메뉴 건너뛰기




Volumn 123, Issue 2, 2011, Pages 501-510

Cross talk between keratinocytes and dendritic cells: Impact on the prediction of sensitization

Author keywords

Antigen presenting cells; Coculture; Cross talk; Keratinocytes; Metabolism; Skin sensitization assay

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; ALLERGEN; BENZALKONIUM; BENZO[A]PYRENE; CD40 ANTIGEN; CD86 ANTIGEN; CREOSOL; CYTOCHROME P450; EUGENOL; HAPTEN; INTERCELLULAR ADHESION MOLECULE 1; IRRITANT AGENT; ISOEUGENOL; PHENOL DERIVATIVE; POLYACRYLAMIDE GEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); UNCLASSIFIED DRUG;

EID: 80053459335     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr174     Document Type: Article
Times cited : (48)

References (47)
  • 1
    • 59149095125 scopus 로고    scopus 로고
    • HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway
    • Ade, N., Leon, F., Pallardy, M., Peiffer, J. L., Kerdine-Romer, S., Tissier, M. H., Bonnet, P. A., Fabre, I., and Ourlin, J. C. (2009). HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway. Toxicol. Sci. 107, 451-460.
    • (2009) Toxicol. Sci. , vol.107 , pp. 451-460
    • Ade, N.1    Leon, F.2    Pallardy, M.3    Peiffer, J.L.4    Kerdine-Romer, S.5    Tissier, M.H.6    Bonnet, P.A.7    Fabre, I.8    Ourlin, J.C.9
  • 5
    • 0036888067 scopus 로고    scopus 로고
    • Disposition and metabolism of isoeugenol in the male Fischer 344 rat
    • Badger, D. A., Smith, R. L., Bao, J., Kuester, R. K., and Sipes, I. G. (2002). Disposition and metabolism of isoeugenol in the male Fischer 344 rat. Food Chem. Toxicol. 40, 1757-1765.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 1757-1765
    • Badger, D.A.1    Smith, R.L.2    Bao, J.3    Kuester, R.K.4    Sipes, I.G.5
  • 6
    • 68949144888 scopus 로고    scopus 로고
    • Updating the skin sensitization in vitro data assessment paradigm in 2009
    • Basketter, D. A., and Kimber, I. (2009). Updating the skin sensitization in vitro data assessment paradigm in 2009. J. Appl. Toxicol. 29, 545-550.
    • (2009) J. Appl. Toxicol. , vol.29 , pp. 545-550
    • Basketter, D.A.1    Kimber, I.2
  • 7
    • 0001191078 scopus 로고    scopus 로고
    • The role of P450 1A in the activation of prophaptens in skin sensitization
    • Basketter, D. A., Pendlington, R. U., Sarll, A., and Scholes, E. (1996). The role of P450 1A in the activation of prophaptens in skin sensitization. J. Invest. Dermatol. 106, 935.
    • (1996) J. Invest. Dermatol. , vol.106 , pp. 935
    • Basketter, D.A.1    Pendlington, R.U.2    Sarll, A.3    Scholes, E.4
  • 8
    • 0028040414 scopus 로고
    • The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test
    • Basketter, D. A., Scholes, E. W., and Kimber, I. (1994). The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test. Food Chem. Toxicol. 32, 543-7.
    • (1994) Food Chem. Toxicol. , vol.32 , pp. 543-547
    • Basketter, D.A.1    Scholes, E.W.2    Kimber, I.3
  • 10
    • 0030938165 scopus 로고    scopus 로고
    • Skin sensitization to eugenol and isoeugenol in mice: possible metabolic pathways involving ortho-quinone and quinone methide intermediates
    • Bertrand, F., Basketter, D. A., Roberts, D. W., and Lepoittevin, J. P. (1997). Skin sensitization to eugenol and isoeugenol in mice: possible metabolic pathways involving ortho-quinone and quinone methide intermediates. Chem. Res. Toxicol. 10, 335-343.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 335-343
    • Bertrand, F.1    Basketter, D.A.2    Roberts, D.W.3    Lepoittevin, J.P.4
  • 11
    • 0028899066 scopus 로고
    • The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended [pi]-conjugation dramatically stabilizes the quinone methide formed from eugenol
    • Bolton, J. L., Comeau, E., and Vukomanovic, V. (1995). The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended [pi]-conjugation dramatically stabilizes the quinone methide formed from eugenol. Chem. Biol. Interact. 95, 279-290.
