메뉴 건너뛰기




Volumn 56, Issue 1, 2010, Pages 118-127

Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels

Author keywords

Central nervous system; GABA A receptor; Liquid chromatography tandem mass spectrometry; Multiple sclerosis; Neurosteroids; Pregnenolone; Progesterone; Rat; Steroid metabolism; Testosterone

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; NEUROSTEROID; PREGNENOLONE; PROGESTERONE; STEROID; TESTOSTERONE;

EID: 73449092476     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2009.09.009     Document Type: Article
Times cited : (58)

References (85)
  • 1
    • 0035936944 scopus 로고    scopus 로고
    • Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism
    • Ahlbom E., Prins G.S., and Ceccatelli S. Testosterone protects cerebellar granule cells from oxidative stress-induced cell death through a receptor mediated mechanism. Brain Res. 892 (2001) 255-262
    • (2001) Brain Res. , vol.892 , pp. 255-262
    • Ahlbom, E.1    Prins, G.S.2    Ceccatelli, S.3
  • 2
    • 16244372059 scopus 로고    scopus 로고
    • Isoallopregnanolone; an antagonist to the anaesthetic effect of allopregnanolone in male rats
    • Backstrom T., Wahlstrom G., Wahlstrom K., Zhu D., and Wang M.D. Isoallopregnanolone; an antagonist to the anaesthetic effect of allopregnanolone in male rats. Eur. J. Pharmacol. 512 (2005) 15-21
    • (2005) Eur. J. Pharmacol. , vol.512 , pp. 15-21
    • Backstrom, T.1    Wahlstrom, G.2    Wahlstrom, K.3    Zhu, D.4    Wang, M.D.5
  • 3
    • 59449097638 scopus 로고    scopus 로고
    • Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitis
    • Barnard A.L., Chidgey A.P., Bernard C.C., and Boyd R.L. Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitis. Blood 113 (2009) 204-213
    • (2009) Blood , vol.113 , pp. 204-213
    • Barnard, A.L.1    Chidgey, A.P.2    Bernard, C.C.3    Boyd, R.L.4
  • 4
    • 34249994344 scopus 로고    scopus 로고
    • Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone
    • Barreto G., Veiga S., Azcoitia I., Garcia-Segura L.M., and Garcia-Ovejero D. Testosterone decreases reactive astroglia and reactive microglia after brain injury in male rats: role of its metabolites, oestradiol and dihydrotestosterone. Eur. J. Neurosci. 25 (2007) 3039-3046
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 3039-3046
    • Barreto, G.1    Veiga, S.2    Azcoitia, I.3    Garcia-Segura, L.M.4    Garcia-Ovejero, D.5
  • 5
    • 35549010987 scopus 로고    scopus 로고
    • The origin and application of experimental autoimmune encephalomyelitis
    • Baxter A.G. The origin and application of experimental autoimmune encephalomyelitis. Nat. Rev. Immunol. 7 (2007) 904-912
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 904-912
    • Baxter, A.G.1
  • 6
    • 0025918687 scopus 로고
    • Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor
    • Bitran D., Hilvers R.J., and Kellogg C.K. Anxiolytic effects of 3 alpha-hydroxy-5 alpha[beta]-pregnan-20-one: endogenous metabolites of progesterone that are active at the GABAA receptor. Brain Res. 561 (1991) 157-161
    • (1991) Brain Res. , vol.561 , pp. 157-161
    • Bitran, D.1    Hilvers, R.J.2    Kellogg, C.K.3
  • 9
    • 0030915317 scopus 로고    scopus 로고
    • Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis
    • Calza L., Giardino L., Pozza M., Micera A., and Aloe L. Time-course changes of nerve growth factor, corticotropin-releasing hormone, and nitric oxide synthase isoforms and their possible role in the development of inflammatory response in experimental allergic encephalomyelitis. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 3368-3373
