Protein aggregation in aging and age-related neurodegenerative disorders

Prevention and Treatment of Age-related Diseases

Volumn , Issue , 2006, Pages 297-312

  Keller, Jeffrey N ^a   Ding, Qunxing ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Aging; Alzheimer's disease; Lysosome; Neuron; Oxidative stress; Proteasome

Indexed keywords

EID: 80054886683     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/1-4020-5058-5_15     Document Type: Chapter

References (98)

1. Adam, G., Gausz, J., Noselli, S., Kurucz, E., Ando, I. and Udvardy, A. (2004) Tissue- and developmental stage-specific changes in the subcellular localization of the 26S proteasome in the ovary of Drosophila melanogaster. Gene Expr Patterns, 4:329-333.
2. Agarwal, S. and Sohal, R. S. (1994) Aging and proteolysis of oxidized proteins. Arch Biochem Biophys, 309:24-28.
3. Amici, M., Lupidi, G., Angeletti, M., Fioretti, E. and Eleuteri, A. M. (2003) Peroxynitrite-induced oxidation and its effects on isolated proteasomal systems. Free Radic Biol Med, 34:987-996.
4. Anselmi, B., Conconi, M., Veyrat-Durebex, C., Turlin, E., Biville, F., Alliot, J. and Friguet, B. (1998) Dietary self-selection can compensate an age-related decrease of rat liver 20 S proteasome activity observed with standard diet. J Gerontol A Biol Sci Med Sci, 53:B173-179.
5. Auluck, P. K., Meuleener, M. C. and Bonini, N. M. (2005) Mechanisms of suppression of a-synuclein neurotoxicity by geldamycin in Drosophila. J Biol Chem, 280:2873-2878.
6. Barja, G. (2002) Rate of generation of oxidative stress-related damage and animal longevity. Free Radic Biol Med, 33:1167-1172.
7. Beckman, K. B. and Ames, B. N. (1998) The free radical theory of aging matures. Physiol Rev, 78:547-581.
8. Beedholm, R., Clark, B. F. and Rattan, S. I. (2004) Mild heat stress stimulates 20S proteasome and its 11S activator in human fibroblasts undergoing aging in vitro. Cell Stress Chaperones, 9:49-57.
9. Benaroudj, N., Tarcsa, E., Cascio, P. and Goldberg, A. L. (2001) The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes. Biochimie, 83:311-318.
10. Breedholm, R., Clark, B. F. and Rattan, S. I. (2004) Mild heat stress stimulates 20S proteasome and its 11S activator in human fibroblasts undergoing aging in vitro. Cell Stress Chaperones, 9:49-57.
11. Bulteau, A. L., Petropoulos, I. and Friguet, B. (2000) Age-related alterations of proteasome structure and function in aging epidermis. Exp Gerontol, 35:767-777.
12. Bulteau, A. L., Szweda, L. I. and Friguet, B. (2002) Age-dependent declines in proteasome activity in the heart. Arch Biochem Biophys, 397:298-304.
13. Caballero, M., Liton, P. B., Challa, P., Epstein, D. L. and Gonzalez, P. (2004) Effects of donor age on proteasome activity and senescence in trabecular meshwork cells. Biochem Biophys Res Commun, 323:1048-1054.
14. Chen, Q., Thorpe, J., Ding, Q., El-Amouri, I. S. and Keller, J. N. (2004) Proteasome synthesis and assembly are required for survival during stationary phase. Free Radic Biol Med, 37:859-868.
15. Chondrogianni, N. and Gonos, E. S. (2004) Proteasome inhibition induces a senescence-like phenotype in primary human fibroblasts cultures. Biogerontology, 5:55-61.
16. Chondrogianni, N., Stratford, F. L., Trougakos, I. P., Friguet, B., Rivett, A. J. and Gonos, E. S. (2003) Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation. J Biol Chem, 278:28026-28037.
17. Conconi, M., Szweda, L. I., Levine, R. L., Stadtman, E. R. and Friguet, B. (1996) Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90. Arch Biochem Biophys, 331:232-240.