    • (1995) Chem. Biol. Interact. , vol.95 , pp. 279-290
    • Bolton, J.L.1    Comeau, E.2    Vukomanovic, V.3
  • 12
    • 77649182330 scopus 로고    scopus 로고
    • Evaluation of cytochrome p450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: implications for the development of in vitro techniques for predictive testing of contact sensitizers
    • Bonifas, J., Hennen, J., Dierolf, D., Kalmes, M., and Blömeke, B. (2010). Evaluation of cytochrome p450 1 (CYP1) and N-acetyltransferase 1 (NAT1) activities in HaCaT cells: implications for the development of in vitro techniques for predictive testing of contact sensitizers. Toxicol. In Vitro 24, 973-980.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 973-980
    • Bonifas, J.1    Hennen, J.2    Dierolf, D.3    Kalmes, M.4    Blömeke, B.5
  • 13
    • 79151476650 scopus 로고    scopus 로고
    • Use of the human monocytic leukemia THP-1 cell line and co-incubation with microsomes to identify and differentiate hapten and prohapten sensitizers
    • Chipinda, I., Ruwona, T. B., Templeton, S. P., and Siegel, P. D. (2011). Use of the human monocytic leukemia THP-1 cell line and co-incubation with microsomes to identify and differentiate hapten and prohapten sensitizers. Toxicology 280, 135-143.
    • (2011) Toxicology , vol.280 , pp. 135-143
    • Chipinda, I.1    Ruwona, T.B.2    Templeton, S.P.3    Siegel, P.D.4
  • 14
    • 0025818145 scopus 로고
    • Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content
    • Darley-Usmar, V. M., Severn, A., O'Leary, V. J., and Rogers, M. (1991). Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content. Biochem. J. 278, 429-434.
    • (1991) Biochem. J. , vol.278 , pp. 429-434
    • Darley-Usmar, V.M.1    Severn, A.2    O'Leary, V.J.3    Rogers, M.4
  • 15
    • 27144479286 scopus 로고    scopus 로고
    • Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization
    • Divkovic, M., Pease, C. K., Gerberick, G. F., and Basketter, D. A. (2005). Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization. Contact Dermatitis 53, 189-200.
    • (2005) Contact Dermatitis , vol.53 , pp. 189-200
    • Divkovic, M.1    Pease, C.K.2    Gerberick, G.F.3    Basketter, D.A.4
  • 16
    • 63649098913 scopus 로고    scopus 로고
    • Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound
    • Dos Santos, G. G., Reinders, J., Ouwehand, K., Rustemeyer, T., Scheper, R. J., and Gibbs, S. (2009). Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound. Toxicol. Appl. Pharmacol. 236, 372-382.
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , pp. 372-382
    • Dos Santos, G.G.1    Reinders, J.2    Ouwehand, K.3    Rustemeyer, T.4    Scheper, R.J.5    Gibbs, S.6
  • 17
    • 27944484399 scopus 로고    scopus 로고
    • Metabolism of Delta(3)-carene by human cytochrome p450 enzymes: identification and characterization of two new metabolites
    • Duisken, M., Benz, D., Peiffer, T. H., Blomeke, B., and Hollender, J. (2005). Metabolism of Delta(3)-carene by human cytochrome p450 enzymes: identification and characterization of two new metabolites. Curr. Drug Metab. 6, 593-601.
    • (2005) Curr. Drug Metab. , vol.6 , pp. 593-601
    • Duisken, M.1    Benz, D.2    Peiffer, T.H.3    Blomeke, B.4    Hollender, J.5
  • 18
    • 6544266295 scopus 로고
    • Chemically reactive functions in haptens and in proteins
    • (G. Dupuis and C. Benezra, Eds.). Dekker, New York
    • Dupuis, G., and Benezra, C. (1982). Chemically reactive functions in haptens and in proteins. In Allergic Contact Dermatitis to Simple Chemicals. A Molecular Approach (G. Dupuis and C. Benezra, Eds.), pp. 47-85. Dekker, New York.