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 3368-3373
    • Calza, L.1    Giardino, L.2    Pozza, M.3    Micera, A.4    Aloe, L.5
  • 10
    • 38349123293 scopus 로고    scopus 로고
    • Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes
    • Caruso D., Scurati S., Maschi O., De Angelis L., Roglio I., Giatti S., Garcia-Segura L.M., and Melcangi R.C. Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes. Neurochem. Int. 52 (2008) 560-568
    • (2008) Neurochem. Int. , vol.52 , pp. 560-568
    • Caruso, D.1    Scurati, S.2    Maschi, O.3    De Angelis, L.4    Roglio, I.5    Giatti, S.6    Garcia-Segura, L.M.7    Melcangi, R.C.8
  • 11
    • 0742272125 scopus 로고    scopus 로고
    • Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo
    • Ciriza I., Azcoitia I., and Garcia-Segura L.M. Reduced progesterone metabolites protect rat hippocampal neurones from kainic acid excitotoxicity in vivo. J. Neuroendocrinol. 16 (2004) 58-63
    • (2004) J. Neuroendocrinol. , vol.16 , pp. 58-63
    • Ciriza, I.1    Azcoitia, I.2    Garcia-Segura, L.M.3
  • 12
    • 33747099290 scopus 로고    scopus 로고
    • Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective
    • Ciriza I., Carrero P., Frye C.A., and Garcia-Segura L.M. Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective. J. Neurobiol. 66 (2006) 916-928
    • (2006) J. Neurobiol. , vol.66 , pp. 916-928
    • Ciriza, I.1    Carrero, P.2    Frye, C.A.3    Garcia-Segura, L.M.4
  • 13
    • 0035987826 scopus 로고    scopus 로고
    • Testosterone treatment attenuates the effects of facial nerve transection on glial fibrillary acidic protein (GFAP) levels in the hamster facial motor nucleus
    • Coers S., Tanzer L., and Jones K.J. Testosterone treatment attenuates the effects of facial nerve transection on glial fibrillary acidic protein (GFAP) levels in the hamster facial motor nucleus. Metab. Brain Dis. 17 (2002) 55-63
    • (2002) Metab. Brain Dis. , vol.17 , pp. 55-63
    • Coers, S.1    Tanzer, L.2    Jones, K.J.3
  • 14
    • 0037379402 scopus 로고    scopus 로고
    • Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process
    • Confavreux C., Vukusic S., and Adeleine P. Early clinical predictors and progression of irreversible disability in multiple sclerosis: an amnesic process. Brain 126 (2003) 770-782
    • (2003) Brain , vol.126 , pp. 770-782
    • Confavreux, C.1    Vukusic, S.2    Adeleine, P.3
  • 15
    • 0031179506 scopus 로고    scopus 로고
    • Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response
    • Dalal M., Kim S., and Voskuhl R.R. Testosterone therapy ameliorates experimental autoimmune encephalomyelitis and induces a T helper 2 bias in the autoantigen-specific T lymphocyte response. J. Immunol. 159 (1997) 3-6
    • (1997) J. Immunol. , vol.159 , pp. 3-6
    • Dalal, M.1    Kim, S.2    Voskuhl, R.R.3
  • 16
  • 17
    • 0034332969 scopus 로고    scopus 로고
    • Female sex steroids: effects upon microglial cell activation
    • Drew P.D., and Chavis J.A. Female sex steroids: effects upon microglial cell activation. J. Neuroimmunol. 111 (2000) 77-85
    • (2000) J. Neuroimmunol. , vol.111 , pp. 77-85
    • Drew, P.D.1    Chavis, J.A.2
  • 18
    • 33845528763 scopus 로고    scopus 로고
    • Serum levels of soluble CD95 are not associated with amelioration of multiple sclerosis during pregnancy
    • Ehrlich S., Haas J., Zipp F., and Infante-Duarte C. Serum levels of soluble CD95 are not associated with amelioration of multiple sclerosis during pregnancy. J. Neurol. Sci. 252 (2007) 83-87
    • (2007) J. Neurol. Sci. , vol.252 , pp. 83-87
    • Ehrlich, S.1    Haas, J.2    Zipp, F.3    Infante-Duarte, C.4