18. Corcoran, L. J., Mitchison, T. J. and Liu, Q. (2004) A novel action of histone deactylase inhibitors in a protein aggresome disease model. Curr Biol, 14:488-492.
19. Davies, K. J. (2001) Degradation of oxidized proteins by the 20S proteasome. Biochimie, 83:301-310.
20. Deng, G. Y., Muir, A., Maclaren, N. K. and She, J. X. (1995) Association of LMP2 and LMP7 genes within the major histocompatibility complex with insulin-dependent diabetes mellitus: population and family studies. Am J Hum Genet, 56:528-534.
21. Dietrich, P., Rideout, H. J., Wang, Q. and Stefanis, L. (2003) Lack of p53 delays apoptosis, but increases ubiquitinated inclusions, in proteasomal inhibitor-treated cultured cortical neurons. Mol Cell Neurosci, 24:430-441.
22. Ding, Q. and Keller, J. N. (2001) Proteasomes and proteasome inhibition in the central nervous system. Free Radic Biol Med, 31:574-584.
23. Ding, Q. and Keller, J. N. (2001) Proteasome inhibition in oxidative stress neurotoxicity: implications for heat shock proteins. J Neurochem, 77:1010-1017.
24. Ding, Q., Lewis, J. J., Strum, K. M., Dimayuga, E., Bruce-Keller, A. J., Dunn, J. C. and Keller, J. N. (2002) Polyglutamine expansion, protein aggregation, proteasome activity, and neural survival. J Biol Chem, 277:13935-13942.
25. Ding, Q., Dimayuga, E., Martin, S., Bruce-Keller, A. J., Nukala, V., Cuervo, A. M. and Keller, J. N. (2003) Characterization of chronic low-level proteasome inhibition on neural homeostasis. J Neurochem, 86:489-497.
26. Ding, Q., Bruce-Keller, A. J., Chen, Q. and Keller, J. N. (2004a) Analysis of gene expression in neural cells subject to chronic proteasome inhibition. Free Radic Biol Med, 36:445-455.
27. Ding, Q., Dimayuga, E., Markesbery, W. R. and Keller, J. N. (2004b) Proteasome inhibition increases DNA and RNA oxidation in astrocyte and neuron cultures. J Neurochem, 91:1211-1218.
28. Elsasser, S., Chandler-Militello, D., Muller, B., Hanna, J. and Finley, D. (2004) Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem, 279:26817-26822.
29. Esterbauer, H., Schaur, R. J. and Zollner, H. (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med, 11:81-128.
30. Ferrington, D. A. and Kapphahn, R. J. (2004) Catalytic site-specific inhibition of the 20S proteasome by 4-hydroxynonenal. FEBS Lett, 578:217-223.
31. Forster, M. J., Sohal, B. H. and Sohal, R. S. (2000) Reversible effects of long-term caloric restriction on protein oxidative damage. J Gerontol A Biol Sci Med Sci, 55:B522-529.
32. Fribley, A., Zeng, Q. and Wang, C. Y. (2004) Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Biol, 24:9695-9704.
33. Friguet, B. and Szweda, L. I. (1997) Inhibition of the multicatalytic proteinase (proteasome) by 4-hydroxy-2-nonenal cross-linked protein. FEBS Lett, 405:21-25.
34. Friguet, B., Bulteau, A. L., Conconi, M. and Petropoulos, I. (2002) Redox control of 20S proteasome. Methods Enzymol, 353:253-262.
35. Glockzin, S., von Knethen, A., Scheffner, M. and Brune, B. (1999) Activation of the cell death program by nitric oxide involves inhibition of the proteasome. J Biol Chem, 274:19581-19586.
36. Goto, S., Takahashi, R., Araki, S. and Nakamoto, H. (2002) Dietary restriction initiated in late adulthood can reverse age-related alterations of protein and protein metabolism. Ann N Y Acad Sci, 959:50-56.
37. Gray, D. A., Tsirigotis, M. and Woulfe, J. (2003) Ubiquitin, proteasomes, and the aging brain. Sci Aging Knowledge Environ 2003, RE6.
