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Volumn 11, Issue 21, 2011, Pages 2613-2622

Non-classical structures among current platinum complexes with potential as antitumor drugs

Author keywords

Biomolecules binding; Metallodrugs; Platinum

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CISPLATIN; OXALIPLATIN; PICOPLATIN; THIOSEMICARBAZIDE DERIVATIVE; TRIPLATIN TETRANITRATE;

EID: 80055076602     PISSN: 15680266     EISSN: 18734294     Source Type: Journal    
DOI: 10.2174/156802611798040723     Document Type: Article
Times cited : (17)

References (102)
  • 1
    • 80055095560 scopus 로고    scopus 로고
    • Front Matter
    • Prof. Bernhard, L., Ed
    • Front Matter. In: Cisplatin, Prof. Bernhard, L., Ed. 2006; pp I-XII.
    • (2006) In: Cisplatin
  • 2
    • 6444234760 scopus 로고    scopus 로고
    • The role of the medicinal chemist in drug discovery -Then and now
    • Lombardino, J. G.; Lowe, J. A. The role of the medicinal chemist in drug discovery -Then and now. Nat. Rev. Drug. Discov., 2004, 3(10), 853-862.
    • (2004) Nat. Rev. Drug. Discov , vol.3 , Issue.10 , pp. 853-862
    • Lombardino, J.G.1    Lowe, J.A.2
  • 3
    • 18244370796 scopus 로고    scopus 로고
    • How molecular profiling could revolutionize drug discovery
    • Stoughton, R. B.; Friend, S. H. How molecular profiling could revolutionize drug discovery. Nat. Rev. Drug Discov., 2005, 4(4), 345-350.
    • (2005) Nat. Rev. Drug Discov , vol.4 , Issue.4 , pp. 345-350
    • Stoughton, R.B.1    Friend, S.H.2
  • 4
    • 67650735457 scopus 로고    scopus 로고
    • DNA structure and integrity checkpoints during the cell cycle and their role in drug targeting and sensitivity of tumor cells to anticancer treatment
    • Skladanowski, A.; Bozko, P.; Sabisz, M. DNA structure and integrity checkpoints during the cell cycle and their role in drug targeting and sensitivity of tumor cells to anticancer treatment. Chem. Rev., 2009, 109(7), 2951-2973.
    • (2009) Chem. Rev , vol.109 , Issue.7 , pp. 2951-2973
    • Skladanowski, A.1    Bozko, P.2    Sabisz, M.3
  • 6
    • 67650663259 scopus 로고    scopus 로고
    • Introduction to Cancer Chemotherapeutics
    • Shewach, D. S.; Kuchta, R. D. Introduction to Cancer Chemotherapeutics. Chem. Rev., 2009, 109(7), 2859-2861.
    • (2009) Chem. Rev , vol.10 , Issue.7 , pp. 2859-2861
    • Shewach, D.S.1    Kuchta, R.D.2
  • 7
    • 34547100275 scopus 로고    scopus 로고
    • The resurgence of platinum-based cancer chemotherapy
    • Kelland, L. The resurgence of platinum-based cancer chemotherapy. Nat. Rev. Cancer, 2007, 7, (8), 573-584.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.8 , pp. 573-584
    • Kelland, L.1
  • 8
    • 0029691338 scopus 로고    scopus 로고
    • Trans-diammineplatinum(II): What makes it different from cis-DDP? Coordination chemistry of a neglected relative of cisplatin and its interaction with nucleic acids
    • Lippert, B., Trans-diammineplatinum(II): What makes it different from cis-DDP? Coordination chemistry of a neglected relative of cisplatin and its interaction with nucleic acids. Metal. Ions. Biol. Sys., 1996, 33, 105-141.
    • (1996) Metal. Ions. Biol. Sys , vol.33 , pp. 105-141
    • Lippert, B.1
  • 11
    • 0344466805 scopus 로고    scopus 로고
    • Preparation and characterization of novel trans-[PtCl2(amine)(isopropylamine)] compounds: Cytotoxic activity and apoptosis induction in ras-transformed cells
    • Montero, E. I.; Diaz, S.; Gonzalez-Vadillo, A. M.; Perez, J. M.; Alonso, C.; Navarro-Ranninger, C. Preparation and characterization of novel trans-[PtCl2(amine)(isopropylamine)] compounds: Cytotoxic activity and apoptosis induction in ras-transformed cells. J. Med. Chem., 1999, 42(20), 4264-4268.
    • (1999) J. Med. Chem , vol.42 , Issue.20 , pp. 4264-4268
    • Montero, E.I.1    Diaz, S.2    Gonzalez-Vadillo, A.M.3    Perez, J.M.4    Alonso, C.5    Navarro-Ranninger, C.6
  • 13
    • 63449107893 scopus 로고    scopus 로고
    • Towards Antitumor Active trans-Platinum Compounds
    • Sheena, M. A.; Nicholas, P. F. Towards Antitumor Active trans-Platinum Compounds. Euro. J. Inorg. Chem., 2009, 2009, (10), 1293-1302.
    • (2009) Euro. J. Inorg. Chem , vol.2009 , Issue.10 , pp. 1293-1302
    • Sheena, M.A.1    Nicholas, P.F.2
  • 14
    • 10644259645 scopus 로고    scopus 로고
    • Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations
    • Fojo, T.; Farrell, N.; Ortuzar, W.; Tanimura, H.; Weinstein, J.; Myers, T. G. Identification of non-cross-resistant platinum compounds with novel cytotoxicity profiles using the NCI anticancer drug screen and clustered image map visualizations. Crit. Rev. Oncol. Hematol., 2005, 53, (1), 25-34.
    • (2005) Crit. Rev. Oncol. Hematol , vol.53 , Issue.1 , pp. 25-34
    • Fojo, T.1    Farrell, N.2    Ortuzar, W.3    Tanimura, H.4    Weinstein, J.5    Myers, T.G.6
  • 15
    • 0037153219 scopus 로고    scopus 로고
    • Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines
    • Najajreh, Y.; Perez, J. M.; Navarro-Ranninger, C.; Gibson, D. Novel soluble cationic trans-diaminedichloroplatinum(II) complexes that are active against cisplatin resistant ovarian cancer cell lines. J. Med. Chem., 2002, 45(24), 5189-5195.
    • (2002) J. Med. Chem , vol.45 , Issue.24 , pp. 5189-5195
    • Najajreh, Y.1    Perez, J.M.2    Navarro-Ranninger, C.3    Gibson, D.4
  • 16
    • 0037991203 scopus 로고    scopus 로고
    • Synthesis and characterization of new transplatinum complexes containing phosphane groups -Cytotoxic studies in cisplatin-resistant cells
    • Ramos-Lima, F. J.; Quiroga, A. G.; Perez, J. M.; Font-Bardia, M.; Solans, X.; Navarro-Ranninger, C. Synthesis and characterization of new transplatinum complexes containing phosphane groups -Cytotoxic studies in cisplatin-resistant cells. Eur. J. Inorg. Chem., 2003, (8), 1591-1598.
