Selective antagonists of mouse trace amine-associated receptor 1 (mTAAR1): Discovery of EPPTB (RO5212773)

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 4, 2011, Pages 1227-1231

  Stalder, Henri ^a   Hoener, Marius C ^a   Norcross, Roger D ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Antagonists; Benzanilides; EPPTB; Inverse agonists; RO5212773; TAAR1

Indexed keywords

BENZAMIDE DERIVATIVE; G PROTEIN COUPLED RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; N (3 ETHOXYPHENYL) 4 PYRROLIDIN 1 YL 3 TRIFLUOROMETHYLBENZAMIDE; RO 5215773; TRACE AMINE ASSOCIATED RECEPTOR 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IC 50; LIPOPHILICITY; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAMIDES; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; MICROSOMES, LIVER; PROTEIN BINDING; PYRROLIDINES; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79851516221     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.075     Document Type: Article

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