Redox regulation of ubiquitin-conjugating enzymes: Mechanistic insights using the thiol-specific oxidant diamide

FASEB Journal

Volumn 12, Issue 7, 1998, Pages 561-569

  Obin, Martin ^a   Shang, Fu ^a   Gong, Xin ^a   Handelman, Garry ^a   Blumberg, Jeffrey ^a   Taylor, Allen ^a  

^a TUFTS UNIVERSITY   (United States)

Author keywords

Diamide; E1; E2; Glutathione; Ubiquitin activating enzyme; Ubiquitin proteasome pathway

Indexed keywords

GLUTATHIONE; GLUTATHIONE DISULFIDE; UBIQUITIN CONJUGATING ENZYME;

ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME REGULATION; HUMAN; HUMAN CELL; LIGAND BINDING; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION;

EID: 0031893232     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.12.7.561     Document Type: Article

References (38)

1. Wilkinson, K. D. (1995) Roles of ubiquitinylation in proteolysis and cellular regulation. Annu. Rev. Nutr. 15, 161-189
2. Hochstrasser, M. (1996) Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405-439
3. Hershko, A., and Ciechanover, A. (1992) The ubiquitin system for protein degradation. Annu. Rev. Biochem. 61, 761-807
4. Ciechanover, A., and Schwartz, A. L. (1994) The ubiquitin-mediated proteolytic pathway: mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins. FASEB J. 8, 182-191
5. Chen, Z. J., Parent, L., and Maniatis, T. (1996) Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84, 853-862
6. Hicke, L., and Riezman, H. (1996) Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84, 277-287
7. Matunis, M. J., Coutavas, E., and Blobel, G. (1996) A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex. J. Cell Biol. 135, 1457-1470
8. Cheng, L., Watt, R., and Piper, P. W. (1994) Polyubiquitin gene expression contributes to oxidative stress resistance in respiratory yeast (Saccharomyces cerevisiae). Mol. Gen. Genet. 246, 358-362
9. Jahngen-Hodge, J., Obin, M., Gong, X., Shang, F., Nowell, T., Gong, J., Abasi, H., Blumberg, J., and Taylor, A. (1997) Regulation of ubiquitin conjugating enzymes by glutathione following oxidative stress. J. Biol. Chem. 272, 28218-28226
10. Shang, F., Gong, X., and Taylor, A. (1997) Activity of ubiquitin dependent pathway in response to oxidative stress: ubiquitin activating enzyme (E1) is transiently upregulated. J. Biol. Chem. 272, 23086-23093
11. Shang, F., and Taylor, A. (1995) Oxidative stress and recovery from oxidative stress are associated with altered ubiquitin conjugating and proteolytic activities in bovine lens epithelial cells. Biochem. J. 307, 297-303
12. Haas, A. L., and Rose, I. A. (1982) The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. J. Biol. Chem. 257, 10329-10337
13. Hershko, A., Heller, H., Elias, S., and Ciechanover, A. (1983) Components of the ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J. Biol. Chem. 258, 8206-8214
14. Scheffner, M., Nuber, U., and Huibregtse, J. M. (1995) Protein ubiquitination involving a E1-E2-E3 thiolester cascade. Nature (London) 373, 81-83
15. Berlett, B. S., and Stadtman, E. R. (1997) Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 272, 20313-20316
16. Kosower, N. S., and Kosower, E. M. (1995) Diamide: an oxidant probe for thiols. Methods Enzymol. 251, 123-133
17. Obin, M., Nowell, T., and Taylor, A. (1995) A comparison of ubiquitin-dependent proteolysis of rod outer segment proteins in reticulocyte lysate and a retinal pigment epithelial cell line. Curr. Eye Res. 14, 751-760
18. Handley-Gearhart, P. M., Stephen, A. G., Trausch-Azar, J. S., Ciechanover, A., and Schwartz, A. L. (1994) Human ubiquitin-activating enzyme, E1. Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs. J. Biol. Chem. 269, 33171-33178