    • (2003) Eur. J. Inorg. Chem , Issue.8 , pp. 1591-1598
    • Ramos-Lima, F.J.1    Quiroga, A.G.2    Perez, J.M.3    Font-Bardia, M.4    Solans, X.5    Navarro-Ranninger, C.6
  • 17
    • 34247570828 scopus 로고    scopus 로고
    • New trans-platinum drugs with phosphines and amines as carrier ligands induce apoptosis in tumor cells resistant to cisplatin
    • Ramos-Lima, F. J.; Quiroga, A. G.; Garcia-Serrelde, B.; Blanco, F.; Carnero, A.; Navarro-Ranninger, C. New trans-platinum drugs with phosphines and amines as carrier ligands induce apoptosis in tumor cells resistant to cisplatin. J. Med. Chem., 2007, 50(9), 2194-2199.
    • (2007) J. Med. Chem , vol.50 , Issue.9 , pp. 2194-2199
    • Ramos-Lima, F.J.1    Quiroga, A.G.2    Garcia-Serrelde, B.3    Blanco, F.4    Carnero, A.5    Navarro-Ranninger, C.6
  • 18
    • 24744432080 scopus 로고    scopus 로고
    • Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile
    • Ma, E. S. F.; Bates, W. D.; Edmunds, A.; Kelland, L. R.; Fojo, T.; Farrell, N. Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile. J. Med. Chem., 2005, 48(18), 5651-5654.
    • (2005) J. Med. Chem , vol.48 , Issue.18 , pp. 5651-5654
    • Ma, E.S.F.1    Bates, W.D.2    Edmunds, A.3    Kelland, L.R.4    Fojo, T.5    Farrell, N.6
  • 19
    • 30444444838 scopus 로고    scopus 로고
    • 2O2] donor sets. Cellular pharmacology and apoptosis induction in Pam 212-ras cells
    • Quiroga, A. G.; Perez, J. M.; Alonso, C.; Navarro-Ranninger, C.; Farrell, N. Novel transplatinum(II) complexes with [N2O2] donor sets. Cellular pharmacology and apoptosis induction in Pam 212-ras cells. J. Med. Chem., 2006, 49(1), 224-231.
    • (2006) J. Med. Chem , vol.49 , Issue.1 , pp. 224-231
    • Quiroga, A.G.1    Perez, J.M.2    Alonso, C.3    Navarro-Ranninger, C.4    Farrell, N.5
  • 20
    • 0035993852 scopus 로고    scopus 로고
    • Trans-platinum complexes as anticancer drugs: Recent developments and future prospects
    • Radulovic, S.; Tesic, Z.; Manic, S. Trans-platinum complexes as anticancer drugs: Recent developments and future prospects. Curr. Med. Chem., 2002, 9(17), 1611-1618.
    • (2002) Curr. Med. Chem , vol.9 , Issue.17 , pp. 1611-1618
    • Radulovic, S.1    Tesic, Z.2    Manic, S.3
  • 21
    • 33846057929 scopus 로고    scopus 로고
    • Trans-platinum complexes in cancer therapy
    • Coluccia, M.; Natile, G. Trans-platinum complexes in cancer therapy. Anticancer Agents Med. Chem., 2007, 7(1), 111-123.
    • (2007) Anticancer Agents Med. Chem , vol.7 , Issue.1 , pp. 111-123
    • Coluccia, M.1    Natile, G.2
  • 22
    • 3042740471 scopus 로고    scopus 로고
    • Antitumor active trans-platinum compounds
    • Natile, G.; Coluccia, M. Antitumor active trans-platinum compounds. Met. Ions. Biol. Syst., 2004, 42, 209-250.
    • (2004) Met. Ions. Biol. Syst , vol.42 , pp. 209-250
    • Natile, G.1    Coluccia, M.2
  • 23
    • 33745763300 scopus 로고    scopus 로고
    • Interactions of antitumor metallodrugs with serum proteins: Advances in characterization using modern analytical methodology
    • Timerbaev, A. R.; Hartinger, C. G.; Aleksenko, S. S.; Keppler, B. K. Interactions of antitumor metallodrugs with serum proteins: advances in characterization using modern analytical methodology. Chem. Rev., 2006, 106(6), 2224-2248.
    • (2006) Chem. Rev , vol.106 , Issue.6 , pp. 2224-2248
    • Timerbaev, A.R.1    Hartinger, C.G.2    Aleksenko, S.S.3    Keppler, B.K.4
  • 24
    • 0002038061 scopus 로고    scopus 로고
    • PKa values of aqua ligands of platinum(II) anticancer complexes: H-1, N-15 and Pt-195 NMR studies of cis-and trans-PtCl2(NH3)(cyclohexylamine)
    • Barton, S. J.; Barnham, K. J.; Habtemariam, A.; Sue, R. E.; Sadler, P. J. PKa values of aqua ligands of platinum(II) anticancer complexes: H-1, N-15 and Pt-195 NMR studies of cis-and trans-PtCl2(NH3)(cyclohexylamine). Inorg. Chim. Acta, 1998, 273, (1-2), 8-13.
    • (1998) Inorg. Chim. Acta , vol.2 , Issue.1-2 , pp. 8-13
    • Barton, S.J.1    Barnham, K.J.2    Habtemariam, A.3    Sue, R.E.4    Sadler, P.J.5
  • 25
    • 0036026129 scopus 로고    scopus 로고
    • Kinetic study of the reaction between an antitumor N-15 labeled trans-platinum iminoether complex and GMP by H-1, N-15 HMQC NMR
    • Liu, Y. Z.; Intini, F. P.; Natile, G.; Sletten, E. Kinetic study of the reaction between an antitumor N-15 labeled trans-platinum iminoether complex and GMP by H-1, N-15 HMQC NMR. J. Chem. Soc. Dalton, 2002, (18), 3489-3495.
    • (2002) J. Chem. Soc. Dalton , Issue.18 , pp. 3489-3495
    • Liu, Y.Z.1    Intini, F.P.2    Natile, G.3    Sletten, E.4
  • 26
    • 27544452085 scopus 로고    scopus 로고
    • Contrasting chemistry of cis-and trans-platinum(II) diamine anticancer compounds: Hydrolysis studies of picoline complexes
    • McGowan, G.; Parsons, S.; Sadler, P. J. Contrasting chemistry of cis-and trans-platinum(II) diamine anticancer compounds: hydrolysis studies of picoline complexes. Inorg. Chem., 2005, 44(21), 7459-67.
    • (2005) Inorg. Chem , vol.44 , Issue.21 , pp. 7459-7467
    • McGowan, G.1    Parsons, S.2    Sadler, P.J.3
  • 30
    • 0034638878 scopus 로고    scopus 로고
    • Slowing of cisplatin aquation in the presence of DNA but not in the presence of phosphate: Improved understanding of sequence selectivity and the roles of monoaquated and diaquated species in the binding of cisplatin to DNA
    • Davies, M. S.; Berners-Price, S. J.; Hambley, T. W. Slowing of cisplatin aquation in the presence of DNA but not in the presence of phosphate: Improved understanding of sequence selectivity and the roles of monoaquated and diaquated species in the binding of cisplatin to DNA. Inorg. Chem., 2000, 39 (25), 5603-5613.
