메뉴 건너뛰기




Volumn 134, Issue 9, 2011, Pages 2703-2721

Impaired neurosteroid synthesis in multiple sclerosis

Author keywords

experimental autoimmune encephalomyelitis; microRNA; multiple sclerosis; neurosteroid

Indexed keywords

20ALPHA3ALPHA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE 3; CD3EPSILON PROTEIN; CELL PROTEIN; HYDROXYSTEROID DEHYDROGENASE; IBA1 PROTEIN; INTERLEUKIN 8; MESSENGER RNA; MICRORNA; MYELIN; NEUROSTEROID; PRASTERONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 80052925627     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/awr200     Document Type: Article
Times cited : (192)

References (70)
  • 2
    • 33644817555 scopus 로고    scopus 로고
    • Human peripheral blood mononuclear cells express GABAA receptor subunits
    • DOI 10.1016/j.molimm.2005.07.025, PII S0161589005003044
    • Alam S, Laughton DL, Walding A, Wolstenholme AJ. Human peripheral blood mononuclear cells express GABAA receptor subunits. Mol Immunol 2006; 43: 1432-42. (Pubitemid 43356383)
    • (2006) Molecular Immunology , vol.43 , Issue.9 , pp. 1432-1442
    • Alam, S.1    Laughton, D.L.2    Walding, A.3    Wolstenholme, A.J.4
  • 3
    • 0035966319 scopus 로고    scopus 로고
    • MicroRNAs: Tiny regulators with great potential
    • DOI 10.1016/S0092-8674(01)00616-X
    • Ambros V. microRNAs: tiny regulators with great potential. Cell 2001; 28; 107: 823-6. (Pubitemid 34084973)
    • (2001) Cell , vol.107 , Issue.7 , pp. 823-826
    • Ambros, V.1
  • 4
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • DOI 10.1038/nature02871
    • Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-5. (Pubitemid 39265675)
    • (2004) Nature , vol.431 , Issue.7006 , pp. 350-355
    • Ambros, V.1
  • 6
    • 9744228702 scopus 로고    scopus 로고
    • Neurosteroidogenesis: Relevance to neurosteroid actions in brain and modulation by psychotropic drugs
    • DOI 10.1615/CritRevNeurobiol.v16.i12.70
    • Barbaccia ML. Neurosteroidogenesis: relevance to neurosteroid actions in brain and modulation by psychotropic drugs. Crit Rev Neurobiol 2004; 16: 67-74. (Pubitemid 39586904)
    • (2004) Critical Reviews in Neurobiology , vol.16 , Issue.1-2 , pp. 67-74
    • Barbaccia, M.L.1
  • 8
    • 70349794459 scopus 로고    scopus 로고
    • Innate and adaptive autoimmunity directed to the central nervous system
    • Bhat R, Steinman L. Innate and adaptive autoimmunity directed to the central nervous system. Neuron 2009; 64: 123-32.
    • (2009) Neuron , vol.64 , pp. 123-132
    • Bhat, R.1    Steinman, L.2
  • 9
    • 33745591621 scopus 로고    scopus 로고
    • Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: Allopregnanolone as a proof of concept neurogenic agent
    • DOI 10.2174/156720506777632817
    • Brinton RD, Wang JM. Therapeutic potential of neurogenesis for prevention and recovery from Alzheimer's disease: allopregnanolone as a proof of concept neurogenic agent. Curr Alzheimer Res 2006; 3: 185-90. (Pubitemid 43988130)
    • (2006) Current Alzheimer Research , vol.3 , Issue.3 , pp. 185-190
    • Brinton, R.D.1    Jun, M.W.2
  • 10
    • 0038299558 scopus 로고    scopus 로고
    • Role of microRNAs in plant and animal development
    • DOI 10.1126/science.1085242
    • Carrington JC, Ambros V. Role of microRNAs in plant and animal development. Science 2003; 301: 336-8. (Pubitemid 36877060)
    • (2003) Science , vol.301 , Issue.5631 , pp. 336-338
    • Carrington, J.C.1    Ambros, V.2
  • 13
    • 70449716915 scopus 로고    scopus 로고
    • MicroRNA miR-326 regulates T(H)-17 differentiation and is associated with the pathogen-esis of multiple sclerosis
    • Du C, Liu C, Kang J, Zhao G, Ye Z, Huang S, et al. MicroRNA miR-326 regulates T(H)-17 differentiation and is associated with the pathogen-esis of multiple sclerosis. Nat Immunol 2009; 10: 1252-9.
