Selective inhibition of adenylyl cyclase by octopamine via a human cloned α(2A)-adrenoceptor

British Journal of Pharmacology

Volumn 122, Issue 2, 1997, Pages 191-198

  Airriess, Chris N ^a   Rudling, Jane E ^a   Midgley, John M ^b   Evans, Peter D ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

(2A) adrenoceptor; Adenylyl cyclase; Adrenaline; Cyclic AMP; Noradrenaline; Octopamine; Synephrine

Indexed keywords

ADENYLATE CYCLASE; ADRENALIN; ALPHA 2A ADRENERGIC RECEPTOR; AMINOPHENOL; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; NORADRENALIN; OCTOPAMINE; OXEDRINE; PERTUSSIS TOXIN;

ANIMAL CELL; ARTICLE; CHO CELL; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL; SECOND MESSENGER;

ADENYLATE CYCLASE; ADRENERGIC ALPHA-AGONISTS; ANIMALS; CHO CELLS; CRICETINAE; EPINEPHRINE; HUMANS; NOREPINEPHRINE; OCTOPAMINE; RECEPTORS, ADRENERGIC, ALPHA-2; SECOND MESSENGER SYSTEMS; SYNEPHRINE; TRANSFECTION;

EID: 0030770911     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701348     Document Type: Article

References (35)

