New antimitotic agents with activity in multi-drug-resistant cell lines and in vivo efficacy in murine tumor models

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4416-4430

  Szczepankiewicz, B G bruce g ^a   Chiou, W J ^a   Credo, R B ^a   Alder, J D ^a   Nukkala, M A ^a   Zielinski, N A ^a   Jarvis, K ^a   Mollison, K W ^a   Frost, D J ^a   Bauch, J L ^a   Hui, Y H ^a   Liu, G bruce g ^a   Claiborne, A K ^a   Li, Q ^a   Rosenberg, S H ^a   Jae, H S ^a   Tasker, A S ^a,b   Gunawardana, I W ^a   Von Geldern, T W ^a   Gwaltney II, S L ^a   Wu Wong, J R ^a   Gehrke, L ^a   more..

^a ABBOTT LABORATORIES   (United States)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 METHYL 2,3 DIHYDROINDOL 5 YL) 5 (3,4,5 TRIMETHOXYPHENYL) DELTA2,3 OXAZOLINE; A 105972; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; OXAZOLINE DERIVATIVE; PACLITAXEL; UNCLASSIFIED DRUG; VINCRISTINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG HALF LIFE; DRUG SCREENING; DRUG STRUCTURE; FEMALE; MALE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLCHICINE; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; OXAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0035818922     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010231w     Document Type: Article

References (16)

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