  • 20
    • 18844429202 scopus 로고    scopus 로고
    • Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands
    • Elloso M.M., Phiel K., Henderson R.A., Harris H.A., and Adelman S.J. Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands. J. Endocrinol. 185 (2005) 243-252
    • (2005) J. Endocrinol. , vol.185 , pp. 243-252
    • Elloso, M.M.1    Phiel, K.2    Henderson, R.A.3    Harris, H.A.4    Adelman, S.J.5
  • 23
    • 0038643772 scopus 로고    scopus 로고
    • Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis
    • Foster S.C., Daniels C., Bourdette D.N., and Bebo Jr. B.F. Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis. J. Neuroimmunol. 140 (2003) 78-87
    • (2003) J. Neuroimmunol. , vol.140 , pp. 78-87
    • Foster, S.C.1    Daniels, C.2    Bourdette, D.N.3    Bebo Jr., B.F.4
  • 24
    • 54249124952 scopus 로고    scopus 로고
    • Remyelination in the CNS: from biology to therapy
    • Franklin R.J., and Ffrench-Constant C. Remyelination in the CNS: from biology to therapy. Nat. Rev. Neurosci. 9 (2008) 839-855
    • (2008) Nat. Rev. Neurosci. , vol.9 , pp. 839-855
    • Franklin, R.J.1    Ffrench-Constant, C.2
  • 25
    • 54149103046 scopus 로고    scopus 로고
    • Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
    • Frye C.A., Koonce C.J., Edinger K.L., Osborne D.M., and Walf A.A. Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice. Horm. Behav. 54 (2008) 726-734
    • (2008) Horm. Behav. , vol.54 , pp. 726-734
    • Frye, C.A.1    Koonce, C.J.2    Edinger, K.L.3    Osborne, D.M.4    Walf, A.A.5
  • 26
    • 0030248197 scopus 로고    scopus 로고
    • Behavioral effects of 3 alpha-androstanediol. I. Modulation of sexual receptivity and promotion of GABA-stimulated chloride flux
    • Frye C.A., Van Keuren K.R., and Erskine M.S. Behavioral effects of 3 alpha-androstanediol. I. Modulation of sexual receptivity and promotion of GABA-stimulated chloride flux. Behav. Brain Res. 79 (1996) 109-118
    • (1996) Behav. Brain Res. , vol.79 , pp. 109-118
    • Frye, C.A.1    Van Keuren, K.R.2    Erskine, M.S.3
  • 27
    • 0035542992 scopus 로고    scopus 로고
    • Progesterone and the oligodendroglial lineage: stage-dependent biosynthesis and metabolism
    • Gago N., Akwa Y., Sananes N., Guennoun R., Baulieu E.E., El-Etr M., and Schumacher M. Progesterone and the oligodendroglial lineage: stage-dependent biosynthesis and metabolism. Glia 36 (2001) 295-308
    • (2001) Glia , vol.36 , pp. 295-308
    • Gago, N.1    Akwa, Y.2    Sananes, N.3    Guennoun, R.4    Baulieu, E.E.5    El-Etr, M.6    Schumacher, M.7
  • 31
    • 0027520373 scopus 로고
    • Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury
    • Garcia-Estrada J., Del Rio J.A., Luquin S., Soriano E., and Garcia-Segura L.M. Gonadal hormones down-regulate reactive gliosis and astrocyte proliferation after a penetrating brain injury. Brain Res. 628 (1993) 271-278
    • (1993) Brain Res. , vol.628 , pp. 271-278
    • Garcia-Estrada, J.1    Del Rio, J.A.2    Luquin, S.3    Soriano, E.4    Garcia-Segura, L.M.5
  • 32
    • 4043163411 scopus 로고    scopus 로고
    • Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis
    • Garidou L., Laffont S., Douin-Echinard V., Coureau C., Krust A., Chambon P., and Guery J.C. Estrogen receptor alpha signaling in inflammatory leukocytes is dispensable for 17beta-estradiol-mediated inhibition of experimental autoimmune encephalomyelitis. J. Immunol. 173 (2004) 2435-2442
    • (2004) J. Immunol. , vol.173 , pp. 2435-2442
    • Garidou, L.1    Laffont, S.2    Douin-Echinard, V.3    Coureau, C.4    Krust, A.5    Chambon, P.6    Guery, J.C.7
  • 33