    • (1982) Allergic Contact Dermatitis to Simple Chemicals. A Molecular Approach , pp. 47-85
    • Dupuis, G.1    Benezra, C.2
  • 19
    • 77952950728 scopus 로고    scopus 로고
    • Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro
    • Emter, R., Ellis, G., and Natsch, A. (2010). Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol. Appl. Pharmacol. 245, 281-290.
    • (2010) Toxicol. Appl. Pharmacol. , vol.245 , pp. 281-290
    • Emter, R.1    Ellis, G.2    Natsch, A.3
  • 20
    • 1442299041 scopus 로고    scopus 로고
    • Langerhans cells integrated into human reconstructed epidermis respond to known sensitizers and ultraviolet exposure
    • Facy, V., Flouret, V., Regnier, M., and Schmidt, R. (2004). Langerhans cells integrated into human reconstructed epidermis respond to known sensitizers and ultraviolet exposure. J. Invest. Dermatol. 122, 552-553.
    • (2004) J. Invest. Dermatol. , vol.122 , pp. 552-553
    • Facy, V.1    Flouret, V.2    Regnier, M.3    Schmidt, R.4
  • 21
    • 20444437874 scopus 로고    scopus 로고
    • Reactivity of Langerhans cells in human reconstructed epidermis to known allergens and UV radiation
    • Facy, V., Flouret, V., Regnier, M., and Schmidt, R. (2005). Reactivity of Langerhans cells in human reconstructed epidermis to known allergens and UV radiation. Toxicol. In Vitro 19, 787-795.
    • (2005) Toxicol. In Vitro , vol.19 , pp. 787-795
    • Facy, V.1    Flouret, V.2    Regnier, M.3    Schmidt, R.4
  • 22
    • 0018332851 scopus 로고
    • The metabolism of benzo(alpha)pyrene by cytochrome P-450 in transformable and nontransformable C3H mouse fibroblasts
    • Gehly, E. B., Fahl, W. E., Jefcoate, C. R., and Heidelberger, C. (1979). The metabolism of benzo(alpha)pyrene by cytochrome P-450 in transformable and nontransformable C3H mouse fibroblasts. J. Biol. Chem. 254, 5041-5048.
    • (1979) J. Biol. Chem. , vol.254 , pp. 5041-5048
    • Gehly, E.B.1    Fahl, W.E.2    Jefcoate, C.R.3    Heidelberger, C.4
  • 24
    • 56249123225 scopus 로고    scopus 로고
    • Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens
    • Hagvall, L., Baron, J. M., Borje, A., Weidolf, L., Merk, H., and Karlberg, A. T. (2008). Cytochrome P450-mediated activation of the fragrance compound geraniol forms potent contact allergens. Toxicol. Appl. Pharmacol. 233, 308-313.
    • (2008) Toxicol. Appl. Pharmacol. , vol.233 , pp. 308-313
    • Hagvall, L.1    Baron, J.M.2    Borje, A.3    Weidolf, L.4    Merk, H.5    Karlberg, A.T.6
  • 25
    • 33846893672 scopus 로고    scopus 로고
    • Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase
    • Han, E. H., Hwang, Y. P., Jeong, T. C., Lee, S. S., Shin, J. G., and Jeong, H. G. (2007). Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase. FEBS Lett. 581, 749-756.
    • (2007) FEBS Lett , vol.581 , pp. 749-756
    • Han, E.H.1    Hwang, Y.P.2    Jeong, T.C.3    Lee, S.S.4    Shin, J.G.5    Jeong, H.G.6
  • 26
    • 33745996629 scopus 로고    scopus 로고
    • A future approach to measuring relative skin sensitising potency: a proposal
    • Jowsey, I. R., Basketter, D. A., Westmoreland, C., and Kimber, I. (2006). A future approach to measuring relative skin sensitising potency: a proposal. J. Appl. Toxicol. 26, 341-350.
    • (2006) J. Appl. Toxicol. , vol.26 , pp. 341-350
    • Jowsey, I.R.1    Basketter, D.A.2    Westmoreland, C.3    Kimber, I.4
  • 27
    • 79958086561 scopus 로고    scopus 로고
    • Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis
    • Kim, B. S., Miyagawa, F., Cho, Y.-H., Bennett, C. L., Clausen, B. E., and Katz, S. I. (2009). Keratinocytes function as accessory cells for presentation of endogenous antigen expressed in the epidermis. J. Invest. Dermatol. 129, 2805-2817.
