Antimycobacterial activity of new 3,5-disubstituted 1,3,4-oxadiazol-2(3H)-one derivatives. Molecular modeling investigations

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4693-4707

  Zampieri, Daniele ^a   Mamolo, Maria Grazia ^a   Laurini, Erik ^a   Fermeglia, Maurizio ^a   Posocco, Paola ^a   Pricl, Sabrina ^a   Banfi, Elena ^a   Scialino, Giuditta ^a   Vio, Luciano ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

3,5 Disubstituted 1,3,4 oxadiazol 2(3H) one derivatives; Antimycobacterial activity; Molecular modeling

Indexed keywords

1,3,4 OXADIAZOL 2(3H) ONE DERIVATIVE; 3 [(2 METHYLPIPERIDIN 1 YL)METHYL] 5 PYRIDIN 2 YL 1,3,4 OXADIAZOL 2(3H) ONE; 3 [(3 METHYLPIPERIDIN 1 YL)METHYL] 5 PYRIDIN 2 YL 1,3,4 OXADIAZOL 2(3H) ONE; 3 [(4 METHYLPIPERIDIN 1 YL)METHYL] 5 PYRIDIN 2 YL 1,3,4 OXADIAZOL 2(3H) ONE; 3 [(PIPERIDIN 1 YL)METHYL] 5 PYRIDIN 2 YL 1,3,4 OXADIAZOL 2(3H) ONE; 5 (PYRIDIN 2 YL) 1,3,4 OXADIAZOL 2(3H) ONE; ANTIMYCOBACTERIAL AGENT; CYTOCHROME P450; ISONIAZID; OXADIAZOLE DERIVATIVE; RIFAMPICIN; STEROL 14ALPHA DEMETHYLASE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; CALCULATION; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; IN VITRO STUDY; MATHEMATICAL COMPUTING; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MODEL; MYCOBACTERIUM TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS H37RV; NONHUMAN; STEROL SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; OXADIAZOLES; PROTEIN BINDING; THERMODYNAMICS; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 66749144739     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.04.055     Document Type: Article

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