    • (2000) Inorg. Chem , vol.39 , Issue.25 , pp. 5603-5613
    • Davies, M.S.1    Berners-Price, S.J.2    Hambley, T.W.3
  • 31
    • 57049163592 scopus 로고    scopus 로고
    • Phosphodiester-Mediated Reaction of Cisplatin with Guanine in Oligodeoxyribonucleotides
    • Campbell, M. A.; Miller, P. S. Phosphodiester-Mediated Reaction of Cisplatin with Guanine in Oligodeoxyribonucleotides. Biochemistry, 2008, 47(48), 12931-12938.
    • (2008) Biochemistry , vol.47 , Issue.48 , pp. 12931-12938
    • Campbell, M.A.1    Miller, P.S.2
  • 32
    • 25144520199 scopus 로고    scopus 로고
    • Cisplatin carbonato complexes. implications for uptake, antitumor properties, and toxicity
    • Centerwall, C. R.; Goodisman, J.; Kerwood, D. J.; Dabrowiak, J. C. Cisplatin carbonato complexes. implications for uptake, antitumor properties, and toxicity. J. Am. Chem. Soc., 2005, 127(37), 12768-12769.
    • (2005) J. Am. Chem. Soc , vol.127 , Issue.37 , pp. 12768-12769
    • Centerwall, C.R.1    Goodisman, J.2    Kerwood, D.J.3    Dabrowiak, J.C.4
  • 33
    • 34249062927 scopus 로고    scopus 로고
    • Understanding the effect of carbonate ion on cisplatin binding to DNA
    • Todd, R. C.; Lovejoy, K. S.; Lippard, S. J. Understanding the effect of carbonate ion on cisplatin binding to DNA. J. Am. Chem. Soc., 2007, 129, (20), 6370-1.
    • (2007) J. Am. Chem. Soc , vol.129 , Issue.20 , pp. 6370-6371
    • Todd, R.C.1    Lovejoy, K.S.2    Lippard, S.J.3
  • 34
    • 35648949865 scopus 로고    scopus 로고
    • Insights into the molecular mechanisms of protein platination from a case study: The reaction of anticancer Platinum(II) iminoethers with horse heart cytochrome c
    • Casini, A.; Gabbiani, C.; Mastrobuoni, G.; Pellicani, R. Z.; Intini, F. P.; Arnesano, F.; Natile, G.; Moneti, G.; Francese, S.; Messori, L. Insights into the molecular mechanisms of protein platination from a case study: The reaction of anticancer Platinum(II) iminoethers with horse heart cytochrome c. Biochemistry, 2007, 46(43), 12220-12230.
    • (2007) Biochemistry , vol.46 , Issue.43 , pp. 12220-12230
    • Casini, A.1    Gabbiani, C.2    Mastrobuoni, G.3    Pellicani, R.Z.4    Intini, F.P.5    Arnesano, F.6    Natile, G.7    Moneti, G.8    Francese, S.9    Messori, L.10
  • 35
    • 70349094106 scopus 로고    scopus 로고
    • Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(ii) complexes bearing aliphatic amine ligands
    • Cubo, L.; Casini, A.; Gabbiani, C.; Mastrobuoni, G.; Messori, L.; Jimenez-Barbero, J.; Navarro-Ranninger, C.; Quiroga, A. G. Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(ii) complexes bearing aliphatic amine ligands. Chem-Eur. J., 2009, 15(36), 9139-9146.
    • (2009) Chem-Eur. J , vol.15 , Issue.36 , pp. 9139-9146
    • Cubo, L.1    Casini, A.2    Gabbiani, C.3    Mastrobuoni, G.4    Messori, L.5    Jimenez-Barbero, J.6    Navarro-Ranninger, C.7    Quiroga, A.G.8
  • 36
    • 53849088542 scopus 로고    scopus 로고
    • Effects of geometric isomerism and anions on the kinetics and mechanism of the stepwise formation of long-range DNA interstrand crosslinks by dinuclear platinum antitumor complexes
    • Zhang, J. Y.; Thomas, D. S.; Berners-Price, S. J.; Farrell, N. Effects of geometric isomerism and anions on the kinetics and mechanism of the stepwise formation of long-range DNA interstrand crosslinks by dinuclear platinum antitumor complexes. Chem-Eur. J., 2008, 14(21), 6391-6405.
    • (2008) Chem-Eur. J , vol.14 , Issue.21 , pp. 6391-6405
    • Zhang, J.Y.1    Thomas, D.S.2    Berners-Price, S.J.3    Farrell, N.4
  • 37
    • 70350343647 scopus 로고    scopus 로고
    • Methionine can favor DNA platination by trans-coordinated platinum antitumor drugs
    • Li, C.; Li, Z. Y.; Sletten, E.; Arnesano, F.; Losacco, M.; Natile, G.; Liu, Y. Z. Methionine can favor DNA platination by trans-coordinated platinum antitumor drugs. Angew. Chem. Int. Edit., 2009, 48(45), 8497-8500.
    • (2009) Angew. Chem. Int. Edit , vol.48 , Issue.45 , pp. 8497-8500
    • Li, C.1    Li, Z.Y.2    Sletten, E.3    Arnesano, F.4    Losacco, M.5    Natile, G.6    Liu, Y.Z.7
  • 38
    • 34249900982 scopus 로고    scopus 로고
    • Direct cellular responses to platinum-induced DNA damage
    • Jung, Y.; Lippard, S. J. Direct cellular responses to platinum-induced DNA damage. Chem. Rev., 2007, 107, (5), 1387-1407.
    • (2007) Chem. Rev , vol.107 , Issue.5 , pp. 1387-1407
    • Jung, Y.1    Lippard, S.J.2
  • 39
    • 71549115853 scopus 로고    scopus 로고
    • Inhibition of transcription by platinum antitumor compounds
    • Todd, R. C.; Lippard, S. J. Inhibition of transcription by platinum antitumor compounds. Metallomics, 2009, 1, (4), 280-291.
    • (2009) Metallomics , vol.1 , Issue.4 , pp. 280-291
    • Todd, R.C.1    Lippard, S.J.2
  • 40
    • 70350645330 scopus 로고    scopus 로고
    • Platinum Drug Distribution in Cancer Cells and Tumors
    • Klein, A. V.; Hambley, T. W. Platinum Drug Distribution in Cancer Cells and Tumors. Chem. Rev., 2009, 109, (10), 4911-4920.
    • (2009) Chem. Rev , vol.109 , Issue.10 , pp. 4911-4920
    • Klein, A.V.1    Hambley, T.W.2
  • 41
    • 0033578010 scopus 로고    scopus 로고
    • Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins
    • Ohndorf, U.-M.; Rould, M. A.; He, Q.; Pabo, C. O.; Lippard, S. J. Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins. Nature, 1999, 399, (6737), 708-712.
    • (1999) Nature , vol.3 , Issue.6737 , pp. 708-712
    • Ohndorf, U.-M.1    Rould, M.A.2    He, Q.3    Pabo, C.O.4    Lippard, S.J.5
  • 42
    • 0000472993 scopus 로고    scopus 로고
    • Platinum thioether bonds can be reverted by guanine N7 bonds in Pt(dien)2+ model adducts
    • van Boom, S. S. G. E.; Chen, B. W.; Teuben, J. M.; Reedijk, J. Platinum thioether bonds can be reverted by guanine N7 bonds in Pt(dien)2+ model adducts. Inorg. Chem., 1999, 38, (7), 1450-1455.
