Basis for recognition of cisplatin-modified DNA by high-mobility-group proteins

Nature

Volumn 399, Issue 6737, 1999, Pages 708-712

  Ohndorf, Uta Maria ^a   Rould, Mark A ^b,c   He, Qing ^a   Pabo, Carl O ^b   Lippard, Stephen J ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CISPLATIN; DNA; DOUBLE STRANDED DNA; HIGH MOBILITY GROUP PROTEIN; PHENYLALANINE;

AMINO ACID SUBSTITUTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CROSS LINKING; DNA ADDUCT; DNA DAMAGE; DNA MODIFICATION; DNA STRUCTURE; DRUG MECHANISM; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; ANTINEOPLASTIC AGENTS; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DNA ADDUCTS; DNA FOOTPRINTING; HIGH MOBILITY GROUP PROTEINS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION;

EID: 0033578010     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/21460     Document Type: Article

References (30)

1. Lepre, C. A. & Lippard, S. J. in Nucleic Acids and Molecular Biology (eds Eckstein, F. & Lilley, D. M. J.) 9-58 (Springer, Heidelberg, 1990).
2. Zlatanova, J., Yaneva, J. & Leuba, S. H. Proteins that specifically recognize cisplatin-damaged DNA: a clue to anticancer activity of cisplatin. FASEB J. 12, 791-799 (1998).
3. Zamble, D. B. & Lippard, S. J. Cisplatin and DNA repair in cancer chemotherapy. Trends Biochem. Sci. 20, 435-439 (1995).
4. Zhai, X., Beckmann, H., Jantzen, H.-M. & Essigmann, J. M. Cisplatin-DNA adductsinhibit ribosomal RNA synthesis by hijacking the transcription factor human upstream binding factor. Biochemistry 37, 16307-16315 (1998).
5. Bustin, M. & Reeves, R. in Progr. Nucleic Acid Res. Mol. Biol. (eds Cohn, W. E. & Moldave, K.) 35-100 (Academic, San Diego, 1996).
6. Read, C. M. et al. in Nucleic Acids and Molecular Biology (eds Eckstein, F. & Lilley, D. M. J.) 222-250 (Springer, Berlin, 1995).
7. Dunham, S. U. & Lippard, S. J. DNA sequence context and protein composition modulate HMG-domain protein recognition of cisplatin-modified DNA. Biochemistry 36, 11428-11436 (1997).
8. Chow, C. S., Barnes, C. M. & Lippard, S. J. A single HMG domain in high-mobility group 1 protein binds to DNAs as small as 20 base pairs containing the major cisplatin adduct. Biochemistry 34, 2956-2964 (1995).
9. Werner, M. H., Huth, J. R., Gronenborn, A. M. & Clore, G. M. Molecular basis of human 46X,Y sex reversal revealed from the three-dimensional solution structure of the human SRV-DNA complex. Cell 81, 705-714 (1995).
10. Love, J. J. et al. Structural basis for DNA bending by the architectural transcription factor LEF-1. Nature 376, 791-795 (1995).
11. Lavery, R. & Sklenar, H. The definition of generalized helicoidal parameters and of axis curvature for irregular nucleic acids. J. Biomol. Struct. Dyn. 6, 63-91 (1988).
12. Dunham, S. U., Dunham, S. U., Turner, C. J. & Lippard, S. J. Solution structure of a DNA duplex containing a nitroxide spin-labeled platinum d(GpG) intrastrand cross-link refined with NMR-derived long-range electron-proton distance restraints. J. Am. Chem. Soc. 120, 5395-5406 (1998).
13. Gelasco, A. & Lippard, S. J. NMR solution structure of a DNA dodecamer duplex containing a cis-diammineplatinum(II) d(GpG) intrastrand cross-link, the major adduct of the anticancer drug cisplatin. Biochemistry 37, 9230-9239 (1998).
14. Takahara, P. M., Frederick, C. A. & Lippard, S. J. Crystal structure of the anticancer drug cisplatin bound to duplex DNA. J. Am. Chem. Soc. 118, 12309-12321 (1996).
15. Hardman, C. H. et al. Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three- and four-dimensional NMR spectroscopy. Biochemistry 34, 16596-16607 (1995).
16. 15N NMR spectroscopy. Biochemistry 34, 16608-16617 (1995).
17. 2{d(pGpG)}], the principal adduct formed by cis-diamminedichloroplatinum(II) with DNA. J. Am. Chem. Soc. 110, 7368-7381 (1988).
18. Dickerson, R. E. DNA bending: the prevalence of kinkiness and the virtues of normality. Nucleic Acids Res. 26, 1906-1926 (1998).
19. Yang, D., van Boom, S. S. G. E., Reedijk, J., van Boom, J. H. & Wang, A. H.-J. Structure and isomerization of an intrastrand cisplatin-corsslinked octamer DNA duplex by NMR analysis. Biochemistry 34, 12912-12920 (1995).
20. Teo, S.-H., Grasser, K. D. & Thomas, J. O. Differences in the DNA-binding properties of the HMG-box domains of HMG1 and the sex-determining factor SRY. Eur. J. Biochem. 230, 943-950 (1995).
21. Weiss, M. A., Ukiyama, E. & King, C.-Y. The SRY cantilever motif discriminates between sequence- and structure-specific DNA recognition: alanine mutagenesis of an HMG box. J. Biomol. Struct. Dyn. 15, 177-184 (1997).
22. Berners-Price, S. J. et al. Structural transitions of a GG-platinated DNA duplex induced by pH, temperature and box A of high-mobility group protein 1. Eur. J. Biochem. 243, 782-791 (1997).
23. Balaeff, A., Churchill, M. E. A. & Schulten, K. Structure prediction of a complex between the chromosomal protein HMG-D and DNA. Proteins 30, 113-135 (1998).
24. Yoshioka, K. et al. Differences in DNA recognition and conformational change activity between boxes A and B in HMG2 protein. Biochemistry 38, 589-595 (1999).
25. Falciola, L., Murchie, A. I. H., Lilley, D. M. J. & Bianchi, M. E. Mutational analysis of the DNA binding domain A of chromosomal protein HMG1. Nucleic Acids Res. 22, 285-292 (1994).
26. Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276, 307-326 (1997).
27. Rould, M. A. Screening for heavy-atom derivatives and obtaining accurate isomorphous differences. Methods Enzymol. 276, 461-472 (1997).
28. Collaborative Computational Project number 4. The CCP4 Suite: programs for protein crystallography. Acta Crystallogr. D 50, 760-763 (1994).
29. Brünger, A. T. XPLOR Version 3.1, A system for X-ray crystallography and NMR (Yale University Press, New Haven, Connecticut, 1992).
30. Baxevanis, A. D. & Landsman, D. The HMG-1 box protein family: classification and functional relationships. Nucleic Acids Res. 25, 1604-1613 (1995).