Insights into the molecular activation mechanism of the RhoA-specific guanine nucleotide exchange factor, PDZRhoGEF

Journal of Biological Chemistry

Volumn 286, Issue 40, 2011, Pages 35163-35175

  Bielnicki, Jakub A ^a   Shkumatov, Alexander V ^b   Derewenda, Urszula ^a   Somlyo, Avril V ^a   Svergun, Dmitri I ^b   Derewenda, Zygmunt S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOINHIBITION; BINDING SURFACE; BIOCHEMICAL METHODS; CRITICAL STEPS; CYTOSOLS; G PROTEIN; G PROTEIN COUPLED RECEPTORS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MOLECULAR ACTIVATION; MOLTEN GLOBULE; MULTIDOMAIN PROTEINS; NUCLEOTIDE-EXCHANGE FACTOR; PLECKSTRIN HOMOLOGY; REGULATION MECHANISMS; TWO-TIER MODELS;

BINDING SITES; NUCLEOTIDES;

PROTEINS;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PDZ PROTEIN; PROTEIN PRG; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONTROLLED STUDY; HUMAN; MOLECULAR MECHANICS; MUTATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN TARGETING; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; BINDING SITES; CIRCULAR DICHROISM; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LIGHT; MODELS, STATISTICAL; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RHOA GTP-BINDING PROTEIN; SCATTERING, RADIATION; SEQUENCE HOMOLOGY, AMINO ACID; ULTRAVIOLET RAYS; X-RAYS;

EID: 80053404901     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.270918     Document Type: Article

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