    • 0023681634 scopus 로고
    • Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action
    • Gee K.W., Bolger M.B., Brinton R.E., Coirini H., and McEwen B.S. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. 246 (1988) 803-812
    • (1988) J. Pharmacol. Exp. Ther. , vol.246 , pp. 803-812
    • Gee, K.W.1    Bolger, M.B.2    Brinton, R.E.3    Coirini, H.4    McEwen, B.S.5
  • 34
    • 24044550032 scopus 로고    scopus 로고
    • Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures
    • Ghoumari A.M., Baulieu E.E., and Schumacher M. Progesterone increases oligodendroglial cell proliferation in rat cerebellar slice cultures. Neuroscience 135 (2005) 47-58
    • (2005) Neuroscience , vol.135 , pp. 47-58
    • Ghoumari, A.M.1    Baulieu, E.E.2    Schumacher, M.3
  • 36
    • 33746729791 scopus 로고    scopus 로고
    • Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research
    • Gold R., Linington C., and Lassmann H. Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. Brain 129 (2006) 1953-1971
    • (2006) Brain , vol.129 , pp. 1953-1971
    • Gold, R.1    Linington, C.2    Lassmann, H.3
  • 37
    • 0035006622 scopus 로고    scopus 로고
    • Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons
    • Hammond J., Le Q., Goodyer C., Gelfand M., Trifiro M., and LeBlanc A. Testosterone-mediated neuroprotection through the androgen receptor in human primary neurons. J. Neurochem. 77 (2001) 1319-1326
    • (2001) J. Neurochem. , vol.77 , pp. 1319-1326
    • Hammond, J.1    Le, Q.2    Goodyer, C.3    Gelfand, M.4    Trifiro, M.5    LeBlanc, A.6
  • 38
    • 0032788240 scopus 로고    scopus 로고
    • Benign multiple sclerosis? Clinical course, long term follow up, and assessment of prognostic factors
    • Hawkins S.A., and McDonnell G.V. Benign multiple sclerosis? Clinical course, long term follow up, and assessment of prognostic factors. J. Neurol. Neurosurg. Psychiatry 67 (1999) 148-152
    • (1999) J. Neurol. Neurosurg. Psychiatry , vol.67 , pp. 148-152
    • Hawkins, S.A.1    McDonnell, G.V.2
  • 39
    • 0023265037 scopus 로고
    • A quantitative immunohistochemical comparison of actively versus adoptively induced experimental allergic encephalomyelitis in the Lewis rat
    • Hickey W.F., Cohen J.A., and Burns J.B. A quantitative immunohistochemical comparison of actively versus adoptively induced experimental allergic encephalomyelitis in the Lewis rat. Cell Immunol. 109 (1987) 272-281
    • (1987) Cell Immunol. , vol.109 , pp. 272-281
    • Hickey, W.F.1    Cohen, J.A.2    Burns, J.B.3
  • 40
    • 0034800706 scopus 로고    scopus 로고
    • Divergent effects of ovarian steroids on neuronal survival during experimental allergic encephalitis in Lewis rats
    • Hoffman G.E., Le W.W., Murphy A.Z., and Koski C.L. Divergent effects of ovarian steroids on neuronal survival during experimental allergic encephalitis in Lewis rats. Exp. Neurol. 171 (2001) 272-284
    • (2001) Exp. Neurol. , vol.171 , pp. 272-284
    • Hoffman, G.E.1    Le, W.W.2    Murphy, A.Z.3    Koski, C.L.4
  • 41
    • 33748075167 scopus 로고    scopus 로고
    • Symptoms of multiple sclerosis in women in relation to sex steroid exposure
    • Holmqvist P., Wallberg M., Hammar M., Landtblom A.M., and Brynhildsen J. Symptoms of multiple sclerosis in women in relation to sex steroid exposure. Maturitas 54 (2006) 149-153
    • (2006) Maturitas , vol.54 , pp. 149-153
    • Holmqvist, P.1    Wallberg, M.2    Hammar, M.3    Landtblom, A.M.4    Brynhildsen, J.5
  • 43
    • 0842308720 scopus 로고    scopus 로고
    • Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats
