Studies on the mechanism of hypoxic selectivity in copper bis(thiosemicarbazone) radiopharmaceuticals

Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2002, Pages 1420-1431

  Maurer, Richard I ^a   Blower, Philip J ^b   Dilworth, Jonathan R ^c   Reynolds, Christopher A ^a   Zheng, Yifan ^a,c   Mullen, Gregory E D ^c  

^a UNIVERSITY OF ESSEX   (United Kingdom)

^b UNIVERSITY OF KENT   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACID; COPPER BIS(THIOSEMICARBAZONE); COPPER COMPLEX; COPPER DIACETYLBIS(N 4 METHYLTHIOSEMICARBAZONE); METAL; RADIOPHARMACEUTICAL AGENT; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG;

ACIDITY; ALKYLATION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MODEL; CORRELATION ANALYSIS; DISSOCIATION; DRUG MECHANISM; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTROCHEMICAL ANALYSIS; HYPOXIA; LIGAND BINDING; OXIDATION; OXIDATION REDUCTION POTENTIAL; REDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THERMODYNAMICS; ULTRAVIOLET SPECTROSCOPY;

ALGORITHMS; ANOXIA; COPPER; ELECTRONS; FREE RADICAL SCAVENGERS; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, CHEMICAL; MODELS, MOLECULAR; MODELS, THEORETICAL; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; RADIOPHARMACEUTICALS; SOFTWARE; SPECTROPHOTOMETRY; STRUCTURE-ACTIVITY RELATIONSHIP; THIOSEMICARBAZONES; ULTRAVIOLET RAYS;

EID: 0037187390     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0104217     Document Type: Article

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