Bound water at protein-protein interfaces: Partners, roles and hydrophobic bubbles as a conserved motif

PLoS ONE

Volumn 6, Issue 9, 2011, Pages

  Ahmed, Mostafa H ^a   Spyrakis, Francesca ^b,c   Cozzini, Pietro ^b,c   Tripathi, Parijat K ^b   Mozzarelli, Andrea ^b,c   Scarsdale, J Neel ^a   Safo, Martin A ^a   Kellogg, Glen E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF PARMA   (Italy)

^c Institute of Biostructures and Biosystems   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

WATER; AMINO ACID; PROTEIN; PROTEIN SERINE THREONINE KINASE; SOLVENT; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR BETA3; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; GEOMETRY; HYDRATION; HYDROGEN BOND; HYDROPHOBICITY; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; PROCESS OPTIMIZATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; ALGORITHM; CHEMICAL MODEL; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; CLASSIFICATION; CLUSTER ANALYSIS; HUMAN; METABOLISM; PH; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SURFACE PROPERTY; THERMODYNAMICS; X RAY CRYSTALLOGRAPHY;

ALGORITHMS; AMINO ACID MOTIFS; AMINO ACIDS; CLUSTER ANALYSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PROTEINS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SOLVENTS; SURFACE PROPERTIES; THERMODYNAMICS; TRANSFORMING GROWTH FACTOR BETA3; WATER;

EID: 80053090565     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0024712     Document Type: Article

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