Endogenous hallucinogens as ligands of the trace amine receptors: A possible role in sensory perception

Medical Hypotheses

Volumn 72, Issue 1, 2009, Pages 91-94

  Wallach, J V ^a  

^a BS Cell and Molecular Biology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 5 METHOXY N,N DIMETHYLTRYPTAMINE; BROLAMFETAMINE; BUFOTENINE; KETANSERIN; LIGAND; LYSERGIDE; MESCALINE; N,N DIETHYLTRYPTAMINE; N,N DIMETHYLTRYPTAMINE; NEUROTRANSMITTER; PINDOLOL; PSILOCIN; RISPERIDONE; SEROTONIN 2A AGONIST; SEROTONIN 2A RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CENTRAL NERVOUS SYSTEM; HORMONE RESPONSE; HUMAN; NONHUMAN; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY; VISUAL DISCRIMINATION;

ANIMALS; CELL CYCLE PROTEINS; HALLUCINOGENS; HUMANS; LIGANDS; MAMMALS; NEUROTRANSMITTER AGENTS; NUCLEAR PROTEINS; RECEPTORS, ODORANT; SENSATION; VISUAL PERCEPTION;

MAMMALIA;

EID: 56549112734     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2008.07.052     Document Type: Article

References (34)

1. Axelrod T. Enzymatic formation of psychotomimetic metabolites from normally occurring compounds. Science 134 (1961) 343
2. Borowsky B., Adham N., Jones K.A., et al. Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc Natl Acad Sci 98 (2001) 8966-8971
3. Bunzow J.R., Sonders M.S., Arttamangkul S., et al. Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamide, and metabolites of the catecholamine neurotransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 60 (2001) 1181-1188
4. Scheiner R., Plückhahn S., Oney B., Blenau W., and Erber J. Behavioral pharmacology of octopamine, tyramine and dopamine in honey bees. Behav Brain Res 136 (2002) 545-553
5. Blenau W., and Baumann A. Molecular and pharmacological properties of insect biogenic amine receptors: lessons from Drosophila melanogaster and Apis mellifera. Arch Insect Biochem Physiol 48 (2001) 13-38
6. Kutsukake M., Komatsu A., Yamamoto D., and Ishiwa-Chigusa S. A tyramine receptor gene mutation causes a defective olfactory behavior in Drosophila melanogaster. Gene 245 (2000) 31-42
7. Vladimrov V., Thiselton D.L., Kuo P.H., et al. A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families. Mol Psychiatry 9 (2007) 842-853
8. Pae C.U., Yu H.S., Amann D., et al. Association of the trace amine receptor 6 (TAAR6) gene with schizophrenia and bipolar disorder in a Korean case control sample. Psychiat Res 42 (2008) 35-40
9. Duran J., Martinez M., Sanders A.R., et al. Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. Am J Hum Genet 75 (2004) 624-638
10. Vollenweider F.X. Brain mechanisms of hallucinogens and entactogens. Dialogues Clin Neurosci 3 (2001) 265-279
11. Jacob M.J., and Presti D.E. Endogenous psychoactive tryptamines reconsidered: an anxiolytic role for dimethyltryptamine. Med Hypotheses 64 (2005) 930-937
12. Strassman R.J. Human psychopharmacology of N,N-dimethyltryptamine. Behav Brain Res 73 (1996) 121-124
13. Cardinale G.J., Donnerer J., Finck A.D., Kantrowitz J.D., Oka K., and Spector S. Morphine and codeine are endogenous components of human cerebrospinal fluid. Life Sci 40 3 (1987) 301-306
14. 3 receptors. Eur J Pharmacol 511 (2005) 9-19
15. 2A receptor-mediated signaling pathways to affect behavior. Neuron 53 (2007) 439-452
16. Saunders B., et al. Lysergic acid diethylamide and 2,5 dimethoxy-4 methylamphetamine are partial agonists at the serotonin receptors linked to phosphoinositide hydrolysis. J Pharmacol Exp Ther 246 (1988) 924-928
17. Vollenweider F.X., Vollenweider-Scherpenhuyzen M.F., Babler A., Vogel H., and Hell D. Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. Neuroreport 9 (1998) 3897-3902
18. Blair J.B., Kurrasch-Orbaugh D., Marona-Lewicka D., et al. Effect of ring fluorination on the pharmacology of hallucinogenic tryptamines. J Med Chem 43 (2000) 4701-4710
19. 2A receptor-stimulated phosphoinositide hydrolysis in the stimulus effects of hallucinogens. Pharmacol Biochem Behav 72 (2002) 29-37
20. Mckenna D.J. DMT: nature's ubiquitous hallucinogen. Interdependences (1992)
21. Ebersole B.J., Visiers I., Weinstein H., and Sealfon S.C. Molecular basis of partial agonism: orientation of indoleamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. Mol Pharmacol 63 (2003) 36-43
22. McKenna D.J., Repke D.B., Lo L., and Peroutka S.J. Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes. Neuropharmacology 29 (1990) 193-198
23. Corbett L., Christian S.T., Morin R.D., Benington F., and Symthies J.R. Hallucinogenic N-methylated indolealkylamines in the cerebrospinal fluid of psychiatric and control populations. Br J Psychiat 132 (1978) 139-144
24. Burchett S.A., and Hicks T.P. The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brain. Prog Neurobiol 5 (2006) 223-246
25. Fantegrossi W.E., Kiessel C.L., Leach P.T., et al. Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice. Psychopharmacology 173 (2004) 270-277
26. Shulgin A., and Shulgin A. TIHKAL: tryptamines I have known and loved (1997), Transform Press, Berkeley
27. Franzen F., and Gross H. Tryptamine, N,N-dimethyltryptamine, N,N-dimethyl-5-hydroxytryptamine and 5-methoxy-tryptamine in human blood and urine. Nature 206 (1965) 1052
28. Angrist B.S., Gershon G., Sathananthan R.W., et al. Dimethyltryptamine levels in blood of schizophrenic patients and control subjects. Psychopharmacology 47 (1976) 29-32
29. Zucchi R., Chiellini G., Scanlan T.S., and Grandy D.K. Trace amine-associated receptors and their ligands. Br J Pharmacol 149 (2006) 967-978
30. Araneda R., and Andrade R. 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 40 (1991) 399-412
31. Callaway J.C. A proposed mechanism for the visions of dream sleep. Med Hypotheses 26 (1988) 119-124
32. Strassman R., Wojtowicz S., Luna L.E., and Frescska E. Inner paths to outer space. Journeys to alien worlds through psychedelics and other spiritual technologies (2008), Park Street Press, Rochester Vermont
33. Murray R.M., Oon M.C., Rodnight R., Birley J.L., and Smith A. Increased excretion of dimethyltryptamine and certain features of psychosis: a possible association. Arch Gen Psychiat 36 (1979) 644-649
34. Ciprian-Ollivier J., and Cetkovich-Bakmas M.G. Altered consciousness states and endogenous psychoses: a common molecular pathway?. Schizophr Res 28 (1997) 257-265