TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 20, 2011, Pages 8485-8490

  Revel, Florent G ^a   Moreau, Jean Luc ^a   Gainetdinov, Raul R ^b   Bradaia, Amyaouch ^c   Sotnikova, Tatyana D ^b   Mory, Roland ^a   Durkin, Sean ^a   Zbinden, Katrin Groebke ^a   Norcross, Roger ^a   Meyer, Claas A ^a   Metzler, Veit ^a   Chaboz, Sylvie ^a   Ozmen, Laurence ^a   Trube, Gerhard ^a   Pouzet, Bruno ^a   Bettler, Bernhard ^d   Caron, Marc G ^e   Wettstein, Joseph G ^a   Hoener, Marius C ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^c Neuroservice   (France)

^d UNIVERSITY OF BASEL   (Switzerland)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Anxiety; Depression; Drug discovery; Schizophrenia; Serotonin

Indexed keywords

4 [(ETHYLPHENYLAMINO)METHYL] 4,5 DIHYDROOXAZOL 2 YLAMINE; AMINE; AMINO ACID; ANXIOLYTIC AGENT; COCAINE; G PROTEIN COUPLED RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENETHYLAMINE; RO 5166017; TRACE AMINE ASSOCIATED RECEPTOR 1; TYRAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DORSAL RAPHE NUCLEUS; DRUG STRUCTURE; HYPERTHERMIA; LOCUS CERULEUS; MENTAL DISEASE; MOUSE; NEUROTRANSMISSION; NONHUMAN; NORADRENERGIC NERVE; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY; VENTRAL TEGMENTUM;

ANIMALS; BENZODIOXOLES; BIOGENIC MONOAMINES; DOPAMINE; GLUTAMINE; HEK293 CELLS; HUMANS; MENTAL DISORDERS; MICE; PHENYLPROPIONATES; RECEPTORS, G-PROTEIN-COUPLED; SYNAPTIC TRANSMISSION;

MACACA FASCICULARIS; MUS; RATTUS;

EID: 79957730167     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1103029108     Document Type: Article

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