Thyroid-specific expression of cholera toxin A1 subunit causes thyroid hyperplasia and hyperthyroidism in transgenic mice

Endocrinology

Volumn 138, Issue 8, 1997, Pages 3133-3140

  Zeiger, Martha A ^a,c   Saji, Motoyasu ^a   Gusev, Yuriy ^a   Westra, William H ^a   Takiyama, Yumi ^a   Dooley, William C ^a   Kohn, Leonard D ^b   Levine, Michael A ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; CHOLERA TOXIN; CYCLIC AMP; GUANINE NUCLEOTIDE BINDING PROTEIN; THYROID HORMONE; THYROTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL GROWTH; CONTROLLED STUDY; HYPERTHYROIDISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYROID CARCINOMA; THYROID FOLLICLE CELL; THYROID HYPERPLASIA; TRANSGENIC MOUSE;

EID: 0030741024     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.8.5347     Document Type: Article

References (50)

1. Kosugi S, Okajima F, Ban T, Hidaka A, Shenker A, Kohn LD 1992 Mutation of alanine 623 in the third cytoplasmic loop of the rat thyrotropin (TSH) receptor results in a loss in the phosphoinositide but not cAMP signal induced by TSH and receptor autoantibodies. J Biol Chem 267:24153-24156
2. Van Sande J, Lejeune C, Ludgate M, Munro DS, Vassart G, Dumont JE, Mockel J 1992 Thyroid stimulating immunoglobulins, like thyrotropin activate both the cyclic AMP and the PIP2 cascades in CHO cells expressing the TSH receptor. Mol Cell Endocrinol 88:R1-R5
3. Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE 1994 The human thyrotropin receptor activates G-proteins Gs and Gq/11. J Biol Chem 269:13733-13735
4. Wynford-Thomas D 1993 Molecular basis of epithelial tumorigenesis: the thyroid model. [Review]. Crit Rev Oncog 4:1-23
5. Duh QY, Grossman RF 1995 Thyroid growth factors, signal transduction pathways, and oncogenes. [Review]. Surg Clin North Am 75:421-437
6. Jemec B 1980 Studies of the goitrogenic and tumorigenic effect of two goitrogens in combination with hypophysectomy or thyroid hormone treatment. Cancer 45:2138-2148
7. Wahner HW, Cuello C, Correa P, Uribe LF, Gaitan E 1966 Thyroid carcinoma in an endemic goiter area, Cali, Colombia. Am J Med 40:58-66
8. Williams ED, Doniach I, Bjarnason O, Michie W 1977 Thyroid cancer in an iodide rich area. Cancer 39:222-215
9. Mazzaferri EL, Young RL, Ortel JE, Kemmerer WT, Page CP 1977 Papillary thyroid carcinoma: the impact of therapy in 576 patients. Medicine (Baltimore) 56:171-196
10. Mazzaferri EL, Jhiang SM 1994 Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 97:418-428
11. Lyons J, Landis CA, Harsh G, Vallar L, Grunewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR, McCormick F 1990 Two G protein oncogenes in human endocrine tumors. Science 249:655-659
12. O'Sullivan C, Barton CM, Staddon SL, Brown CL, Lemoine NR 1991 Activating point mutations of the gsp oncogene in human thyroid adenomas. Mol Carcinog 4:345-349
13. Suarez HG, du Villard JA, Caillou B, Schlumberger M, Parmentier C, Monier R 1991 gsp mutations in human thyroid tumours. Oncogene 6:677-679
14. Goretzki PE, Lyons J, Stacy-Phipps S, Rosenau W, Demeure M, Clark OH, McCormick F, Roher HD, Bourne HR 1992 Mutational activation of RAS and GSP oncogenes in differentiated thyroid cancer and their biological implications. World J Surg 16:576-581
15. Parma J, Duprez L, Van Sande J, Cochaux P, Gervy C, Mockel J, Dumont J, Vassart G 1993 Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas. Nature 365:649-651
16. Russo D, Arturi F, Schlumberger M, Caillou B, Monier R, Filetti S, Suarez HG 1995 Activating mutations of the TSH receptor in differentiated thyroid carcinomas. Oncogene 11:1907-1911
17. Michiels FM, Caillou B, Talbot M, Dessarps-Freichey F, Maunoury MT, Schlumberger M, Mercken L, Monier R, Feunteun J 1994 Oncogenic potential of guanine nucleotide stimulatory factor alpha subunit in thyroid glands of transgenic mice. Proc Natl Acad Sci USA 91:10488-10492
18. Ledent C, Dumont JE, Vassart G, Parmentier M 1992 Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyper-thyroidism. EMBO J 11:537-542
19. Hosteller AL, Hrafnkelsson J, Wingren SO, Enestrom S, Nordenskjold B 1988 A comparative study of DNA cytometry methods for benign and malignant thyroid tissue. Am J Clin Pathol 89:760-763
20. Schelfhout LJ, Cornelisse CJ, Goslings BM, Hamming JF, Kuipers-Dijkshoorn NJ, van de Velde CJ, Fleuren GJ 1990 Frequency and degree of aneuploidy in benign and malignant thyroid neoplasms. Int J Cancer 45:16-20
21. Grant CS, Hay ID, Ryan JJ, Bergstralh EJ, Rainwater LM, Goellner JR 1990 Diagnostic and prognostic utility of flow cytometric DNA measurements in follicular thyroid tumors. World J Surg 14:283-289
