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Volumn 107, Issue 5, 2003, Pages 1194-1207

Kinetics of irreversible protein aggregation: Analysis of extended Lumry-Eyring models and implications for predicting protein shelf life

Author keywords

[No Author keywords available]

Indexed keywords

INTRINSIC AGGREGATION KINETICS; IRREVERSIBLE PROTEIN AGGREGATION; LUMRY-EYRING MODELS; NON-NATIVE CONFORMATIONS; REVERSIBLE CONFORMATIONAL TRANSITIONS;

EID: 0037421836     PISSN: 10895647     EISSN: None     Source Type: Journal    
DOI: 10.1021/jp026827s     Document Type: Article
Times cited : (146)

References (69)
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    • (1992) Stability of Protein Pharmaceuticals , pp. 249-272
    • Zaks, A.1
  • 32
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    • note
    • We use the term conformational state within its thermodynamic and statistical thermodynamic sense to indicate all conformations of a protein and its environment (i.e., solvent and additional solutes) within a given ensemble, or rational subdivision of an ensemble, consistent with a set of macroscopic observables specific to that state.
  • 39
    • 0013373092 scopus 로고    scopus 로고
    • note
    • 38,40,41
  • 40
    • 0008863560 scopus 로고
    • Anfinsen, C. B., anson, M. L., Bailey, K., Edsall, J. T., Eds.; Academic Press: New York
    • Kauzmann, W. In Advances in Protein Chemistry; Anfinsen, C. B., Anson, M. L., Bailey, K., Edsall, J. T., Eds.; Academic Press: New York, 1959; Vol. 14, pp 1-63.
    • (1959) Advances in Protein Chemistry , vol.14 , pp. 1-63
    • Kauzmann, W.1
  • 43
    • 0013419250 scopus 로고    scopus 로고
    • note
    • For the purposes of the extended Lumry-Eyring model employed here as well for extrapolating shelf-life predictions, it is not necessary to know detailed identity (e.g., in terms of structural details) of the aggregation-prone state(s). The major requirement is that it(they) remain the predominant aggregation-prone state(s) over the range of the variable being extrapolated.
  • 52
    • 0013326631 scopus 로고    scopus 로고
    • note
    • 0).
  • 56
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    • Creighton, T. E., Ed.; Oxford University Press: Oxford, U.K.
    • Pace, C. N.; Shirley, B. A.; Thomson, J. A. In Protein Structure; Creighton, T. E., Ed.; Oxford University Press: Oxford, U.K., 1990; p. 311.
    • (1990) Protein Structure , pp. 311
    • Pace, C.N.1    Shirley, B.A.2    Thomson, J.A.3
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    • note
    • 3 days.
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    • 0003224438 scopus 로고    scopus 로고
    • Arrhenius consequences of IL-1R(II) aggregation in the vicinity of the Tm
    • IBC USA, Miami, FL
    • Remmele, R. A. Arrhenius Consequences of IL-1R(II) Aggregation in the Vicinity of the Tm. Formulation Strategies for Biopharmaceuticals, IBC USA, Miami, FL, 2002.
    • (2002) Formulation Strategies for Biopharmaceuticals
    • Remmele, R.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.