    • (2009) Nat Immunol , vol.10 , pp. 1252-1259
    • Du, C.1    Liu, C.2    Kang, J.3    Zhao, G.4    Ye, Z.5    Huang, S.6
  • 14
    • 68949116243 scopus 로고    scopus 로고
    • Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells
    • Ellestad KK, Tsutsui S, Noorbakhsh F, Warren KG, Yong VW, Pittman QJ, et al. Early life exposure to lipopolysaccharide suppresses experimental autoimmune encephalomyelitis by promoting tolerogenic dendritic cells and regulatory T cells. J Immunol 2009; 183: 298-309.
    • (2009) J Immunol , vol.183 , pp. 298-309
    • Ellestad, K.K.1    Tsutsui, S.2    Noorbakhsh, F.3    Warren, K.G.4    Yong, V.W.5    Pittman, Q.J.6
  • 15
    • 0034104079 scopus 로고    scopus 로고
    • Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis
    • DOI 10.1002/1531-8249(200003)47:3<391::AID-ANA20>3.0.CO;2-J
    • Evangelou N, Esiri MM, Smith S, Palace J, Matthews PM. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann Neurol 2000; 47: 391-5. (Pubitemid 30141854)
    • (2000) Annals of Neurology , vol.47 , Issue.3 , pp. 391-395
    • Evangelou, N.1    Esiri, M.M.2    Smith, S.3    Palace, J.4    Matthews, P.M.5
  • 16
    • 27444448187 scopus 로고    scopus 로고
    • MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system
    • DOI 10.1007/s00415-005-5004-5
    • Filippi M, Rocca MA. MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system. J Neurol 2005; 252 (Suppl 5): v16-24. (Pubitemid 41532351)
    • (2005) Journal of Neurology , vol.252 , Issue.SUPPL. 5
    • Filippi, M.1    Rocca, M.A.2
  • 17
    • 33845787007 scopus 로고    scopus 로고
    • GABA sets the tempo for activity-dependent adult neurogenesis
    • DOI 10.1016/j.tins.2006.11.001, PII S0166223606002633
    • Ge S, Pradhan DA, Ming GL, Song H. GABA sets the tempo for activity-dependent adult neurogenesis. Trends Neurosci 2007; 30: 1-8. (Pubitemid 46001680)
    • (2007) Trends in Neurosciences , vol.30 , Issue.1 , pp. 1-8
    • Ge, S.1    Pradhan, D.A.2    Ming, G.-l.3    Song, H.4
  • 18
    • 24044550032 scopus 로고    scopus 로고
    • Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures
    • DOI 10.1016/j.neuroscience.2005.05.023, PII S0306452205005518
    • Ghoumari AM, Baulieu EE, Schumacher M. Progesterone increases oligo-dendroglial cell proliferation in rat cerebellar slice cultures. Neuroscience 2005; 135: 47-58. (Pubitemid 41219737)
    • (2005) Neuroscience , vol.135 , Issue.1 , pp. 47-58
    • Ghoumari, A.M.1    Baulieu, E.E.2    Schumacher, M.3
  • 20
    • 73449092476 scopus 로고    scopus 로고
    • Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels
    • Giatti S, D'Intino G, Maschi O, Pesaresi M, Garcia-Segura LM, Calza L, et al. Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels. Neurochem Int 2010; 56: 118-27.
    • (2010) Neurochem Int , vol.56 , pp. 118-127
    • Giatti, S.1    D'Intino, G.2    Maschi, O.3    Pesaresi, M.4    Garcia-Segura, L.M.5    Calza, L.6
  • 22
    • 3142774112 scopus 로고    scopus 로고
    • Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone
    • DOI 10.1038/nm1073
    • Griffin LD, Gong W, Verot L, Mellon SH. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnano-lone. Nat Med 2004; 10: 704-11. (Pubitemid 38937635)
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 704-711
    • Griffin, L.D.1    Gong, W.2    Verot, L.3    Mellon, S.H.4
  • 23
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010; 466: 835-40.
