Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde

Toxicology and Applied Pharmacology

Volumn 239, Issue 3, 2009, Pages 273-283

  Python, François ^a   Goebel, Carsten ^b   Aeby, Pierre ^a  

^a Wella Cosmital SA   (Switzerland)

^b PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Cell line; Dendritic cell; In vitro; Microarray; Sensitizer; Skin sensitization

Indexed keywords

CARBOXYLESTERASE; CARBOXYLESTERASE 1; CELL PROTEIN; CINNAMALDEHYDE; IRON BINDING PROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE; TRANSCRIPTION FACTOR NRF2; TRIPARTITE MOTIF PROTEIN 16; UNCLASSIFIED DRUG;

ARTICLE; CELL ACTIVATION; CELL STRAIN U937; COMPARATIVE STUDY; CONTROLLED STUDY; DENDRITIC CELL; DNA MICROARRAY; DRUG SCREENING; EXPOSURE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN SENSITIZATION; UNINDEXED SEQUENCE;

ACROLEIN; CELL LINE, TUMOR; CELL SURVIVAL; DERMATITIS, CONTACT; FLOW CYTOMETRY; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; LANGERHANS CELLS; MONOCYTES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SKIN;

ANIMALIA;

EID: 69049105262     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.06.003     Document Type: Article

References (53)