    • (1999) Inorg. Chem , vol.38 , Issue.7 , pp. 1450-1455
    • van Boom, S.S.G.E.1    Chen, B.W.2    Teuben, J.M.3    Reedijk, J.4
  • 45
    • 0031774413 scopus 로고    scopus 로고
    • Structural and reactivity studies on the ternary system guanine/methionine/ trans -[PtCl2(NH3)L] (L=NH3, quinoline): Implications for the mechanism of action of nonclassical trans -platinum antitumor complexes
    • Bierbach, U.; Farrell, N. Structural and reactivity studies on the ternary system guanine/methionine/ trans -[PtCl2(NH3)L] (L=NH3, quinoline): implications for the mechanism of action of nonclassical trans -platinum antitumor complexes. J. Biol. Inorg. Chem., 1998, 3, (6), 570-580.
    • (1998) J. Biol. Inorg. Chem , vol.3 , Issue.6 , pp. 570-580
    • Bierbach, U.1    Farrell, N.2
  • 46
    • 33646510074 scopus 로고    scopus 로고
    • Donor atom preferences in substitution reactions of trans-platinum mononucleobase compounds: Implications for DNA-protein selectivity
    • Anzellotti, A.; Stefan, S.; Gibson, D.; Farrell, N. Donor atom preferences in substitution reactions of trans-platinum mononucleobase compounds: Implications for DNA-protein selectivity. Inorg. Chim. Acta, 2006, 359, (9), 3014-3019.
    • (2006) Inorg. Chim. Acta , vol.359 , Issue.9 , pp. 3014-3019
    • Anzellotti, A.1    Stefan, S.2    Gibson, D.3    Farrell, N.4
  • 47
    • 23244452191 scopus 로고    scopus 로고
    • Pyridine-carboxylate complexes of platinum. Effect of N,O-chelate formation on model bifunctional DNA-DNA and DNA-protein interactions
    • Quintal, S. M. O.; Qu, Y.; Quiroga, A. G.; Moniodis, J.; Nogueira, H. I. S.; Farrell, N, Pyridine-carboxylate complexes of platinum. Effect of N,O-chelate formation on model bifunctional DNA-DNA and DNA-protein interactions. Inorg. Chem., 2005, 44, (15), 5247-5253.
    • (2005) Inorg. Chem , vol.44 , Issue.15 , pp. 5247-5253
    • Quintal, S.M.O.1    Qu, Y.2    Quiroga, A.G.3    Moniodis, J.4    Nogueira, H.I.S.5    Farrell, N.6
  • 48
    • 33646550188 scopus 로고    scopus 로고
    • Targeting retroviral Zn finger-DNA interactions: A small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds
    • Anzellotti, A. I.; Liu, Q.; Bloemink, M. J.; Scarsdale, J. N.; Farrell, N. Targeting retroviral Zn finger-DNA interactions: A small-molecule approach using the electrophilic nature of trans-platinum-nucleobase compounds. Chem. Biol., 2006, 13, (5), 539-548.
    • (2006) Chem. Biol , vol.13 , Issue.5 , pp. 539-548
    • Anzellotti, A.I.1    Liu, Q.2    Bloemink, M.J.3    Scarsdale, J.N.4    Farrell, N.5
  • 49
    • 25144446167 scopus 로고    scopus 로고
    • Thiolate-bridged heterodinuclear platinum-zinc chelates as models for ternary platinum-DNA-protein complexes and zinc ejection from zinc fingers. Evidence from studies using ESI-mass spectrometry
    • Liu, Q.; Golden, M.; Darensbourg, M. Y.; Farrell, N. Thiolate-bridged heterodinuclear platinum-zinc chelates as models for ternary platinum-DNA-protein complexes and zinc ejection from zinc fingers. Evidence from studies using ESI-mass spectrometry. Chem. Commun., 2005, (34), 4360-4362.
    • (2005) Chem. Commun , Issue.34 , pp. 4360-4362
    • Liu, Q.1    Golden, M.2    Darensbourg, M.Y.3    Farrell, N.4
  • 50
    • 43249085802 scopus 로고    scopus 로고
    • Thiolate bridging and metal exchange in adducts of a zinc finger model and Pt-II complexes: Biomimetic studies of protein/Pt/DNA interactions
    • Almaraz, E.; de Paula, Q. A.; Liu, Q.; Reibenspies, J. H.; Darensbourg, M. Y.; Farrell, N. P. Thiolate bridging and metal exchange in adducts of a zinc finger model and Pt-II complexes: Biomimetic studies of protein/Pt/DNA interactions. J. Am. Chem. Soc., 2008, 130(19), 6272-6280.
    • (2008) J. Am. Chem. Soc , vol.130 , Issue.19 , pp. 6272-6280
    • Almaraz, E.1    de Paula, Q.A.2    Liu, Q.3    Reibenspies, J.H.4    Darensbourg, M.Y.5    Farrell, N.P.6
  • 51
    • 34548128309 scopus 로고    scopus 로고
    • Reaction of Zn(7)Metallothionein with cis-and trans-[Pt(N-donor)(2)Cl-2] anticancer complexes: Trans-Pt-II complexes retain their N-donor ligands
    • Knipp, M.; Karotki, A. V.; Chesnov, S.; Natile, G.; Sadler, P. J.; Brabec, V.; Vasak, M. Reaction of Zn(7)Metallothionein with cis-and trans-[Pt(N-donor)(2)Cl-2] anticancer complexes: trans-Pt-II complexes retain their N-donor ligands. J. Med. Chem., 2007, 50, (17), 4075-4086.
    • (2007) J. Med. Chem , vol.50 , Issue.17 , pp. 4075-4086
    • Knipp, M.1    Karotki, A.V.2    Chesnov, S.3    Natile, G.4    Sadler, P.J.5    Brabec, V.6    Vasak, M.7
  • 52
    • 53749087919 scopus 로고    scopus 로고
    • Interaction of metallothionein-2 with platinum-modified 5 '-guanosine monophosphate and DNA
    • Karotki, A. V.; Vasak, M. Interaction of metallothionein-2 with platinum-modified 5 '-guanosine monophosphate and DNA. Biochemistry, 2008, 47(41), 10961-10969.
    • (2008) Biochemistry , vol.47 , Issue.41 , pp. 10961-10969
    • Karotki, A.V.1    Vasak, M.2
  • 53
    • 37549050199 scopus 로고    scopus 로고
    • Kinetically favored platination of adenine in the g-rich human telomeric repeat
    • Rao, L.; Bierbach, U. Kinetically favored platination of adenine in the g-rich human telomeric repeat. J. Am. Chem. Soc., 2007, 129, (51), 15764-15765.
    • (2007) J. Am. Chem. Soc , vol.129 , Issue.51 , pp. 15764-15765
    • Rao, L.1    Bierbach, U.2
  • 54
    • 38949126885 scopus 로고    scopus 로고
    • Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex
    • Reed, J. E.; Neidle, S.; Vilar, R. Stabilisation of human telomeric quadruplex DNA and inhibition of telomerase by a platinum-phenanthroline complex. Chem. Commun., 2007, (42), 4366-4368.
