Eugenol inhibit 7,12-dimethylbenz[a]anthracene-induced genotoxicity in MCF-7 cells: Bifunctional effects on CYP1 and NAD(P)H:quinone oxidoreductase

FEBS Letters

Volumn 581, Issue 4, 2007, Pages 749-756

  Han, Eun Hee ^a   Hwang, Yong Pil ^a   Jeong, Tae Cheon ^b   Lee, Sang Seop ^c   Shin, Jae Gook ^c   Jeong, Hye Gwang ^a  

^a Research Institute of Drug Development   (South Korea)

^b Yeungnam University   (South Korea)

^c Inje University College of Medicine   (South Korea)

Author keywords

7,12 dimethylbenz a anthracene; Chemoprevention; CYP1; Eugenol; NAD(P)H:quinone oxidoreductase

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; EUGENOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; BIOTRANSFORMATION; CATALYSIS; CELL STRAIN MCF 7; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DNA BINDING; DNA DAMAGE; DOSE RESPONSE; DRUG DETOXIFICATION; DRUG INHIBITION; DRUG POTENTIATION; GENOTOXICITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; RAT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ARYL HYDROCARBON HYDROXYLASES; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DNA ADDUCTS; DNA DAMAGE; EUGENOL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICROSOMES; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; RECEPTORS, ARYL HYDROCARBON; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS);

EID: 33846893672     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.01.044     Document Type: Article

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