Structure of the RGS-like domain from PDZ-RhoGEF: Linking heterotrimeric G protein-coupled signaling to Rho GTPases

Structure

Volumn 9, Issue 7, 2001, Pages 559-569

  Longenecker, Kenton L ^a   Lewis, Mary E ^a   Chikumi, Hiroki ^b   Gutkind, J Silvio ^b   Derewenda, Zygmunt S ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

G 12 13; GPCR signaling; GTRAP48; KIAA0380; RGS proteins; RhoGEF

Indexed keywords

ALANINE; GLUTAMIC ACID; GUANOSINE TRIPHOSPHATASE; LYSINE; PROTEIN PDZ RHOGEF; RECOMBINANT DNA; RGS PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MUTAGENESIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; ESCHERICHIA COLI; GENE CONSTRUCT; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; EPITOPES; GREEN FLUORESCENT PROTEINS; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; LUMINESCENT PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; RGS PROTEINS; RHO GTP-BINDING PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

ESCHERICHIA COLI;

EID: 0034928967     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00620-7     Document Type: Article

References (54)

1. Rho GTPases and the actin cytoskeleton
2. Rho GTPases and their effector proteins
3. The Rho family G proteins play a critical role in muscle differentiation
4. A balance of signaling by Rho family small GTPases RhoA, Rac1 and Cdc42 coordinates cytoskeletal morphology but not cell survival
5. Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells
6. Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
7. Untying the Gordian knot of cytokinesis. Role of small G proteins and their regulators
8. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II
9. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
10. Rho family proteins and Ras transformation: The RHOad less traveled gets congested
11. The role of Rho in G protein-coupled receptor signal transduction
12. Rho as a mediator of G protein-coupled receptor signaling
13. Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13
14. A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho
15. Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member
16. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins
17. Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G12 family to Rho
18. Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with MLL in acute myeloid leukemia
19. GEFs, GAPs, GDIs and effectors: Taking a closer (3D) look at the regulation of Ras-related GTP-binding proteins
20. Dbl family proteins
21. The DH protein family, exchange factors for Rho-like GTPases
22. Signaling through scaffold, anchoring, and adaptor proteins
23. Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors
24. Identification of a novel guanine nucleotide exchange factor for the Rho GTPase
25. The Rho GTPase and a putative RhoGEF mediate a signaling pathway for the cell shape changes in Drosophila gastrulation
26. DRhoGEF2 encodes a member of the Dbl family of oncogenes and controls cell shape changes during gastrulation in Drosophila
27. Divergence of RGS proteins: Evidence for the existence of six mammalian RGS subfamilies
28. GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins
29. The regulator of G protein signaling family
30. p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13
31. Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein
32. Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1
33. Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
34. Crystal structures of a complexed and peptide-free membrane protein-binding domain: Molecular basis of peptide recognition by PDZ
35. NMR structure of free RGS4 reveals an induced conformational change upon binding Galpha
36. Solution structure of human GAIP (Galpha interacting protein): A regulator of G protein signaling
37. Structural basis of the Axin-adenomatous polyposis coli interaction
38. Structure of RGS4 bound to AlF4-activated G(i alpha 1): Stabilization of the transition state for GTP hydrolysis
39. Protein crystallization by rational mutagenesis of surface residues: Lys to Ala mutations promote crystallization of RhoGDI
40. Expression, purification and crystallization of the RGS-like domain from the Rho nucleotide exchange factor, PDZ-RhoGEF, using the surface entropy reduction approach
41. Procheck: A program to check the stereochemical quality of protein structures
42. The 2.0 Å crystal structure of a heterotrimeric G protein
43. Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue
44. Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP
45. Signaling from G protein-coupled receptors to ERK5/Big MAPK 1 involves Galpha q and Galpha 12/13 families of heterotrimeric G proteins. Evidence for the existence of a novel Ras AND Rho-independent pathway
46. Processing of X-Ray diffraction data collected in oscillation mode
47. The CCP4 (Collaborative Computational Project Number 4) suite: Programs for protein crystallography
48. Automated MAD and MIR structure solution
49. Improved methods for building protein models in electron density maps and the location of errors in these models
50. Crystallography & NMR system: A new software suite for macromolecular structure determination
51. On the treatment of negative intensity observations
52. Molscript: A program to produce both detailed and schematic plots of protein structures
53. An extensively modified version of Mol-Script that includes greatly enhanced coloring capabilities
54. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons