TSH compensates thyroid-specific IGF-I receptor knockout and causes papillary thyroid hyperplasia

Molecular Endocrinology

Volumn 25, Issue 11, 2011, Pages 1867-1879

  Müller, Kathrin ^a   Führer, Dagmar ^a   Mittag, Jens ^c   Klöting, Nora ^a   Blüher, Matthias ^a   Weiss, Roy E ^d   Many, Marie Christine ^e   Schmid, Kurt Werner ^f   Krohn, Knut ^a,b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b UNIVERSITY HOSPITAL LEIPZIG   (Germany)

^c KAROLINSKA INSTITUTE   (Sweden)

^d UNIVERSITY OF CHICAGO   (United States)

^e UNIVERSITY OF LOUVAIN MEDICAL SCHOOL   (Belgium)

^f UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; SODIUM IODIDE; SOMATOMEDIN 1 RECEPTOR; SOMATOMEDIN 2 RECEPTOR; SOMATOMEDIN RECEPTOR; THYROID PEROXIDASE; THYROTROPIN; THYROTROPIN RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; FEMALE; GENE LOCUS; GENE MUTATION; GENOTYPE; HETEROZYGOSITY; HISTOPATHOLOGY; HOMOZYGOSITY; HYPOTHALAMUS HYPOPHYSIS THYROID SYSTEM; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; THYROID FOLLICLE; THYROID HYPERPLASIA;

ANIMALS; CYCLIC AMP; FEMALE; GENOTYPE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; MICE; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTOR, IGF TYPE 1; THYROID DYSGENESIS; THYROID GLAND; THYROTROPIN;

MUS;

EID: 80054967628     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.2011-0065     Document Type: Article

References (52)

