Trace amine receptors as targets for novel therapeutics: Legend, myth and fact

Current Opinion in Pharmacology

Volumn 3, Issue 1, 2003, Pages 90-97

  Branchek, Theresa A ^a   Blackburn, Thomas P ^a  

^a H LUNDBECK A S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXYPHENYLACETIC ACID; 4 HYDROXYPHENYLACETIC ACID; AMINE OXIDASE (FLAVIN CONTAINING); AMPHETAMINE; BENZODIAZEPINE DERIVATIVE; CHLORDIAZEPOXIDE; COCAINE; DIAZEPAM; DOPAMINE; G PROTEIN COUPLED RECEPTOR; INDOLEACETIC ACID; LEVODOPA; LYSERGIDE; METHYLPHENIDATE; MONOAMINE OXIDASE INHIBITOR; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; NORADRENALIN; OCTOPAMINE; PENTETRAZOLE; PHENELZINE; PHENETHYLAMINE; PHENYLACETIC ACID; PHENYLALANINE; RESERPINE; SELEGILINE; SEROTONIN; TRYPTAMINE; TYRAMINE; UNINDEXED DRUG;

ATTENTION DEFICIT DISORDER; DEPRESSION; DRUG ANTAGONISM; DRUG RESEARCH; DRUG RESPONSE; EPILEPSY; HUMAN; MIGRAINE; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN TARGETING; PSYCHOSIS; RAT; REVIEW; SCHIZOPHRENIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOGENIC AMINES; DRUG DELIVERY SYSTEMS; HUMANS; MENTAL DISORDERS; NERVOUS SYSTEM DISEASES; RECEPTORS, CELL SURFACE;

EID: 0037302160     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1471-4892(02)00028-0     Document Type: Review

References (58)