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 25
    • 63349094897 scopus 로고    scopus 로고
    • Alterations of the microRNA network cause neurodegenerative disease
    • Hebert SS, De Strooper B. Alterations of the microRNA network cause neurodegenerative disease. Trends Neurosci 2009; 32: 199-206.
    • (2009) Trends Neurosci , vol.32 , pp. 199-206
    • Hebert, S.S.1    De Strooper, B.2
  • 27
    • 34548639993 scopus 로고    scopus 로고
    • Neurosteroid binding sites on GABAA receptors
    • DOI 10.1016/j.pharmthera.2007.03.011, PII S0163725807000733, Neurosteroids Special Issue
    • Hosie AM, Wilkins ME, Smart TG. Neurosteroid binding sites on GABA(A) receptors. Pharmacol Ther 2007; 116: 7-19. (Pubitemid 47398919)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.1 , pp. 7-19
    • Hosie, A.M.1    Wilkins, M.E.2    Smart, T.G.3
  • 30
    • 0029665318 scopus 로고    scopus 로고
    • GABAA receptor pharmacology
    • Johnston GA. GABAA receptor pharmacology. Pharmacol Ther 1996; 69: 173-98.
    • (1996) Pharmacol Ther , vol.69 , pp. 173-198
    • Johnston, G.A.1
  • 31
    • 72649095061 scopus 로고    scopus 로고
    • MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47
    • Junker A, Krumbholz M, Eisele S, Mohan H, Augstein F, Bittner R, et al. MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47. Brain 2009; 132 (Pt 12): 3342-52.
    • (2009) Brain , vol.132 , Issue.PART 12 , pp. 3342-3352
    • Junker, A.1    Krumbholz, M.2    Eisele, S.3    Mohan, H.4    Augstein, F.5    Bittner, R.6
  • 33
    • 77149132365 scopus 로고    scopus 로고
    • Multiple sclerosis: MicroRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls
    • Keller A, Leidinger P, Lange J, Borries A, Schroers H, Scheffler M, et al. Multiple sclerosis: microRNA expression profiles accurately differentiate patients with relapsing-remitting disease from healthy controls. PLoS One 2009; 4: e7440.
    • (2009) PLoS One , vol.4
    • Keller, A.1    Leidinger, P.2    Lange, J.3    Borries, A.4    Schroers, H.5    Scheffler, M.6
  • 35
    • 33748928159 scopus 로고    scopus 로고
    • The diverse functions of microRNAs in animal development and disease
    • DOI 10.1016/j.devcel.2006.09.009, PII S1534580706004023
    • Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-50. (Pubitemid 44430905)
    • (2006) Developmental Cell , vol.11 , Issue.4 , pp. 441-450
    • Kloosterman, W.P.1    Plasterk, R.H.A.2
  • 37
    • 0033821412 scopus 로고    scopus 로고
    • Assessment of ganaxolone's anticonvulsant activity using a randomized, double-blind, presurgical trial design
    • Ganaxolone Presurgical Study Group
    • Laxer K, Blum D, Abou-Khalil BW, Morrell MJ, Lee DA, Data JL, et al. Assessment of ganaxolone's anticonvulsant activity using a randomized, double-blind, presurgical trial design. Ganaxolone Presurgical Study Group. Epilepsia 2000; 41: 1187-94.
