Extended hormone binding site of the human thyroid stimulating hormone receptor: Distinctive acidic residues in the hinge region are involved in bovine thyroid stimulating hormone binding and receptor activation

Journal of Biological Chemistry

Volumn 283, Issue 26, 2008, Pages 18048-18055

  Mueller, Sandra ^a   Kleinau, Gunnar ^b   Jaeschke, Holger ^c   Paschke, Ralf ^a   Krause, Gerd ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINATION; AMINES; AMINO ACIDS; BACTERIOPHAGES; BINDING ENERGY; ENDOCRINOLOGY; ENZYME ACTIVITY; GLYCOPROTEINS; HORMONES; ORGANIC ACIDS; SERPENTINE; SIGNAL TRANSDUCTION; SILICATE MINERALS;

ACIDIC RESIDUES; ALANINE MUTANTS; ASSEMBLED MODELS; BINDING MODES; CHARGED AMINO ACIDS; CHARGED RESIDUES; DO-MAINS; EXTRACELLULAR; EXTRACELLULAR DOMAINS; GLYCOPROTEIN HORMONE RECEPTORS; HORMONE BINDINGS; HUMAN THYROIDS; INTERMEDIATE CONNECTORS; NEGATIVE CHARGES; POSITIVELY CHARGED; RECEPTOR ACTIVATIONS; SIDE CHAINS; STIMULATING HORMONES;

BINDING SITES;

ASPARTIC ACID; GLUTAMIC ACID; LEUCINE; SERPENTINE; THYROTROPIN; THYROTROPIN RECEPTOR; ALANINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; COW; HINGE REGION; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HUMAN; HUMAN CELL; LEUCINE RICH REPEAT DOMAIN; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS; THYROTROPIN RELEASE; ANIMAL; BIOLOGICAL MODEL; CATTLE; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; IC 50; METABOLISM; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION;

BOVINAE;

ALANINE; ANIMALS; BINDING SITES; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, THYROTROPIN; SIGNAL TRANSDUCTION; THYROTROPIN;

EID: 49649125175     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800449200     Document Type: Article

References (42)