1. Skerrit JH, Guihot SL, McDonald SE, Culvenor RA: Development of immunoassays for tyramine and tryptamine toxins of Phalaris aquatica L. J Agric Food Chem 2000, 48:27-32.
2. Coe DS, Coe MD: In The True History of Chocolate. London: Thames & Hudson Ltd; 2000.
3. Lacy C, Scheuer PJ: New Moloka'iamine derivatives from an undescribed verongid sponge. J Nat Prod 2000, 63:119-121.
4. Raiteri M, del Carmine R, Bertollini A, Levi G: Effect of sympathomimetic amines on the synaptosomal transport of noradrenaline, dopamine and 5-hyroxytryptamine. Eur J Pharmacol 1977, 41:133-143.
5. Baker GB, Martin IL, Mtichel PR: The effects of some indolalkylamines on the uptake and release of 5-hydroxytryptamine in rat striatum [proceedings]. Br J Pharmacol 1977, 61:151P-152P.
6. Jones RS: Tryptamine: a neuromodulator or neurotransmitter in mammalian brain? Prog Neurobiol 1982, 19:117-139.
7. Paterson IA, Boulton AA: Beta-phenylethylamie enhances single cortical neurone responses to noradrenaline in the rat. Brain Res Bull 1988, 20:173-177.
8. Usdin E, Sandler M: Trace Amines and the Brain. New York: Dekker; 1976.
9. Boulton AA: Trace amines: comparative and clinical neurobiology. In Experimental and Clinical Neuroscience. Edited by Jourio AV, Downer RGH. New Jersey: Humana; 1988.
10. Premont RT, Gainetdinov RR, Caron MG: Following the trace of elusive amines. Proc Natl Acad Sci USA 2001, 98:9474-9475.
11. Borowsky B, Adham N, Jones KA, Raddatz R, Artymyshyn R, Ogozalek KL, Durkin MM, Lakhlani PP, Bonini JA, Pathirana S et al.: Trace amines: identification of a family of mammalian G protein-couple receptors. Proc Natl Acad Sci USA 2001, 98:8966-8971.
12. Kosa E, Marcilhac-Flouriot A, Fache MP, Siaud P: Effects of beta-phenylethylamine on the hypothalamo-pituitary-adrenal axis in the male rat. Pharmacol Biochem Behav 2000, 67:527-535.
13. Holschneider DP, Chen K, Seif I, Shih JC: Biochemical, behavioral physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B. Brain Res Bull 2001, 56:453-462.
14. 3H] trytamine autoradiography in rat brain and choroid plexus reveals two distinct sites. J Pharmacol Exp Ther 1986, 236:548-559.
15. 3H] tryptamine: high affinity binding sites in rat brain. Eur J Pharmacol 1982, 78:475-478.
16. 3H]tryptamine binding site in human brain. Prog Brain Res 1995, 106:285-291.
17. Nguyen TV, Juorio AV: Binding sites for brain trace amines. Cell Mol Neurobiol 1989, 9:297-311.
18. 3H] beta-phenylethylamine binding sites in rat brain. Eur J Pharmacol 1982, 83:147-148.
19. 3H]octopamine-binding sites in Drosophila melanogaster: interaction with ligands and relationship to octopamine receptors. Comp Biochem Physiol C 1984, 77:145-151.
20. Dyck LE: Release of some endogenous trace amines from rat striatal slices in the presence and absence of a monoamine oxidase inhibitor. Life Sci 1989, 44:1149-1156.
21. Juorio AV: Lesion of selected brain areas as a tool for the demonstration of some trace biogenic amines neural pathways. Gen Pharmacol 1987, 18:1-5.
22. McCormack JK, Beitz AJ, Larson AA: Autoradiographic localization of tryptamine binding sites in the rat and dog central nervous system. J Neurosci 1986, 6:94-101.
23. Jansen PA, Leysen JE, Megens AA, Awouters FH: Does phenylethylamine act as an endogenous amphetamine in some patients? Int J Neuropsychopharmcol 1999, 2:229-240.
24. Cao Q, Martinez M, Zhang J, Sanders AR, Badner JA, Cravchik A, Markey CJ, Beshah E, Guroff JJ, Maxwell ME et al.: Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. Genomics 1997, 43:1-8.
25. 3H]aceytlcholine from slices of rat striatum in the presence of pargyline: similarities between beta-phenylethylamine and amphetamine. J Pharmacol Exp Ther 1985, 235:220-229.
26. Sandler M, Reynolds GP: Does phenylethylamine cause schizophrenia? Lancet 1976, 10:70-71.
27. Borowsky B, Adham N, Raddatz R, Jones KA, Artymyshyn R, Ogozalek KL, Bonini JA, Pathirana S, Boyle N, Pu X et al.: Trace amines: identification of a novel family of mammalian G-protein-coupled receptors. Neurosci Abst 2001, 264:11.
28. Bunzow JR, Sonders MS, Arttamangkus S, Harrison LM, Zhang G, Quigley DI, Darland T, Suchland KL, Pasumamula S, Kennedy JL et al.: Amphetamine, 3,4-methylenedioxymethamphetamine, lysergic acid diethylamie, and metabolites of the catecholamine neurotrransmitters are agonists of a rat trace amine receptor. Mol Pharmacol 2001, 6:1181-1188.
29. McChung C, Hirsh J: The trace amine tyramine is essential for sensitization to cocaline in Drosophila. Curr Biol 1999, 9:853-860.
30. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR: Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci 2001, 98:6917-6920.