22. Salmon I, Gasperin P, Remmelink M, Rahier I, Rocmans P, Pasteels J-L, Heimann R, Kiss R 1993 Ploidy level and proliferative activity measurements in a series of 407 thyroid tumors or other pathologic conditions. Hum Pathol 24:912-920
23. Burton FH, Hasel KW, Bloom FE, Sutcliffe JG 1991 Pituitary hyperplasia and gigantism in mice caused by a cholera toxin transgene. Nature 350:74-77
24. Saji M, Levine MA, Zeiger MA 1994 An in vitro model of thyroid neoplasia - permanently transfected Frtl-5 cells with thyroglobulin promoter cholera toxin A1 subunit minigene. Surgery 116:1048-1053
25. Laglia G, Zeiger MA, Leipricht A, Caturegli P, Levine MA, Kohn LD, Saji M 1996 Increased cyclic adenosine 3′,5′-monophosphate inhibits G protein-coupled activation of phospholipase C in rat FRTL-5 thyroid cells. Endocrinology 137:3170-3176
26. Zeiger MA, Saji M, Caturegli P, Westra WH, Kohn LD, Levine MA 1996 Transformation of rat thyroid follicular cells stably transfected with cholera toxin A1 fragment. Endocrinology 137:5392-5399
27. Hogan BLM, Constantini F, Lacy E 1986 Manipulating the Mouse Embryo-A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
28. McKnight RA, Shamay A, Sankaran L, Wall RJ, Hennighausen L 1992 Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice. Proc Natl Acad Sci USA 89:6943-6947
29. Stein SA, Shanklin DR, Krulich L, Roth MG, Chub CM, Adams PM 1989 Evaluation and characterization of the hyt/hyt hypothyroid mouse. II. Abnormalities of TSH and the thyroid gland. Neuroendocrinology 49:509-519
30. Burton K 1956 A study of the conditions and mechanisms of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62:315-323
31. Dooley WC, Allison DC 1992 Non-random distribution of abnormal mitosis in heteroploid cell lines. Cytometry 13:462-468
32. 1) mice. J Natl Cancer Inst 63:849-854
33. Taketo T, Schroeder AC, Mobraaten LE, Gunning KB, Hanten G, Fox RR, Roderick TH, Stewart CL, Lilly F, Hansen DT, Overbeek PA 1991 FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci USA 88:2065-2069
34. Mahler JF, Mann P, Takaoka M, Maronpot RR 1995 Spontaneous lesions of the FVB/N mouse. Toxicol Pathol 23:744-745
35. Fagin JA, Matsuo K, Karmakar A, Chen DL, Tang S, Koeffler HP 1993 High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas. J Clin Invest 91:179-184
36. Wynford-Thomas D 1993 Molecular genetics of thyroid cancer. Trends Endocrinol Metab 4:224-232
37. Zou M, Shi Y, Farid NR 1993 p53 mutations in all stages of thyroid carcinomas. J Clin Endocrinol Metab 77:1054-1058
38. Moore Jr JH, Bacharach B, Choi HY 1985 Anaplastic transformation of metastatic follicular carcinoma of the thyroid. J Surg Oncol 29:216-221
39. Venkatesh YS, Ordonez NG, Schultz PN, Hickey RC, Goepfert H, Samaan NA 1990 Anaplastic carcinoma of the thyroid. Cancer 66:321-330
40. Heitz P, Moser H, Staub JJ 1976 Thyroid cancer: a study of 573 thyroid tumors and 161 autopsy cases. Cancer 37:2329-2337
41. Thomas GA, Williams D, Williams ED 1989 The clonal origin of thyroid nodules and adenomas. Am J Pathol 134:141-147
42. Hicks DG, LiVolsi VA, Neidich JA, Puck JM, Kant JA 1990 Clonal analysis of solitary follicular nodules in the thyroid. Am J Pathol 137:553-562
43. Namba H, Matsuo K, Fagin JA 1990 Clonal composition of benign and malignant human thyroid tumors. J Clin Invest 86:120-125
44. Land H, Parada LF, Weinberg RA 1983 Cellular oncogenes and multistep carcinogenesis. [Review]. Science 222:771-778
45. Jhiang SM, Sagartz JE, Tong Q, Parker-Thornburg J, Capen CC, Cho JY, Xing S, Ledent C 1996 Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas. Endocrinology 137:375-378
46. Weiss SJ, Philp NJ, Ambesi-Impiombato FS, Grollman EF 1984 Thyrotropin-stimulated iodide transport mediated by adenosine 3′,5′-monophosphate and dependent on protein synthesis. Endocrinology 114:1099-1107
47. Murakami S, Summer CN, Iida-Klein A, Anderson DG, Sugawara M 1990 Physiological de novo thyroid hormone formation in primary culture of porcine thyroid follicles: adenosine 3′,5′-monophosphate alone is sufficient for thyroid hormone formation. Endocrinology 126:1692-1698
48. Ambesi-Impiombato FS, Parks LAM, Coon HG 1980 Culture of hormone-dependent functional epithelial cells from rat thyroids. Proc Natl Acad Sci USA 77:3455-3459
49. Ossendorp FA, Bruning PF, Schuuring MD, Van Den Brink JAM, Van Der Heide D, De Vijlder JJM, De Bruin TWA 1990 Thyrotropin dependent and independent thyroid cell lines selected from FRTL-5 derived tumors grown in nude mice. Endocrinology 127:419-430
50. Derwahl M, Harnacher C, Russo D, Broecker M, Manole D, Schatz H, Kopp P, Filetti S 1996 Constitutive activation of the Gs alpha protein-adenylate cyclase pathway may not be sufficient to generate toxic thyroid adenomas. J Clin Endocrinol Metab 81:1898-1904