1. Dumont JE, Maenhaut C, Pirson I, Baptist M, Roger PP 1991 Growth factors controlling the thyroid gland. Baillieres Clin Endo-crinol Metab 5:727-754
2. Eggo MC, Bachrach LK, Burrow GN 1990 Interaction of TSH, insulin and insulin-like growth factors in regulating thyroid growth and function. Growth Factors 2:99-109
3. Kimura T, Van Keymeulen A, Golstein J, Fusco A, Dumont JE, Roger PP 2001 Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. Endocr Rev 22:631-656
4. Cissewski K, Wolf M, Moses AC 1992 Characterization of insulinlike growth factor receptors in human thyroid tissue. Receptor 2:145-153
5. Clément S, Refetoff S, Robaye B, Dumont JE, Schurmans S 2001 Low TSH requirement and goiter in transgenic mice overexpressing IGF-I and IGF-Ir receptor in the thyroid gland. Endocrinology 142: 5131-5139
6. Völzke H, Friedrich N, Schipf S, Haring R, Lüdemann J, Nauck M, Dörr M, Brabant G, Wallaschofski H 2007 Association between serum insulin-like growth factor-I levels and thyroid disorders in a population-based study. J Clin Endocrinol Metab 92:4039-4045
7. Vella V, Sciacca L, Pandini G, Mineo R, Squatrito S, Vigneri R, Belfiore A 2001 The IGF system in thyroid cancer: new concepts. Mol Pathol 54:121-124
8. Ciampolillo A, De Tullio C, Perlino E, Maiorano E 2007 The IGF-I axis in thyroid carcinoma. Curr Pharm Des 13:729-735
9. Bruni P, Boccia A, Baldassarre G, Trapasso F, Santoro M, Chiap-petta G, Fusco A, Viglietto G 2000 PTEN expression is reduced in a subset of sporadic thyroid carcinomas: evidence that PTEN-growth suppressing activity in thyroid cancer cells mediated by p27kip1. Oncogene 19:3146-3155
10. Wang Y, Hou P, Yu H, Wang W, Ji M, Zhao S, Yan S, Sun X, Liu D, Shi B, Zhu G, Condouris S, Xing M 2007 High prevalence and mutual exclusivity of genetic alterations in the phosphatidylinosi-tol-3-kinase/akt pathway in thyroid tumors. J Clin Endocrinol Metab 92:2387-2390
11. Dupont J, Holzenberger M 2003 Biology of insulin-like growth factors in development. Birth Defects Res C Embryo Today 69: 257-271
12. Butler AA, Yakar S, Gewolb IH, Karas M, Okubo Y, le Roith D 1998 Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology. Comp Biochem Physiol B Biochem Mol Biol 121:19-26
13. Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A 1993 Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 75:59-72
14. Holzenberger M, Dupont J, Ducos B, Leneuve P, Géloën A, Even PC, Cervera P, Le Bouc Y 2003 IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421:182-187
15. Kappeler L, De Magalhaes Filho C, Dupont J, Leneuve P, Cervera P, Périn L, Loudes C, Blaise A, Klein R, Epelbaum J, Le Bouc Y, Holzenberger M 2008 Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol 6:e254
16. Baker J, Liu JP, Robertson EJ, Efstratiadis A 1993 Role of insulinlike growth factors in embryonic and postnatal growth. Cell 75: 73-82
17. Zhang M, Xuan S, Bouxsein ML, von Stechow D, Akeno N, Faugere MC, Malluche H, Zhao G, Rosen CJ, Efstratiadis A, Cle-mens TL 2002 Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization. J Biol Chem 277:44005-44012
18. He J, Rosen CJ, Adams DJ, Kream BE 2006 Postnatal growth and bone mass in mice with IGF-I haploinsufficiency. Bone 38:826-835
19. Fernandez AM, Dupont J, Farrar RP, Lee S, Stannard B, Le Roith D 2002 Muscle-specific inactivation of the IGF-I receptor induces compensatory hyperplasia in skeletal muscle. J Clin Invest 109: 347-355
20. Coleman ME, DeMayo F, Yin KC, Lee HM, Geske R, Montgomery C, Schwartz RJ 1995 Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem 270:12109-12116
21. Kulkarni RN, Holzenberger M, Shih DQ, Ozcan U, Stoffel M, Magnuson MA, Kahn CR 2002 β-Cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass. Nat Genet 31:111-115
22. Kloting N, Koch L, Wunderlich T, Kern M, Ruschke K, Krone W, Brüning JC, Blüher M 2008 Autocrine IGF-1 action in adipocytes controls systemic IGF-1 concentrations and growth. Diabetes 57: 2074-2082
23. Eszlinger M, Krohn K, Beck M, Kipling D, Forbes-Robertson S, Lauter J, Toenjes A, Wynford-Thomas D, Paschke R 2006 Comparison of differential gene expression of hot and cold thyroid nodules with primary epithelial cell culture models by investigation of co-regulated gene sets. Biochim Biophys Acta 1763:263-271
24. Kosir R, Acimovic J, Golicnik M, Perse M, Majdic G, Fink M, Rozman D 2010 Determination of reference genes for circadian studies in different tissues and mouse strains. BMC Mol Biol 11: 60.:60
25. Hoperia V, Larin A, Jensen K, Bauer A, Vasko V 2010 Thyroid fine needle aspiration biopsies in children: study of cytological-histological correlation and immunostaining with thyroid peroxidase monoclonal antibodies. Int J Pediatr Endocrinol 2010:690108