    • (2007) Chem. Commun , Issue.42 , pp. 4366-4368
    • Reed, J.E.1    Neidle, S.2    Vilar, R.3
  • 55
    • 3843105727 scopus 로고    scopus 로고
    • Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells
    • Farrell, N.; Povirk, L. F.; Dange, Y.; DeMasters, G.; Gupta, M. S.; Kohlhagen, G.; Khan, Q. A.; Pommier, Y.; Gewirtz, D. A. Cytotoxicity, DNA strand breakage and DNA-protein crosslinking by a novel transplatinum compound in human A2780 ovarian and MCF-7 breast carcinoma cells. Biochem. Pharm., 2004, 68(5), 857-866.
    • (2004) Biochem. Pharm , vol.68 , Issue.5 , pp. 857-866
    • Farrell, N.1    Povirk, L.F.2    Dange, Y.3    Demasters, G.4    Gupta, M.S.5    Kohlhagen, G.6    Khan, Q.A.7    Pommier, Y.8    Gewirtz, D.A.9
  • 56
    • 38749084242 scopus 로고    scopus 로고
    • Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach
    • Hartinger, C. G.; Tsybin, Y. O.; Fuchser, J.; Dyson, P. J. Characterization of platinum anticancer drug protein-binding sites using a top-down mass spectrometric approach. Inorg. Chem., 2008, 47(1), 17-19.
    • (2008) Inorg. Chem , vol.47 , Issue.1 , pp. 17-19
    • Hartinger, C.G.1    Tsybin, Y.O.2    Fuchser, J.3    Dyson, P.J.4
  • 57
    • 67649525571 scopus 로고    scopus 로고
    • Exploring metallodrug-protein interactions by mass spectrometry: Comparisons between platinum coordination complexes and an organometallic ruthenium compound
    • Casini, A.; Gabbiani, C.; Michelucci, E.; Pieraccini, G.; Moneti, G.; Dyson, P. J.; Messori, L. Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound. J. Biol. Inorg. Chem., 2009, 14, (5), 761-770.
    • (2009) J. Biol. Inorg. Chem , vol.14 , Issue.5 , pp. 761-770
    • Casini, A.1    Gabbiani, C.2    Michelucci, E.3    Pieraccini, G.4    Moneti, G.5    Dyson, P.J.6    Messori, L.7
  • 59
    • 33748102436 scopus 로고    scopus 로고
    • Insights into the mechanism of action of platinum anticancer drugs from multinuclear NMR spectroscopy
    • Berners-Price, S. J.; Ronconi, L.; Sadler, P. J. Insights into the mechanism of action of platinum anticancer drugs from multinuclear NMR spectroscopy. Prog. Nucl. Mag. Res. Sp., 2006, 49(1), 65-98.
    • (2006) Prog. Nucl. Mag. Res. Sp , vol.49 , Issue.1 , pp. 65-98
    • Berners-Price, S.J.1    Ronconi, L.2    Sadler, P.J.3
  • 60
    • 0345256652 scopus 로고    scopus 로고
    • Cisplatin: Mode of cytotoxic action and molecular basis of resistance
    • Siddik, Z. H. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene, 2003, 22(47), 7265-7279.
    • (2003) Oncogene , vol.22 , Issue.47 , pp. 7265-7279
    • Siddik, Z.H.1
  • 62
    • 0028144364 scopus 로고
    • The role of apoptosis in cell-killing by cisplatin -a flow cytometric study
    • Ormerod, M. G.; Orr, R. M.; Peacock, J. H. The role of apoptosis in cell-killing by cisplatin -a flow cytometric study. Brit. J. Cancer, 1994, 69(1), 93-100.
    • (1994) Brit. J. Cancer , vol.69 , Issue.1 , pp. 93-100
    • Ormerod, M.G.1    Orr, R.M.2    Peacock, J.H.3
  • 63
    • 0024234729 scopus 로고
    • Influence of cis-diamminedichloroplatinum(Ii) on DNA-synthesis and cell-cycle progression in excision repair proficient and deficient chinese-hamster ovary cells
    • Sorenson, C. M.; Eastman, A. Influence of cis-diamminedichloroplatinum(Ii) on DNA-synthesis and cell-cycle progression in excision repair proficient and deficient chinese-hamster ovary cells. Cancer Res., 1988, 48(23), 6703-6707.
    • (1988) Cancer Res , vol.48 , Issue.23 , pp. 6703-6707
    • Sorenson, C.M.1    Eastman, A.2
  • 64
    • 0023681189 scopus 로고
    • Mechanism of cis-diamminedichloroplatinum(Ii)-induced cyto-toxicity -role of G2 arrest and DNA double-strand breaks
    • Sorenson, C. M.; Eastman, A. Mechanism of cis-diamminedichloroplatinum(Ii)-induced cyto-toxicity -role of G2 arrest and DNA double-strand breaks. Cancer Res., 1988, 48(16), 4484-4488.
    • (1988) Cancer Res , vol.48 , Issue.16 , pp. 4484-4488
    • Sorenson, C.M.1    Eastman, A.2
  • 66
    • 33745648088 scopus 로고    scopus 로고
    • Coluccia, M. Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells
    • Boccarelli, A.; Giordano, D.; Natile, G.; Coluccia, M. Differential processing of antitumour-active and antitumour-inactive trans platinum compounds by SKOV-3 ovarian cancer cells. Biochem. Pharmacol., 2006, 72(3), 280-292.
    • (2006) Biochem. Pharmacol , vol.72 , Issue.3 , pp. 280-292
    • Boccarelli, A.1    Giordano, D.2    Natile, G.3
  • 67
    • 0043073120 scopus 로고    scopus 로고
    • New metal complexes as potential therapeutics
    • Zhang, C. X.; Lippard, S. J. New metal complexes as potential therapeutics. Curr. Opin. Chem. Biol., 2003, 7(4), 481-489.
    • (2003) Curr. Opin. Chem. Biol , vol.7 , Issue.4 , pp. 481-489
    • Zhang, C.X.1    Lippard, S.J.2
  • 68
    • 0742304476 scopus 로고    scopus 로고
    • Preparation, characterization and cytotoxic activity of new compounds trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3(4-(hydroxymethyl)-pyridine)]
    • Ramos-Lima, F. J.; Quiroga, A. G.; Perez, J. M.; Navarro-Ranninger, C. Preparation, characterization and cytotoxic activity of new compounds trans-[PtCl2NH3(3-(hydroxymethyl)-pyridine)] and trans-[PtCl2NH3(4-(hydroxymethyl)-pyridine)]. Polyhedron, 2003, 22(25-26), 3379-3381.
    • (2003) Polyhedron , vol.22 , Issue.25-26 , pp. 3379-3381
    • Ramos-Lima, F.J.1    Quiroga, A.G.2    Perez, J.M.3    Navarro-Ranninger, C.4
  • 69
    • 33645037498 scopus 로고    scopus 로고
    • Recognition of DNA modified by trans-[PtCl2NH3(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex
    • Stehlikova, K.; Kasparkova, J.; Novakova, O.; Martinez, A.; Moreno, V.; Brabec, V. Recognition of DNA modified by trans-[PtCl2NH3(4-hydroxymethylpyridine)] by tumor suppressor protein p53 and character of DNA adducts of this cytotoxic complex. Febs J., 2006, 273(2), 301-314.