    • (2000) Epilepsia , vol.41 , pp. 1187-1194
    • Laxer, K.1    Blum, D.2    Abou-Khalil, B.W.3    Morrell, M.J.4    Lee, D.A.5    Data, J.L.6
  • 39
    • 3042653294 scopus 로고    scopus 로고
    • Multiple sclerosis as a generalized CNS disease - Comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS
    • DOI 10.1016/j.jneuroim.2004.03.011, PII S0165572804001134
    • Lindberg RL, De Groot CJ, Certa U, Ravid R, Hoffmann F, Kappos L, et al. Multiple sclerosis as a generalized CNS disease-comparative microarray analysis of normal appearing white matter and lesions in secondary progressive MS. J Neuroimmunol 2004; 152: 154-67. (Pubitemid 38829713)
    • (2004) Journal of Neuroimmunology , vol.152 , Issue.1-2 , pp. 154-167
    • Lindberg, R.L.P.1    De Groot, C.J.A.2    Certa, U.3    Ravid, R.4    Hoffmann, F.5    Kappos, L.6    Leppert, D.7
  • 42
    • 0347627643 scopus 로고    scopus 로고
    • Actions of progesterone and its 5α-reduced metabolites on the major proteins of the myelin of the peripheral nervous system
    • DOI 10.1016/S0039-128X(03)00134-X
    • Martini L, Magnaghi V, Melcangi RC. Actions of progesterone and its 5alpha-reduced metabolites on the major proteins of the myelin of the peripheral nervous system. Steroids 2003; 68: 825-9. (Pubitemid 37532406)
    • (2003) Steroids , vol.68 , Issue.10-13 , pp. 825-829
    • Martini, L.1    Magnaghi, V.2    Melcangi, R.C.3
  • 43
    • 34548563903 scopus 로고    scopus 로고
    • Neurosteroid regulation of central nervous system development
    • DOI 10.1016/j.pharmthera.2007.04.011, PII S016372580700109X, Neurosteroids Special Issue
    • Mellon SH. Neurosteroid regulation of central nervous system development. Pharmacol Ther 2007; 116: 107-24. (Pubitemid 47391034)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.1 , pp. 107-124
    • Mellon, S.H.1
  • 44
    • 0036133869 scopus 로고    scopus 로고
    • Neurosteroids: Biochemistry and clinical significance
    • DOI 10.1016/S1043-2760(01)00503-3, PII S1043276001005033
    • Mellon SH, Griffin LD. Neurosteroids: biochemistry and clinical significance. Trends Endocrinol Metab 2002; 13: 35-43. (Pubitemid 36734014)
    • (2002) Trends in Endocrinology and Metabolism , vol.13 , Issue.1 , pp. 35-43
    • Mellon, S.H.1    Griffin, L.D.2
  • 45
    • 1642512297 scopus 로고    scopus 로고
    • Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis
    • DOI 10.1007/s00415-003-0243-9
    • Miller DH, Thompson AJ, Filippi M. Magnetic resonance studies of abnormalities in the normal appearing white matter and grey matter in multiple sclerosis. J Neurol 2003; 250: 1407-19. (Pubitemid 38121836)
    • (2003) Journal of Neurology , vol.250 , Issue.12 , pp. 1407-1419
    • Miller, D.H.1    Thompson, A.J.2    Filippi, M.3
  • 46
    • 58949094360 scopus 로고    scopus 로고
    • Deciphering complex mechanisms in neurodegenerative diseases: The advent of systems biology
    • Noorbakhsh F, Overall CM, Power C. Deciphering complex mechanisms in neurodegenerative diseases: the advent of systems biology. Trends Neurosci 2009; 32: 88-100.
    • (2009) Trends Neurosci , vol.32 , pp. 88-100
    • Noorbakhsh, F.1    Overall, C.M.2    Power, C.3
  • 47
    • 77953489202 scopus 로고    scopus 로고
    • MicroRNA profiling reveals new aspects of HIV neuro-degeneration: Caspase-6 regulates astrocyte survival
    • Noorbakhsh F, Ramachandran R, Barsby N, Ellestad KK, Leblanc A, Dickie P, et al. MicroRNA profiling reveals new aspects of HIV neuro-degeneration: caspase-6 regulates astrocyte survival. FASEB J 2010; 24: 1799-812.
    • (2010) FASEB J , vol.24 , pp. 1799-1812
    • Noorbakhsh, F.1    Ramachandran, R.2    Barsby, N.3    Ellestad, K.K.4    Leblanc, A.5    Dickie, P.6
  • 52
    • 0034287545 scopus 로고    scopus 로고
    • Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: Functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones
    • Penning TM, Burczynski ME, Jez JM, Hung CF, Lin HK, Ma H, et al. Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones. Biochem J 2000; 351 (Pt 1): 67-77.
