Oxidative stress and protein aggregation during biological aging

Experimental Gerontology

Volumn 36, Issue 9, 2001, Pages 1539-1550

  Squier, T C ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Adaptive cellular response; Biological aging; Calcium regulatory proteins; Energy metabolism; Reactive oxygen species

Indexed keywords

AMYLOID; CALCIUM; CELL PROTEIN; PROTEIN; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN;

AGING; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CELL REGENERATION; CELL SURVIVAL; CELL VIABILITY; ENERGY METABOLISM; HUMAN; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; REGULATORY MECHANISM; RESPIRATORY CHAIN; REVIEW; SIGNAL TRANSDUCTION;

ANIMALIA; VERTEBRATA;

EID: 0034881033     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00139-5     Document Type: Article

References (39)

1. Protein oxidation in aging, disease, and oxidative stress
2. Inherent abnormalities in energy metabolism in Alzheimer's disease
3. Biomarkers as early predictors of long-term health status and human immune function
4. Reversal of age-related increases in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitrone
5. Age-related decline of rat liver multicatalytic proteinase activity and protection from oxidative inactivation by heat-shock protein 90
6. 2 sensor and NO signaling functions
7. Selective degradation of oxidized calmodulin by the 20S proteasome
8. Oxidants, oxidative stress and the biology of aging
9. Nitrone inhibition of age-associated oxidative damage
10. Structural modifications of proteins during aging
11. Progressive decline in the ability of calmodulin isolated from aged brain to activate the plasma membrane Ca-ATPase
12. Oxidatively modified calmodulin binds to the plasma membrane Ca-ATPase in a non-productive and conformationally disordered complex
13. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome
14. Genetic pathways that regulate ageing in model organisms
15. An activity in rat tissues that modifies nitrotyrosine-containing proteins
16. Intracellular calcium mobilization regulates the activity of 26S proteasome during the metaphase-anaphase transition in the Ascidian meiotic cell cycle
17. Calcium homeostasis in aged neurons
18. Why do we age?
19. Gene expression profile of aging and its retardation by caloric restriction
20. Methionine residues as endogenous antioxidants in proteins
21. Structure and mechanism of peptide methionine sulfoxide reductase, an 'antioxidation' enzyme
22. Extended life-span conferred by cotransporter gene mutation in Drosophila
23. Diastereoselective reduction of protein-bound methionine sulfoxide by methionine sulfoxide reductase
24. Oxidative damage in Alzheimer's
25. Oxidative stress, caloric restriction, and aging
26. Protein oxidation and age-dependent alterations in calcium homeostasis
27. 2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26S proteasomes without ubiquitination
28. Detecting and measuring cotranslational protein degradation in vivo
29. Supeoxide production by the mitochondrial respiratory chain
30. Long-lived Caenorhabditis elegans mutants have reduced metabolic rates
31. 2+-ATPase in skeletal muscle
32. Peroxynitrite modification of protein thiols: oxidation, nitrosylation and S-glutathilations of functionally important cysteine residue(s) in the sarcoplasmic reticulum Ca-ATPase
33. The 26S proteasome: a molecular machine designed for controlled proteolysis
34. Oxidation of methionyl residues in proteins: tools, targets, and reversal
35. Post-translational quality control: folding, refolding, and degrading proteins
36. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
37. 2 modulates the ability to activate the plasma membrane Ca-ATPase
38. Deleterious network hypothesis of aging