    • (2009) J. Invest. Dermatol. , vol.129 , pp. 2805-2817
    • Kim, B.S.1    Miyagawa, F.2    Cho, Y.-H.3    Bennett, C.L.4    Clausen, B.E.5    Katz, S.I.6
  • 29
    • 33645082936 scopus 로고    scopus 로고
    • Metabolism versus chemical transformation or proversus prehaptens?
    • Lepoittevin, J. P. (2006). Metabolism versus chemical transformation or proversus prehaptens? Contact Dermatitis 54, 73-74.
    • (2006) Contact Dermatitis , vol.54 , pp. 73-74
    • Lepoittevin, J.P.1
  • 30
    • 0021981951 scopus 로고
    • Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol
    • Lubet, R. A., Nims, R. W., Mayer, R. T., Cameron, J. W., and Schechtman, L. M. (1985). Measurement of cytochrome P-450 dependent dealkylation of alkoxyphenoxazones in hepatic S9s and hepatocyte homogenates: effects of dicumarol. Mutat. Res. 142, 127-131.
    • (1985) Mutat. Res. , vol.142 , pp. 127-131
    • Lubet, R.A.1    Nims, R.W.2    Mayer, R.T.3    Cameron, J.W.4    Schechtman, L.M.5
  • 32
    • 77955116693 scopus 로고    scopus 로고
    • A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/ EpRE-mediated gene expression in human skin cells
    • McKim, J. M., Keller, D. J., and Gorski, J. R. (2010). A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/ EpRE-mediated gene expression in human skin cells. Cutan. Ocul. Toxicol. 29, 171-192.
    • (2010) Cutan. Ocul. Toxicol. , vol.29 , pp. 171-192
    • McKim, J.M.1    Keller, D.J.2    Gorski, J.R.3
  • 33
    • 61449211195 scopus 로고    scopus 로고
    • TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation
    • Ohtani, T., Mizuashi, M., Nakagawa, S., Sasaki, Y., Fujimura, T., Okuyama, R., and Aiba, S. (2009). TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation. Immunology 126, 485-499.
    • (2009) Immunology , vol.126 , pp. 485-499
    • Ohtani, T.1    Mizuashi, M.2    Nakagawa, S.3    Sasaki, Y.4    Fujimura, T.5    Okuyama, R.6    Aiba, S.7
  • 35
    • 73349087840 scopus 로고    scopus 로고
    • The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics
    • Pickard, C., Louafi, F., McGuire, C., Lowings, K., Kumar, P., Cooper, H., Dearman, R. J., Cumberbatch, M., Kimber, I., Healy, E., et al. (2009). The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics. J. Immunol. 183, 7576-7584.
    • (2009) J. Immunol. , vol.183 , pp. 7576-7584
    • Pickard, C.1    Louafi, F.2    McGuire, C.3    Lowings, K.4    Kumar, P.5    Cooper, H.6    Dearman, R.J.7    Cumberbatch, M.8    Kimber, I.9    Healy, E.10
  • 36
    • 69049105262 scopus 로고    scopus 로고
    • Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde
    • Python, F., Goebel, C., and Aeby, P. (2009). Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol. Appl. Pharmacol. 239, 273-283.
    • (2009) Toxicol. Appl. Pharmacol. , vol.239 , pp. 273-283
    • Python, F.1    Goebel, C.2    Aeby, P.3
  • 37
    • 0027320776 scopus 로고
    • Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drugmetabolizing enzymes in the rat liver
    • Rompelberg, C. J., Verhagen, H., and van Bladeren, P. J. (1993). Effects of the naturally occurring alkenylbenzenes eugenol and trans-anethole on drugmetabolizing enzymes in the rat liver. Food Chem. Toxicol. 31, 637-645.
