Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile

Journal of Medicinal Chemistry

Volumn 48, Issue 18, 2005, Pages 5651-5654

  Ma, Erin S F ^a   Bates, W Douglas ^a   Edmunds, Armistead ^a   Kelland, Lloyd R ^b   Fojo, Tito ^c   Farrell, Nicholas ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; AMINE; CARBOPLATIN; CARBOXYLIC ACID; CHLORIDE; CISPLATIN; CYTOTOXIC AGENT; LIGAND; NITROGEN DIOXIDE; OXALIPLATIN; PLATINUM DERIVATIVE; TRANSPLATIN; WATER;

ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; CRYSTAL STRUCTURE; DRUG ACTIVATION; DRUG DNA BINDING; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; GEOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; SOLUBILIZATION; STEREOSPECIFICITY; STRUCTURE ANALYSIS; TRANS ISOMER; X RAY CRYSTALLOGRAPHY;

ACETIC ACIDS; AMINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHELATING AGENTS; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROLYSIS; ORGANOPLATINUM COMPOUNDS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; WATER;

EID: 24744432080     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050539d     Document Type: Article

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