Langerhans Cells Integrated into Human Reconstructed Epidermis Respond to Known Sensitizers and Ultraviolet Exposure [4]

Journal of Investigative Dermatology

Volumn 122, Issue 2, 2004, Pages 552-553

  Facy, Valérie ^a   Flouret, Virginie ^a   Régnier, Marcelle ^a   Schmidt, Rainer ^a  

^a L ORÉAL RECHERCHE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; ALLERGEN; CD34 ANTIGEN; CD86 ANTIGEN; HAPTEN; IRRITANT AGENT; SUNSCREEN;

ANTIGEN PRESENTATION; CELL COUNT; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROTECTION; CELL STRUCTURE; CELL TYPE; CELLULAR DISTRIBUTION; DENDRITIC CELL; EPIDERMIS; HUMAN; IMMUNE DEFICIENCY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KERATINOCYTE; LANGERHANS CELL; LETTER; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; ULTRAVIOLET IRRADIATION; UPREGULATION;

EID: 1442299041     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-202X.2004.22209.x     Document Type: Letter

References (14)

1. Aberer W, Schuler G, Stingl G, Hönigsmann H, Wolff K: Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 76:202-210, 1981
2. Aiba S, Terunuma A, Manome H, Tagami H: Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur J Immunol 27:3031-3038, 1997
3. Aiba S, Manome H, Yoshino Y, Tagami H: In vitro treatment of human transforming growth factor-β1-treated monocyte-derived dendritic cells with haptens can induce the phenotypic and functional changes similar to epidermal Langerhans cells in the initiation phase of allergic contact sensitivity reaction. Immunology 101:68-75, 2000
4. Bacci S, Romagnoli P, Strellein W: Reduction in number and morphologic alterations of Langerhans cells after UVB radiation in vivo are accompanied by an influx of monocytoid cells into epidermis. J Invest Dermatol 111:1134-1139, 1998
5. Cooper KD, Oberhelman L, Hamilton TA, et al: UV exposure reduces immunization rates and promotes tolerance to epicutaneous antigens in human: Relationship to dose CD1a-DR + epidermal macrophage induction and Langerhans cell depletion. Proc Natl Acad Sci USA 89:8497-8501, 1992
6. Dumay O, Karam A, Vian D, et al: Ultraviolet AI exposure of human skin results in Langerhans cell depletion and reduction of epidermal antigen-presenting cell function: Partial protection by a broad-spectrum sunscreen. Br J Dermatol 144:1161-1168, 2001
7. Kelly DA, Walker SL, McGregor JM, Young AR: A single exposure of solar simulated radiation suppresses contact hypersensitivity responses both locally and systemically in humans: Quantitative studies with high-frequency ultrasound. J Photochem Photobiol B 44:130-142, 1998
8. Kripke ML, Morison WL: Modulation of immune function by UV radiation. J Invest Dermatol 85:62S-66S, 1985
9. Larsen CP, Steinman RM, Witmer-Pack M, Hankins DF, Morris PJ, Austyn JM: Migration and maturation of Langerhans cells in skin transplants and explants. J Exp Med 172:1483-1493, 1990
10. Moyal DD, Fourtanier AM: Broad-spectrum sunscreens provide better protection from the suppression of the elicitation phase of delayed-type hypersensitivity response in humans. J Invest Dermatol 117:1186-1192, 2001
11. Neale R, Russell A, Muller HK, Green A: Sun exposure, sunscreen and their effect on epidermal Langerhans cells. Photochem Photobiol 66:260-264, 1997
12. Rėgnier M, Staquet MJ, Schmitt D, Schmidt R: Integration of Langerhans cells into a pigmented reconstructed human epidermis. J Invest Dermatol 109:510-512, 1997
13. Schempp CM, Dittmar HC, Hummler D, Simon-Haarhaus B, Schulte- Mönting J, Schöpf E, Simon JC: Magnesium ions inhibit the antigen-presenting function of human epidermal Langerhans cells in vivo and in vitro. Involvement of ATPase, HLA-DR, B7 molecules, and cytokines. J Invest Dermatol 115:680-686, 2000
14. Ullrich SE: Modulation of immunity by ultraviolet radiation: Key effects or antigen presentation. J Invest Dermatol 105:30s-36s, 1995