38. Griffin, T. A., Slack, J. P., McCluskey, T. S., Monaco, J. J. and Colbert, R. A. (2000) Identification of proteassemblin, a mammalian homologue of the yeast protein, Ump1p, that is required for normal proteasome assembly. Mol Cell Biol Res Commun, 3:212-217.
39. Grimm, L. M. and Osborne, B. A. (1999) Apoptosis and the proteasome. Results Probl Cell Differ, 23:209-228.
40. Grune, T. and Davies, K. J. (1997) Breakdown of oxidized proteins as a part of secondary antioxidant defenses in mammalian cells. Biofactors, 6:165-172.
41. Grune, T., Reinheckel, T. and Davies, K. J. (1997) Degradation of oxidized proteins in mammalian cells. Faseb J, 11:526-534.
42. Grune, T., Blasig, I. E., Sitte, N., Roloff, B., Haseloff, R. and Davies, K. J. (1998) Peroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome. J Biol Chem, 273:10857-10862.
43. Grune, T., Shringarpure, R., Sitte, N. and Davies, K. (2001) Age-related changes in protein oxidation and proteolysis in mammalian cells. J Gerontol A Biol Sci Med Sci, 56:B459-467.
44. Harman, D. (2001) Aging: overview. Ann N Y Acad Sci, 928:1-21.
45. Hensley, K. and Floyd, R. A. (2002) Reactive oxygen species and protein oxidation in aging: a look back, a look ahead. Arch Biochem Biophys, 397:377-383.
46. Heward, J. M., Allahabadia, A., Sheppard, M. C., Barnett, A. H., Franklyn, J. A. and Gough, S. C. (1999) Association of the large multifunctional proteasome (LMP2) gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1?0304-DQB1?02-DQA1?0501. Clin Endocrinol (Oxf), 51:115-118.
47. Hyun, D. H., Lee, M. H., Halliwell, B. and Jenner, P. (2002) Proteasomal dysfunction induced by 4-hydroxy-2, 3-trans-nonenal, an end-product of lipid peroxidation: a mechanism contributing to neurodegeneration? J Neurochem, 83:360-370.
48. Jesenberger, V. and Jentsch, S. (2002) Deadly encounter: ubiquitin meets apoptosis. Nat Rev Mol Cell Biol, 3:112-121.
49. Keller, J. N. and Markesbery, W. R. (2000) Proteasome inhibition results in increased poly-ADP-ribosylation: implications for neuron death. J Neurosci Res, 61:436-442.
50. Keller, J. N., Hanni, K. B. and Markesbery, W. R. (2000a) Possible involvement of proteasome inhibition in aging: implications for oxidative stress. Mech Ageing Dev, 113:61-70.
51. Keller, J. N., Huang, F. F. and Markesbery, W. R. (2000b) Decreased levels of proteasome activity and proteasome expression in aging spinal cord. Neuroscience, 98:149-156.
52. Keller, J. N., Huang, F. F., Dimayuga, E. R. and Maragos, W. F. (2000c) Dopamine induces proteasome inhibition in neural PC12 cell line. Free Radic Biol Med, 29:1037-1042.
53. Keller, J. N., Dimayuga, E., Chen, Q., Thorpe, J., Gee, J. and Ding, Q. (2004) Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain. Int J Biochem Cell Biol, 36:2376-2391.
54. Kruger, E., Kloetzel, P. M. and Enenkel, C. (2001) 20S proteasome biogenesis. Biochimie, 83:289-293.
55. Larsen, K. E. and Sulzer, D. (2002) Autophagy in neurons: a review. Histol Histopathol, 17:897-908.
56. Ling, Y. H., Liebes, L., Zou, Y. and Perez-Soler, R. (2003) Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem, 278:33714-33723.
57. Lopes, U. G., Erhardt, P., Yao, R. and Cooper, G. M. (1997) p53-dependent induction of apoptosis by proteasome inhibitors. J Biol Chem, 272:12893-12896.
58. Louie, J. L., Kapphahn, R. J. and Ferrington, D. A. (2002) Proteasome function and protein oxidation in the aged retina. Exp Eye Res, 75:271-284.