    • Ibanez C., Shields S.A., El-Etr M., Baulieu E.E., Schumacher M., and Franklin R.J. Systemic progesterone administration results in a partial reversal of the age-associated decline in CNS remyelination following toxin-induced demyelination in male rats. Neuropathol. Appl. Neurobiol. 30 (2004) 80-89
    • (2004) Neuropathol. Appl. Neurobiol. , vol.30 , pp. 80-89
    • Ibanez, C.1    Shields, S.A.2    El-Etr, M.3    Baulieu, E.E.4    Schumacher, M.5    Franklin, R.J.6
  • 44
    • 0033567837 scopus 로고    scopus 로고
    • Androgenic regulation of the central glia response following nerve damage
    • Jones K.J., Coers S., Storer P.D., Tanzer L., and Kinderman N.B. Androgenic regulation of the central glia response following nerve damage. J. Neurobiol. 40 (1999) 560-573
    • (1999) J. Neurobiol. , vol.40 , pp. 560-573
    • Jones, K.J.1    Coers, S.2    Storer, P.D.3    Tanzer, L.4    Kinderman, N.B.5
  • 45
    • 0030773788 scopus 로고    scopus 로고
    • Alterations in glial fibrillary acidic protein (GFAP) mRNA levels in the hamster facial motor nucleus: effects of axotomy and testosterone
    • Jones K.J., Kinderman N.B., and Oblinger M.M. Alterations in glial fibrillary acidic protein (GFAP) mRNA levels in the hamster facial motor nucleus: effects of axotomy and testosterone. Neurochem. Res. 22 (1997) 1359-1366
    • (1997) Neurochem. Res. , vol.22 , pp. 1359-1366
    • Jones, K.J.1    Kinderman, N.B.2    Oblinger, M.M.3
  • 46
    • 0032504559 scopus 로고    scopus 로고
    • Age- and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes p450scc, P450c17 and 3beta-HSD in the postnatal rat brain
    • Kohchi C., Ukena K., and Tsutsui K. Age- and region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes p450scc, P450c17 and 3beta-HSD in the postnatal rat brain. Brain Res. 801 (1998) 233-238
    • (1998) Brain Res. , vol.801 , pp. 233-238
    • Kohchi, C.1    Ukena, K.2    Tsutsui, K.3
  • 47
    • 0029091866 scopus 로고
    • Inhibition of the accelerative effects of testosterone on hamster facial nerve regeneration by the antiandrogen flutamide
    • Kujawa K.A., Tanzer L., and Jones K.J. Inhibition of the accelerative effects of testosterone on hamster facial nerve regeneration by the antiandrogen flutamide. Exp. Neurol. 133 (1995) 138-143
    • (1995) Exp. Neurol. , vol.133 , pp. 138-143
    • Kujawa, K.A.1    Tanzer, L.2    Jones, K.J.3
  • 49
    • 41949104261 scopus 로고    scopus 로고
    • Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats
    • Lewis D.K., Johnson A.B., Stohlgren S., Harms A., and Sohrabji F. Effects of estrogen receptor agonists on regulation of the inflammatory response in astrocytes from young adult and middle-aged female rats. J. Neuroimmunol. 195 (2008) 47-59
    • (2008) J. Neuroimmunol. , vol.195 , pp. 47-59
    • Lewis, D.K.1    Johnson, A.B.2    Stohlgren, S.3    Harms, A.4    Sohrabji, F.5
  • 50
    • 18844481386 scopus 로고    scopus 로고
    • Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnan-20-one (isoallopregnanolone)
    • Lundgren P., Stromberg J., Backstrom T., and Wang M. Allopregnanolone-stimulated GABA-mediated chloride ion flux is inhibited by 3beta-hydroxy-5alpha-pregnan-20-one (isoallopregnanolone). Brain Res. 982 (2003) 45-53
    • (2003) Brain Res. , vol.982 , pp. 45-53
    • Lundgren, P.1    Stromberg, J.2    Backstrom, T.3    Wang, M.4
  • 51
    • 21344431856 scopus 로고    scopus 로고
    • Oral testosterone in male rats and the development of experimental autoimmune encephalomyelitis
    • Maccio D.R., Calfa G., and Roth G.A. Oral testosterone in male rats and the development of experimental autoimmune encephalomyelitis. Neuroimmunomodulation 12 (2005) 246-254