1. Ade N., Leon F., Pallardy M., Peiffer J.L., Kerdine-Romer S., Tissier M.H., Bonnet P.A., Fabre I., and Ourlin J.C. HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway. Toxicol. Sci. 107 2 (2009) 451-460
2. Aeby P., Wyss C., Beck H., Griem P., Scheffler H., and Goebel C. Characterization of the sensitizing potential of chemicals by in vitro analysis of dendritic cell activation and skin penetration. J. Invest. Dermatol. 122 (2004) 1154-1164
3. Aeby P., Python F., and Goebel C. Skin sensitization: understanding the in vivo situation for the development of reliable in vitro test approaches. Altex 24 (2007) 3-5 Special Issue
4. Aeby P., Sieber T., Beck H., Gerberick G.F., and Goebel C. Skin sensitization to p-phenylenediamine: the diverging roles of oxidation and N-acetylation for dendritic cell activation and the immune response. J. Invest. Dermatol. 129 1 (2009) 99-109
5. Aiba S., Terunuma A., Manome H., and Tagami H. Dendritic cells differently respond to haptens and irritants by their production of cytokines and expression of co-stimulatory molecules. Eur. J. Immunol. 27 (1997) 3031-3038
6. Ashburner M., Ball C.A., Blake J.A., Botstein D., Butler H., Cherry J.M., Davis A.P., Dolinski K., Dwight S.S., and Eppig J.T. Gene ontology: tool for the unification of biology. Nat. Genet. 25 (2000) 25-29
7. Azam P., Peiffer J.L., Chamousset D., Tissier M.H., Bonnet P.A., Vian L., Fabre I., and Ourlin J.C. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol. Appl. Pharmacol. 212 (2006) 14-23
8. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-252
9. Basketter D.A., Gerberick G.F., and Kimber I. The local lymph node assay: current position in the regulatory classification of skin sensitizing chemicals. Cutan. Ocul. Toxicol. 26 4 (2007) 293-301
10. Beer H.D., Munding C., Dubois N., Mamie C., Hohl D., and Werner S. The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation. J. Biol. Chem. 277 23 (2002) 20740-20749
11. Boislève F., Kerdine-Römer S., Rougier-Larzat N., and Pallardy M. Nickel and DNCB induce CCR7 expression on human dendritic cells through different signalling pathways: role of TNF-α and MAPK. J. Invest. Dermatol. 123 (2004) 494-502
12. Casati S., Aeby P., Basketter D.A., Cavani A., Gennari A., Gerberick G.F., Griem P., Hartung T., Kimber I., Lepoittevin J.P., Meade B.J., Pallardy M., Rougier N., Rousset F., Rubinstenn G., Sallusto F., Verheyen G.R., and Zuang V. Dendritic cells as a tool for the predictive identification of skin sensitization hazard. ATLA 33 (2005) 47-62
13. Dinkova-Kostova A.T., Holtzclaw W.D., and Kensler T.W. The role of Keap1 in cellular protective responses. Chem. Res. Toxicol. 18 12 (2005) 1779-1791
14. Gerberick G.F., Ryan C.A., Dearman R.J., and Kimber I. Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals. Methods 41 1 (2007) 54-60
15. Gerberick G.F., Vassallo J.D., Foertsch L.M., Price B.B., Chaney J.G., and Lepoittevin J.P. Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicol. Sci. 97 2 (2007) 417-427
16. Hirota M., and Moro O. MIP-1β, a novel biomarker for in vitro sensitization test using human monocytic cell line. Toxicol. In Vitro 20 (2006) 736-742
17. Hu Z.B., Ma W., Zaborski M., MacLeod RAF., Quentmeier H., and Drexler H.G. Establishment and characterization of two novel cytokine-responsive acute myeloid and monocytic leukemia cell lines, MUTZ-2 and MUTZ-3. Leukemia 10 (1996) 1025-1040
18. Hulette B.C., Ryan C.A., and Gerberick G.F. Elucidating changes in surface marker expression of dendritic cells following chemical allergen treatment. Toxicol. Appl. Pharmacol. 182 (2002) 226-233
19. Hulette B.C., Ryan C.A., Gildea L.A., and Gerberick G.F. Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen. Toxicol. Appl. Pharmacol. 209 2 (2005) 159-166
20. Jowsey I.R., Basketter D.A., Westmoreland C., and Kimber I. A future approach to measuring relative skin sensitising potency: a proposal. J. Appl. Toxicol. 26 4 (2006) 341-350
21. Kimber I., Dearman R.J., Basketter D.A., Ryan C.A., and Gerberick G.F. The local lymph node assay: past, present and future. Contact Dermatitis 47 (2002) 315-328
22. Kwak M.-K., Wakabayashi N., and Kensler T.W. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat. Res. 555 (2004) 133-148
23. Larsson K., Lindstedt M., and Borrebaek C.A.K. Functional and transcriptional profiling of MUTZ-3, a myeloid cell line acting as a model for dendritic cells. Immunology 117 (2006) 156-166
24. Leon F., Peiffer J.L., Tissier M.H., Bonnet P.-A., Fabre I., and Ourlin J.C. Chemical sensitizers activate stress-response genes HMOX1 and NQO1 in THP-1 and U-937 cells. Toxicol. Lett. 172S (2007) S85-S86 (Poster presentation)
25. Masterson J.A., Sombroek C.C., de Gruijl T.D., Graus Y.M.F., van der Vliet H.J.J., Lougheed S.M., van den Eertwegh A.J.M., Pinedo H.M., and Scheper R.J. MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors. Blood 100 2 (2002) 701-703
26. Mitjans M., Viviani B., Lucchi L., Galli C.L., Marinovich M., and Corsini E. Role of p38 MAPK in the selective release of IL-8 induced by chemical allergen in naïve THP-1 cells. Toxicol. In Vitro 22 2 (2008) 386-395
27. Munding C., Keller M., Niklaus G., Papin S., Tschopp J., Werner S., and Beer H.D. The estrogen-responsive B box protein: a novel enhancer of interleukin-1β secretion. Cell Death Differ. 13 11 (2006) 1938-1949