    • (2000) Biochem J , vol.351 , Issue.PART 1 , pp. 67-77
    • Penning, T.M.1    Burczynski, M.E.2    Jez, J.M.3    Hung, C.F.4    Lin, H.K.5    Ma, H.6
  • 53
    • 35148899318 scopus 로고    scopus 로고
    • Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy
    • DOI 10.1111/j.1528-1167.2007.01182.x
    • Pieribone VA, Tsai J, Soufflet C, Rey E, Shaw K, Giller E, et al. Clinical evaluation of ganaxolone in pediatric and adolescent patients with refractory epilepsy. Epilepsia 2007; 48: 1870-4. (Pubitemid 47537451)
    • (2007) Epilepsia , vol.48 , Issue.10 , pp. 1870-1874
    • Pieribone, V.A.1    Tsai, J.2    Soufflet, C.3    Rey, E.4    Shaw, K.5    Giller, E.6    Dulac, O.7
  • 55
    • 71749092463 scopus 로고    scopus 로고
    • MicroRNAs: Novel therapeutic targets in neurodegenerative diseases
    • Roshan R, Ghosh T, Scaria V, Pillai B. MicroRNAs: novel therapeutic targets in neurodegenerative diseases. Drug Discov Today 2009; 14: 1123-9.
    • (2009) Drug Discov Today , vol.14 , pp. 1123-1129
    • Roshan, R.1    Ghosh, T.2    Scaria, V.3    Pillai, B.4
  • 56
    • 0033198566 scopus 로고    scopus 로고
    • Neuroactive steroids: Mechanisms of action and neuropsychopharmacological perspectives
    • DOI 10.1016/S0166-2236(99)01399-5, PII S0166223699013995
    • Rupprecht R, Holsboer F. Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 1999; 22: 410-6. (Pubitemid 29453646)
    • (1999) Trends in Neurosciences , vol.22 , Issue.9 , pp. 410-416
    • Rupprecht, R.1    Holsboer, F.2
  • 57
    • 0037023245 scopus 로고    scopus 로고
    • Dendritic spine formation in response to progesterone synthesized de novo in the developing Purkinje cell in rats
    • PII S0304394002000770
    • Sakamoto H, Ukena K, Tsutsui K. Dendritic spine formation in response to progesterone synthesized de novo in the developing Purkinje cell in rats. Neurosci Lett 2002; 322: 111-5. (Pubitemid 34212033)
    • (2002) Neuroscience Letters , vol.322 , Issue.2 , pp. 111-115
    • Sakamoto, H.1    Ukena, K.2    Tsutsui, K.3
  • 59
    • 45849126771 scopus 로고    scopus 로고
    • Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission
    • Sedlacek M, Korinek M, Petrovic M, Cais O, Adamusova E, Chodounska H, et al. Neurosteroid modulation of ionotropic glutamate receptors and excitatory synaptic transmission. Physiol Res 2008; 57 (Suppl 3): S49-57.
    • (2008) Physiol Res , vol.57 , Issue.SUPPL. 3
    • Sedlacek, M.1    Korinek, M.2    Petrovic, M.3    Cais, O.4    Adamusova, E.5    Chodounska, H.6
  • 60
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • DOI 10.1146/annurev.immunol.23.021704.115707
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23: 683-747. (Pubitemid 40563183)
    • (2005) Annual Review of Immunology , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 61
    • 48249139449 scopus 로고    scopus 로고
    • Multiple sclerosis: An immune or neurodegenerative disorder?
    • Trapp BD, Nave KA. Multiple sclerosis: an immune or neurodegenerative disorder? Annu Rev Neurosci 2008; 31: 247-69.
    • (2008) Annu Rev Neurosci , vol.31 , pp. 247-269
    • Trapp, B.D.1    Nave, K.A.2
  • 62
    • 1242336753 scopus 로고    scopus 로고
    • A1 Adenosine Receptor Upregulation and Activation Attenuates Neuroinflammation and Demyelination in a Model of Multiple Sclerosis
    • DOI 10.1523/JNEUROSCI.4271-03.2004
    • Tsutsui S, Schnermann J, Noorbakhsh F, Henry S, Yong VW, Winston BW, et al. A1 adenosine receptor upregulation and activation attenuates neuroinflammation and demyelination in a model of multiple sclerosis. J Neurosci 2004; 24: 1521-9. (Pubitemid 38223004)
    • (2004) Journal of Neuroscience , vol.24 , Issue.6 , pp. 1521-1529
    • Tsutsui, S.1    Schnermann, J.2    Noorbakhsh, F.3    Henry, S.4    Yong, V.W.5    Winston, B.W.6    Warren, K.7    Power, C.8
  • 63
    • 67049099173 scopus 로고    scopus 로고
    • Preactive lesions in multiple sclerosis
    • van der Valk P, Amor S. Preactive lesions in multiple sclerosis. Curr Opin Neurol 2009; 22: 207-13.