59. Maksymowych, W. P., Tao, S., Vaile, J., Suarez-Almazor, M., Ramos-Remus, C. and Russell, A. S. (2000) LMP2 polymorphism is associated with extraspinal disease in HLA-B27 negative Caucasian and Mexican Mestizo patients with ankylosing spondylitis. J Rheumatol, 27:183-189.
60. Mangel, M. (2001) Complex adaptive systems, aging and longevity. J Theor Biol, 213:559-571.
61. Merker, K., Stolzing, A. and Grune, T. (2001) Proteolysis, caloric restriction and aging. Mech Ageing Dev, 122:595-615.
62. Mishto, M., Bonafe, M., Salvioli, S., Olivieri, F. and Franceschi, C. (2002) Age dependent impact of LMP polymorphisms on TNFalpha-induced apoptosis in human peripheral blood mononuclear cells. Exp Gerontol, 37:301-308.
63. Mishto, M., Bellavista, E., Santoro, A., Stolzing, A., Ligorio, C., Nacmias, B., Spazzafumo, L., Chiappelli, M., Licastro, F., Sorbi, S., Pession, A., Ohm, T., Grune, T. and Franceschi, C. (2006) Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. Neurobiol Aging, 27:54-66.
64. Nakaso, K., Yoshimoto, Y., Yano, H., Takeshima, T. and Nakashima, K. (2004) p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells. Neurosci Lett, 354:213-216.
65. Noda, C., Tanahashi, N., Shimbara, N., Hendil, K. B. and Tanaka, K. (2000) Tissue distribution of constitutive proteasomes, immunoproteasomes, and PA28 in rats. Biochem Biophys Res Commun, 277:348-354.
66. Obin, M., Shang, F., Gong, X., Handelman, G., Blumberg, J. and Taylor, A. (1998) Redox regulation of ubiquitin-conjugating enzymes: mechanistic insights using the thiol-specific oxidant diamide. Faseb J, 12:561-569.
67. Ogiso, Y., Tomida, A. and Tsuruo, T. (2002) Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs. Cancer Res, 62:5008-5012.
68. Okada, K., Wangpoengtrakul, C., Osawa, T., Toyokuni, S., Tanaka, K. and Uchida, K. (1999) 4-Hydroxy-2-nonenal-mediated impairment of intracellular proteolysis during oxidative stress. Identification of proteasomes as target molecules. J Biol Chem, 274:23787-23793.
69. Pacifici, R. E., Salo, D. C. and Davies, K. J. (1989) Macroxyproteinase (M. O. P.): a 670 kDa proteinase complex that degrades oxidatively denatured proteins in red blood cells. Free Radic Biol Med, 7:521-536.
70. Pacifici, R. E., Kono, Y. and Davies, K. J. (1993) Hydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome. J Biol Chem, 268:15405-15411.
71. Parsons, P. A. (2003) From the stress theory of aging to energetic and evolutionary expectations for longevity. Biogerontology, 4:63-73.
72. Pasquini, L. A., Besio Moreno, M., Adamo, A. M., Pasquini, J. M. and Soto, E. F. (2000) Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells. J Neurosci Res, 59:601-611.
73. Petropoulos, I., Conconi, M., Wang, X., Hoenel, B., Bregegere, F., Milner, Y. and Friguet, B. (2000) Increase of oxidatively modified protein is associated with a decrease of proteasome activity and content in aging epidermal cells. J Gerontol A Biol Sci Med Sci, 55:B220-227.
74. Piccinini, M., Mostert, M., Croce, S., Baldovino, S., Papotti, M. and Rinaudo, M. T. (2003) Interferongamma-inducible subunits are incorporated in human brain 20S proteasome. J Neuroimmunol, 135:135-140.
75. Qiu, J. H., Asai, A., Chi, S., Saito, N., Hamada, H. and Kirino, T. (2000) Proteasome inhibitors induce cytochrome c-caspase-3-like protease-mediated apoptosis in cultured cortical neurons. J Neurosci, 20:259-265.