    • (2005) Neuroimmunomodulation , vol.12 , pp. 246-254
    • Maccio, D.R.1    Calfa, G.2    Roth, G.A.3
  • 52
    • 4344655869 scopus 로고    scopus 로고
    • Serum testosterone and corticosterone levels in acute experimental autoimmune encephalomyelitis (EAE) in male Wistar rats
    • Maccio D.R., Calfa G., Volosin M., and Roth G.A. Serum testosterone and corticosterone levels in acute experimental autoimmune encephalomyelitis (EAE) in male Wistar rats. Neuroendocrinol. Lett. 25 (2004) 196-200
    • (2004) Neuroendocrinol. Lett. , vol.25 , pp. 196-200
    • Maccio, D.R.1    Calfa, G.2    Volosin, M.3    Roth, G.A.4
  • 53
    • 0442310642 scopus 로고    scopus 로고
    • Interaction between gonadal steroids and neuroimmune system in acute experimental autoimmune encephalomyelitis (EAE) in Wistar rats
    • Maccio D.R., Ditamo Y., Degano A.L., and Roth G.A. Interaction between gonadal steroids and neuroimmune system in acute experimental autoimmune encephalomyelitis (EAE) in Wistar rats. Autoimmunity 37 (2004) 17-25
    • (2004) Autoimmunity , vol.37 , pp. 17-25
    • Maccio, D.R.1    Ditamo, Y.2    Degano, A.L.3    Roth, G.A.4
  • 54
    • 17444374900 scopus 로고    scopus 로고
    • Oligodendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones
    • Marin-Husstege M., Muggironi M., Raban D., Skoff R.P., and Casaccia-Bonnefil P. Oligodendrocyte progenitor proliferation and maturation is differentially regulated by male and female sex steroid hormones. Dev. Neurosci. 26 (2004) 245-254
    • (2004) Dev. Neurosci. , vol.26 , pp. 245-254
    • Marin-Husstege, M.1    Muggironi, M.2    Raban, D.3    Skoff, R.P.4    Casaccia-Bonnefil, P.5
  • 55
    • 0037673169 scopus 로고    scopus 로고
    • 17Beta-estradiol treatment profoundly down-regulates gene expression in spinal cord tissue in mice protected from experimental autoimmune encephalomyelitis
    • Matejuk A., Dwyer J., Hopke C., Vandenbark A.A., and Offner H. 17Beta-estradiol treatment profoundly down-regulates gene expression in spinal cord tissue in mice protected from experimental autoimmune encephalomyelitis. Arch. Immunol. Ther. Exp. (Warsz) 51 (2003) 185-193
    • (2003) Arch. Immunol. Ther. Exp. (Warsz) , vol.51 , pp. 185-193
    • Matejuk, A.1    Dwyer, J.2    Hopke, C.3    Vandenbark, A.A.4    Offner, H.5
  • 56
    • 13544251736 scopus 로고    scopus 로고
    • Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy
    • Matejuk A., Hopke C., Vandenbark A.A., Hurn P.D., and Offner H. Middle-age male mice have increased severity of experimental autoimmune encephalomyelitis and are unresponsive to testosterone therapy. J. Immunol. 174 (2005) 2387-2395
    • (2005) J. Immunol. , vol.174 , pp. 2387-2395
    • Matejuk, A.1    Hopke, C.2    Vandenbark, A.A.3    Hurn, P.D.4    Offner, H.5
  • 57
    • 34249782015 scopus 로고    scopus 로고
    • Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry
    • Meffre D., Pianos A., Liere P., Eychenne B., Cambourg A., Schumacher M., Stein D.G., and Guennoun R. Steroid profiling in brain and plasma of male and pseudopregnant female rats after traumatic brain injury: analysis by gas chromatography/mass spectrometry. Endocrinology 148 (2007) 2505-2517
    • (2007) Endocrinology , vol.148 , pp. 2505-2517
    • Meffre, D.1    Pianos, A.2    Liere, P.3    Eychenne, B.4    Cambourg, A.5    Schumacher, M.6    Stein, D.G.7    Guennoun, R.8
  • 59
    • 33644534158 scopus 로고    scopus 로고
    • Neuroactive steroids: old players in a new game
    • Melcangi R.C., and Panzica G.C. Neuroactive steroids: old players in a new game. Neuroscience 138 (2006) 733-739
