A second class of chemosensory receptors in the olfactory epithelium

Nature

Volumn 442, Issue 7103, 2006, Pages 645-650

  Liberles, Stephen D ^a   Buck, Linda B ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CELLS; HORMONES; STRESSES;

CHEMOSENSORY FUNCTION; ODORANT RECEPTORS; PHEROMONE; TRACE AMINE-ASSOCIATED RECEPTORS (TAARS);

SENSORY PERCEPTION;

AMINE; CHEMOSENSORY RECEPTOR; PHEROMONE; RECEPTOR SUBUNIT; TRACE AMINE ASSOCIATED RECEPTOR; UNCLASSIFIED DRUG;

CHEMORECEPTION; MAMMAL; ODOR; OLFACTION; RODENT; SENSORY SYSTEM;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE FUNCTION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; MOUSE; NERVE CELL; NONHUMAN; OLFACTORY EPITHELIUM; OLFACTORY SYSTEM; PERCEPTIVE DISCRIMINATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; RECEPTOR INTRINSIC ACTIVITY; SMELLING; STRESS; URINE LEVEL;

MAMMALIA;

EID: 33747035856     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05066     Document Type: Article

References (40)

1. Buck, L. & Axel, R. A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell 65, 175-187 (1991).
2. Kandel, E. R., Schwartz, J. H. & Jessell, T. M. Principles of Neural Science (McGraw-Hill, New York, 2000).
3. Buck, L. B. The molecular architecture of odor and pheromone sensing in mammals. Cell 100, 611-618 (2000).
4. Shepherd, G. M., Chen, W. R. & Greer, C. A. in The Synaptic Organization of the Brain (ed. Shepherd, G. M.) 165-216 (Oxford Univ. Press, New York, 2004).
5. Malnic, B., Hirono, J., Sato, T. & Buck, L. B. Combinatorial receptor codes for odors. Cell 96, 713-723 (1999).
6. Ressler, K. J., Sullivan, S. L. & Buck, L. B. A zonal organization of odorant receptor gene expression in the olfactory epithelium. Cell 73, 597-609 (1993).
7. Vassar, R., Ngai, J. & Axel, R. Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell 74, 309-318 (1993).
8. Zhang, X. & Firestein, S. The olfactory receptor gene superfamily of the mouse. Nature Neurosci. 5, 124-133 (2002).
9. Young, J. M. & Trask, B. J. The sense of smell: genomics of vertebrate odorant receptors. Hum. Mol. Genet. 11, 1153-1160 (2002).
10. Godfrey, P. A., Malnic, B. & Buck, L. B. The mouse olfactory receptor gene family. Proc. Natl Acad. Sci. USA 101, 2156-2161 (2004).
11. Meyer, M. R., Angele, A., Kremmer, E., Kaupp, U. B. & Muller, F. A cGMP-signaling pathway in a subset of olfactory sensory neurons. Proc. Natl Acad. Sci. USA 97, 10595-10600 (2000).
12. olf: an olfactory neuron specific-G protein involved in odorant signal transduction. Science 244, 790-795 (1989).
13. Spehr, M. et al. Essential role of the main olfactory system in social recognition of major histocompatibility complex peptide ligands. J. Neurosci. 26, 1961-1970 (2006).
14. Halpern, M. & Martinez-Marcos, A. Structure and function of the vomeronasal system: an update. Prog. Neurobiol. 70, 245-318 (2003).
15. Restrepo, D., Arellano, J., Oliva, A. M., Schaefer, M. L. & Lin, W. Emerging views on the distinct but related roles of the main and accessory olfactory systems in responsiveness to chemosensory signals in mice. Horm. Behav. 46, 247-256 (2004).
16. Boehm, U., Zou, Z. & Buck, L. B. Feedback loops link odor and pheromone signaling with reproduction. Cell 123, 683-695 (2005).
17. Yoon, H., Enquist, L. W. & Dulac, C. Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Cell 123, 669-682 (2005).