28. Natsch A., and Emter R. Skin sensitizers induce antioxidant response element dependent genes: application to the in vitro testing of the sensitization potential of chemicals. Toxicol. Sci. 102 1 (2008) 110-119
29. Nioi P., and Hayes J.D. Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors. Mutat. Res. 555 (2004) 149-171
30. Nukada Y., Miyazawa M., Kosaka N., Ito Y., Sakaguchi H., and Nishiyama N. Production of IL-8 in THP-1 cells following contact allergen stimulation via mitogen-activated protein kinase activation or tumor necrosis factor-α production. J. Toxicol. Sci. 33 2 (2008) 175-185
31. Pang H., Bartlam M., Zeng Q., Miyatake H., Hisano T., Miki K., Wong L.L., Gao G.F., and Rao Z. Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor. J. Biol. Chem. 279 2 (2004) 1491-1498
32. Patlewicz G., Aptula A.O., Roberts D.W., and Uriarte E. A minireview of available skin sensitization (Q)SARs/expert systems. QSAR Comb. Sci. 27 1 (2008) 60-76
33. Python F., Goebel C., and Aeby P. Assessment of the U937 cell line for the detection of contact allergens. Toxicol. Appl. Pharmacol. 220 (2007) 113-124
34. Ross D., Kepa J.K., Winski S.L., Beall H.D., Anwar A., and Siegel D. NAD(P)H: quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms. Chem. Biol. Interact. 129 (2000) 77-97
35. Ryan C.A., Gildea L.A., Hulette B.C., Dearman R.J., Kimber I., and Gerberick G.F. Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen. Toxicol. Lett. 150 (2004) 301-316
36. Ryan C.A., Gerberick G.F., Gildea L.A., Hulette B.C., Betts C.J., Cumberbatch M., Dearman R.J., and Kimber I. Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessment. Toxicol. Sci. 88 1 (2005) 4-11
37. Ryan C.A., Kimber I., Basketter D.A., Pallardy M., Gildea L.A., and Gerberick G.F. Dendritic cells and skin sensitization: biological roles and uses in hazard identification. Toxicol. Appl. Pharmacol. 221 3 (2007) 384-394
38. Sakaguchi H., Miyazawa M., Yoshida Y., Ito Y., and Suzuki H. Prediction of preservative sensitization potential using surface marker CD86 and/or CD54 expression on human cell line, THP-1. Arch. Dermatol. Res. 298 (2007) 427-437
39. Sakaguchi H., Ashikaga T., Miyazawa M., Kosaka N., Ito Y., Yoneyama K., Sono S., Itagaki H., Toyoda H., and Suzuki H. The relationship between CD86/CD54 expression and THP-1 cell viability in an in vitro skin sensitization test - human cell line activation test (h-CLAT). Cell Biol. Toxicol. 25 2 (2009) 109-126
40. Satoh T., and Hosokawa M. Structure, function and regulation of carboxylesterases. Chem. Biol. Interact. 162 3 (2006) 195-211
41. + Langerhans cell precursor. J. Leukocyte Biol. 80 6 (2006) 1337-1344
42. Schoeters E., Nuijten J.-M., van den Heuvel R.L., Nelissen I., Witters H., Schoeters G.E.R., van Tendeloo V.F., Berneman Z.N., and Verheyen G.R. Gene expression signatures in CD34+-progenitor-derived dendritic cells exposed to the chemical contact allergen nickel sulfate. Toxicol. Appl. Pharmacol. 216 (2006) 131-149
43. Schoeters E., Verheyen G.R., Nelissen I., Van Rompay A.R., Hooyberghs J., van den Heuvel R.L., Witters H., Schoeters G.E., van Tendeloo F., and Berneman Z.N. Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol. Immunol. 44 12 (2007) 3222-3233
44. Staquet M.J., Sportouch M., Jacquet C., Schmitt D., Guesnet J., and Péguet-Navarro J. Moderate skin sensitizers can induce phenotypic changes on in vitro generated dendritic cells. Toxicol. In Vitro 18 (2004) 493-500
45. Tietze C., and Blömeke B. Sensitization assays: monocyte-derived dendritic cells versus a monocytic cell line (THP-1). J. Toxicol. Environ. Health A 71 13-14 (2008) 965-968
46. Toebak M.J., Pohlmann P.R., Sampat-Sardjoepersad S.C., von Blomberg B.M.E., Bruynzeel D.P., Scheper R.J., Rustemeyer T., and Gibbs S. CXCL8 secretion by dendritic cells predicts contact allergens from irritants. Toxicol. In Vitro 20 (2006) 117-124
47. Tusher V.G., Tibshirani R., and Chu G. Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. U. S. A. 98 9 (2001) 5116-5121
48. Thimmulappa R.K., Mai K.H., Srisuma S., Kensler T.W., Yamamoto M., and Biswal S. Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray. Cancer Res. 62 18 (2002) 5196-5203
49. Vandebriel R.J., Van Och F.M., and van Loveren H. In vitro assessment of sensitizing activity of low molecular weight compounds. Toxicol. Appl. Pharmacol. 207 (2005) S142-S148
50. Verstraelen S., Wens B., Hooyberghs J., Nelissen I., Witters H., Schoeters G., Cauwenberge P.V., and Heuvel R.V. Gene expression profiling of in vitro cultured macrophages after exposure to the respiratory sensitizer hexamethylene diisocyanate. Toxicol. In Vitro 22 4 (2008) 1107-1114
51. Wakabayashi N., Dinkova-Kostova A.T., Holtzclaw W.D., Kang M.I., Kobayashi A., Yamamoto M., Kensler T.W., and Talalay P. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc. Natl. Acad. Sci. U. S. A. 101 7 (2004) 2040-2045
52. Yoshida Y., Sakaguchi H., Ito Y., Okuda M., and Suzuki H. Evaluation of the skin sensitization potential of chemicals using expression of co-stimulatory molecules, CD54 and CD86, on the naive THP-1 cell line. Toxicol. In Vitro 17 (2003) 221-228
53. Zhang X., Chen X., Song H., Chen H.-Z., and Rovin B.H. Activation of the Nrf2/antioxidant response pathway increases IL-8 expression. Eur. J. Immunol. 35 (2005) 3258-3267