Proteasomal degradation of oxidatively damaged endogenous histones in K562 human leukemic cells

Free Radical Biology and Medicine

Volumn 31, Issue 7, 2001, Pages 887-893

  Ullrich, Oliver ^a   Grune, Tilman ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Free radicals; Histones; Oxidative stress; Proteasome; Protein oxidation; Tumor cells

Indexed keywords

3 AMINOBENZAMIDE; HISTONE; HISTONE H1; LACTACYSTIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NUCLEAR PROTEIN; PROTEASOME; PROTEASOME INHIBITOR;

ARTICLE; CELL STRAIN K 562; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRESS; TIME;

ACETYLCYSTEINE; BENZAMIDES; CELL NUCLEUS; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; HISTONES; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, CHRONIC; MULTIENZYME COMPLEXES; OXIDATION-REDUCTION; OXIDATIVE STRESS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 0035478982     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00672-4     Document Type: Article

References (40)

1. Free radicals and anticancer drug resistance; oxygen free radicals in the mechanisms of drug cytotoxicity and resistance by certain tumors
2. Redox cycling of anthracyclines by cardiac mitochondria: I. Anthracycline radical formation by NADH dehydrogenase
3. Redox cycling of anthracyclins by cardiac mitochondria: II. Formation of superoxide anion, hydrogen peroxide, and hydroxyl radical
4. Oxidative and non-oxidative mechanisms in the inactivation of cardiac mitochondrial electron transport chain components by doxorubicin
5. Dependence of nucleic acid degradation on in situ free-radical production by adriamycin
6. Cellullar and chromosomal hypersensitivity to DNA crosslinking agents and toposiomerase inhibitors in the radiosensitive Chinese hamster irs mutants: Phenotypic similarities to ataxia teleangiectasia and Fanconi's anaemia cells
7. Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions
8. Nucleosomal histone proteins protects DNA from iron-mediated damage
9. Influence of DNA binding in the degradation of oxidatively damaged histones by the 20S proteasome
10. Histone shuttling by poly(ADP-ribosylation)
11. DNA repair: PARP - Another guardian angel?
12. Histone synthesis and turnover in alfalfa
13. Protein damage and degradation by oxygen radicals
14. Structure and functions of the 20S and 26S proteasomes
15. Protein degradation in cultured liver epithelial cells during oxidative stress: Role of the multicatalytic proteinase complex, proteasome
16. Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome
17. Poly-ADP-ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones
18. Functional interaction of poly(ADP-ribose) with the 20S proteasome in vitro
19. The nuclear pore complex protein p62 is one of several sialic acid-containing proteins of the nuclear envelope
20. High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors
21. Carbonyl assays for determination of oxidatively modified proteins
22. Lactacystin, proteasome function, and cell fate
23. Poly(ADP-ribose) polymerase: Molecular biology aspects
24. Poly(ADP-ribose) polymerase: A molecular nick-sensor
25. Role of poly(ADP-ribose) formation in DNA repair
26. Synthesis and degradation of H1 histone subtypes in mouse lymphoma L5178Y cells
27. Metabolic behaviors of the core histones in proliferating Friend cells
28. Histone H1
29. Effects of histone H1 variant overexpression on chromatin structure
30. Histone H1: Location and role
31. Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
32. Intracellular distribution of proteasomes
33. Repair of DNA damage induced by oxygen radicals in human non-proliferating and proliferating lymphocytes
34. Gamma-irradiated DNA activates histone H1-specific proteinase of rat liver nuclei
35. Effect of protease inhibitors on early events of apoptosis
36. Activation of intracellular proteases is an early event in TNF-induced apoptosis
37. Calcium-dependent, interleukin 1-converting enzyme inhibitor-insensitive degradation of lamin B1 and DNA fragmentation isolated thymocyte nuclei
38. Role of macrophage lysosomal enzymes in the degradation of nucleosomes of apoptotic cells
39. Proteolysis of nuclear proteins by μ-calpain and m-calpain
40. A comparison of the intracellular distribution of μ-calpain, m-calpain, and calpastatin in proliferating human A431 cells