26. Mazumder S, Plesca D, Almasan A 2008 Caspase-3 activation is a critical determinant of genotoxic stress-induced apoptosis. Methods Mol Biol 414:13-21
27. Bauer M, Heinz A, Whybrow PC 2002 Thyroid hormones, serotonin and mood: of synergy and significance in the adult brain. Mol Psychiatry 7:140-156
28. Samuels MH, Schuff KG, Carlson NE, Carello P, Janowsky JS 2008 Health status, mood, and cognition in experimentally induced subclinical thyrotoxicosis. J Clin Endocrinol Metab 93:1730-1736
29. Karl T, Pabst R, von Horsten S 2003 Behavioral phenotyping of mice in pharmacological and toxicological research. Exp Toxicol Pathol 55:69-83
30. Kim CS, Zhu X 2009 Lessons from mouse models of thyroid cancer. Thyroid 19:1317-1331
31. Zeiger MA, Saji M, Gusev Y, Westra WH, Takiyama Y, Dooley WC, Kohn LD, Levine MA 1997 Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice. Endocrinology 138:3133-3140
32. Fiore E, Rago T, Provenzale MA, Scutari M, Ugolini C, Basolo F, Di Coscio G, Berti P, Grasso L, Elisei R, Pinchera A, Vitti P 2009 Lower levels of TSH are associated with a lower risk of papillary thyroid cancer in patients with thyroid nodular disease: thyroid autonomy may play a protective role. Endocr Relat Cancer 16: 1251-1260
33. Nikiforov YE 2008 Thyroid carcinoma: molecular pathways and therapeutic targets. Mod Pathol 21(Suppl 2):S37-S43
34. Garcia-Jimenez C, Santisteban P 2007 TSH signalling and cancer. Arq Bras Endocrinol Metabol 51:654-671
35. Paschke R, Ludgate M 1997 The thyrotropin receptor in thyroid diseases. N Engl J Med 337:1675-1681
36. Boelaert K 2009 The association between serum TSH concentration and thyroid cancer. Endocr Relat Cancer 16:1065-1072
37. Arufe MC, Lu M, Lin RY 2009 Differentiation of murine embryonic stem cells to thyrocytes requires insulin and insulin-like growth factor-1. Biochem Biophys Res Commun 381:264-270
38. Larsen PR 1982 Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med 306: 23-32
39. Persani L 1998 Hypothalamic thyrotropin-releasing hormone and thyrotropin biological activity. Thyroid 8:941-946
40. Zhang H, Fagan DH, Zeng X, Freeman KT, Sachdev D, Yee D 2010 Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene 29:2517-2527
41. Ledent C, Coppee F, Dumont JE, Vassart G, Parmentier M 1996 Transgenic models for proliferative and hyperfunctional thyroid diseases. Exp Clin Endocrinol Diabetes 104(Suppl 3):43-46
42. Kero J, Ahmed K, Wettschureck N, Tunaru S, Wintermantel T, Greiner E, Schütz G, Offermanns S 2007 Thyrocyte-specific Gq/ G11 deficiency impairs thyroid function and prevents goiter development. J Clin Invest 117:2399-2407
43. Moeller LC, Alonso M, Liao X, Broach V, Dumitrescu A, Van Sande J, Montanelli L, Skjei S, Goodwin C, Grasberger H, Refetoff S, Weiss RE 2007 Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats. Endocrinology 148:4727-4733
44. Weiss RE, Gehin M, Xu J, Sadow PM, O'Malley BW, Chambon P, Refetoff S 2002 Thyroid functionin mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactiva-tors: evidence for haploinsufficiency. Endocrinology 143:1554-1557
45. Flamant F, Poguet AL, Plateroti M, Chassande O, Gauthier K, Streichenberger N, Mansouri A, Samarut J 2002 Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRa gene. Mol Endocrinol 16:24-32
46. Mueller S, Gozu HI, Bircan R, Jaeschke H, Eszlinger M, Luebling-hoff J, Krohn K, Paschke R 2009 Cases of borderline in vitro constitutive thyrotropin receptor activity: how to decide whether a thyrotropin receptor mutation is constitutively active or not? Thyroid 19:765-773
47. Mueller S, Kleinau G, Jaeschke H, Paschke R, Krause G 2008 Extended hormone binding site of the human thyroid stimulating hormone receptor: distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation. J Biol Chem 283:18048-18055
48. Mittag J, Davis B, Vujovic M, Arner A, Vennstrom B 2010 Adaptations of the autonomous nervous system controlling heart rate are impaired by a mutant thyroid hormone receptor-a1. Endocrinology 151:2388-2395
49. Schafer MK, Day R 1995 In situ hybridization techniques to study processing enzyme expression at the cellular level. Methods Neu-rosci 23:16-44
50. Ruf J, Toubert ME, Czarnocka B, Durand-Gorde JM, Ferrand M, Carayon P 1989 Relationship between immunological structure and biochemical properties of human thyroid peroxidase. Endocrinology 125:1211-1218
51. Krohn K, Wohlgemuth S, Gerber H, Paschke R 2000 Hot microscopic areas of iodine-deficient euthyroid goitres contain constitutively activating TSH receptor mutations. J Pathol 192:37-42
52. Nikiforov YE 2011 Molecular analysis of thyroid tumors. Mod Pathol 24(Suppl 2):S34-S43