18. Fiering, S. N. et al. Improved FACS-Gal: flow cytometric analysis and sorting of viable eukaryotic cells expressing reporter gene constructs. Cytometry 12, 291-301 (1991).
19. Vassilatis, D. K. et al. The G protein-coupled receptor repertoires of human and mouse. Proc. Natl Acad. Sci. USA 100, 4903-4908 (2003).
20. Lewin, A. H. Receptors of mammalian trace amines. AAPS J. 8, E138-E145 (2006).
21. Lindemann, L. & Hoener, M. C. A renaissance in trace amines inspired by a novel GPCR family. Trends Pharmacol. Sci. 26, 274-281 (2005).
22. Gloriam, D. E. et al. The repertoire of trace amine G-protein-coupled receptors: large expansion in zebrafish. Mol. Phylogenet. Evol. 35, 470-482 (2005).
23. Borowsky, B. et al. Trace amines: identification of a family of mammalian G protein-coupled receptors. Proc. Natl Acad. Sci. USA 98, 8966-8971 (2001).
24. Vanti, W. B. et al. Discovery of a null mutation in a human trace amine receptor gene. Genomics 82, 531-536 (2003).
25. Montmayeur, J. P., Liberles, S. D., Matsunami, H. & Buck, L. B. A candidate taste receptor gene near a sweet taste locus. Nature Neurosci. 4, 492-498 (2001).
26. Serizawa, S. et al. Negative feedback regulation ensures the one receptor-one olfactory neuron rule in mouse. Science 302, 2088-2094 (2003).
27. Durocher, Y. et al. A reporter gene assay for high-throughput screening of G-protein-coupled receptors stably or transiently expressed in HEK293 EBNA cells grown in suspension culture. Anal. Biochem. 284, 316-326 (2000).
28. Krautwurst, D., Yau, K. W. & Reed, R. R. Identification of ligands for olfactory receptors by functional expression of a receptor library. Cell 95, 917-926 (1998).
29. Kajiya, K. et al. Molecular bases of odor discrimination: reconstitution of olfactory receptors that recognize overlapping sets of odorants. J. Neurosci. 21, 6018-6025 (2001).
30. Paulos, M. A. & Tessel, R. E. Excretion of β-phenethylamine is elevated in humans after profound stress. Science 215, 1127-1129 (1982).
31. Snoddy, A. M., Heckathorn, D. & Tessel, R. E. Cold-restraint stress and urinary endogenous β-phenylethylamine excretion in rats. Pharmacol. Biochem. Behav. 22, 497-500 (1985).
32. Grimsby, J. et al. Increased stress response and β-phenylethylamine in MAOB-deficient mice. Nature Genet. 17, 206-210 (1997).
33. Gavaghan McKee, C. L., Wilson, I. D. & Nicholson, J. K. Metabolic phenotyping of nude and normal (Alpk:ApfCD, C57BL10J) mice. J. Proteome Res. 5, 378-384 (2006).
34. Nishimura, K., Utsumi, K., Yuhara, M., Fujitani, Y. & Iritani, A. Identification of puberty-accelerating pheromones in male mouse urine. J. Exp. Zool. 251, 300-305 (1989).
35. Price, M. A. & Vandenbergh, J. G. Analysis of puberty-accelerating pheromones. J. Exp. Zool. 264, 42-45 (1992).
36. 1H NMR spectroscopy as an analytical tool for methylamine metabolites in urine. Clin. Chim. Acta 365, 264-269 (2006).
37. Novotny, M. V. Pheromones, binding proteins and receptor responses in rodents. Biochem. Soc. Trans. 31, 117-122 (2003).
38. Del Punta, K. et al. Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature 419, 70-74 (2002).
39. Wittwer, C. T., Herrmann, M. G., Moss, A. A. & Rasmussen, R. P. Continuous fluorescence monitoring of rapid cycle DNA amplification. Biotechniques 22, 130-139 (1997).
40. Clipstone, N. A. & Crabtree, G. R. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697 (1992).