76. Radak, Z., Takahashi, R., Kumiyama, A., Nakamoto, H., Ohno, H., Ookawara, T. and Goto, S. (2002) Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Exp Gerontol, 37:1423-1430.
77. Rattan, S. I. (2004) Hormetic mechanisms of anti-aging and rejuvenating effects of repeated mild heat stress on human fibroblasts in vitro. Rejuvenation Res, 7:40-48.
78. Rivett, A. J. (1993) Proteasomes: multicatalytic proteinase complexes. Biochem J, 291 (Pt 1), 1-10.
79. Ryu, H., Smith, K., Camelo, S. I., Carreras, I., Lee, J., Iglesias, A. H., Dandond, F., Cormier, K. A., Cudkowicz, M. F., Brown, R. H. and Ferrante, R. J. (2005) Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J Neurochem, 93:1087-1098.
80. Schmidt, M. and Kloetzel, P. M. (1997) Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme. Faseb J, 11:1235-1243.
81. Singh, S., Awasthi, N., Egwuagu, C. E. and Wagner, B. J. (2002) Immunoproteasome expression in a nonimmune tissue, the ocular lens. Arch Biochem Biophys, 405:147-153.
82. Sitte, N., Merker, K., von Zglinicki, T. and Grune, T. (2000a) Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic Biol Med, 28:701-708.
83. Sitte, N., Huber, M., Grune, T., Ladhoff, A., Doecke, W. D., Von Zglinicki, T. and Davies, K. J. (2000b) Proteasome inhibition by lipofuscin/ceroid during postmitotic aging of fibroblasts. Faseb J, 14:1490-1498.
84. Sitte, N., Merker, K., Von Zglinicki, T., Davies, K. J. and Grune, T. (2000c) Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II-aging of nondividing cells. Faseb J, 14:2503-2510.
85. Sitte, N., Merker, K., Von Zglinicki, T., Grune, T. and Davies, K. J. (2000d) Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I-effects of proliferative senescence. Faseb J, 14:2495-2502.
86. Sittler, A., Lurz, R., Lueder, G., Priller, J., Leharch, H., Hayer-Hartl, M. K., Hartl, F. U. and Wanker, E. E (2001) Geldamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease. Hum Mol Genet, 10:1307-1315.
87. Sohal, R. S. and Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science, 273:59-63.
88. Squier, T. C. (2001) Oxidative stress and protein aggregation during biological aging. Exp Gerontol, 36:1539-1550.
89. Sullivan, P. G., Dragicevic, N. B., Deng, J. H., Bai, Y., Dimayuga, E., Ding, Q., Chen, Q., Bruce-Keller, A. J. and Keller, J. N. (2004) Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover. J Biol Chem, 279:20699-20707.
90. Uchida, K. (2003) 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res, 42:318-343.
91. Ullrich, O. and Grune, T. (2001) Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells. Free Radic Biol Med, 31:887-893.
92. Ullrich, O., Reinheckel, T., Sitte, N., Hass, R., Grune, T. and Davies, K. J. (1999) Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones. Proc Natl Acad Sci USA, 96:6223-6228.
93. Vinasco, J., Fraile, A., Nieto, A., Beraun, Y., Pareja, E., Mataran, L. and Martin, J. (1998) Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis. Ann Rheum Dis, 57:33-37.
94. Viteri, G., Carrard, G., Birlouez-Aragon, I., Silva, E. and Friguet, B. (2004) Age-dependent protein modifications and declining proteasome activity in the human lens. Arch Biochem Biophys, 427:197-203.
95. Walters, K. J., Lech, P. J., Goh, A. M., Wang, Q. and Howley, P. M. (2003) DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. Proc Natl Acad Sci USA, 100:12694-12699.
96. Weindruch, R. (1996) The retardation of aging by caloric restriction: studies in rodents and primates. Toxicol Pathol, 24:742-745.
97. Williams, S. A. and McConkey, D. J. (2003) The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells. Cancer Res, 63:7338-7344.
98. Wojcik, C. (1999) Proteasomes in apoptosis: villains or guardians? Cell Mol Life Sci, 56:908-917.