414
    • Masliah, E.1    Ellisman, M.2    Carragher, B.3    Mallory, M.4    Young, S.5    Hansen, L.6
  • 31
    • 0026002029 scopus 로고
    • Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat
    • Masliah E., Fagan A.M., Terry R.D., DeTeresa R., Mallory M., Gage F.H. Reactive synaptogenesis assessed by synaptophysin immunoreactivity is associated with GAP-43 in the dentate gyrus of the adult rat. Exp. Neurol. 113:1991;131-142.
    • (1991) Exp. Neurol. , vol.113 , pp. 131-142
    • Masliah, E.1    Fagan, A.M.2    Terry, R.D.3    Deteresa, R.4    Mallory, M.5    Gage, F.H.6
  • 32
    • 0028173758 scopus 로고
    • Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus
    • Masliah E., Honer W.G., Mallory M., Voight M., Kushner P., Hansen L.et al. Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus. Acta Neuropathol. 87:1994;135-142.
    • (1994) Acta Neuropathol. , vol.87 , pp. 135-142
    • Masliah, E.1    Honer, W.G.2    Mallory, M.3    Voight, M.4    Kushner, P.5    Hansen, L.6
  • 33
    • 0030025635 scopus 로고    scopus 로고
    • Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease
    • Masliah E., Iwai A., Mallory M., Uéda K., Saitoh T. Altered presynaptic protein NACP is associated with plaque formation and neurodegeneration in Alzheimer's disease. Am. J. Pathol. 148:1996;201-210.
    • (1996) Am. J. Pathol. , vol.148 , pp. 201-210
    • Masliah, E.1    Iwai, A.2    Mallory, M.3    Uéda, K.4    Saitoh, T.5
  • 34
    • 0035830408 scopus 로고    scopus 로고
    • Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
    • Masliah E., Mallory M., Alford M., DeTeresa R., Hansen L.A., McKeel D.W.et al. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology. 56:2001;127-129.
    • (2001) Neurology , vol.56 , pp. 127-129
    • Masliah, E.1    Mallory, M.2    Alford, M.3    Deteresa, R.4    Hansen, L.A.5    McKeel, D.W.6
  • 36
    • 0026032039 scopus 로고
    • Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease
    • Masliah E., Terry R.D., Alford M., DeTeresa R., Hansen L.A. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. Am. J. Pathol. 138:1991;235-246.
    • (1991) Am. J. Pathol. , vol.138 , pp. 235-246
    • Masliah, E.1    Terry, R.D.2    Alford, M.3    Deteresa, R.4    Hansen, L.A.5
  • 37
    • 0024364877 scopus 로고
    • Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
    • Masliah E., Terry R.D., DeTeresa R.M., Hansen L.A. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci. Lett. 103:1989;234-239.
    • (1989) Neurosci. Lett. , vol.103 , pp. 234-239
    • Masliah, E.1    Terry, R.D.2    Deteresa, R.M.3    Hansen, L.A.4
  • 38
    • 0025600931 scopus 로고
    • Diffuse plaques do not accentuate synapse loss in Alzheimer's disease
    • Masliah E., Terry R.D., Mallory M., Alford M., Hansen L.A. Diffuse plaques do not accentuate synapse loss in Alzheimer's disease. Am. J. Pathol. 137:1990;1293-1297.
    • (1990) Am. J. Pathol. , vol.137 , pp. 1293-1297
    • Masliah, E.1    Terry, R.D.2    Mallory, M.3    Alford, M.4    Hansen, L.A.5
  • 40
    • 0033899864 scopus 로고    scopus 로고
    • Staging of cytoskeletal and β-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease
    • Mukaetova-Ladinska E.B., Garcia-Siera F., Hurt J., Gertz H.-J., Xuereb J.H., Hills R.et al. Staging of cytoskeletal and β-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease. Am. J. Pathol. 157:2000;623-636.
    • (2000) Am. J. Pathol. , vol.157 , pp. 623-636
    • Mukaetova-Ladinska, E.B.1    Garcia-Siera, F.2    Hurt, J.3    Gertz, H.-J.4    Xuereb, J.H.5    Hills, R.6
  • 41
    • 0021191259 scopus 로고
    • Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia
    • Perdahl E., Adolfsson R., Alafuzoff I., Albert K., Nestler E., Greengard P.et al. Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia. J. Neural Trans. 60:1984;133-141.
    • (1984) J. Neural Trans. , vol.60 , pp. 133-141
    • Perdahl, E.1    Adolfsson, R.2    Alafuzoff, I.3    Albert, K.4    Nestler, E.5    Greengard, P.6
  • 42
    • 0030781194 scopus 로고    scopus 로고
    • Dementia with Lewy bodies versus pure Alzheimer disease: Differences in cognition, neuropathology, cholinergic dysfunction, and synapse density
    • Samuel W., Alford M., Hofstetter C.R., Hansen L. Dementia with Lewy bodies versus pure Alzheimer disease: differences in cognition, neuropathology, cholinergic dysfunction, and synapse density. J. Neuropathol. Exp. Neurol. 56:1997;499-508.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 499-508
    • Samuel, W.1    Alford, M.2    Hofstetter, C.R.3    Hansen, L.4
  • 43
    • 0028132966 scopus 로고
    • Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia
    • Samuel W., Terry R.D., DeTeresa R., Butters N., Masliah E. Clinical correlates of cortical and nucleus basalis pathology in Alzheimer dementia. Arch. Neurol. 51:1994;772-778.