    • (2006) Febs J , vol.273 , Issue.2 , pp. 301-314
    • Stehlikova, K.1    Kasparkova, J.2    Novakova, O.3    Martinez, A.4    Moreno, V.5    Brabec, V.6
  • 70
    • 72049085004 scopus 로고    scopus 로고
    • The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine
    • Ramos-Lima, F. J.; Moneo, V.; Quiroga, A. G.; Carnero, A.; Navarro-Ranninger, C. The role of p53 in the cellular toxicity by active trans-platinum complexes containing isopropylamine and hydroxymethylpyridine. Eur. J. Med. Chem., 2010, 45(1), 134-141.
    • (2010) Eur. J. Med. Chem , vol.45 , Issue.1 , pp. 134-141
    • Ramos-Lima, F.J.1    Moneo, V.2    Quiroga, A.G.3    Carnero, A.4    Navarro-Ranninger, C.5
  • 71
    • 33947379700 scopus 로고    scopus 로고
    • Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([trans-PtCl(NH3)(2)]2μ-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis
    • Kabolizadeh, P.; Ryan, J.; Farrell, N. Differences in the cellular response and signaling pathways of cisplatin and BBR3464 ([trans-PtCl(NH3)(2)]2μ-(trans-Pt(NH3)(2)(H2N(CH2)(6)-NH2)2)]4+) influenced by copper homeostasis. Biochem. Pharmacol., 2007, 73(9), 1270-1279.
    • (2007) Biochem. Pharmacol , vol.73 , Issue.9 , pp. 1270-1279
    • Kabolizadeh, P.1    Ryan, J.2    Farrell, N.3
  • 73
    • 12444340794 scopus 로고    scopus 로고
    • High-turnover palladium catalysts in cross-coupling and heck chemistry: A critical overview
    • Farina, V. High-turnover palladium catalysts in cross-coupling and heck chemistry: a critical overview. Adv. Synthesis Catalysis, 2004, 346(13-15), 1553-1582.
    • (2004) Adv. Synthesis Catalysis , vol.346 , Issue.13-15 , pp. 1553-1582
    • Farina, V.1
  • 74
    • 21944441002 scopus 로고    scopus 로고
    • The potential of palladacycles: More than just precatalysts
    • Dupont, J.; Consorti, C. S.; Spencer, J. The potential of palladacycles: More than just precatalysts. Chem. Rev., 2005, 105(6), 2527-2571.
    • (2005) Chem. Rev , vol.105 , Issue.6 , pp. 2527-2571
    • Dupont, J.1    Consorti, C.S.2    Spencer, J.3
  • 75
    • 0027144755 scopus 로고
    • Analysis of two cycloplatinated compounds derived from N-(4-methoxyphenyl)-.alpha.-benzoylbenzylidenamine. Comparison of the activity of these compounds with other isostructural cyclopal-ladated compounds
    • Navarro-Ranniger, C.; Lopez-Solera, I.; Perez, J. M.; Rodriguez, J.; Garcia-Ruano, J. L.; Raithby, P. R.; Masaguer, J.; Alonso, C. Analysis of two cycloplatinated compounds derived from N-(4-methoxyphenyl)-.alpha.-benzoylbenzylidenamine. Comparison of the activity of these compounds with other isostructural cyclopal-ladated compounds. J. Med. Chem., 1993, 36(24), 3795-3801.
    • (1993) J. Med. Chem , vol.36 , Issue.24 , pp. 3795-3801
    • Navarro-Ranniger, C.1    Lopez-Solera, I.2    Perez, J.M.3    Rodriguez, J.4    Garcia-Ruano, J.L.5    Raithby, P.R.6    Masaguer, J.7    Alonso, C.8
  • 76
    • 0032560227 scopus 로고    scopus 로고
    • Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemi-carbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA
    • Quiroga, A. G.; Perez, J. M.; Lopez-Solera, I.; Masaguer, J. R.; Luque, A.; Roman, P.; Edwards, A.; Alonso, C.; Navarro-Ranninger, C. Novel tetranuclear orthometalated complexes of Pd(II) and Pt(II) derived from p-isopropylbenzaldehyde thiosemi-carbazone with cytotoxic activity in cis-DDP resistant tumor cell lines. Interaction of these complexes with DNA. J. Med. Chem., 1998, 41(9), 1399-1408.
    • (1998) J. Med. Chem , vol.41 , Issue.9 , pp. 1399-1408
    • Quiroga, A.G.1    Perez, J.M.2    Lopez-Solera, I.3    Masaguer, J.R.4    Luque, A.5    Roman, P.6    Edwards, A.7    Alonso, C.8    Navarro-Ranninger, C.9
  • 77
    • 1142309887 scopus 로고    scopus 로고
    • Contribution to the SAR field of metallated and coordination complexes. Studies of the palladium and platinum derivatives with selected thiosemicarbazones as antitumoral drugs
    • Quiroga, A. G.; Ranninger, C. N. Contribution to the SAR field of metallated and coordination complexes. Studies of the palladium and platinum derivatives with selected thiosemicarbazones as antitumoral drugs. Coord. Chem. Rev., 2004, 248, (1-2), 119-133.
    • (2004) Coord. Chem. Rev , vol.248 , Issue.1-2 , pp. 119-133
    • Quiroga, A.G.1    Ranninger, C.N.2
  • 80
    • 0037187390 scopus 로고    scopus 로고
    • Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) Radiopharmaceuticals
    • Maurer, R. I.; Blower, P. J.; Dilworth, J. R.; Reynolds, C. A.; Zheng, Y.; Mullen, G. E. D. Studies on the Mechanism of Hypoxic Selectivity in Copper Bis(Thiosemicarbazone) Radiopharmaceuticals. J. Med. Chem., 2002, 45(7), 1420-1431.
    • (2002) J. Med. Chem , vol.45 , Issue.7 , pp. 1420-1431
    • Maurer, R.I.1    Blower, P.J.2    Dilworth, J.R.3    Reynolds, C.A.4    Zheng, Y.5    Mullen, G.E.D.6
  • 81
    • 0037122708 scopus 로고    scopus 로고
    • Synthesis, Biological evaluation, and quantitative structureâˆ'activity relationship analysis of new schiff bases of hydroxysemicarbazide as potential antitumor agentsâ
    • Ren, S.; Wang, R.; Komatsu, K.; Bonaz-Krause, P.; Zyrianov, Y.; McKenna, C. E.; Csipke, C.; Tokes, Z. A.; Lien, E. J. Synthesis, Biological evaluation, and quantitative structureâˆ'activity relationship analysis of new schiff bases of hydroxysemicarbazide as potential antitumor agentsâ. J. Med. Chem., 2001, 45(2), 410-419.
    • (2001) J. Med. Chem , vol.45 , Issue.2 , pp. 410-419
    • Ren, S.1    Wang, R.2    Komatsu, K.3    Bonaz-Krause, P.4    Zyrianov, Y.5    McKenna, C.E.6    Csipke, C.7    Tokes, Z.A.8    Lien, E.J.9
  • 82
    • 17444427138 scopus 로고    scopus 로고
    • Combinatorial optimization of isatin-thiosemicarbazones as anti-poxvirus agents
    • Pirrung, M. C.; Pansare, S. V.; Sarma, K. D.; Keith, K. A.; Kern, E. R. Combinatorial optimization of isatin-thiosemicarbazones as anti-poxvirus agents. J. Med. Chem., 2005, 48(8), 3045-3050.