1. Simoni, M., Gromoll, J., and Nieschlag, E. (1997) Endocr. Rev. 18, 739-773
2. Szkudlinski, M. W., Fremont, V., Ronin, C., and Weintraub, B. D. (2002) Physiol. Rev. 82, 473-502
3. Themmen, A. P. N., and Huhtaniemi, I. T. (2000) Endocr. Rev. 21, 551-583
4. Braun, T., Schofield, P. R., and Sprengel, R. (1991) EMBO J. 10, 1885-1890
5. Smits, G., Campillo, M., Govaerts, C., Janssens, V., Richter, C., Vassart, G., Pardo, L., and Costagliola, S. (2003) EMBO J. 22, 2692-2703
6. Kleinau, G., Brehm, M., Wiedemann, U., Labudde, D., Leser, U., and Krause, G. (2007) Mol. Endocrinol. 21, 574-580
7. Fan, Q. R., and Hendrickson, W. A. (2005) Nature 433, 269-277
8. Sanders, J., Chirgadze, D. Y., Sanders, P., Baker, S., Sullivan, A., Bhardwaja, A., Bolton, J., Reeve, M., Nakatake, N., Evans, M., Richards, T., Powell, M., Miguel, R. N., Blundell, T. L., Furmaniak, J., and Smith, B. R. (2007) Thyroid 17, 395-410
9. Costagliola, S., Panneels, V., Bonomi, M., Koch, J., Many, M. C., Smits, G., and Vassart, G. (2002) EMBO J. 21, 504-513
10. Jeffreys, J., Depraetere, H., Sanders, J., Oda, Y., Evans, M., Kiddie, A., Richards, T., Furmaniak, J., and Rees, S. B. (2002) Thyroid 12, 1051-1061
11. Kosugi, S., Ban, T., Akamizu, T., and Kohn, L. D. (1991) J. Biol. Chem. 266, 19413-19418
12. Shepherd, P. S., Da Costa, C. R., Cridland, J. C., Gilmore, K. S., and Johnstone, A. P. (1999) Mol. Cell. Endocrinol. 149, 197-206
13. Morris, J. C., Bergert, E. R., and McCormick, D. J. (1993) J. Biol. Chem. 268, 10900-10905
14. Dallas, J. S., Desai, R. K., Cunningham, S. J., Morris, J. C., Seetharamaiah, G. S., Wagle, N., Goldblum, R. M., and Prabhakar, B. S. (1994) Mol. Endocrinol. 134, 1437-1445
15. Johnstone, A. P., Cridland, J. C., Da Costa, C. R., Nussey, S. S., and Shepherd, P. S. (2003) Clin. Endocrinol. (Oxf) 59, 437-441
16. Nagayama, Y., Wadsworth, H. L., Chazenbalk, G. D., Russo, D., Seto, P., and Rapoport, B. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 902-905
17. Bonomi, M., Busnelli, M., Persani, L., Vassart, G., and Costagliola, S. (2006) Mol. Endocrinol. 20, 3351-3363
18. Szkudlinski, M. W., Teh, N. G., Grossmann, M., Tropea, J. E., and Weintraub, B. D. (1996) Nat. Biotechnol. 14, 1257-1263
19. Szkudlinski, M. W. (2004) Cancer Treat. Res. 122, 345-356
20. Chazenbalk, G. D., Tanaka, K., Nagayama, Y., Kakinuma, A., Jaume, J. C., McLachlan, S. M., and Rapoport, B. (1997) Mol. Endocrinol. 138, 2893-2899
21. Wadsworth, H. L., Chazenbalk, G. D., Nagayama, Y., Russo, D., and Rapoport, B. (1990) Science 249, 1423-1425
22. Libert, F., Lefort, A., Gerard, C., Parmentier, M., Perret, J., Ludgate, M., Dumont, J. E., and Vassart, G. (1989) Biochem. Biophys. Res. Commun. 165, 1250-1255
23. Wonerow, P., Schoneberg, T., Schultz, G., Gudermann, T., and Paschke, R. (1998) J. Biol. Chem. 273, 7900-7905
24. Kleinau, G., Jaschke, H., Neumann, S., Lattig, J., Paschke, R., and Krause, G. (2004) J. Biol. Chem. 279, 51590-51600
25. Swillens, S. (1995) Mol. Pharmacol. 47, 1197-1203
26. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le, T. I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Science 289, 739-745
27. Salom, D., Lodowski, D. T., Stenkamp, R. E., Le, T. I., Golczak, M., Jastrzebska, B., Harris, T., Ballesteros, J. A., and Palczewski, K. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 16123-16128
28. Standfuss, J., Xie, G., Edwards, P. C., Burghammer, M., Oprian, D. D., and Schertler, G. F. (2007) J. Mol. Biol. 372, 1179-1188
29. Rasmussen, S. G., Choi, H. J., Rosenbaum, D. M., Kobilka, T. S., Thian, F. S., Edwards, P. C., Burghammer, M., Ratnala, V. R., Sanishvili, R., Fischetti, R. F., Schertler, G. F., Weis, W. I., and Kobilka, B. K. (2007) Nature 450, 383-387
30. Cherezov, V., Rosenbaum, D. M., Hanson, M. A., Rasmussen, S. G., Thian, F. S., Kobilka, T. S., Choi, H. J., Kuhn, P., Weis, W. I., Kobilka, B. K., and Stevens, R. C. (2007) Science 318, 1258-1265
31. Dragic, T., Trkola, A., Lin, S. W., Nagashima, K. A., Kajumo, F., Zhao, L., Olson, W. C., Wu, L., Mackay, C. R., Allaway, G. P., Sakmar, T. P., Moore, J. P., and Maddon, P. J. (1998) J. Virol. 72, 279-285
32. Aarons, E. J., Beddows, S., Willingham, T., Wu, L., and Koup, R. A. (2001) Virology 287, 382-390
33. Kleinau, G., Claus, M., Jaeschke, H., Mueller, S., Neumann, S., Paschke, R., and Krause, G. (2007) J. Biol. Chem. 282, 518-525
34. Case, D. A., Pearlman, D. A., Caldwell, J. W. Cheatham, T. E., III, Wang, J., Ross, W. S., Simmerling, C. L., Darden, T. A., Merz, K. M., Stanton, R. V., Cheng, A. L., Vincent, J. J., Crowley, M., Tsui, V., Gohlke, H., Radmer, R. J., Duan, Y., Pitera, J., Massova, I., Seibel, G. L., Singh, U. C., Weiner, P. K., and Kollman, P. A. (2002) AMBER 7, University of California, San Francisco
35. Laskowski, R. A., Moss, D. S., and Thornton, J. M. (1993) J. Mol. Biol. 231, 1049-1067
36. Russo, D., Chazenbalk, G. D., Nagayama, Y., Wadsworth, H. L., and Rapoport, B. (1991) Mol. Endocrinol. 5, 29-33
37. Gromoll, J., Schulz, A., Borta, H., Gudermann, T., Teerds, K. J., Greschniok, A., Nieschlag, E., and Seif, F. J. (2002) Eur. J. Endocrinol. 147, 597-608
38. Muller, T., Gromoll, J., and Simoni, M. (2003) J. Clin. Endocrinol. Metab 88, 2242-2249
39. Bundgaard, J. R., Vuust, J., and Rehfeld, J. F. (1997) J. Biol. Chem. 272, 21700-21705
40. Huang, C. C., Lam, S. N., Acharya, P., Tang, M., Xiang, S. H., Hussan, S. S., Stanfield, R. L., Robinson, J., Sodroski, J., Wilson, I. A., Wyatt, R., Bewley, C. A., and Kwong, P. D. (2007) Science 317, 1930-1934
41. Grossmann, M., Leitolf, H., Weintraub, B. D., and Szkudlinski, M. W. (1998) Nat. Biotechnol. 16, 871-875
42. Leitolf, H., Tong, K. P., Grossmann, M., Weintraub, B. D., and Szkudlinski, M. W. (2000) J. Biol. Chem. 275, 27457-27465