31. Miller GM, Madras BK: Cloning of Rhesus monkey TAR-1, a novel G-protein-linked receptor for 'trace' amines. Soc Neurosci Abst 2002, 10:1.
32. Schildkraut JJ: The catecholomine hypothesis of affective disorders. A review of supporting evidence. Int J Psychiatry 1967, 4:203-217.
33. Heller B, Fischer E, Martin R: Therapeutic action of D-phenylalanine in Parkinson's disease. Arzneimittelforschung 1976, 26:577-579.
34. Davis BA, Boulton AA: The trace amines and their acidic metabolites in depression-an overview. Prog Neuropsychopharmacol Biol Psychiatry 1994, 18:17-45.
35. Locock RA, Baker GB, Coutts RT, Dewhurst WG: Displacement of serotonin from binding sites in rat cortex: the effects of biogenic 'trace' amines. Prog Neuropsychopharmacol Biol Psychiatry 1984, 8:701-704.
36. Szabo A, Billett E, Turner J: Phenylethylamine, a possible link to the antidepressant effects of exercise? Br J Sports Med 2001, 35:342-343.
37. Saelli H, Fink P, Fawcett J, Tom C: Sustained antidepressant effect of PEA replacement. J Neuropsychiatry Clin Neurosci 1996, 8:168-171.
38. Buckland PR, Marshall R, Watkins P, McGuffin P: Does phenylethylamine have a role in schizophrenia? LSD and PCP up-regulate aromatic L-amino acid decarbosylae mRNA levels. Brain Res Mol Brain Res 1997, 49:266-270.
39. Baker GB, Coutts RT, Greenshaw AJ: Neurochemical and metabolic aspects of antidepressants: an overview. J Psychiatry Neurosci 2000, 25:481-496.
40. Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC: Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet 1997, 17:206-210.
41. Boulton AA: Trace amines and mental disorders. Can J Neurol Sci 1980, 7:261-263.
42. Wyatt RJ: In The Nature of Schizophrenia. Edited by Wynne LC, Cromwell RL, Matthysse S. New York: Willey & Sons; 1978:116-125.
43. Potkin SG, Karoum F, Chuang LW, Cannon-Spoor HE, Phillips I, Wyatt RJ: Phenylethylamine in paranoid chronic schizophrenia. Science 1979, 206:470-471.
44. Potkin SG, Wyatt RJ, Karoum F: Phenylethylamine (PEA) and phenylacetic acid (PAA) in the urine of chronic schizophrenic patients and controls. Psychopharmacol Bull 1980, 16:52-54.
45. Lenders JW, Eisenhofer G, Abeling NG, Berger W, Murphy DL, Koning CH, Wagemakers LM, Kopin IJ, Karoum F, van Gennip AH, Brunner HG: Specific genetic deficiencies of the A and B isoenzymes of monoamine oxidase are characterized by distinct neurochemical and clinial phenotypes. J Clin Invest 1996, 97:1010-1019.
46. O'Malley KL, Harmon S, Moffat M, Uhland-Smith A, Wong S: The human aromatic L-amino acid decarboxylase gene can be alternatiely spliced to generate unique protein isoforms. J Neurochem 1995, 65:2409-2416.
47. Baker G, Bomstein RA, Rouget AC, Schton SE, van Meyden JC, Couts RT: Phenylethylaminergic mechanisms in attention-deficit disorder. Biol Psychiatry 1991, 29:15-22.
48. Kasuga A: Decreased beta-phenylethylamine in urine of children with attention deficit hyperactivity disorder and autistic disorder. No To Hattatsu 2002, 34:243-248.
49. Kuroki T, Tsutsumi T, Hirano M, Matsumoto T, Tatebayashi Y, Nishiyama K, Uchimura H, Shiraishi A, Nakahara T, Nakamura K: Behavioral sensitization to beta-phenylethylamine (PEA): enduring modifications of specific dopaminergic neuron systems in the rat. Psychopharmacology (Berl) 1990, 102:5-10.
50. Katsukake M, Kamatsu A, Yamamoto D, Ishiwa-Chigusa S: A tyramine receptor gene mutation causes a defective olfactory behavior in Drosophila melanogaster. Genetics 2000, 245:31-42.
51. Wolf ME, Mosnaim AD: Phenylethylamine in neuropsychiatric disorders. Gen Pharmacol 1983, 14:385-390.
52. Durden DA, Philips SR, Boulton AA: Identification and distribution of beta-phenylethylamine in the rat. Can J Biochem 1973, 51:995-1002.
53. Blenau W, Balfanz S, Baumann A: Amtyr1: characterization of a gene from honeybee (Apis mellifera) brain encoding a functional tyramine receptor. J Neurochem 2000, 74:900-908.
54. Dourish CT, Cooper SJ: Pharmacology of beta-phenylethylamine-induced seizures in mice. Prog Neuropsychopharmacol Biol Psychiatyr 1983, 7:787-790.
55. Vaugha TR: The role of food inthe pathogenesis of migraine headache. Clin Rev Allergy 1994, 2:67-180.
56. Strong FC III: Why do some dietary migrain patients claim they get headaches from placebos? Clin Exp Allergy 2000, 5:739-743.
57. Peatfield RC, Jarrett N, Glover V: The pharmacology of food and drink. In Migraine: Pharmacology and genetics. Edited by Sandler M, Ferrari M, Hamett S. New York: Chapman & Hall; 1996. 127-143.
58. Carpene C, Galitzky J, Fontana E, Atgie C, Lafontan M, Berlan M: Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol 1999, 359:310-321.