    • (1994) Arch. Neurol. , vol.51 , pp. 772-778
    • Samuel, W.1    Terry, R.D.2    Deteresa, R.3    Butters, N.4    Masliah, E.5
  • 44
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe D.J. Alzheimer's disease is a synaptic failure. Science. 298:2002;789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 45
    • 0031577277 scopus 로고    scopus 로고
    • Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease
    • Shimohama S., Kamiya, Taniguchi T., Akagawa K., Kimura J. Differential involvement of synaptic vesicle and presynaptic plasma membrane proteins in Alzheimer's disease. Biochem. Biophys. Res. Commun. 236:1997;239-242.
    • (1997) Biochem. Biophys. Res. Commun. , vol.236 , pp. 239-242
    • Shimohama, S.1    Kamiya2    Taniguchi, T.3    Akagawa, K.4    Kimura, J.5
  • 46
    • 0028241915 scopus 로고
    • Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease
    • Simpson I.A., Chundu K.R., Davies-Hill T., Honer W.G., Davies P. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann. Neurol. 35:1994;546-551.
    • (1994) Ann. Neurol. , vol.35 , pp. 546-551
    • Simpson, I.A.1    Chundu, K.R.2    Davies-Hill, T.3    Honer, W.G.4    Davies, P.5
  • 47
    • 0031446859 scopus 로고    scopus 로고
    • Transneuronal degeneration in the spread of Alzheimer's disease pathology: Immunohistochemical evidence for the transmission of tau hyperphosphorylation
    • Su J.H., Deng G., Cotman C.W. Transneuronal degeneration in the spread of Alzheimer's disease pathology: immunohistochemical evidence for the transmission of tau hyperphosphorylation. Neurobiol. Dis. 4:1997;365-375.
    • (1997) Neurobiol. Dis. , vol.4 , pp. 365-375
    • Su, J.H.1    Deng, G.2    Cotman, C.W.3
  • 49
    • 0030872413 scopus 로고    scopus 로고
    • Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
    • Sze C.-I., Troncoso J.C., Kawas C., Mouton P., Price D.L., Martin L.J. Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J. Neuropathol. Exp. Neurol. 56:1997;933-944.
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 933-944
    • Sze, C.-I.1    Troncoso, J.C.2    Kawas, C.3    Mouton, P.4    Price, D.L.5    Martin, L.J.6
  • 50
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R.et al. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 30:1991;572-580.
    • (1991) Ann. Neurol. , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6
  • 51
    • 0034649440 scopus 로고    scopus 로고
    • The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease
    • Tiraboschi P., Hansen L.A., Alford M., Masliah E., Thal L.J., Corey-Bloom J. The decline in synapses and cholinergic activity is asynchronous in Alzheimer's disease. Neurology. 55:2000;1278-1283.
    • (2000) Neurology , vol.55 , pp. 1278-1283
    • Tiraboschi, P.1    Hansen, L.A.2    Alford, M.3    Masliah, E.4    Thal, L.J.5    Corey-Bloom, J.6
  • 52
    • 0028587094 scopus 로고
    • Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease
    • Wakabayashi K., Honer W.G., Masliah E. Synapse alterations in the hippocampal-entorhinal formation in Alzheimer's disease with and without Lewy body disease. Brain Res. 667:1994;24-32.
    • (1994) Brain Res. , vol.667 , pp. 24-32
    • Wakabayashi, K.1    Honer, W.G.2    Masliah, E.3
  • 53
    • 0025327264 scopus 로고
    • A high ration of chromogranin a to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease
    • Weiler R., Lassmann H., Fischer P., Jellinger K., Winkler H. A high ration of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease. FEBS Lett. 263:1990;337-339.
    • (1990) FEBS Lett. , vol.263 , pp. 337-339
    • Weiler, R.1    Lassmann, H.2    Fischer, P.3    Jellinger, K.4    Winkler, H.5
  • 55
    • 0034667686 scopus 로고    scopus 로고
    • Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease
    • Yang L.-B., Li R., Meri S., Rogers J., Shen Y. Deficiency of complement defense protein CD59 may contribute to neurodegeneration in Alzheimer's disease. J. Neurosci. 20:2000;7505-7509.
    • (2000) J. Neurosci. , vol.20 , pp. 7505-7509
    • Yang, L.-B.1    Li, R.2    Meri, S.3    Rogers, J.4    Shen, Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.