    • (2009) Curr Opin Neurol , vol.22 , pp. 207-213
    • Van Der Valk, P.1    Amor, S.2
  • 64
    • 0037606195 scopus 로고    scopus 로고
    • A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13
    • DOI 10.1194/jlr.M200399-JLR200
    • Vergnes L, Phan J, Stolz A, Reue K. A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13. J Lipid Res 2003; 44: 503-11. (Pubitemid 37287563)
    • (2003) Journal of Lipid Research , vol.44 , Issue.3 , pp. 503-511
    • Vergnes, L.1    Phan, J.2    Stolz, A.3    Reue, K.4
  • 65
    • 18644371723 scopus 로고    scopus 로고
    • The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression
    • DOI 10.1523/JNEUROSCI.4520-04.2005
    • Wang JM, Johnston PB, Ball BG, Brinton RD. The neurosteroid allopreg-nanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression. J Neurosci 2005; 25: 4706-18. (Pubitemid 40664119)
    • (2005) Journal of Neuroscience , vol.25 , Issue.19 , pp. 4706-4718
    • Wang, J.M.1    Johnston, P.B.2    Ball, B.G.3    Brinton, R.D.4
  • 66
    • 40749139886 scopus 로고    scopus 로고
    • Regenerative potential of allopregnanolone
    • DOI 10.1016/j.brainresrev.2007.08.010, PII S0165017307001890
    • Wang JM, Liu L, Irwin RW, Chen S, Brinton RD. Regenerative potential of allopregnanolone. Brain Res Rev 2008a; 57: 398-409. (Pubitemid 351381778)
    • (2008) Brain Research Reviews , vol.57 , Issue.2 , pp. 398-409
    • Wang, J.M.1    Liu, L.2    Irwin, R.W.3    Chen, S.4    Brinton, R.D.5
  • 67
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1
    • DOI 10.1523/JNEUROSCI.5065-07.2008
    • Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 2008b; 28: 1213-23. (Pubitemid 351186356)
    • (2008) Journal of Neuroscience , vol.28 , Issue.5 , pp. 1213-1223
    • Wang, W.-X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6    Rigoutsos, I.7    Nelson, P.T.8
  • 68
    • 63149148210 scopus 로고    scopus 로고
    • Short non-coding RNA biology and neurode-generative disorders: Novel disease targets and therapeutics
    • Weinberg MS, Wood MJ. Short non-coding RNA biology and neurode-generative disorders: novel disease targets and therapeutics. Hum Mol Genet 2009; 18: R27-39.
    • (2009) Hum Mol Genet , vol.18
    • Weinberg, M.S.1    Wood, M.J.2
  • 69
    • 77649177200 scopus 로고    scopus 로고
    • Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice
    • Zhang Z, Yang R, Zhou R, Li L, Sokabe M, Chen L. Progesterone promotes the survival of newborn neurons in the dentate gyrus of adult male mice. Hippocampus 2010; 20: 402-12.
    • (2010) Hippocampus , vol.20 , pp. 402-412
    • Zhang, Z.1    Yang, R.2    Zhou, R.3    Li, L.4    Sokabe, M.5    Chen, L.6
  • 70
    • 70349349151 scopus 로고    scopus 로고
    • CXCR3 activation by lentivirus infection suppresses neuronal autophagy: Neuroprotective effects of antiretroviral therapy
    • Zhu Y, Vergote D, Pardo C, Noorbakhsh F, McArthur JC, Hollenberg MD, et al. CXCR3 activation by lentivirus infection suppresses neuronal autophagy: neuroprotective effects of antiretroviral therapy. FASEB J 2009; 23: 2928-41.
    • (2009) FASEB J , vol.23 , pp. 2928-2941
    • Zhu, Y.1    Vergote, D.2    Pardo, C.3    Noorbakhsh, F.4    McArthur, J.C.5    Hollenberg, M.D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.