Functional analyses and molecular modeling of two c-Kit mutations responsible for imatinib secondary resistance in GIST patients

Oncogene

Volumn 25, Issue 45, 2006, Pages 6140-6146

  Tamborini, E ^a   Pricl, S ^b   Negri, T ^a   Lagonigro, M S ^a   Miselli, F ^a   Greco, A ^a   Gronchi, A ^a   Casali, P G ^a   Ferrone, M ^b   Fermeglia, M ^b   Carbone, A ^a   Pierotti, M A ^a,c   Pilotti, S ^a  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

^c FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

Author keywords

Gastrointestinal stromal tumors (GIST); Imatinib secondary resistance; Molecular modeling

Indexed keywords

ALANINE; IMATINIB; ISOLEUCINE; THREONINE; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CANCER RESISTANCE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SENSITIVITY; GASTROINTESTINAL STROMAL TUMOR; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; MOLECULAR MODEL; NONHUMAN; ONCOGENE C KIT; PLASMID; POINT MUTATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE;

ANTINEOPLASTIC AGENTS; DRUG RESISTANCE, NEOPLASM; GASTROINTESTINAL STROMAL TUMORS; HUMANS; MODELS, MOLECULAR; MUTATION; PIPERAZINES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES;

EID: 33749824425     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209639     Document Type: Article

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