9 solution behaviour and biomolecular interactions of two cytotoxic transplatinum(ii) complexes bearing aliphatic amine ligands

Chemistry - A European Journal

Volumn 15, Issue 36, 2009, Pages 9139-9146

  Cubo, Leticia ^a   Casini, Angela ^b   Gabbiani, Chiara ^c   Mastrobuoni, Guido ^c   Messori, Luigi ^c   Jiménez Barbero, Jesús ^d   Navarro Ranninger, Carmen ^a   Quiroga, Adoración G ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b EPFL   (Switzerland)

^c UNIVERSITY OF FLORENCE   (Italy)

^d CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Cytochromes, cytotoxicity, hydrolysis, platinum, proteins

Indexed keywords

ADDUCT FORMATION; ALIPHATIC AMINES; ANTIPROLIFERATIVE PROPERTIES; BIOMOLECULAR INTERACTIONS; CALF THYMUS DNA; CIS-PLATIN; CYTOCHROME C; CYTOCHROMES, CYTOTOXICITY, HYDROLYSIS, PLATINUM, PROTEINS; CYTOTOXIC; DIMETHYLAMINES; ELECTROSPRAY MASS SPECTROMETRY; EXPERIMENTAL CONDITIONS; HSQC NMR; ICP-OES; IN-VITRO; INDUCTIVELY COUPLED PLASMA-OPTICAL EMISSION SPECTROSCOPY; ISOPROPYLAMINE; MECHANISM OF ACTION; METALATIONS; PLATINUM COMPLEXES; PLATINUM COORDINATION; SERUM PROTEINS; SIDE CHAINS; TRANS-PLATINUM COMPLEXES;

AMINES; BEARINGS (STRUCTURAL); BINDING ENERGY; BINDING SITES; DNA; EMISSION SPECTROSCOPY; GENES; HYDROLYSIS; INDUCTIVELY COUPLED PLASMA; LIGANDS; MASS SPECTROMETERS; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACIDS; OPTICAL EMISSION SPECTROSCOPY; ORGANIC COMPOUNDS; PLATINUM; PROTEINS;

PLATINUM COMPOUNDS;

AMINE; ANTINEOPLASTIC AGENT; CISPLATIN; DNA; LIGAND; PLATINUM DERIVATIVE; TRANSPLATIN; WATER;

ARTICLE; CHEMISTRY; HUMAN; MASS SPECTROMETRY; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS; TUMOR CELL LINE;

AMINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DNA; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PLATINUM COMPOUNDS; WATER;

EID: 70349094106     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200901090     Document Type: Article

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