    • (2006) Neuroscience , vol.138 , pp. 733-739
    • Melcangi, R.C.1    Panzica, G.C.2
  • 60
    • 0027381252 scopus 로고
    • Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain
    • Mellon S.H., and Deschepper C.F. Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 629 (1993) 283-292
    • (1993) Brain Res. , vol.629 , pp. 283-292
    • Mellon, S.H.1    Deschepper, C.F.2
  • 61
    • 33845965027 scopus 로고    scopus 로고
    • Progesterone and its metabolites 5-dihydroprogesterone and 5-3-tetrahydroprogesterone decrease LPS-induced NO release in the murine microglial cell line, BV-2
    • Muller E., and Kerschbaum H.H. Progesterone and its metabolites 5-dihydroprogesterone and 5-3-tetrahydroprogesterone decrease LPS-induced NO release in the murine microglial cell line, BV-2. Neuroendocrinol. Lett. 27 (2006) 675-678
    • (2006) Neuroendocrinol. Lett. , vol.27 , pp. 675-678
    • Muller, E.1    Kerschbaum, H.H.2
  • 62
    • 63849107960 scopus 로고    scopus 로고
    • Gender and sex hormones in multiple sclerosis pathology and therapy
    • Nicot A. Gender and sex hormones in multiple sclerosis pathology and therapy. Front Biosci. 14 (2009) 4477-4515
    • (2009) Front Biosci. , vol.14 , pp. 4477-4515
    • Nicot, A.1
  • 63
    • 0037039238 scopus 로고    scopus 로고
    • Prevalence estimates for MS in the United States and evidence of an increasing trend for women
    • Noonan C.W., Kathman S.J., and White M.C. Prevalence estimates for MS in the United States and evidence of an increasing trend for women. Neurology 58 (2002) 136-138
    • (2002) Neurology , vol.58 , pp. 136-138
    • Noonan, C.W.1    Kathman, S.J.2    White, M.C.3
  • 64
    • 10644259532 scopus 로고    scopus 로고
    • Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis
    • Offner H. Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: therapeutic implications for multiple sclerosis. J. Neurosci. Res. 78 (2004) 603-624
    • (2004) J. Neurosci. Res. , vol.78 , pp. 603-624
    • Offner, H.1
  • 66
    • 1542396010 scopus 로고    scopus 로고
    • Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    • Palaszynski K.M., Liu H., Loo K.K., and Voskuhl R.R. Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J. Neuroimmunol. 149 (2004) 84-89
    • (2004) J. Neuroimmunol. , vol.149 , pp. 84-89
    • Palaszynski, K.M.1    Liu, H.2    Loo, K.K.3    Voskuhl, R.R.4
  • 67
    • 0347362902 scopus 로고    scopus 로고
    • Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    • Palaszynski K.M., Loo K.K., Ashouri J.F., Liu H.B., and Voskuhl R.R. Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J. Neuroimmunol. 146 (2004) 144-152
    • (2004) J. Neuroimmunol. , vol.146 , pp. 144-152
    • Palaszynski, K.M.1    Loo, K.K.2    Ashouri, J.F.3    Liu, H.B.4    Voskuhl, R.R.5
  • 68
    • 24144478952 scopus 로고    scopus 로고
    • Effects of sex hormones on costimulatory molecule expression in multiple sclerosis
    • Pelfrey C.M., Moldovan I.R., Cotleur A.C., Zamor N., and Rudick R.A. Effects of sex hormones on costimulatory molecule expression in multiple sclerosis. J. Neuroimmunol. 167 (2005) 190-203
    • (2005) J. Neuroimmunol. , vol.167 , pp. 190-203
    • Pelfrey, C.M.1    Moldovan, I.R.2    Cotleur, A.C.3    Zamor, N.4    Rudick, R.A.5
  • 69
    • 73049086234 scopus 로고    scopus 로고
    • Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats
    • 10.1016/j.yhbeh.2009.04.008
    • Pesaresi M., Maschi O., Giatti S., Garcia-Segura L.M., Caruso D., and Melcangi R.C. Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats. Horm. Behav. (2009) 10.1016/j.yhbeh.2009.04.008
    • (2009) Horm. Behav.
