An automated system for the analysis of G protein-coupled receptor transmembrane binding pockets: Alignment, receptor-based pharmacophores, and their application

Journal of Chemical Information and Modeling

Volumn 45, Issue 5, 2005, Pages 1324-1336

  Kratochwil, Nicole A ^a   Malherbe, Pari ^a   Lindemann, Lothar ^a   Ebeling, Martin ^a   Hoener, Marius C ^a   Mühlemann, Andreas ^a   Porter, Richard H P ^a   Stahl, Martin ^a   Gerber, Paul R ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BINDING ENERGY; BIOLOGICAL MEMBRANES; EXTRACTION; MUTAGENESIS; PROTEINS;

ALLOSTERIC MODULATORS; BINDING POCKETS; G PROTEIN-COUPLED RECEPTORS; TRANSMEMBRANE (TM) DOMAINS;

AUTOMATION;

G PROTEIN COUPLED RECEPTOR;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; AUTOMATION; BINDING SITE; CELL MEMBRANE; CHEMISTRY; DRUG ANTAGONISM; GENETICS; METABOLISM; MOLECULAR GENETICS; PHYLOGENY; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; AUTOMATION; BINDING SITES; CELL MEMBRANE; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26944485524     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci050221u     Document Type: Article

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