Synthesis and anti-picornaviridae in vitro activity of a new class of helicase inhibitors the N,N′-bis[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl] alkyldicarboxamides

Medicinal Chemistry

Volumn 3, Issue 6, 2007, Pages 520-532

  Carta, A ^a   Loriga, M ^a   Piras, S ^a   Paglietti, G ^a   Ferrone, M ^b   Fermeglia, M ^b   Pricl, S ^b   La Colla, P ^c   Collu, G ^c   Sanna, T ^c   Loddo, R ^c  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Anti viral activity; Benzotriazol 1(2) yl phenylalkyldicarboxamides; Cytotoxicity; Flaviviridae; Helicase; In silico evaluation; Picornaviridae; SAR

Indexed keywords

ANTIINFECTIVE AGENT; ANTIPICORNAVIRUS AGENT; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOTRIAZOLE DERIVATIVE; BENZOTRIAZOLODICARBOXAMIDE DERIVATIVE; HELICASE INHIBITOR; N,N' BIS[4 (1H BENZOTRIAZOL 1 YL)PHENYL]ADIPYLCARBOXAMIDE; N,N' BIS[4 (1H BENZOTRIAZOL 1 YL)PHENYL]ALKYLDICARBOXAMIDE DERIVATIVE; N,N' BIS[4 (1H BENZOTRIAZOL 1 YL)PHENYL]GLUTARYLCARBOXAMIDE; N,N' BIS[4 (1H BENZOTRIAZOL 1 YL)PHENYL]SUCCINYLCARBOXAMIDE; N,N' BIS[4 (2 BENZIMIDAZOLYL)PHENYL]ALKYLDICARBOXAMIDE DERIVATIVE; N,N' BIS[4 (2 BENZIMIDAZOLYL)PHENYL]SUCCINYLCARBOXAMIDE DERIVATIVE; N,N' BIS[4 (2H BENZOTRIAZOL 2 YL)PHENYL]ADIPYLCARBOXAMIDE; N,N' BIS[4 (2H BENZOTRIAZOL 2 YL)PHENYL]ALKYLDICARBOXAMIDE DERIVATIVE; N,N' BIS[4 (2H BENZOTRIAZOL 2 YL)PHENYL]GLUTARYLCARBOXAMIDE; N,N' BIS[4 (2H BENZOTRIAZOL 2 YL)PHENYL]SUCCINYLCARBOXAMIDE; N,N' BIS[4 (5 TRIFLUOROMETHYL 1H BENZOTRIAZOL 1 YL)PHENYL]SUCCINYLCARBOXAMIDE; N,N' BIS[4 (5 TRIFLUOROMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]SUCCINYLCARBOXAMIDE; N,N' BIS[4 (5,6 DICHLORO 2H BENZOTRIAZOL 2 YL)PHENYL]ADIPYLCARBOXAMIDE; N,N' BIS[4 (5,6 DICHLORO 2H BENZOTRIAZOL 2 YL)PHENYL]ALKYLDICARBOXAMIDE DERIVATIVE; N,N' BIS[4 (5,6 DICHLORO 2H BENZOTRIAZOL 2 YL)PHENYL]GLUTARYLCARBOXAMIDE; N,N' BIS[4 (5,6 DICHLORO 2H BENZOTRIAZOL 2 YL)PHENYL]SUCCINYLCARBOXAMIDE; N,N' BIS[4 (5,6 DIMETHYL 1H BENZOTRIAZOL 1 YL)PHENYL]SUCCINYLCARBOXAMIDE; N,N' BIS[4 (5,6 DIMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]ADIPYLCARBOXAMIDE; N,N' BIS[4 (5,6 DIMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]ALKYLDICARBOXAMIDE DERIVATIVE; N,N' BIS[4 (5,6 DIMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]GLUTARYLCARBOXAMIDE; N,N' BIS[4 (5,6 DIMETHYL 2H BENZOTRIAZOL 2 YL)PHENYL]SUCCINYLCARBOXAMIDE; N,N' BIS[4 (6 TRIFLUOROMETHYL 1H BENZOTRIAZOL 1 YL)PHENYL]SUCCINYLCARBOXAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; BOVINE DIARRHEA VIRUS; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; COXSACKIE VIRUS B; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; NONHUMAN; PICORNAVIRUS; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS STRAIN; YELLOW FEVER FLAVIVIRUS;

AMIDES; ANTIVIRAL AGENTS; CELL LINE; CELL SURVIVAL; ENTEROVIRUS; FLAVIVIRIDAE; HUMANS; PICORNAVIRIDAE; RNA HELICASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 37349033895     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607782360308     Document Type: Article

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