Crystal structure of the Rac activator, asef, reveals its autoinhibitory mechanism

Journal of Biological Chemistry

Volumn 282, Issue 7, 2007, Pages 4238-4242

  Murayama, Kazutaka ^a,b   Shirouzu, Mikako ^b   Kawasaki, Yoshihiro ^c   Kato Murayama, Miyuki ^b   Hanawa Suetsugu, Kyoko ^b   Sakamoto, Ayako ^b   Katsura, Yasuhiro ^b,d   Suenaga, Atsushi ^b   Toyama, Mitsutoshi ^b   Terada, Takaho ^b   Taiji, Makoto ^b   Akiyama, Tetsu ^c   Yokoyama, Shigeyuki ^b,c  

^a TOHOKU UNIVERSITY   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE; PLECKSTRIN HOMOLOGY (PH); TUMOR CELLS;

BINDING SITES; CRYSTAL STRUCTURE; GENES; MOLECULAR STRUCTURE; NUCLEOTIDES; TUMORS;

PEPTIDES;

ASEF PROTEIN; PEPTIDE; PROLINE DERIVATIVE; PROTEIN; PROTEIN SH3; RAC PROTEIN; UNCLASSIFIED DRUG; APC PROTEIN; ARHGEF4 PROTEIN, HUMAN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MCF2 PROTEIN, HUMAN; ONCOPROTEIN; POLYPROLINE;

ANIMAL CELL; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN COS7; CONTROLLED STUDY; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TERTIARY STRUCTURE; ANIMAL; CELL MOTION; CHEMISTRY; COLORECTAL TUMOR; GENETICS; HUMAN; METABOLISM; MUTATION; SRC HOMOLOGY DOMAIN; STRUCTURAL HOMOLOGY; X RAY CRYSTALLOGRAPHY;

ADENOMATOUS POLYPOSIS COLI PROTEIN; AMINO ACID MOTIFS; ANIMALS; CELL MOVEMENT; COLORECTAL NEOPLASMS; CRYSTALLOGRAPHY, X-RAY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MUTATION; PEPTIDES; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; RAS GUANINE NUCLEOTIDE EXCHANGE FACTORS; SRC HOMOLOGY DOMAINS; STRUCTURAL HOMOLOGY, PROTEIN;

EID: 33947520119     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C600234200     Document Type: Article

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