1. BERG, K.A., MAAYANI, S. & CLARKE, W.P. (1995). Relative efficacy of hallucinogen versus non-hallucinogen agonists is signal transduction pathway dependent. Soc. Neurosci. Abstr., 21, 1365.
2. 2A receptor agonists is signal transduction pathway dependent. Soc. Neurosci. Abstr., 22, 1777.
3. BOZZI, A., CARDELLI-CANGIANO, P., STROM, R., RIGGIO, O., ROSSI FANELLI, F., CANGIANO, C., GENTILES, S. & CAPOCACCIA, L. (1981). Simultaneous radioenzymatic determination of phenylethylamine, phenylethanolamine, tyramine and octopamine in plasma of patients with hepatic encephalopathy. Clin. Biochem., 14, 187-190.
4. BROWN, C.M., MCGRATH, J.C., MIDGLEY, J.M., MUIR, A.G.B., O'BRIEN, J.W., THONOOR, C.M., WILLIAMS, C.M. & WILSON, V.G. (1988). Activities of octopamine and synephrine stereo-isomers on α-adrenoceptors. Br. J. Pharmacol., 93, 417-429.
5. BYLUND, D.B., EIKENBURG, D.C., HIEBLE, J.P., LANGER, S.Z., LEFKOWITZ, R.J., MINNEMAN, K.P., MOLINOFF, P.B., RUFFOLO, R.R. & TRENDELENBURG, U. (1994). IV. International union of pharmacology nomenclature of adrenoceptors. Pharmacol. Rev., 46, 121-136.
6. 2-adrenergic and γ-aminobutyric acid receptor modulation of cyclic AMP accumulation in rat brain slices. J. Neurochem., 47, 800-810.
7. S. Mol. Pharmacol., 45, 696-702.
8. 2-adrenergic receptors to two G-proteins with opposing effects. J. Biol. Chem., 267, 15795-15801.
9. 2A-adrenergic receptor. J. Biol. Chem., 271, 12826-12832.
10. 2A-adrenergic receptor to multiple second messengers. Soc. Neurosci. Abstr., 21, 1613.
11. EVANS, P.D., ROBB, S., CHEEK, T.R., REALE, V., HANNAN, F.L., SWALES, L.S., HALL, L.M. & MIDGLEY, J.M. (1995b). Agonist-specific coupling of G-protein-coupled receptors to second messenger systems. Prog. Brain Res., 106, 259-268.
12. 2-adrenergic receptor in Chinese hamster ovary cells. J. Biol. Chem., 264, 11754-11761.
13. GURWITZ, D., HARING, H., HELDMAN, E., ERASER, C.M., MANOR, D. & FISHER, A. (1994). Discrete activation of transduction pathways associated with acetylcholine ml receptor by several muscarinic ligands. Eur. J. Pharmacol., 267, 21-31.
14. HÖRTNAGL, H., LOCHS, H., KLEINBERGER, G., HACKL, J.M., HAMMERLE, A.F., BINDER, H. & WEWALKA, F. (1981). Plasma catecholamines in hepatic coma and liver cirrhosis: role of octopamine. Klin. Wochenschr., 59, 1159-1164.
15. 1-adrenergic receptor agonist binding and activation. J. Biol. Chem., 271, 6322-6327.
16. IBRAHIM, K.E., COUCH, M.W., WILLIAMS, C.M., FREGLY, M.J. & MIDGLEY, J.M. (1985). m-Octopamine: Normal occurrence with p-octopamine in mammalian sympathetic nerves. J. Neurochem., 44, 1862-1867.
17. 2-adrenergic receptors. In The Alpha-2 Adrenergic Receptors, ed. Limbird, L.E., pp. 323-326. Clifton, New Jersey, U.S.A.: The Humana Press.
18. KENAKIN, T. (1995). Agonist-receptor efficacy II: agonist trafficking of receptor signals. Trends Pharmacol. Sci., 16, 232-238.
19. KENAKIN, T. (1996). The classification of seven transmembrane receptors in recombinant expression systems. Pharmacol Rev., 48, 413-463.
20. KINNIBURGH, D.W. & BOYD, N.D. (1979). Determination of plasma octopamine and its level in renal disease. Clin. Biochem., 12, 27-32.
21. 2A-adrenergic receptor inhibition of stimulus-secretion coupling. Mol. Pharmacol., 50, 96-103.
22. LIMBIRD, L.E. (1988). Receptors linked to inhibition of adenylate cyclase: additional signaling mechanisms. FASEB J., 2, 2686-2695.
23. MIDGLEY, J.M., THONOOR, C.M., DRAKE, A.F., WILLIAMS, C.M., KOZIOL, A.E. & PALENIK, G.J. (1989). The resolution and the absolute-configuration by X-ray crystallography of the isomeric octopamines and synephrines. J. Chem. Soc., Perkin Trans. II, 8, 963-969.
24. MOLINOFF, P. & AXELROD, J. (1969). Octopamine: normal occurrence in sympathetic nerves of rat. Science, 164, 428-429.
25. PEREZ, D.M., HWA, J., GAIVIN, R., MATHUR, M., BROWN, F. & GRAHAM, R.M. (1996). Constitutive activation of a single-effector pathway: evidence for multiple activation states of a G-protein-coupled receptor. Mol. Pharmacol., 49, 112-122.
26. REIMANN, W. (1984). Evidence for neuronal uptake and release of norfenefrine and evaluation of its α-agonistic effects in the rabbit pulmonary artery. Arzneimittelforsch 34, 575-578.
27. ROBB, S., CHEEK, T.R., HANNAN, F.L., HALL, L.M., MIDGLEY, J.M. & EVANS, P.D. (1994). Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems. EMBO J., 13, 1325-1330.
28. 2-adrenoceptor subtypes. Annu. Rev. Pharmacol. Toxicol., 32, 243-279.
29. 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation. EMBO J., 15, 3566-3578.
30. SPENGLER, D., WAEBER, C., PANTALONI, C., HOLSBOER, F., BOCKAERT, J., SEEBURG, P.H. & JOURNOT, L. (1993). Differential signal transduction by five splice variants of the PACAP receptor. Nature, 365, 170-175.
31. STRADER, C.D., CANDELORE, M.R., HILL, W.S., SIGAL, I.S. & DIXON, R.A.F. (1989). Identification of two serine residues involved in agonist activation of the β-adrenergic receptor. J. Biol. Chem., 264, 13572-13578.
32. 2-adrenergic inhibition of insulin release: studies with epinephrine and forskolin. J. Biol. Chem., 259, 4111-4115.
33. 2A-adrenergic receptors: Identification of amino acids involved in ligand binding and receptor activation by agonists. Mol. Pharmacol., 40, 168-179.
34. WILLIAMS, C.M., COUCH, M.W. & MIDGLEY, J.M. (1984). Natural occurrence and metabolism of the isommeric octopamines and synephrines. In Neurobiology of Trace Amines. ed. Boulton, A.A., Baker, G.B., Dewherst, W.G. & Sandler, M., pp. 97-105. Clifton, New Jersey, U.S.A.: The Humana Press.
35. WILLIAMS, C.M., COUCH, M.W., THONOOR, C.M. & MIDGLEY, J.M. (1987). Isomeric octopamines: their occurrence and functions. J. Pharm. Pharmacol., 39, 153-157.