Metabolism of Δ3-carene by human cytochrome P450 enzymes: Identification and characterization of two new metabolites

Current Drug Metabolism

Volumn 6, Issue 6, 2005, Pages 593-601

  Duisken, Mike ^a   Benz, Dorina ^a   Peiffer, Thomas H ^a   Blömeke, Brunhilde ^b   Hollender, Juliane ^a,b  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b Department of Ecotoxicology and Toxicology ^*  (Switzerland)

Author keywords

3 carene; 3 carene 10 ol; 3 carene epoxide; Cytochrome P450; Metabolism

Indexed keywords

3 CARENE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME REDUCTASE;

BACTERIAL CELL; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; EPOXIDATION; ESCHERICHIA COLI; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROXYLATION; IN VITRO STUDY; INCUBATION TIME; KINETICS; LIVER MICROSOME; LUNG; MASS SPECTROMETRY; METABOLIC PARAMETERS; METABOLITE; MICHAELIS CONSTANT; NONHUMAN; OXIDATION; PROTEIN EXPRESSION; REVIEW; TOXICITY TESTING;

BICYCLO COMPOUNDS; CYTOCHROME P-450 ENZYME SYSTEM; EPOXY COMPOUNDS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; HYDROXYLATION; LUNG; METHANOL; MICROSOMES; MICROSOMES, LIVER; MONOTERPENES; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; SMOKING;

EID: 27944484399     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920005774832614     Document Type: Review

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