Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target

Life Sciences

Volumn 85, Issue 5-6, 2009, Pages 211-219

  Rai, Santosh Kumar ^a   Sharma, Meenakshi ^b   Tiwari, Manisha ^a  

^a UNIVERSITY OF DELHI   (India)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

CREB; Diallyldisulfide; HMG CoA reductase; NF B; NF Y; SREBP 2

Indexed keywords

ALLICIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DIALLYL DISULFIDE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MEVINOLIN; NUCLEAR FACTOR Y; OXIDIZED LOW DENSITY LIPOPROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; GARLIC; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; LIPID LIVER LEVEL; LIPID PEROXIDATION; LIVER MICROSOME; MALE; NONHUMAN; PROTEIN EXPRESSION; RAT; TRANSCRIPTION REGULATION;

ALLYL COMPOUNDS; ANIMALS; ANTILIPEMIC AGENTS; BLOTTING, WESTERN; CHOLESTEROL; CREB-BINDING PROTEIN; DISEASE MODELS, ANIMAL; DISULFIDES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GARLIC; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYDROXYMETHYLGLUTARYL COA REDUCTASES; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPERCHOLESTEROLEMIA; LIPID PEROXIDATION; LIPOPROTEINS, LDL; LIVER; MALE; NF-KAPPA B; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEINS; TRIGLYCERIDES;

ALLIUM SATIVUM; ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 67649803075     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2009.05.020     Document Type: Article

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