Fragile sites: Breaking up over a slowdown

Current Biology

Volumn 13, Issue 6, 2003, Pages

  Cimprich, Karlene A ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0037452872     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(03)00158-1     Document Type: Short Survey

References (15)

1. Richards, R.I. (2001). Fragile and unstable chromosomes in cancer: causes and consequences. Trends Genet. 17, 339-345.
2. Casper, A.M., Nghiem, P., Arlt, M.F. and Glover, T.W. (2002). ATR regulates fragile site stability. Cell 111, 779-789.
3. Brown, E.J. and Baltimore, D. (2003). Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17, 615-628.
4. Huebner, K. and Croce, C.M. (2001). FRA3B and other common fragile sites: the weakest links. Nat. Rev. Cancer. 1, 214-221.
5. Nyberg, K.A., Michelson, R.J., Putnam, C.W. and Weinert, T.A. (2002). Toward maintaining the genome: DNA damage and replication checkpoints. Annu. Rev. Genet. 36, 617-656.
6. Yunis, J.J. and Soreng, A.L. (1984). Constitutive fragile sites and cancer. Science 226, 1199-1204.
7. Brown, E.J. and Baltimore, D. (2000). ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397-402.
8. Cha, R.S. and Kleckner, N. (2002). ATR homolog Mec1 promotes fork progression, thus averting breaks in replication slow zones. Science 297, 602-606.
9. Hekmat-Nejad, M., You, Z., Yee, M.-C., Newport, J. and Cimprich, K.A. (2000). Xenopus ATR is a replication-dependent chromatin binding protein required for the DNA replication checkpoint. Curr. Biol. 10, 1565-1573.
10. Guo, Z., Kumagai, A., Wang, S.X. and Dunphy, W.G. (2000). Requirement for ATR in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts. Genes Dev. 14, 2745-2756.
11. Osbom, A.J., Elledge, S.J. and Zou, L. (2002). Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol. 12, 509-516.
12. Carr, A.M. (2002). Checking that replication breakdown is not terminal. Science 297, 557-558.
13. Sogo, J.M., Lopes M. and Foiani, M. (2002). Fork reversal and ssDNA accumulation at stalled replication forks owing to checkpoint defects. Science 297, 599-602.
14. Mon, M., Mimon, K., Masuda, T., Yoshinaga, K., Yamashita, K., Matsuyama, A. and Inoue, H. (2001). Absence of Msh2 protein expression is associated with alteration in the FHIT locus and Fhit protein expression in colorectal carcinoma. Cancer Res. 61, 7379-7382.
15. Ingvarsson, S., Agnarsson, B.A., Sigbjornsdottir, B.I., Kononen, J., Kallioniemi, O.P., Barkardottir, R.B., Kovatich, A.J., Schwarting, R., Hauck, W.W., Huebner, K. et al. (1999). Reduced Fhit expression in sporadic and BRCA2-linked breast carcinomas. Cancer Res. 59, 2682-2689.