    • Pesaresi, M.1    Maschi, O.2    Giatti, S.3    Garcia-Segura, L.M.4    Caruso, D.5    Melcangi, R.C.6
  • 73
    • 56649105356 scopus 로고    scopus 로고
    • Evaluation of endocrine profile, hypothalamic-pituitary-testis axis and semen quality in multiple sclerosis
    • Safarinejad M.R. Evaluation of endocrine profile, hypothalamic-pituitary-testis axis and semen quality in multiple sclerosis. J. Neuroendocrinol. 20 (2008) 1368-1375
    • (2008) J. Neuroendocrinol. , vol.20 , pp. 1368-1375
    • Safarinejad, M.R.1
  • 77
    • 35548975206 scopus 로고    scopus 로고
    • Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment
    • Tiwari-Woodruff S., Morales L.B., Lee R., and Voskuhl R.R. Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 14813-14818
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 14813-14818
    • Tiwari-Woodruff, S.1    Morales, L.B.2    Lee, R.3    Voskuhl, R.R.4
  • 79
    • 33646592531 scopus 로고    scopus 로고
    • Sex hormones: a role in the control of multiple sclerosis?
    • Tomassini V., and Pozzilli C. Sex hormones: a role in the control of multiple sclerosis?. Expert Opin. Pharmacother. 7 (2006) 857-868
    • (2006) Expert Opin. Pharmacother. , vol.7 , pp. 857-868
    • Tomassini, V.1    Pozzilli, C.2
  • 80
    • 20144371258 scopus 로고    scopus 로고
    • The influence of sex hormones on cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis: a review
    • van den Broek H.H., Damoiseaux J.G., De Baets M.H., and Hupperts R.M. The influence of sex hormones on cytokines in multiple sclerosis and experimental autoimmune encephalomyelitis: a review. Mult. Scler. 11 (2005) 349-359
    • (2005) Mult. Scler. , vol.11 , pp. 349-359
    • van den Broek, H.H.1    Damoiseaux, J.G.2    De Baets, M.H.3    Hupperts, R.M.4
  • 81
    • 0034997562 scopus 로고    scopus 로고
    • Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis
    • Voskuhl R.R., and Palaszynski K. Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. Neuroscientist 7 (2001) 258-270
    • (2001) Neuroscientist , vol.7 , pp. 258-270
    • Voskuhl, R.R.1    Palaszynski, K.2
  • 82
    • 33644629885 scopus 로고    scopus 로고
    • Pregnancy and multiple sclerosis: the children of PRIMS
    • Vukusic S., and Confavreux C. Pregnancy and multiple sclerosis: the children of PRIMS. Clin. Neurol. Neurosurg. 108 (2006) 266-270
    • (2006) Clin. Neurol. Neurosurg. , vol.108 , pp. 266-270
    • Vukusic, S.1    Confavreux, C.2
  • 85
    • 10744230574 scopus 로고    scopus 로고
    • Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis
    • Zhang G.X., Yu S., Gran B., Li J., Siglienti I., Chen X., Calida D., Ventura E., Kamoun M., and Rostami A. Role of IL-12 receptor beta 1 in regulation of T cell response by APC in experimental autoimmune encephalomyelitis. J. Immunol. 171 (2003) 4485-4492
    • (2003) J. Immunol. , vol.171 , pp. 4485-4492
    • Zhang, G.X.1    Yu, S.2    Gran, B.3    Li, J.4    Siglienti, I.5    Chen, X.6    Calida, D.7    Ventura, E.8    Kamoun, M.9    Rostami, A.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.