19. Handley, P. M., Mueckler, M., Siegel, N. R., Ciechanover, A., and Schwartz, A. L. (1991) Molecular cloning, sequence and tissue distribution of human ubiquitin-activating enzyme E1. Proc. Natl. Acad. Sci. USA 88, 258-262
20. Fariss, M. W., and Reed, D. J. (1987) High performance liquid chromatography of thiols and disulfide: dinitrophenol derivatives. Methods Enzymol. 143, 101-109
21. Sedlak, J., and Lindsay, R. H. (1968) Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellmans's reagent. Anal. Biochem. 25, 192-205
22. Obin, M., Jahngen-Hodge, J., Nowell, T., and Taylor, A. (1996) Ubiquitinylation and ubiquitin-dependent proteolysis in vertebrate photoreceptors (rod outer segments): evidence for ubiquitinylation of Gt and rhodopsin. J. Biol. Chem. 271, 14473-14484
23. Carelli, S., Ceriotti, A., Cabibbo, A., Fassina, G., Ruvo, M., and Sitia, R. (1997) Gysteine and glutathione secretion in response to protein disulfide bond formation in ER. Science 277, 1681-1684
24. Rock, K. L., Gramm, C., Rothstein, L., Clark, K., Stein, R., Dick, L., Hwang, D., and Goldberg, A. L. (1994) Inhibitors of the pro- teasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78, 761-771
25. Palombella, V. J., Rando, O. J., Goldberg, A. L., and Maniatis, T. (1994) The ubiquitin-proteasome pathway is required for processing of NF-κB procursor protein and the activation of NF-κB. Cell 78, 773-785
26. Akamatsu, Y., Ohno, T., Hirota, K., Kagoshima, H.,Yodoi, J., and Shigesada, K. (1997) Redox regulation of the DNA binding activity in transcription factor PEBP2. The roles of two conserved cysteine residues. J. Biol. Chem. 272, 14497-14500
27. Shrimpton, C. N., Glucksman, M. J., Lew, R. A., Tullai, J. W., Margulies, E. H., Roberts, J. L., and Smith, A. I. (1997) Thiol activation of endopeptidase EC 3.4..24.15. J. Biol. Chem. 272, 17395-17399
28. Liu, H., Lightfoot, R., and Stevens, J. L. (1996) Activation of heat shock factor by alkylating agents is triggered by glutathione depletion and oxidation of protein thiols. J. Biol. Chem. 271, 4805-4812
29. Haas, A. L., Warms, J. V. B., Hershko, A., and Rose, I. A. (1982) Ubiquitin-activating enzyme, mechanism and role in protein-ubiquitin conjugation. J. Biol. Chem. 257, 2543-2548
30. Pickart, C. M., and Rose, I. A. (1985) Functional heterogeneity of ubiquitin carrier proteins. J. Biol. Chem. 260, 1573-1581
31. 25k) and overexpression of the functional enzyme in Escherichia coli. J. Biol. Chem. 266, 15698-15704
32. Miller, R. M., Sies, H., Park, E. M., and Thomas, J. A. (1990) Phosphorylase and creatine kinase modification by thiol-disulfide exchange and by xanthine oxidase-initiated S-thiolation. Arch. Biochem. Biophys. 276, 355-363
33. Vessey, D. A., Lee, K. H., and Blacker, K. L. (1992) Characterization of the oxidative stress initiated in cultured human keratinocytes by treatment with peroxides. J. Invest. Dermat. 99, 859-863
34. Brot, N., Weissbach, L., Werth, J., and Weissbach, H. (1981) Enzymatic reduction of protein-bound methionine sulfoxide. Proc. Natl. Acad. Sci. USA 78, 2155-2158
35. Holmgren, A. (1985) Thioredoxin. Annu. Rev. Biochem. 54, 237-271
36. Taylor, A., Dorey, C. K., and Nowell, T. J. (1997) Oxidative stress and ascorbate in relation to risk for cataract and age-related maculopathy. In Vitamin C in Health and Disease (Packer, L. A. F., Jr., ed) pp. 267-283, Marcel Dekker, New York
37. Di Monte, D. A., Chan, P., and Sandy, M. S. (1992) Glutathione in Parkinson's disease: a link between oxidative stress and mitochondrial damage? Ann. Neurol. 32 (Suppl.), 111-115
38. Jenner, P. (1996) Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathol. Biol. 44, 57-64