    • (1993) Food Chem. Toxicol. , vol.31 , pp. 637-645
    • Rompelberg, C.J.1    Verhagen, H.2    van Bladeren, P.J.3
  • 38
    • 63649113845 scopus 로고    scopus 로고
    • The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test-human cell line activation test (h-CLAT)
    • Sakaguchi, H., Ashikaga, T., Miyazawa, M., Kosaka, N., Ito, Y., Yoneyama, K., Sono, S., Itagaki, H., Toyoda, H., and Suzuki, H. (2009). The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test-human cell line activation test (h-CLAT). Cell Biol. Toxicol. 25, 109-126.
    • (2009) Cell Biol. Toxicol. , vol.25 , pp. 109-126
    • Sakaguchi, H.1    Ashikaga, T.2    Miyazawa, M.3    Kosaka, N.4    Ito, Y.5    Yoneyama, K.6    Sono, S.7    Itagaki, H.8    Toyoda, H.9    Suzuki, H.10
  • 39
    • 77956173929 scopus 로고    scopus 로고
    • Predicting skin sensitization potential and inter-laboratory reproducibility of a human cell line activation test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials
    • Sakaguchi, H., Ryan, C., Ovigne, J. M., Schroeder, K. R., and Ashikaga, T. (2010). Predicting skin sensitization potential and inter-laboratory reproducibility of a human cell line activation test (h-CLAT) in the European Cosmetics Association (COLIPA) ring trials. Toxicol. In Vitro 24, 1810-1820.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 1810-1820
    • Sakaguchi, H.1    Ryan, C.2    Ovigne, J.M.3    Schroeder, K.R.4    Ashikaga, T.5
  • 40
    • 35748932338 scopus 로고    scopus 로고
    • A loose-fit coculture of activated keratinocytes and dendritic cell-related cells for prediction of sensitizing potential
    • Schreiner, M., Peiser, M., Briechle, D., Stahlmann, R., Zuberbier, T., and Wanner, R. (2007). A loose-fit coculture of activated keratinocytes and dendritic cell-related cells for prediction of sensitizing potential. Allergy 62, 1419-1428.
    • (2007) Allergy , vol.62 , pp. 1419-1428
    • Schreiner, M.1    Peiser, M.2    Briechle, D.3    Stahlmann, R.4    Zuberbier, T.5    Wanner, R.6
  • 42
    • 0142185373 scopus 로고    scopus 로고
    • Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:-quinone oxidoreductase
    • Stiborova, M., Frei, E., Sopko, B., Sopkova, K., Markova, V., Lankova, M., Kumstyrova, T., Wiessler, M., and Schmeiser, H. H. (2003). Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:-quinone oxidoreductase. Carcinogenesis 24, 1695-1703.
    • (2003) Carcinogenesis , vol.24 , pp. 1695-1703
    • Stiborova, M.1    Frei, E.2    Sopko, B.3    Sopkova, K.4    Markova, V.5    Lankova, M.6    Kumstyrova, T.7    Wiessler, M.8    Schmeiser, H.H.9
  • 43
    • 0036257348 scopus 로고    scopus 로고
    • Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy
    • Stiborova, M., Frei, E., Sopko, B., Wiessler, M., and Schmeiser, H. H. (2002). Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy. Carcinogenesis 23, 617-625.
    • (2002) Carcinogenesis , vol.23 , pp. 617-625
    • Stiborova, M.1    Frei, E.2    Sopko, B.3    Wiessler, M.4    Schmeiser, H.H.5
  • 45
    • 70449133956 scopus 로고    scopus 로고
    • Effector and regulatory mechanisms in allergic contact dermatitis
    • Vocanson, M., Hennino, A., Rozières, A., Poyet, G., and Nicolas, J.-F. (2009). Effector and regulatory mechanisms in allergic contact dermatitis. Allergy 64, 1699-1714.
    • (2009) Allergy , vol.64 , pp. 1699-1714
    • Vocanson, M.1    Hennino, A.2    Rozières, A.3    Poyet, G.4    Nicolas, J.-F.5
  • 46
    • 0036890106 scopus 로고    scopus 로고
    • Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells
    • Zhang, Y., Gonzalez, V., and Xu, M. J. (2002). Expression and regulation of glutathione S-transferase P1-1 in cultured human epidermal cells. J. Dermatol. Sci. 30, 205-214.
    • (2002) J. Dermatol. Sci. , vol.30 , pp. 205-214
    • Zhang, Y.1    Gonzalez, V.2    Xu, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.