In vitro and in vivo antitumor activity of platinum(II) complexes with thiosemicarbazones derived from 2-formyl and 2-acetyl pyridine and containing ring incorporated at N(4)-position: Synthesis, spectroscopic study and crystal structure of platinum(II) complexes with thiosemicarbazones, potential anticancer agents

European Journal of Medicinal Chemistry

Volumn 44, Issue 3, 2009, Pages 1296-1302

  Kovala Demertzi, Dimitra ^a   Papageorgiou, Athanassios ^b   Papathanasis, Leuteris ^a   Alexandratos, Alexandros ^a   Dalezis, Panagiotis ^b   Miller, John R ^c   Demertzis, Mavroudis A ^a  

^a UNIVERSITY OF IOANNINA   (Greece)

^b THEAGENIO CANCER HOSPITAL   (Greece)

^c UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Biological evaluation; Crystal structure; In vitro and in vivo antitumor activity; Platinum(II) complexes; Thiosemicarbazonato complexes

Indexed keywords

ANTINEOPLASTIC AGENT; N' (PYRIDIN 2 YLMETHYLENE)AZEPANE 1 CARBOTHIOHYDRAZIDE; N' [1 (PYRIDIN 2 YL)ETHYLIDENE]AZEPANE 1 CARBOTHIOHYDRAZIDE; PLATINUM COMPLEX; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; BREAST CANCER; CANCER CELL CULTURE; CHEMICAL REACTION; COMPLEX FORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROBLAST; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LEUKEMIA; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; PLATINUM COMPOUNDS; SPECTRUM ANALYSIS; THIOSEMICARBAZONES;

EID: 60549090050     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.08.007     Document Type: Article

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