    • (2005) J. Med. Chem , vol.48 , Issue.8 , pp. 3045-3050
    • Pirrung, M.C.1    Pansare, S.V.2    Sarma, K.D.3    Keith, K.A.4    Kern, E.R.5
  • 83
    • 0037142343 scopus 로고    scopus 로고
    • Synthesis and structureâˆ'activity relationship study of potent trypanocidal thio semi-carbazone inhibitors of the trypanosomal cysteine protease cruzain
    • Du, X.; Guo, C.; Hansell, E.; Doyle, P. S.; Caffrey, C. R.; Holler, T. P.; McKerrow, J. H.; Cohen, F. E. Synthesis and structureâˆ'activity relationship study of potent trypanocidal thio semi-carbazone inhibitors of the trypanosomal cysteine protease cruzain. J. Med. Chem., 2002, 45(13), 2695-2707.
    • (2002) J. Med. Chem , vol.45 , Issue.13 , pp. 2695-2707
    • Du, X.1    Guo, C.2    Hansell, E.3    Doyle, P.S.4    Caffrey, C.R.5    Holler, T.P.6    McKerrow, J.H.7    Cohen, F.E.8
  • 84
    • 2542533103 scopus 로고    scopus 로고
    • Synthesis and structureâˆ'activity relationships of para-siticidal thiosemicarbazone cysteine protease inhibitors against plasmodium falciparum, trypanosoma brucei, and trypanosoma cruzi
    • Greenbaum, D. C.; Mackey, Z.; Hansell, E.; Doyle, P.; Gut, J.; Caffrey, C. R.; Lehrman, J.; Rosenthal, P. J.; McKerrow, J. H.; Chibale, K. Synthesis and structureâˆ'activity relationships of para-siticidal thiosemicarbazone cysteine protease inhibitors against plasmodium falciparum, trypanosoma brucei, and trypanosoma cruzi. J. Med. Chem., 2004, 47(12), 3212-3219.
    • (2004) J. Med. Chem , vol.47 , Issue.12 , pp. 3212-3219
    • Greenbaum, D.C.1    Mackey, Z.2    Hansell, E.3    Doyle, P.4    Gut, J.5    Caffrey, C.R.6    Lehrman, J.7    Rosenthal, P.J.8    McKerrow, J.H.9    Chibale, K.10
  • 85
    • 66249134216 scopus 로고    scopus 로고
    • Synthesis, activity, and pharmacophore development for isatin-thiosemicarbazones with selective activity toward multidrug-resistant cells
    • Hall, M. D.; Salam, N. K.; Hellawell, J. L.; Fales, H. M.; Kensler, C. B.; Ludwig, J. A.; SzakaÌcs, G.; Hibbs, D. E.; Gottesman, M. M. Synthesis, activity, and pharmacophore development for isatin-thiosemicarbazones with selective activity toward multidrug-resistant cells. J. Med. Chem., 2009, 52(10), 3191-3204.
    • (2009) J. Med. Chem , vol.52 , Issue.10 , pp. 3191-3204
    • Hall, M.D.1    Salam, N.K.2    Hellawell, J.L.3    Fales, H.M.4    Kensler, C.B.5    Ludwig, J.A.6    Szakaìcs, G.7    Hibbs, D.E.8    Gottesman, M.M.9
  • 87
    • 0033694731 scopus 로고    scopus 로고
    • Main group metal complexes of semicarbazones and thiosemicarbazones. A structural review
    • Casas, J. S.; García-Tasende, M. S.; Sordo, J. Main group metal complexes of semicarbazones and thiosemicarbazones. A structural review. Coord. Chem. Rev., 2000, 209(1), 197-261.
    • (2000) Coord. Chem. Rev , vol.209 , Issue.1 , pp. 197-261
    • Casas, J.S.1    García-Tasende, M.S.2    Sordo, J.3
  • 88
    • 61349167114 scopus 로고    scopus 로고
    • Bonding and structure trends of thiosemicarbazone derivatives of metals--An overview
    • Lobana, T. S.; Sharma, R.; Bawa, G.; Khanna, S. Bonding and structure trends of thiosemicarbazone derivatives of metals--An overview. Coord. Chem. Rev., 2009, 253(7-8), 977-1055.
    • (2009) Coord. Chem. Rev , vol.253 , Issue.7-8 , pp. 977-1055
    • Lobana, T.S.1    Sharma, R.2    Bawa, G.3    Khanna, S.4
  • 89
    • 60549090050 scopus 로고    scopus 로고
    • In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemi-carbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: Synthesis, spectroscopic study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agents
    • Kovala-Demertzi, D.; Papageorgiou, A.; Papathanasis, L.; Alexandratos, A.; Dalezis, P.; Miller, J. R.; Demertzis, M. A. In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemi-carbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: Synthesis, spectroscopic study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agents. Eur. J. Med. Chem., 2009, 44(3), 1296-1302.
    • (2009) Eur. J. Med. Chem , vol.44 , Issue.3 , pp. 1296-1302
    • Kovala-Demertzi, D.1    Papageorgiou, A.2    Papathanasis, L.3    Alexandratos, A.4    Dalezis, P.5    Miller, J.R.6    Demertzis, M.A.7
  • 90
    • 33847765400 scopus 로고    scopus 로고
    • In vitro antitumor activity of 2-acetyl pyridine 4N-ethyl thiosemicarbazone and its platinum(II) and palladium(II) com-plexes
    • Kovala-Demertzi, D.; Boccarelli, A.; Demertzis, M. A.; Coluccia, M. In vitro antitumor activity of 2-acetyl pyridine 4N-ethyl thiosemicarbazone and its platinum(II) and palladium(II) com-plexes. Chemotherapy, 2007, 53(2), 148-152.
    • (2007) Chemotherapy , vol.53 , Issue.2 , pp. 148-152
    • Kovala-Demertzi, D.1    Boccarelli, A.2    Demertzis, M.A.3    Coluccia, M.4
  • 91
    • 33947676254 scopus 로고    scopus 로고
    • Gallium(III) and iron(III) complexes of α-N-heterocyclic thiosemicarbazones: ‰ synthesis, characterization, cytotoxicity, and interaction with ribo-nucleotide reductase
    • Kowol, C. R.; Berger, R.; Eichinger, R.; Roller, A.; Jakupec, M. A.; Schmidt, P. P.; Arion, V. B.; Keppler, B. K. Gallium(III) and iron(III) complexes of α-N-heterocyclic thiosemicarbazones:â ‰ synthesis, characterization, cytotoxicity, and interaction with ribo-nucleotide reductase. J. Med. Chem., 2007, 50(6), 1254-1265.
    • (2007) J. Med. Chem , vol.50 , Issue.6 , pp. 1254-1265
    • Kowol, C.R.1    Berger, R.2    Eichinger, R.3    Roller, A.4    Jakupec, M.A.5    Schmidt, P.P.6    Arion, V.B.7    Keppler, B.K.8
  • 92
    • 69149094267 scopus 로고    scopus 로고
    • Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation
    • Kowol, C. R.; Trondl, R.; Heffeter, P.; Arion, V. B.; Jakupec, M. A.; Roller, A.; Galanski, M.; Berger, W.; Keppler, B. K. Impact of metal coordination on cytotoxicity of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (triapine) and novel insights into terminal dimethylation. J. Med. Chem., 2009, 52(16), 5032-5043.
    • (2009) J. Med. Chem , vol.52 , Issue.16 , pp. 5032-5043
    • Kowol, C.R.1    Trondl, R.2    Heffeter, P.3    Arion, V.B.4    Jakupec, M.A.5    Roller, A.6    Galanski, M.7    Berger, W.8    Keppler, B.K.9
  • 94
    • 0344351834 scopus 로고    scopus 로고
    • Binuclear chlorobridged palladated and platinated complexes derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxicity against cisplatin resistant tumor cell lines
    • Quiroga, A. G.; Perez, J. M.; Lopez-Solera, I.; Montero, E. I.; Masaguer, J. R.; Alonso, C.; Navarro-Ranninger, C. Binuclear chlorobridged palladated and platinated complexes derived from p-isopropylbenzaldehyde thiosemicarbazone with cytotoxicity against cisplatin resistant tumor cell lines. J. Inorg. Biochem., 1998, 69(4), 275-281.
    • (1998) J. Inorg. Biochem , vol.69 , Issue.4 , pp. 275-281
    • Quiroga, A.G.1    Perez, J.M.2    Lopez-Solera, I.3    Montero, E.I.4    Masaguer, J.R.5    Alonso, C.6    Navarro-Ranninger, C.7
  • 95
    • 0344447073 scopus 로고    scopus 로고
    • Palladated and platinated com-plexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes
    • Quiroga, A. G.; Perez, J. M.; Montero, E. I.; Masaguer, J. R.; Alonso, C.; Navarro-Ranninger, C. Palladated and platinated com-plexes derived from phenylacetaldehyde thiosemicarbazone with cytotoxic activity in cis-DDP resistant tumor cells. Formation of DNA interstrand cross-links by these complexes. J. Inorg. Biochem., 1998, 70(2), 117-123.
    • (1998) J. Inorg. Biochem , vol.70 , Issue.2 , pp. 117-123
    • Quiroga, A.G.1    Perez, J.M.2    Montero, E.I.3    Masaguer, J.R.4    Alonso, C.5    Navarro-Ranninger, C.6
  • 96
    • 53349146765 scopus 로고    scopus 로고
    • Navarro-ranninger, c. isolation of an intermediate in the platination of p-nitroacetophenone 4-methylthiosemicarbazone: Potential application as an antitumor drug
    • Quiroga, G. A.; Cubo, L.; Sanz Miguel, P. J.; Moneo, V.; Carnero, A.; Navarro-ranninger, c. isolation of an intermediate in the platination of p-nitroacetophenone 4-methylthiosemicarbazone: potential application as an antitumor drug. Eur. J. Inorg. Chem., 2008, 2008, (8), 1183-1187.
    • (2008) Eur. J. Inorg. Chem , vol.2008 , Issue.8 , pp. 1183-1187
    • Quiroga, G.A.1    Cubo, L.2    Sanz Miguel,, P.J.3    Moneo, V.4    Carnero, A.5
  • 97
    • 75649131089 scopus 로고    scopus 로고
    • Anticancer platinum complexes as non-innocent compounds for catalysis in aqueous media
    • Aleman, J.; del Solar, V.; Navarro-Ranninger, C. Anticancer platinum complexes as non-innocent compounds for catalysis in aqueous media. Chem. Commun., 2010, 46(3), 454-456.
    • (2010) Chem. Commun , vol.46 , Issue.3 , pp. 454-456
    • Aleman, J.1    del Solar, V.2    Navarro-Ranninger, C.3
  • 98
    • 34250824768 scopus 로고    scopus 로고
    • Catalytic carbophilic activation: Catalysis by platinum and gold pi acids
    • Furstner, A.; Davies, P. W., Catalytic carbophilic activation: Catalysis by platinum and gold pi acids. Angew. Chem. Int. Edit., 2007, 46(19), 3410-3449.
    • (2007) Angew. Chem. Int. Edit , vol.46 , Issue.19 , pp. 3410-3449
    • Furstner, A.1    Davies, P.W.2
  • 99
    • 33845374097 scopus 로고
    • Palladium-catalyzed regioselective and stereoselective cyclized coupling of lithium alkynoates with allyl halides
    • Yanagihara, N.; Lambert, C.; Iritani, K.; Utimoto, K.; Nozaki, H. Palladium-catalyzed regioselective and stereoselective cyclized coupling of lithium alkynoates with allyl halides. J. Am. Chem. Soc., 1986, 108(10), 2753-2754.
    • (1986) J. Am. Chem. Soc , vol.108 , Issue.10 , pp. 2753-2754
    • Yanagihara, N.1    Lambert, C.2    Iritani, K.3    Utimoto, K.4    Nozaki, H.5
  • 100
    • 33644949668 scopus 로고    scopus 로고
    • Room temperature Au(I)-catalyzed exo-selective cycloisomerization of acetylenic acids: An entry to functionalized gamma-lactones
    • Genin, E.; Toullec, P. Y.; Antoniotti, S.; Brancour, C.; Genet, J. P.; Michelet, W. Room temperature Au(I)-catalyzed exo-selective cycloisomerization of acetylenic acids: An entry to functionalized gamma-lactones. J. Am. Chem. Soc., 2006, 128(10), 3112-3113.
    • (2006) J. Am. Chem. Soc , vol.128 , Issue.10 , pp. 3112-3113
    • Genin, E.1    Toullec, P.Y.2    Antoniotti, S.3    Brancour, C.4    Genet, J.P.5    Michelet, W.6
  • 101
    • 0344012932 scopus 로고    scopus 로고
    • Hydrolysis triggers oxidation of a trans diamine platinum(II) anti-cancer complex
    • Pizarro, A. M.; Munk, V. P.; Navarro-Ranninger, C.; Sadler, P. J. Hydrolysis triggers oxidation of a trans diamine platinum(II) anti-cancer complex. Angew, Chem, Int, Edit, 2003, 42(43), 5339-5342.
    • (2003) Angew, Chem, Int, Edit , vol.42 , Issue.43 , pp. 5339-5342
    • Pizarro, A.M.1    Munk, V.P.2    Navarro-Ranninger, C.3    Sadler, P.J.4
  • 102
    • 54149085919 scopus 로고    scopus 로고
    • Platinum(iv) complexes of 3-and 4-picolinic acids containing ammine or isopropylamine ligands -synthesis, characterization, x-ray structures, and evaluation of their cytotoxic activity against cancer cell lines
    • Macazaga, M. J.; Rodriguez, J.; Quiroga, A. G.; Peregina, S.; Carnero, A.; Navarro-Ranninger, C.; Medina, R. M. Platinum(iv) complexes of 3-and 4-picolinic acids containing ammine or isopropylamine ligands -synthesis, characterization, x-ray structures, and evaluation of their cytotoxic activity against cancer cell lines. Eur. J. Inorg. Chem., 2008, (30), 4762-4769.
    • (2008) Eur. J. Inorg. Chem , Issue.30 , pp. 4762-4769
    • Macazaga, M.J.1    Rodriguez, J.2    Quiroga, A.G.3    Peregina, S.4    Carnero, A.5    Navarro-Ranninger, C.6    Medina, R.M.7


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